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Basic Information
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CGSNL Gene Symbol
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HMA2
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Gene Symbol Synonym
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OsHMA2, osHMA2, OsHMA2v
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CGSNL Gene Name
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HEAVY METAL ATPASE 2
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Gene Name Synonym
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heavy metal ATPase 2, heavy metal transporter 2, heavy metal P-Type ATPase 2, heavy metal P1B-ATPase 2, Zn/ Cd-transporting ATPase 2
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Protein Name
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HEAVY METAL ATPASE 2
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Allele
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oshma2-1, oshma2-2, osham2-3
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Chromosome No.
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6
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Explanation
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HQ646362. AB697186. P1B-ATPase heavy-metal transporter. GO:0071577:zinc ion transmembrane transport. TO:0006059: cadmium concentration
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Trait Class
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Tolerance and resistance
Tolerance and resistance - Stress tolerance
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Expression
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Sequence/Locus
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cDNA Accession No.
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AK107235
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MSU ID
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LOC_Os06g48720.1
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RAP ID
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Os06g0700700
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Links
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Oryzabase Chromosome View
(
IRGSP 1.0
/
Build5
)
RAP-DB
(
IRGSP 1.0
/
Build5
)
Related IDs List (
IRGSP 1.0
/
Build5
)
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INSD Accession List
(Test version)
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-
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Map
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Locate(cM)
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Link map
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Classical linkage map
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References
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Shahzad M., Peng D., Khan A., Ayyaz A., Askri S.M.H., Naz S., Huang B., Zhang G.
Ecotoxicol. Environ. Saf. 2024 288 117386
Sufficient manganese supply is necessary for OsNramp5 knockout rice plants to ensure normal growth and less Cd uptake.
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Tuiwong P., Cho H.K., Rouached H., Prom-U-Thai C.
Plants (Basel) 2024 13(23)
Synergistic Effects of Nitrogen and Zinc Foliar Application on Yield and Nutrient Accumulation in Rice at Various Growth Stages.
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Zhu J., Li J., Hu X., Wang J., Fang J., Wang S., Shou H.
J. Exp. Bot. 2024 75(3) 1112-1127
Role of transcription factor complex OsbHLH156-OsIRO2 in regulating manganese, copper, and zinc transporters in rice.
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Zhang J., Zhu Y., Yu L., Yang M., Zou X., Yin C., Lin Y.
Cells 2022 11(3)
Research Advances in Cadmium Uptake, Transport and Resistance in Rice (<i>Oryza sativa</i> L.).
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Chen Q., Hu Y., Yang L., Zhu B., Luo F.
Curr Issues Mol Biol 2022 44(9) 4070-4086
Phosphorus Regulates the Level of Signaling Molecules in Rice to Reduce Cadmium Toxicity.
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Ma C., Hao Y., Zhao J., Zuverza-Mena N., Meselhy A.G., Dhankher O.P., Rui Y., White J.C., Xing B.
Nanomaterials (Basel) 2021 11(4)
Graphitic Carbon Nitride (C3N4) Reduces Cadmium and Arsenic Phytotoxicity and Accumulation in Rice (<i>Oryza sativa</i> L.).
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Gao Q., Liu L., Zhou H., Liu X., Li W., Min Y., Yan Y., Ji J., Zhang H., Zhao X.
Int J Mol Sci 2021 22(22)
Mutation in <i>OsFWL7</i> Affects Cadmium and Micronutrient Metal Accumulation in Rice.
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Maghrebi M., Baldoni E., Lucchini G., Vigani G., Valè G., Sacchi G.A., Nocito F.F.
Plants (Basel) 2021 10(4)
Analysis of Cadmium Root Retention for Two Contrasting Rice Accessions Suggests an Important Role for <i>OsHMA2</i>.
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Guo J., Zhang X., Ye D., Huang H., Wang Y., Zheng Z., Li T., Yu H.
Ecotoxicol. Environ. Saf. 2020 205 111323
Crucial roles of cadmium retention in nodeⅡ for restraining cadmium transport from straw to ear at reproductive period in a grain low-cadmium rice line (Oryza sativa L.).
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Treesubsuntorn C., Thiravetyan P.
Plant Biol (Stuttg) 2019 21(5) 862-872
Calcium acetate-induced reduction of cadmium accumulation in Oryza sativa: Expression of auto-inhibited calcium-ATPase and cadmium transporters.
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Ding Y., Gong S., Wang Y., Wang F., Bao H., Sun J., Cai C., Yi K., Chen Z., Zhu C.
Plant Physiol. 2018 177(4) 1691-1703
MicroRNA166 Modulates Cadmium Tolerance and Accumulation in Rice.
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Shao J.F., Xia J., Yamaji N., Shen R.F., Ma J.F.
J. Exp. Bot. 2018 69(10) 2743-2752
Effective reduction of cadmium accumulation in rice grain by expressing OsHMA3 under the control of the OsHMA2 promoter.
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Ding Y., Ye Y., Jiang Z., Wang Y., Zhu C.
Front Plant Sci 2016 7 235
MicroRNA390 Is Involved in Cadmium Tolerance and Accumulation in Rice.
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Zhao F.Y.a, Han M.M.a, Zhang S.Y.b, Ren J.a, Hu F.a, Wang X.a
Russian Journal of Plant Physiology 2014 61 608-618
MAPKs as a cross point in H2O2 and auxin signaling under combined cadmium and zinc stress in rice roots
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Yamaji N., Xia J.X., Mitani-Ueno N., Yokosho K., Ma J.F.
Plant Physiol. 2013 162(2) 927-39
Preferential delivery of Zn to developing tissues in rice is mediated by a P-type ATPases, OsHMA2.
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Takahashi R., Bashir K., Ishimaru Y., Nishizawa N.K., Nakanishi H.
Plant Signal Behav 2012 7(12)
The role of heavy-metal ATPases, HMAs, in zinc and cadmium transport in rice.
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Satoh-Nagasawa N., Mori M., Nakazawa N., Kawamoto T., Nagato Y., Sakurai K., Takahashi H., Watanabe A., Akagi H.
Plant Cell Physiol. 2012 53(1) 213-24
Mutations in rice (Oryza sativa) heavy metal ATPase 2 (OsHMA2) restrict the translocation of Zn and Cd.
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Takahashi R., Ishimaru Y., Shimo H., Ogo Y., Senoura T., Nishizawa N.K., Nakanishi H.
Plant Cell Environ. 2012 35(11) 1948-57
The OsHMA2 transporter is involved in root-to-shoot translocation of Zn and Cd in rice.
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Nocito,F.F., Lancilli,C., Dendena,B., Lucchini,G. and Sacchi,G.A.
Plant Cell Environ. 2011 34(6) 994-1008
Cadmium retention in rice roots is influenced by cadmium availability, chelation and translocation
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Baxter I., Tchieu J., Michael R Sussman, Boutry M., Michael G Palmgren, Gribskov M., Jeffrey F Harper, Kristian B Axelsen
Plant Physiol. 2003 132(2) 618-28
Genomic comparison of P-type ATPase ion pumps in Arabidopsis and rice.
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DB Reference
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Gramene ID
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-
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Ontologies
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Gene Ontology
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response to manganese ion( GO:0010042 )
response to nutrient levels( GO:0031667 )
response to nutrient( GO:0007584 )
phloem transport( GO:0010233 )
response to cobalt ion( GO:0032025 )
integral to membrane( GO:0016021 )
metal ion binding( GO:0046872 )
zinc ion transmembrane transporter activity( GO:0005385 )
plasma membrane( GO:0005886 )
ATP binding( GO:0005524 )
ATP biosynthetic process( GO:0006754 )
ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism( GO:0015662 )
metal ion transmembrane transporter activity( GO:0046873 )
zinc ion transport( GO:0006829 )
response to zinc ion( GO:0010043 )
cadmium ion transmembrane transporter activity( GO:0015086 )
cadmium ion transport( GO:0015691 )
zinc ion homeostasis( GO:0055069 )
cadmium ion transmembrane transport( GO:0070574 )
response to cadmium ion( GO:0046686 )
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Trait Ontology
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phosphorus sensitivity( TO:0000102 )
nutrient sensitivity( TO:0000480 )
manganese sensitivity( TO:0000073 )
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Plant Ontology
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root( PO:0009005 )
pericycle cell( PO:0025261 )
phloem( PO:0005417 )
parenchyma cell( PO:0000074 )
vascular bundle( PO:0005020 )
stem node( PO:0020141 )
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Related Strains
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Phenotype images
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Last updated
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Mar 17, 2026
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Update info.