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Basic Information
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CGSNL Gene Symbol
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IRO2
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Gene Symbol Synonym
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OsIRO2, OsbHLH056, bHLH056, bHLH56, OsbHLH56
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CGSNL Gene Name
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IRON-RELATED TRANSCRIPTION FACTOR 2
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Gene Name Synonym
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basic helix-loop-helix protein 056, iron-related transcription factor 2
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Protein Name
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IRON-RELATED TRANSCRIPTION FACTOR 2
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Allele
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iro2-1, iro2, osiro2, osiro2-1, osiro2-2
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Chromosome No.
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1
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Explanation
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BR000688. iron-regulated bHLH transcription factor. Positive transcriptional regulator. GO:1990641: response to iron ion starvation. GO:0071579: regulation of zinc ion transport. GO:0120126: response to copper ion starvation. TO:0006049: iron concentration. TO:0020091: manganese content. TO:0020092: copper content trait. TO:0020090: zinc content trait. TO:0006060: leaf chlorosis. TO:0006059: cadmium content trait.
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Trait Class
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Tolerance and resistance - Stress tolerance
Other
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Expression
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Sequence/Locus
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cDNA Accession No.
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AK073385
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MSU ID
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LOC_Os01g72370.1
LOC_Os01g72370.2
LOC_Os01g72370.3
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RAP ID
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Os01g0952800
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Links
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Oryzabase Chromosome View
(
IRGSP 1.0
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Build5
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RAP-DB
(
IRGSP 1.0
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Build5
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Related IDs List (
IRGSP 1.0
/
Build5
)
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INSD Accession List
(Test version)
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Map
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Locate(cM)
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Link map
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Classical linkage map
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References
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Wang W., He F., Zhang H., Yang Y., Wang X., Fu Y., Shou H., Zheng L.
Abiotech 2025 6(2) 215-231
OsbHLH062 regulates iron homeostasis by inhibiting iron deficiency responses in rice.
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Zhu J., Li J., Hu X., Wang J., Fang J., Wang S., Shou H.
J. Exp. Bot. 2024 75(3) 1112-1127
Role of transcription factor complex OsbHLH156-OsIRO2 in regulating manganese, copper, and zinc transporters in rice.
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Liu P., Sun L., Zhang Y., Tan Y., Zhu Y., Peng C., Wang J., Yan H., Mao D., Liang G., Liang G., Li X., Liang Y., Wang F., He Z., Tang W., Huang D., Chen C.
Mol Plant 2024 17(11) 1733-1752
The metal tolerance protein OsMTP11 facilitates cadmium sequestration in the vacuoles of leaf vascular cells for restricting its translocation into rice grains.
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Xiong X., Zeng J., Ning Q., Liu H., Bu Z., Zhang X., Zeng J., Zhuo R., Cui K., Qin Z., Gao Y., Liu X., Zhu Y.
Nat Commun 2024 15(1) 5012
Ferroptosis induction in host rice by endophyte OsiSh-2 is necessary for mutualism and disease resistance in symbiosis.
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Regon P., Dey S., Rehman M., Pradhan A.K., Chowra U., Tanti B., Talukdar A.D., Panda S.K.
Front Plant Sci 2022 13 798580
Transcriptomic Analysis Revealed Reactive Oxygen Species Scavenging Mechanisms Associated With Ferrous Iron Toxicity in Aromatic Keteki Joha Rice.
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Wang W., Shinwari K.I., Zhang H., Zhang H., Dong L., He F., Zheng L.
Int J Mol Sci 2022 23(23)
The bHLH Transcription Factor OsbHLH057 Regulates Iron Homeostasis in Rice.
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Butt H., Bazin J., Prasad KVSK., Awad N., Crespi M., Reddy A.S.N., Mahfouz M.M.
Cells 2022 11(11)
The Rice Serine/Arginine Splicing Factor RS33 Regulates Pre-mRNA Splicing during Abiotic Stress Responses.
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Chowdhury R., Nallusamy S., Shanmugam V., Loganathan A., Muthurajan R., Subramanian Kizhaeral Sivathapandian, Paramasivam J., Duraialagaraja S.
Biologia 2022 77 39-53
Genome‐wide understanding of evolutionary and functional relationships of rice Yellow Stripe‐Like (YSL) transporter family in comparison with other plant species
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Wang S., Sun S., Guo R., Liao W., Shou H.
Genes (Basel) 2021 12(4)
Transcriptomic Profiling of Fe-Responsive lncRNAs and Their Regulatory Mechanism in Rice.
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Liang G., Zhang H., Li Y., Pu M., Yang Y., Li C., Lu C., Xu P., Yu D.
J Integr Plant Biol 2020 62(5) 668-689
Oryza sativa FER-LIKE FE DEFICIENCY-INDUCED TRANSCRIPTION FACTOR (OsFIT/OsbHLH156) interacts with OsIRO2 to regulate iron homeostasis.
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Wang S., Li L., Ying Y., Wang J., Shao J.F., Yamaji N., Whelan J., Ma J.F., Shou H.
New Phytol. 2020 225(3) 1247-1260
A transcription factor OsbHLH156 regulates Strategy II iron acquisition through localising IRO2 to the nucleus in rice.
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Zhang H., Li Y., Pu M., Xu P., Liang G., Yu D.
Plant Cell Environ. 2020 43(1) 261-274
Oryza sativa POSITIVE REGULATOR OF IRON DEFICIENCY RESPONSE 2 (OsPRI2) and OsPRI3 are involved in the maintenance of Fe homeostasis.
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Hu W., Figueroa-Balderas R., Chi-Ham C., Lagarias J.C.
Plant Direct 2020 4(4) e00210
Regulation of monocot and dicot plant development with constitutively active alleles of phytochrome B.
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Kobayashi T., Ozu A., Kobayashi S., An G., Jeon J.S., Nishizawa N.K.
Plant Mol. Biol. 2019 101(4-5) 471-486
OsbHLH058 and OsbHLH059 transcription factors positively regulate iron deficiency responses in rice.
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Sánchez-Sanuy F., Peris-Peris C., Tomiyama S., Okada K., Hsing Y.I., San Segundo B., Campo S.
BMC Plant Biol. 2019 19(1) 563
Osa-miR7695 enhances transcriptional priming in defense responses against the rice blast fungus.
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Khrueasan N., Chutimanukul P., Plaimas K., Buaboocha T., Siangliw M., Toojinda T., Comai L., Chadchawan S.
Genes (Basel) 2019 10(10)
Comparison between the Transcriptomes of 'KDML105' Rice and a Salt-Tolerant Chromosome Segment Substitution Line.
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Guan S., Xu Q., Ma D., Zhang W., Xu Z., Zhao M., Guo Z.
Gene 2019 685 96-105
Transcriptomics profiling in response to cold stress in cultivated rice and weedy rice.
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Aung M.S., Kobayashi T., Masuda H., Nishizawa N.K.
Physiol Plant 2018
Rice HRZ ubiquitin ligases are crucial for response to excess iron.
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Kurt F., Filiz E.
Biometals 2018 31(4) 489-504
Genome-wide and comparative analysis of bHLH38, bHLH39, bHLH100 and bHLH101 genes in Arabidopsis, tomato, rice, soybean and maize: insights into iron (Fe) homeostasis.
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Su Z., Tang Y., Ritchey L.E., Tack D.C., Zhu M., Bevilacqua P.C., Assmann S.M.
Proc. Natl. Acad. Sci. U.S.A. 2018 115(48) 12170-12175
Genome-wide RNA structurome reprogramming by acute heat shock globally regulates mRNA abundance.
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Wei K., Chen H.
BMC Plant Biol. 2018 18(1) 309
Comparative functional genomics analysis of bHLH gene family in rice, maize and wheat.
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Masuda H., Shimochi E., Hamada T., Senoura T., Kobayashi T., Aung M.S., Ishimaru Y., Ogo Y., Nakanishi H., Nishizawa N.K.
PLoS ONE 2017 12(3) e0173441
A new transgenic rice line exhibiting enhanced ferric iron reduction and phytosiderophore production confers tolerance to low iron availability in calcareous soil.
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Zhang H., Li Y., Yao X., Liang G., Yu D.
Plant Physiol. 2017 175(1) 543-554
POSITIVE REGULATOR OF IRON HOMEOSTASIS1, OsPRI1, Facilitates Iron Homeostasis.
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Andrés-Bordería A., Andrés F., Garcia-Molina A., Perea-García A., Domingo C., Puig S., Peñarrubia L.
Plant Mol. Biol. 2017
Copper and ectopic expression of the Arabidopsis transport protein COPT1 alter iron homeostasis in rice (Oryza sativa L.).
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Wang J., Islam F., Li L., Long M., Yang C., Jin X., Ali B., Mao B., Zhou W.
Int J Mol Sci 2017 18(9)
Complementary RNA-Sequencing Based Transcriptomics and iTRAQ Proteomics Reveal the Mechanism of the Alleviation of Quinclorac Stress by Salicylic Acid in Oryza sativa ssp. japonica.
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Wang B., Wei H., Xue Z., Zhang W.H.
Ann. Bot. 2017 119(6) 945-956
Gibberellins regulate iron deficiency-response by influencing iron transport and translocation in rice seedlings (Oryza sativa).
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Kobayashi T., Itai R.N., Senoura T., Oikawa T., Ishimaru Y., Ueda M., Nakanishi H., Nishizawa N.K.
Plant Mol. Biol. 2016 91(4-5) 533-47
Jasmonate signaling is activated in the very early stages of iron deficiency responses in rice roots.
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Yang A., Zhang W.H.
Plant Cell Physiol. 2016 57(6) 1271-80
A Small GTPase, OsRab6a, is Involved in the Regulation of Iron Homeostasis in Rice.
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Feng S.J., Liu X.S., Tao H., Tan S.K., Chu S.S., Oono Y., Zhang X.D., Chen J., Yang Z.M.
Plant Cell Environ. 2016
Variation of DNA methylation patterns associated with gene expression in rice (Oryza sativa) exposed to cadmium.
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Tan S., Liu F., Pan X.X., Zang Y.P., Jin F., Zu W.X., Qi X.T., Xiao W., Yin L.P.
Sci Rep 2016 6 25485
CSN6, a subunit of the COP9 signalosome, is involved in early response to iron deficiency in Oryza sativa.
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Bashir K., Ishimaru Y., Itai R.N., Senoura T., Takahashi M., An G., Oikawa T., Ueda M., Sato A., Uozumi N., Nakanishi H., Nishizawa N.K.
Plant Mol. Biol. 2015 88(1-2) 165-76
Iron deficiency regulated OsOPT7 is essential for iron homeostasis in rice.
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Kobayashi T.a b, Nakanishi Itai R.c, Nishizawa N.K.b
Rice 2014 7
Iron deficiency responses in rice roots
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Yang A., Li Y., Xu Y., Zhang W.H.
J. Exp. Bot. 2013 64(16) 5009-20
A receptor-like protein RMC is involved in regulation of iron acquisition in rice.
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Kobayashi T., Naoko K Nishizawa
Annu Rev Plant Biol 2012 63 131-52
Iron uptake, translocation, and regulation in higher plants.
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Wang L., Ying Y., Narsai R., Ye L., Zheng L., Tian J., Whelan J., Shou H.
Plant Cell Environ. 2012 36(1) 224-36.
Identification of OsbHLH133 as a regulator of iron distribution between roots and shoots in Oryza sativa.
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Zheng L., Yamaji N., Yokosho K., Ma J.F.
Plant Cell 2012 24(9) 3767-82
YSL16 is a phloem-localized transporter of the copper-nicotianamine complex that is responsible for copper distribution in rice.
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Ricachenevsky F.K., Sperotto R.A., Menguer P.K., Sperb E.R., Lopes K.L., Fett J.P.
BMC Plant Biology 2011 11 -
ZINC-INDUCED FACILITATOR-LIKE family in plants: Lineage-specific expansion in monocotyledons and conserved genomic and expression features among rice (Oryza sativa) paralogs
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Kobayashi T,Itai RN,Ogo Y,Kakei Y,Nakanishi H,Takahashi M,Nishizawa NK
Plant J. 2009 60(6) 948-61
The rice transcription factor IDEF1 is essential for the early response to iron deficiency, and induces vegetative expression of late embryogenesis abundant genes.
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Kobayashi T,Ogo Y,Itai RN,Nakanishi H,Takahashi M,Mori S,Nishizawa NK
Proc. Natl. Acad. Sci. U.S.A. 2007 104 19150-5
The transcription factor IDEF1 regulates the response to and tolerance of iron deficiency in plants.
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Ogo Y,Itai RN,Nakanishi H,Kobayashi T,Takahashi M,Mori S,Nishizawa NK
Plant J. 2007 51 366-77
The rice bHLH protein OsIRO2 is an essential regulator of the genes involved in Fe uptake under Fe-deficient conditions.
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Li X, Duan X, Jiang H, Sun Y, Tang Y, Yuan Z, Guo J, Liang W, Chen L, Yin J, Ma H, Wang J, Zhang D.
Plant Physiol. 2006 141(4) 1167-84
Genome-wide analysis of basic/helix-loop-helix transcription factor family in rice and Arabidopsis.
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Ogo,Y., Itai,R.N., Nakanishi,H., Inoue,H., Kobayashi,T., Suzuki,M., Takahashi,M., Mori,S. and Nishizawa,N.K.
J. Exp. Bot. 2006 57(11) 2867-2878
Isolation and characterization of IRO2, a novel iron-regulated bHLH transcription factor in graminaceous plants
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DB Reference
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Gramene ID
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-
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Ontologies
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Gene Ontology
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zinc ion transport( GO:0006829 )
copper ion transport( GO:0006825 )
manganese ion homeostasis( GO:0055071 )
copper ion homeostasis( GO:0055070 )
manganese ion transport( GO:0006828 )
response to symbiotic bacterium( GO:0009609 )
response to salt stress( GO:0009651 )
response to iron(II) ion( GO:0010040 )
response to starvation( GO:0042594 )
cytoplasm( GO:0005737 )
response to red light( GO:0010114 )
DNA binding( GO:0003677 )
cellular response to iron ion starvation( GO:0010106 )
iron ion homeostasis( GO:0055072 )
response to iron ion( GO:0010039 )
response to gibberellin stimulus( GO:0009739 )
response to copper ion( GO:0046688 )
response to salicylic acid stimulus( GO:0009751 )
nucleus( GO:0005634 )
response to cold( GO:0009409 )
response to heat( GO:0009408 )
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Trait Ontology
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iron sensitivity( TO:0000224 )
gibberellic acid sensitivity( TO:0000166 )
copper sensitivity( TO:0000021 )
cold tolerance( TO:0000303 )
heat tolerance( TO:0000259 )
red light sensitivity( TO:0000158 )
salt tolerance( TO:0006001 )
relative plant height( TO:0001034 )
relative chlorophyll content( TO:0001016 )
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Plant Ontology
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root( PO:0009005 )
shoot system( PO:0009006 )
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Related Strains
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Phenotype images
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Last updated
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Mar 12, 2026
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Update info.