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Basic Information
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CGSNL Gene Symbol
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IRT1
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Gene Symbol Synonym
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OsIRT1, ZIP10, OsZIP10, OsZIP12, ZIP12
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CGSNL Gene Name
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IRON-REGULATED TRANSPORTER 1
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Gene Name Synonym
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IRON-REGULATED TRANSPORTER1, zinc transporter 10, Zrt-Irt-like protein 10, ZRT-IRT-related protein 10, ZIP transporter 10, Zinc- and iron-regulating transport-like protein 12, Zn- and Fe-regulating transport-like protein 12
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Protein Name
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IRON-REGULATED TRANSPORTER 1
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Allele
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Chromosome No.
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3
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Explanation
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Fe2+ transprter. Q75HB1. AB070226, D49213. iron regulated metal transporter. OsZIP12 in Zeng et al. 2024. TO:0006049: iron concentration. TO:0020089: iron content trait. TO:0006053: zinc concentration. TO:0020090: zinc content trait. GO:1990641: response to iron ion starvation. GO:0035864: response to potassium ion. TO:0006059: cadmium content trait. GO: 0120127: response to zinc ion starvation. TO:0020096: mineral and ion transport trait.
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Trait Class
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Biochemical character
Tolerance and resistance - Stress tolerance
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Expression
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Sequence/Locus
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cDNA Accession No.
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AK107681
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MSU ID
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LOC_Os03g46470.1
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RAP ID
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Os03g0667500
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Links
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Oryzabase Chromosome View
(
IRGSP 1.0
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Build5
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RAP-DB
(
IRGSP 1.0
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Build5
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Related IDs List (
IRGSP 1.0
/
Build5
)
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INSD Accession List
(Test version)
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-
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Map
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Locate(cM)
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Link map
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Classical linkage map
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References
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Wang W., He F., Zhang H., Yang Y., Wang X., Fu Y., Shou H., Zheng L.
Abiotech 2025 6(2) 215-231
OsbHLH062 regulates iron homeostasis by inhibiting iron deficiency responses in rice.
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Zeng X., Yang S., Li F., Yao Y., Wu Z., Xue Y., Liu Y.
Genes (Basel) 2024 15(6)
Genome-Wide Identification of <i>OsZIPs</i> in Rice and Gene Expression Analysis under Manganese and Selenium Stress.
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Feng K., Li J., Yang Y., Li Z., Wu W.
Int J Mol Sci 2023 24(9)
Cadmium Absorption in Various Genotypes of Rice under Cadmium Stress.
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Chen Q., Hu Y., Yang L., Zhu B., Luo F.
Curr Issues Mol Biol 2022 44(9) 4070-4086
Phosphorus Regulates the Level of Signaling Molecules in Rice to Reduce Cadmium Toxicity.
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Kobayashi T., Maeda K., Suzuki Y., Nishizawa N.K.
Rice (N Y) 2022 15(1) 54
Simultaneous Enhancement of iron Deficiency Tolerance and Iron Accumulation in Rice by Combining the Knockdown of OsHRZ Ubiquitin Ligases with the Introduction of Engineered Ferric-chelate Reductase.
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Zhan J., Zou W., Li S., Tang J., Lu X., Meng L., Ye G.
Int J Mol Sci 2022 23(19)
OsNAC15 Regulates Tolerance to Zinc Deficiency and Cadmium by Binding to <i>OsZIP7</i> and <i>OsZIP10</i> in Rice.
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Zhang J., Zhu Y., Yu L., Yang M., Zou X., Yin C., Lin Y.
Cells 2022 11(3)
Research Advances in Cadmium Uptake, Transport and Resistance in Rice (<i>Oryza sativa</i> L.).
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Chowdhury R., Nallusamy S., Shanmugam V., Loganathan A., Muthurajan R., Subramanian Kizhaeral Sivathapandian, Paramasivam J., Duraialagaraja S.
Biologia 2022 77 39-53
Genome‐wide understanding of evolutionary and functional relationships of rice Yellow Stripe‐Like (YSL) transporter family in comparison with other plant species
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Liu J., Zhan J., Chen J., Lu X., Zhi S., Ye G.
Front Genet 2021 12 701658
Validation of Genes Affecting Rice Grain Zinc Content Through Candidate Gene-Based Association Analysis.
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Cao L., Gao Y., Yu J., Niu S., Zeng J., Yao Q., Wang X., Bu Z., Xu T., Liu X., Zhu Y.
Plant Physiol. Biochem. 2021 158 275-283
Streptomyces hygroscopicus OsiSh-2-induced mitigation of Fe deficiency in rice plants.
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Wang M., Hasegawa T., Beier M., Hayashi M., Ohmori Y., Yano K., Teramoto S., Kamiya T., Fujiwara T.
Plant Cell Physiol. 2021
Growth and nitrate reductase activity are impaired in rice OsNLP4 mutantssupplied with nitrate.
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Ma C., Hao Y., Zhao J., Zuverza-Mena N., Meselhy A.G., Dhankher O.P., Rui Y., White J.C., Xing B.
Nanomaterials (Basel) 2021 11(4)
Graphitic Carbon Nitride (C3N4) Reduces Cadmium and Arsenic Phytotoxicity and Accumulation in Rice (<i>Oryza sativa</i> L.).
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Tang L., Dong J., Tan L., Ji Z., Li Y., Sun Y., Chen C., Lv Q., Mao B., Hu Y., Zhao B.
Rice (N Y) 2021 14(1) 89
Overexpression of OsLCT2, a Low-Affinity cation transporter Gene, Reduces Cadmium Accumulation in Shoots and Grains of Rice.
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Yang A., Li Q., Chen L., Zhang W.H.
J. Exp. Bot. 2020
A rice small GTPase, OsRab6a, is involved in the regulation of grain yield and iron nutrition in response to CO2 enrichment.
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Wang S., Li L., Ying Y., Wang J., Shao J.F., Yamaji N., Whelan J., Ma J.F., Shou H.
New Phytol. 2020 225(3) 1247-1260
A transcription factor OsbHLH156 regulates Strategy II iron acquisition through localising IRO2 to the nucleus in rice.
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Liang G., Zhang H., Li Y., Pu M., Yang Y., Li C., Lu C., Xu P., Yu D.
J Integr Plant Biol 2020 62(5) 668-689
Oryza sativa FER-LIKE FE DEFICIENCY-INDUCED TRANSCRIPTION FACTOR (OsFIT/OsbHLH156) interacts with OsIRO2 to regulate iron homeostasis.
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Liu A., Zhou Z., Yi Y., Chen G.
BMC Genomics 2020 21(1) 127
Transcriptome analysis reveals the roles of stem nodes in cadmium transport to rice grain.
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Che J., Yokosho K., Yamaji N., Jian Feng Ma
Plant Physiol. 2019 181(1) 276-288
A Vacuolar Phytosiderophore Transporter Alters Iron and Zinc Accumulation in Polished Rice Grains.
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Kobayashi T., Ozu A., Kobayashi S., An G., Jeon J.S., Nishizawa N.K.
Plant Mol. Biol. 2019 101(4-5) 471-486
OsbHLH058 and OsbHLH059 transcription factors positively regulate iron deficiency responses in rice.
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Chen X., Ouyang Y., Fan Y., Qiu B., Zhang G., Zeng F.
J. Exp. Bot. 2018 69(21) 5279-5291
The pathway of transmembrane cadmium influx via calcium-permeable channels and its spatial characteristics along rice root.
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Zheng X., Chen L., Li X.
Botanical Studies 2018 59(1) 22
Arabidopsis and rice showed a distinct pattern in ZIPs genes expression profile in response to Cd stress.
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Shi X., Chen S., Peng Y., Wang Y., Chen J., Hu Z., Wang B., Li A., Chao D., Li Y., Teng S.
J Integr Plant Biol 2018 60(2) 112-129
TSC1 enables plastid development under dark conditions, contributing to rice adaptation to transplantation shock.
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Aung M.S., Kobayashi T., Masuda H., Nishizawa N.K.
Physiol Plant 2018
Rice HRZ ubiquitin ligases are crucial for response to excess iron.
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Tanaka N., Uraguchi S., Kajikawa M., Saito A., Ohmori Y., Fujiwara T.
Plant J. 2018 96(5) 997-1006
A rice PHD-finger protein OsTITANIA, is a growth regulator that functions through elevating expression of transporter genes for multiple metals.
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Zhang H., Li Y., Yao X., Liang G., Yu D.
Plant Physiol. 2017 175(1) 543-554
POSITIVE REGULATOR OF IRON HOMEOSTASIS1, OsPRI1, Facilitates Iron Homeostasis.
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Masuda H., Shimochi E., Hamada T., Senoura T., Kobayashi T., Aung M.S., Ishimaru Y., Ogo Y., Nakanishi H., Nishizawa N.K.
PLoS ONE 2017 12(3) e0173441
A new transgenic rice line exhibiting enhanced ferric iron reduction and phytosiderophore production confers tolerance to low iron availability in calcareous soil.
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Kabir A.H.
Plant Biol (Stuttg) 2016
Biochemical and molecular changes in rice seedlings (Oryza sativa L.) to cope with chromium stress.
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Tan S., Liu F., Pan X.X., Zang Y.P., Jin F., Zu W.X., Qi X.T., Xiao W., Yin L.P.
Sci Rep 2016 6 25485
CSN6, a subunit of the COP9 signalosome, is involved in early response to iron deficiency in Oryza sativa.
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Yang A., Zhang W.H.
Plant Cell Physiol. 2016 57(6) 1271-80
A Small GTPase, OsRab6a, is Involved in the Regulation of Iron Homeostasis in Rice.
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Sebastian A., Prasad M.N.
Protoplasma 2015
Operative photo assimilation associated proteome modulations are critical for iron-dependent cadmium tolerance in Oryza sativa L.
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Agarwal S., Tripura Venkata VG., Kotla A., Mangrauthia S.K., Neelamraju S.
Gene 2014 546(2) 430-6
Expression patterns of QTL based and other candidate genes in Madhukar × Swarna RILs with contrasting levels of iron and zinc in unpolished rice grains.
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Kobayashi T.a b, Nakanishi Itai R.c, Nishizawa N.K.b
Rice 2014 7
Iron deficiency responses in rice roots
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Takahashi R., Ishimaru Y., Shimo H., Bashir K., Senoura T., Sugimoto K., Ono K., Suzui N., Kawachi N., Ishii S., Yin Y.G., Fujimaki S., Yano M., Nishizawa N.K., Nakanishi H.
PLoS ONE 2014 9(6) e98816
From laboratory to field: OsNRAMP5-knockdown rice is a promising candidate for Cd phytoremediation in paddy fields.
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Yang A., Li Y., Xu Y., Zhang W.H.
J. Exp. Bot. 2013 64(16) 5009-20
A receptor-like protein RMC is involved in regulation of iron acquisition in rice.
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Suzuki M., Bashir K., Inoue H., Takahashi M., Nakanishi H., Nishizawa N.K.
Rice (N Y) 2012 5 9
Accumulation of starch in Zn-deficient rice
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Kobayashi T., Naoko K Nishizawa
Annu Rev Plant Biol 2012 63 131-52
Iron uptake, translocation, and regulation in higher plants.
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Lee S., Kim Y.S., Jeon U.S., Kim Y.K., Schjoerring J.K., An G.
Mol. Cells 2012 33(3) 269-75
Activation of Rice nicotianamine synthase 2 (OsNAS2) enhances iron availability for biofortification.
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Anuradha K., Agarwal S., Rao Y.V., Rao K.V., Viraktamath B.C., Sarla N.
Gene 2012 508(2) 233-40
Mapping QTLs and candidate genes for iron and zinc concentrations in unpolished rice of Madhukar×Swarna RILs.
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Zheng L., Yamaji N., Yokosho K., Ma J.F.
Plant Cell 2012 24(9) 3767-82
YSL16 is a phloem-localized transporter of the copper-nicotianamine complex that is responsible for copper distribution in rice.
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Wang L., Ying Y., Narsai R., Ye L., Zheng L., Tian J., Whelan J., Shou H.
Plant Cell Environ. 2012 36(1) 224-36.
Identification of OsbHLH133 as a regulator of iron distribution between roots and shoots in Oryza sativa.
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Sasaki,A., Yamaji,N., Yokosho,K. and Ma,J.F.
Plant Cell 2012 24(5) 2155-2167
Nramp5 is a major transporter responsible for manganese and cadmium uptake in rice
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Takanashi H., Ishimaru Y., Bashir K., Fujimoto M., Shimo H., An G., Nagasaka S., Nishizawa N.K., Nakanishi H., Tsutsumi N.
Nature Communications 2011 2 322
The rice mitochondrial iron transporter is essential for plant growth
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Chou TS,Chao YY,Huang WD,Hong CY,Kao CH
J. Plant Physiol. 2011 168(10) 1021-30
Effect of magnesium deficiency on antioxidant status and cadmium toxicity in rice seedlings.
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Hu B., Zhu C., Li F., Tang J., Wang Y., Lin A., Liu L., Che R., Chu C.
Plant physiology 2011 156 1101-1105
Leaf tip necrosis1 plays a pivotal role in the regulation of multiple phosphate starvation responses in rice
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Takahashi R., Ishimaru Y., Nakanishi H., Nishizawa N.K.
Plant Signal Behav 2011 6(11)
Role of the iron transporter OsNRAMP1 in cadmium uptake and accumulation in rice.
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Yuan,M., Chu,Z., Li,X., Xu,C. and Wang,S.
Plant Cell 2010 22(9) 3164-3176
The Bacterial Pathogen Xanthomonas oryzae Overcomes Rice Defenses by Regulating Host Copper Redistribution
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Ishimaru Y., Masuda H., Bashir K., Inoue H., Tsukamoto T., Takahashi M., Nakanishi H., Aoki N., Hirose T., Ohsugi R., Naoko K Nishizawa
Plant J. 2010 62(3) 379-90
Rice metal-nicotianamine transporter, OsYSL2, is required for the long-distance transport of iron and manganese.
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Kobayashi T,Itai RN,Ogo Y,Kakei Y,Nakanishi H,Takahashi M,Nishizawa NK
Plant J. 2009 60(6) 948-61
The rice transcription factor IDEF1 is essential for the early response to iron deficiency, and induces vegetative expression of late embryogenesis abundant genes.
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Narayanan NN, Vasconcelos MW, Grusak MA.
Plant Physiol. Biochem. 2007 45(5) 277-86.
Expression profiling of Oryza sativa metal homeostasis genes in different rice cultivars using a cDNA macroarray.
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Kobayashi T,Ogo Y,Itai RN,Nakanishi H,Takahashi M,Mori S,Nishizawa NK
Proc. Natl. Acad. Sci. U.S.A. 2007 104 19150-5
The transcription factor IDEF1 regulates the response to and tolerance of iron deficiency in plants.
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Ishimaru,Y., Suzuki,M., Tsukamoto,T., Suzuki,K., Nakazono,M., Kobayashi,T., Wada,Y., Watanabe,S., Matsuhashi,S., Takahashi,M., Nakanishi,H., Mori,S. and Nishizawa,N.K.
Plant J. 2006 45(3) 335-346
Rice plants take up iron as an Fe3+-phytosiderophore and as Fe2+
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Nakanishi H., Ogawa I., Ishimaru Y., Mori S., Nishizawa N.
Soil Sci. Plant Nutr. 2006 52(4) 464 469
Iron deficiency enhances cadmium uptake and translocation mediated by the Fe^<2+> transporters OsIRT1 and OsIRT2 in rice
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Ogo,Y., Itai,R.N., Nakanishi,H., Inoue,H., Kobayashi,T., Suzuki,M., Takahashi,M., Mori,S. and Nishizawa,N.K.
J. Exp. Bot. 2006 57(11) 2867-2878
Isolation and characterization of IRO2, a novel iron-regulated bHLH transcription factor in graminaceous plants
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Bughio,N., Yamaguchi,H., Nishizawa,N.K., Nakanishi,H. and Mori,S.
J. Exp. Bot. 2002 53(374) 1677-1682
Cloning an iron-regulated metal transporter from rice
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DB Reference
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Gramene ID
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Ontologies
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Gene Ontology
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response to selenium ion( GO:0010269 )
response to manganese ion( GO:0010042 )
membrane( GO:0016020 )
zinc ion transmembrane transporter activity( GO:0005385 )
plasma membrane( GO:0005886 )
iron ion transport( GO:0006826 )
cadmium ion transport( GO:0015691 )
integral to membrane( GO:0016021 )
response to cadmium ion( GO:0046686 )
response to nutrient( GO:0007584 )
cadmium ion transmembrane transport( GO:0070574 )
iron ion homeostasis( GO:0055072 )
response to symbiotic bacterium( GO:0009609 )
response to starvation( GO:0042594 )
response to chromate( GO:0046687 )
cellular response to iron ion starvation( GO:0010106 )
response to calcium ion( GO:0051592 )
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Trait Ontology
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chromium sensitivity( TO:0000034 )
iron sensitivity( TO:0000224 )
phosphorus sensitivity( TO:0000102 )
zinc sensitivity( TO:0000351 )
manganese sensitivity( TO:0000073 )
selenium sensitivity( TO:0000032 )
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Plant Ontology
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Related Strains
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Phenotype images
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Last updated
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Jan 17, 2026
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Update info.