Gene - Detail

Detail of Gene

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Basic Information
CGSNL Gene Symbol IRT1
Gene Symbol Synonym OsIRT1, ZIP10, OsZIP10
Gene Name Synonym IRON-REGULATED TRANSPORTER1, zinc transporter 10, Zrt-Irt-like protein 10
Chromosome No. 3
Explanation Fe2+ transprter. Q75HB1. AB070226, D49213. iron regulated metal transporter. TO:0006049: iron concentration. TO:0020089: iron content trait. TO:0006053: zinc concentration. TO:0020090: zinc content trait. GO:1990641: response to iron ion starvation. GO:0035864: response to potassium ion. TO:0006059: cadmium content trait.
Trait Class Biochemical character
Tolerance and resistance - Stress tolerance
cDNA Accession No. AK107681
MSU ID LOC_Os03g46470.1
RAP ID Os03g0667500
Links Oryzabase Chromosome View ( IRGSP 1.0 / Build5 )
RAP-DB ( IRGSP 1.0 / Build5 )
Related IDs List ( IRGSP 1.0 / Build5 )
INSD Accession List
(Test version)
Link map Classical linkage map
Zhang J., Zhu Y., Yu L., Yang M., Zou X., Yin C., Lin Y.
Cells 2022  11(3) 
Research Advances in Cadmium Uptake, Transport and Resistance in Rice (<i>Oryza sativa</i> L.).
Cao L., Gao Y., Yu J., Niu S., Zeng J., Yao Q., Wang X., Bu Z., Xu T., Liu X., Zhu Y.
Plant Physiol. Biochem. 2021  158  275-283
Streptomyces hygroscopicus OsiSh-2-induced mitigation of Fe deficiency in rice plants.
Liu J., Zhan J., Chen J., Lu X., Zhi S., Ye G.
Front Genet 2021  12  701658
Validation of Genes Affecting Rice Grain Zinc Content Through Candidate Gene-Based Association Analysis.
Tang L., Dong J., Tan L., Ji Z., Li Y., Sun Y., Chen C., Lv Q., Mao B., Hu Y., Zhao B.
Rice (N Y) 2021  14(1)  89
Overexpression of OsLCT2, a Low-Affinity cation transporter Gene, Reduces Cadmium Accumulation in Shoots and Grains of Rice.
Ma C., Hao Y., Zhao J., Zuverza-Mena N., Meselhy A.G., Dhankher O.P., Rui Y., White J.C., Xing B.
Nanomaterials (Basel) 2021  11(4) 
Graphitic Carbon Nitride (C3N4) Reduces Cadmium and Arsenic Phytotoxicity and Accumulation in Rice (<i>Oryza sativa</i> L.).
Liu A., Zhou Z., Yi Y., Chen G.
BMC Genomics 2020  21(1)  127
Transcriptome analysis reveals the roles of stem nodes in cadmium transport to rice grain.
Yang A., Li Q., Chen L., Zhang W.H.
J. Exp. Bot. 2020   
A rice small GTPase, OsRab6a, is involved in the regulation of grain yield and iron nutrition in response to CO2 enrichment.
Liang G., Zhang H., Li Y., Pu M., Yang Y., Li C., Lu C., Xu P., Yu D.
J Integr Plant Biol 2020  62(5)  668-689
Oryza sativa FER-LIKE FE DEFICIENCY-INDUCED TRANSCRIPTION FACTOR (OsFIT/OsbHLH156) interacts with OsIRO2 to regulate iron homeostasis.
Wang S., Li L., Ying Y., Wang J., Shao J.F., Yamaji N., Whelan J., Ma J.F., Shou H.
New Phytol. 2020  225(3)  1247-1260
A transcription factor OsbHLH156 regulates Strategy II iron acquisition through localising IRO2 to the nucleus in rice.
Kobayashi T., Ozu A., Kobayashi S., An G., Jeon J.S., Nishizawa N.K.
Plant Mol. Biol. 2019  101(4-5)  471-486
OsbHLH058 and OsbHLH059 transcription factors positively regulate iron deficiency responses in rice.
Che J., Yokosho K., Yamaji N., Jian Feng Ma
Plant Physiol. 2019  181(1)  276-288
A Vacuolar Phytosiderophore Transporter Alters Iron and Zinc Accumulation in Polished Rice Grains.
Aung M.S., Kobayashi T., Masuda H., Nishizawa N.K.
Physiol Plant 2018   
Rice HRZ ubiquitin ligases are crucial for response to excess iron.
Tanaka N., Uraguchi S., Kajikawa M., Saito A., Ohmori Y., Fujiwara T.
Plant J. 2018  96(5)  997-1006
A rice PHD-finger protein OsTITANIA, is a growth regulator that functions through elevating expression of transporter genes for multiple metals.
Chen X., Ouyang Y., Fan Y., Qiu B., Zhang G., Zeng F.
J. Exp. Bot. 2018  69(21)  5279-5291
The pathway of transmembrane cadmium influx via calcium-permeable channels and its spatial characteristics along rice root.
Zheng X., Chen L., Li X.
Botanical Studies 2018  59(1)  22
Arabidopsis and rice showed a distinct pattern in ZIPs genes expression profile in response to Cd stress.
Shi X., Chen S., Peng Y., Wang Y., Chen J., Hu Z., Wang B., Li A., Chao D., Li Y., Teng S.
J Integr Plant Biol 2018  60(2)  112-129
TSC1 enables plastid development under dark conditions, contributing to rice adaptation to transplantation shock.
Zhang H., Li Y., Yao X., Liang G., Yu D.
Plant Physiol. 2017  175(1)  543-554
Masuda H., Shimochi E., Hamada T., Senoura T., Kobayashi T., Aung M.S., Ishimaru Y., Ogo Y., Nakanishi H., Nishizawa N.K.
PLoS ONE 2017  12(3)  e0173441
A new transgenic rice line exhibiting enhanced ferric iron reduction and phytosiderophore production confers tolerance to low iron availability in calcareous soil.
Yang A., Zhang W.H.
Plant Cell Physiol. 2016  57(6)  1271-80
A Small GTPase, OsRab6a, is Involved in the Regulation of Iron Homeostasis in Rice.
Tan S., Liu F., Pan X.X., Zang Y.P., Jin F., Zu W.X., Qi X.T., Xiao W., Yin L.P.
Sci Rep 2016  6  25485
CSN6, a subunit of the COP9 signalosome, is involved in early response to iron deficiency in Oryza sativa.
Kabir A.H.
Plant Biol (Stuttg) 2016   
Biochemical and molecular changes in rice seedlings (Oryza sativa L.) to cope with chromium stress.
Sebastian A., Prasad M.N.
Protoplasma 2015   
Operative photo assimilation associated proteome modulations are critical for iron-dependent cadmium tolerance in Oryza sativa L.
Agarwal S., Tripura Venkata VG., Kotla A., Mangrauthia S.K., Neelamraju S.
Gene 2014  546(2)  430-6
Expression patterns of QTL based and other candidate genes in Madhukar × Swarna RILs with contrasting levels of iron and zinc in unpolished rice grains.
Kobayashi T.a b, Nakanishi Itai R.c, Nishizawa N.K.b
Rice 2014  7 
Iron deficiency responses in rice roots
Takahashi R., Ishimaru Y., Shimo H., Bashir K., Senoura T., Sugimoto K., Ono K., Suzui N., Kawachi N., Ishii S., Yin Y.G., Fujimaki S., Yano M., Nishizawa N.K., Nakanishi H.
PLoS ONE 2014  9(6)  e98816
From laboratory to field: OsNRAMP5-knockdown rice is a promising candidate for Cd phytoremediation in paddy fields.
Yang A., Li Y., Xu Y., Zhang W.H.
J. Exp. Bot. 2013  64(16)  5009-20
A receptor-like protein RMC is involved in regulation of iron acquisition in rice.
Sasaki,A., Yamaji,N., Yokosho,K. and Ma,J.F.
Plant Cell 2012  24(5)  2155-2167
Nramp5 is a major transporter responsible for manganese and cadmium uptake in rice
Kobayashi T., Naoko K Nishizawa
Annu Rev Plant Biol 2012  63  131-52
Iron uptake, translocation, and regulation in higher plants.
Suzuki M., Bashir K., Inoue H., Takahashi M., Nakanishi H., Nishizawa N.K.
Rice (N Y) 2012  5  9
Accumulation of starch in Zn-deficient rice
Anuradha K., Agarwal S., Rao Y.V., Rao K.V., Viraktamath B.C., Sarla N.
Gene 2012  508(2)  233-40
Mapping QTLs and candidate genes for iron and zinc concentrations in unpolished rice of Madhukar×Swarna RILs.
Zheng L., Yamaji N., Yokosho K., Ma J.F.
Plant Cell 2012  24(9)  3767-82
YSL16 is a phloem-localized transporter of the copper-nicotianamine complex that is responsible for copper distribution in rice.
Wang L., Ying Y., Narsai R., Ye L., Zheng L., Tian J., Whelan J., Shou H.
Plant Cell Environ. 2012  36(1)  224-36.
Identification of OsbHLH133 as a regulator of iron distribution between roots and shoots in Oryza sativa.
Lee S., Kim Y.S., Jeon U.S., Kim Y.K., Schjoerring J.K., An G.
Mol. Cells 2012  33(3)  269-75
Activation of Rice nicotianamine synthase 2 (OsNAS2) enhances iron availability for biofortification.
Chou TS,Chao YY,Huang WD,Hong CY,Kao CH
J. Plant Physiol. 2011  168(10)  1021-30
Effect of magnesium deficiency on antioxidant status and cadmium toxicity in rice seedlings.
Hu B., Zhu C., Li F., Tang J., Wang Y., Lin A., Liu L., Che R., Chu C.
Plant physiology 2011  156  1101-1105
Leaf tip necrosis1 plays a pivotal role in the regulation of multiple phosphate starvation responses in rice
Takanashi H., Ishimaru Y., Bashir K., Fujimoto M., Shimo H., An G., Nagasaka S., Nishizawa N.K., Nakanishi H., Tsutsumi N.
Nature Communications 2011  2  322
The rice mitochondrial iron transporter is essential for plant growth
Takahashi R., Ishimaru Y., Nakanishi H., Nishizawa N.K.
Plant Signal Behav 2011  6(11) 
Role of the iron transporter OsNRAMP1 in cadmium uptake and accumulation in rice.
Ishimaru Y., Masuda H., Bashir K., Inoue H., Tsukamoto T., Takahashi M., Nakanishi H., Aoki N., Hirose T., Ohsugi R., Naoko K Nishizawa
Plant J. 2010  62(3)  379-90
Rice metal-nicotianamine transporter, OsYSL2, is required for the long-distance transport of iron and manganese.
Yuan,M., Chu,Z., Li,X., Xu,C. and Wang,S.
Plant Cell 2010  22(9)  3164-3176
The Bacterial Pathogen Xanthomonas oryzae Overcomes Rice Defenses by Regulating Host Copper Redistribution
Kobayashi T,Itai RN,Ogo Y,Kakei Y,Nakanishi H,Takahashi M,Nishizawa NK
Plant J. 2009  60(6)  948-61
The rice transcription factor IDEF1 is essential for the early response to iron deficiency, and induces vegetative expression of late embryogenesis abundant genes.
Narayanan NN, Vasconcelos MW, Grusak MA.
Plant Physiol. Biochem. 2007  45(5)  277-86.
Expression profiling of Oryza sativa metal homeostasis genes in different rice cultivars using a cDNA macroarray.
Kobayashi T,Ogo Y,Itai RN,Nakanishi H,Takahashi M,Mori S,Nishizawa NK
Proc. Natl. Acad. Sci. U.S.A. 2007  104  19150-5
The transcription factor IDEF1 regulates the response to and tolerance of iron deficiency in plants.
Ogo,Y., Itai,R.N., Nakanishi,H., Inoue,H., Kobayashi,T., Suzuki,M., Takahashi,M., Mori,S. and Nishizawa,N.K.
J. Exp. Bot. 2006  57(11)  2867-2878
Isolation and characterization of IRO2, a novel iron-regulated bHLH transcription factor in graminaceous plants
Ishimaru,Y., Suzuki,M., Tsukamoto,T., Suzuki,K., Nakazono,M., Kobayashi,T., Wada,Y., Watanabe,S., Matsuhashi,S., Takahashi,M., Nakanishi,H., Mori,S. and Nishizawa,N.K.
Plant J. 2006  45(3)  335-346
Rice plants take up iron as an Fe3+-phytosiderophore and as Fe2+
Nakanishi H., Ogawa I., Ishimaru Y., Mori S., Nishizawa N.
Soil Sci. Plant Nutr. 2006  52(4)  464 469
Iron deficiency enhances cadmium uptake and translocation mediated by the Fe^<2+> transporters OsIRT1 and OsIRT2 in rice
Bughio,N., Yamaguchi,H., Nishizawa,N.K., Nakanishi,H. and Mori,S.
J. Exp. Bot. 2002  53(374)  1677-1682
Cloning an iron-regulated metal transporter from rice
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DB Reference
Gramene ID -
Gene Ontology cadmium ion transmembrane transport( GO:0070574 )
iron ion homeostasis( GO:0055072 )
response to symbiotic bacterium( GO:0009609 )
response to starvation( GO:0042594 )
response to cadmium ion( GO:0046686 )
integral to membrane( GO:0016021 )
cadmium ion transport( GO:0015691 )
iron ion transport( GO:0006826 )
plasma membrane( GO:0005886 )
zinc ion transmembrane transporter activity( GO:0005385 )
response to chromate( GO:0046687 )
cellular response to iron ion starvation( GO:0010106 )
response to calcium ion( GO:0051592 )
Trait Ontology chromium sensitivity( TO:0000034 )
iron sensitivity( TO:0000224 )
Plant Ontology -
Related Strains
Phenotype images
Last updated
Jul 13, 2022