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Basic Information
CGSNL Gene Symbol NH1
Gene Symbol Synonym OsNH1, OsNPR1, OsNPR1/NH1, NPR1, OsPR2, PR2, DLN5, OsDLN5
Gene Name Synonym NPR1-like 1, NPR1 homologue 1, nonexpresser of PR genes 1, Arabidopsis NPR1 homolog 1, non-expressor of pathogenesis-related gene 1, Arabidopsis NPR1 homologue 1, pathogenesis-related gene 2, nonexpressor of PR genes 1, Nonexpressor of Pathogenesis-Related Genes1, NONEXPRESSOR OF PATHOGENESIS-RELATED1 HOMOLOG1, NONEXPRESSOR OF PATHOGENESIS-RELATED GENES1, non-expressor pathogenesis-related 1, DLN repressor 5, DLN motif protein 5
Protein Name NPR1 HOMOLOG 1
Allele osnpr1, osnpr1-1, osnpr1-2
Chromosome No. 1
Explanation a rice ortholog of Arabidopsis thaliana NPR1 (NON-EXPRESSOR OF PR 1). AY923983. DQ450948. GU722159, GU722160. GO:2000022: regulation of jasmonic acid mediated signaling pathway. GO:2000031: regulation of salicylic acid mediated signaling pathway. XP_015622114.1
Trait Class Character as QTL - Yield and productivity
Tolerance and resistance - Disease resistance
Tolerance and resistance - Stress tolerance
Tolerance and resistance - Insect resistance
Vegetative organ - Culm
Vegetative organ - Root
cDNA Accession No. AK120715
MSU ID LOC_Os01g09800.1
RAP ID Os01g0194300
Links Oryzabase Chromosome View ( IRGSP 1.0 / Build5 )
RAP-DB ( IRGSP 1.0 / Build5 )
Related IDs List ( IRGSP 1.0 / Build5 )
INSD Accession List
(Test version)
Link to INSD Accession List
Link map Classical linkage map
He L., Chen X., Yang J., Zhang T., Li J., Zhang S., Zhong K., Zhang H., Chen J., Yang J.
New Phytol. 2020  225(2)  896-912
Rice black-streaked dwarf virus-encoded P5-1 regulates the ubiquitination activity of SCF E3 ligases and inhibits jasmonate signaling to benefit its infection in rice.
Jiang G., Yin D., Shi Y., Zhou Z., Li C., Liu P., Jia Y., Wang Y., Liu Z., Yu M., Wu X., Zhai W., Zhu L.
Sci Rep 2020  10(1)  6313
OsNPR3.3-dependent salicylic acid signaling is involved in recessive gene xa5-mediated immunity to rice bacterial blight.
Kachewar N.R., Gupta V., Ranjan A., Patel H.K., Sonti R.V.
BMC Plant Biol. 2019  19(1)  530
Overexpression of OsPUB41, a rice E3 ubiquitin ligase induced by cell wall degrading enzymes, enhances immune responses in Rice and Arabidopsis.
Dong Z., Li W., Liu J., Li L., Pan S., Liu S., Gao J., Liu L., Liu X., Wang G.L., Dai L.
Sci Rep 2019  9(1)  5408
The Rice Phosphate Transporter Protein OsPT8 Regulates disease resistance and Plant Growth.
Atul Prakash Sathe, Su X., Chen Z., Chen T., Wei X., Tang S., Xiao-Bo Zhang, Jian-Li Wu
Rice (N Y) 2019  12(1)  68
Identification and characterization of a spotted-leaf mutant spl40 with enhanced bacterial blight resistance in rice.
Singh P., Mathew I.E., Verma A., Tyagi A.K., Agarwal P.
Int J Mol Sci 2019  20(7) 
Analysis of Rice Proteins with DLN repressor Motif/S.
Ke Y., Kang Y., Wu M., Liu H., Hui S., Zhang Q., Li X., Xiao J., Wang S.
Rice (N Y) 2019  12(1)  25
Jasmonic Acid-Involved OsEDS1 Signaling in Rice-Bacteria Interactions.
Liu Q., Li X., Yan S., Yu T., Yang J., Dong J., Zhang S., Zhao J., Yang T., Mao X., Zhu X., Liu B.
BMC Plant Biol. 2018  18(1)  257
OsWRKY67 positively regulates blast and bacteria blight resistance by direct activation of PR genes in rice.
Nanda S., Wan P.J., Yuan S.Y., Lai F.X., Wang W.X., Fu Q.
Int J Mol Sci 2018  19(12) 
Differential Responses of <i>OsMPK</i>s in IR56 Rice to Two BPH Populations of Different Virulence Levels.
Moon S.J., Park H.J., Kim T.H., Kang J.W., Lee J.Y., Cho J.H., Lee J.H., Park D.S., Byun M.O., Kim B.G., Shin D.
PLoS ONE 2018  13(11)  e0206910
OsTGA2 confers disease resistance to rice against leaf blight by regulating expression levels of disease related genes via interaction with NH1.
Wang Z., Xia Y., Lin S., Wang Y., Guo B., Song X., Ding S., Zheng L., Feng R., Chen S., Bao Y., Sheng C., Zhang X., Wu J., Niu D., Jin H., Zhao H.
Plant J. 2018   
osa-miR164a targets OsNAC60 and negatively regulates rice immunity against the blast fungus Magnaporthe oryzae.
Zhong X., Yang J., Shi Y., Wang X., Wang G.L.
Mol. Plant Pathol. 2017   
The DnaJ protein OsDjA6 negatively regulates rice innate immunity to the blast fungus Magnaporthe oryzae.
Hu L., Wu Y., Wu D., Rao W., Guo J., Ma Y., Wang Z., Shangguan X., Wang H., Xu C., Huang J., Shi S., Chen R., Du B., Zhu L., He G.
Plant Cell 2017  29(12)  3157-3185
The Coiled-Coil and Nucleotide Binding Domains of BROWN PLANTHOPPER RESISTANCE14 Function in Signaling and Resistance against Planthopper in Rice.
Kuang J., Liu J., Mei J., Wang C., Hu H., Zhang Y., Sun M., Ning X., Xiao L., Yang L.
Sci Rep 2017  7(1)  11333
A Class II small heat shock protein OsHsp18.0 plays positive roles in both biotic and abiotic defense responses in rice.
Karmakar S., Molla K.A., Das K., Sarkar S.N., Datta S.K., Datta K.
Sci Rep 2017  7(1)  7900
Dual gene expression cassette is superior than single gene cassette for enhancing sheath blight tolerance in transgenic rice.
Takatsuji H.
Front Plant Sci 2017  8  171
Regulating Tradeoffs to Improve Rice Production.
Liu Q., Ning Y., Zhang Y., Yu N., Zhao C., Zhan X., Wu W., Chen D., Wei X., Wang G.L., Cheng S., Cao L.
Plant Cell 2017  29(2)  345-359
OsCUL3a Negatively Regulates Cell Death and Immunity by Degrading OsNPR1 in Rice.
Lin C.W., Huang L.Y., Huang C.L., Wang Y.C., Lai P.H., Wang H.V., Chang W.C., Chiang T.Y., Huang H.J.
Plant Cell Physiol. 2017  58(3)  546-559
Common Stress Transcriptome Analysis Reveals Functional and Genomic Architecture Differences Between Early and Delayed Response Genes.
Harkenrider M., Sharma R., De Vleesschauwer D., Tsao L., Zhang X., Chern M., Canlas P., Zuo S., Ronald P.C.
PLoS ONE 2016  11(1)  e0147310
Overexpression of Rice Wall-Associated Kinase 25 (OsWAK25) Alters Resistance to Bacterial and Fungal Pathogens.
Liu H., Dong S., Sun D., Liu W., Gu F., Liu Y., Guo T., Wang H., Wang J., Chen Z.
PLoS ONE 2016  11(11)  e0166249
CONSTANS-Like 9 (OsCOL9) Interacts with Receptor for Activated C-Kinase 1(OsRACK1) to Regulate Blast Resistance through Salicylic Acid and Ethylene Signaling Pathways.
Li X., Yang D.L., Sun L., Li Q., Mao B., He Z.
Plant Physiol. 2016  172(1)  546-58
The Systemic Acquired Resistance Regulator OsNPR1 Attenuates Growth by Repressing Auxin Signaling through Promoting IAA-Amido Synthase Expression.
Kadotani N., Akagi A., Takatsuji H., Miwa T., Igarashi D.
BMC Plant Biol. 2016  16(1)  60
Exogenous proteinogenic amino acids induce systemic resistance in rice.
Choi C., Hwang S.H., Fang I.R., Kwon S.I., Park S.R., Ahn I., Kim J.B., Hwang D.J.
New Phytol. 2015   
Molecular characterization of Oryza sativa WRKY6, which binds to W-box-like element 1 of the Oryza sativa pathogenesis-related (PR) 10a promoter and confers reduced susceptibility to pathogens.
Ueda Y., Siddique S., Frei M.
Plant Physiol. 2015   
A novel gene OsORAP1 enhances cell death in ozone stress in rice (Oryza sativa L.).
Li S.B., Xu S.R., Zhang R.N., Liu Y., Zhou R.C.
J. Microbiol. Biotechnol. 2015   
The antibiosis action and rice induced resistance, mediated by a lipopeptide from Bacillus amyloliquefaciens B014, in controlling rice disease caused by Xanthomonas oryzae pv. Oryzae.
Khong G.N., Pati P.K., Richaud F., Parizot B., Bidzinski P., Mai C.D., Bès M., Bourrié I., Meynard D., Beeckman T., Selvaraj M.G., Manabu I., Genga A.M., Brugidou C., Nang Do V., Guiderdoni E., Morel J.B., Gantet P.
Plant Physiol. 2015  169(4)  2935-49
OsMADS26 Negatively Regulates Resistance to Pathogens and Drought Tolerance in Rice.
Xu J., Audenaert K., Hofte M., De Vleesschauwer D.
PLoS ONE 2013  8(6)  e67413
Abscisic Acid Promotes Susceptibility to the Rice Leaf Blight Pathogen Xanthomonas oryzae pv oryzae by Suppressing Salicylic Acid-Mediated Defenses.
Mou S., Liu Z., Guan D., Qiu A., Lai Y., He S.
PLoS ONE 2013  8(3)  e59699
Functional Analysis and Expressional Characterization of Rice Ankyrin Repeat-Containing Protein, OsPIANK1, in Basal Defense against Magnaporthe oryzae Attack.
Nakayama A., Fukushima S., Goto S., Matsushita A., Shimono M., Sugano S., Jiang C.J., Akagi A., Yamazaki M., Inoue H., Takatsuji H.
BMC Plant Biol. 2013  13  150
Genome-wide identification of WRKY45-regulated genes that mediate benzothiadiazole-induced defense responses in rice.
Jiang C.J., Shimono M., Sugano S., Kojima M., Liu X., Inoue H., Sakakibara H., Takatsuji H.
Mol. Plant Microbe Interact. 2013  26(3)  287-96
Cytokinins act synergistically with salicylic acid to activate defense gene expression in rice.
Yang D.L., Yang Y., He Z.
Mol Plant 2013  6(3)  675-85
Role of plant hormones and their cross-talks in rice immunity.
Geng S., Li A., Tang L., Yin L., Wu L., Lei C., Guo X., Zhang X., Jiang G., Zhai W., Wei Y., Zheng Y., Lan X., Mao L.
J. Exp. Bot. 2013  64(11)  3125-36
TaCPK2-A, a calcium-dependent protein kinase gene that is required for wheat powdery mildew resistance enhances bacterial blight resistance in transgenic rice.
Chern M., Bai W., Sze-To WH., Canlas P.E., Bartley L.E., Ronald P.C.
Plant Methods 2012  8(1)  6
A rice transient assay system identifies a novel domain in NRR required for interaction with NH1/OsNPR1 and inhibition of NH1-mediated transcriptional activation.
Campos-Soriano L., García-Martínez J., Segundo B.S.
Mol. Plant Pathol. 2012  13(6)  579-92
The arbuscular mycorrhizal symbiosis promotes the systemic induction of regulatory defence-related genes in rice leaves and confers resistance to pathogen infection.
Matsushita A., Inoue H., Goto S., Nakayama A., Sugano S., Hayashi N., Takatsuji H.
Plant J. 2012   
The nuclear ubiquitin proteasome degradation affects WRKY45 function in the rice defense program.
Chen M., Zeng H., Qiu D., Guo L., Yang X., Shi H., Zhou T., Zhao J.
PLoS ONE 2012  7(5)  e37654
Purification and characterization of a novel hypersensitive response-inducing elicitor from Magnaporthe oryzae that triggers defense response in rice.
Li R., Afsheen S., Xin Z., Han X., Lou Y.
Physiol Plant 2012  147(3)  340-51
OsNPR1 negatively regulates herbivore-induced JA and ethylene signaling and plant resistance to a chewing herbivore in rice.
Shen X., Liu H., Yuan B., Li X., Xu C., Wang S.
Plant Cell Environ. 2011  34(2)  179-91
OsEDR1 negatively regulates rice bacterial resistance via activation of ethylene biosynthesis.
Peng D.H., Qiu D.W., Ruan L.F., Zhou C.F., Sun M.
Mol. Plant Microbe Interact. 2011  24(10)  1239-46
Protein elicitor PemG1 from Magnaporthe grisea induces systemic acquired resistance (SAR) in plants.
Xie X.Z., Xue Y.J., Zhou J.J., Zhang B., Chang H., Takano M.
Mol Plant 2011  4(4)  688-96
Phytochromes regulate SA and JA signaling pathways in rice and are required for developmentally controlled resistance to Magnaporthe grisea.
Bai W., Chern M., Ruan D., Canlas P.E., Sze-To WH., Ronald P.C.
Plant Biotechnol. J. 2011  9(2)  205-15
Enhanced disease resistance and hypersensitivity to BTH by introduction of an NH1/OsNPR1 paralog.
Feng,J.X., Cao,L., Li,J., Duan,C.J., Luo,X.M., Le,N., Wei,H.H., Liang,S.J., Chu,C.C., Pan,Q.H. and Tang,J.L.
Eur. J. Plant Pathol. 2011  131(2)  221-235
Involvement of OsNPR1/NH1 in rice basal resistance to blast fungus Magnaporthe oryzae
Rebecca S Bart, Chern M., Miguel E Vega-Sánchez, Canlas P., Pamela C Ronald
PLoS Genet. 2010  6(9)  e1001123
Rice Snl6, a cinnamoyl-CoA reductase-like gene family member, is required for NH1-mediated immunity to Xanthomonas oryzae pv. oryzae.
Sugano S., Jiang C.-J., Miyazawa S.-I., Masumoto C., Yazawa K., Hayashi N., Shimono M., Nakayama A., Miyao M., Takatsuji H.
Plant Mol. Biol. 2010  74(6)  549-562
Role of OsNPR1 in rice defense program as revealed by genome-wide expression analysis.
Shen X,Yuan B,Liu H,Li X,Xu C,Wang S
Plant J. 2010  64(1)  86-99
Opposite functions of a rice mitogen-activated protein kinase in the process of resistance against Xanthomonas oryzae.
Chang-Jie Jiang, Shimono M., Sugano S., Kojima M., Yazawa K., Yoshida R., Inoue H., Hayashi N., Sakakibara H., Takatsuji H.
Mol. Plant Microbe Interact. 2010  23(6)  791-8
Abscisic acid interacts antagonistically with salicylic acid signaling pathway in rice-Magnaporthe grisea interaction.
Tao Z,Liu H,Qiu D,Zhou Y,Li X,Xu C,Wang S
Plant Physiol. 2009  151(2)  936-48
A pair of allelic WRKY genes play opposite roles in rice-bacteria interactions.
Qiu,D., Xiao,J., Ding,X., Xiong,M., Cai,M., Cao,Y., Li,X., Xu,C. and Wang,S.
Mol. Plant Microbe Interact. 2007  20(5)  492-499
OsWRKY13 mediates rice disease resistance by regulating defense-related genes in salicylate- and jasmonate-dependent signaling
Seong ES,Guo J,Kim YH,Cho JH,Lim CK,Hyun Hur J,Wang MH
Biochem. Biophys. Res. Commun. 2007  363  126-32
Regulations of marker genes involved in biotic and abiotic stress by overexpression of the AtNDPK2 gene in rice.
Yuan,B., Shen,X., Li,X., Xu,C. and Wang,S.
Planta. 2007  226(4)  953-960
Mitogen-activated protein kinase OsMPK6 negatively regulates rice disease resistance to bacterial pathogens
Jorge Gómez-Ariza, Campo S., Rufat M., Montserrat Estopà, Messeguer J., Blanca San Segundo, María Coca
Mol. Plant Microbe Interact. 2007  20(7)  832-42
Sucrose-mediated priming of plant defense responses and broad-spectrum disease resistance by overexpression of the maize pathogenesis-related PRms protein in rice plants.
Yuexing Yuan, Sihui Zhong, Qun Li, Zengrong Zhu, Yonggen Lou, Linyou Wang, Jianjun Wang, Muyang Wang, Qiaoli Li, Donglei Yang and Zuhua He
Plant Biotechnol J. 2007  5  313-324
Functional analysis of rice NPR1-like genes reveals that OsNPR1/NH1 is the rice orthologue conferring disease resistance with enhanced herbivore susceptibility.
Shimono M,Sugano S,Nakayama A,Jiang CJ,Ono K,Toki S,Takatsuji H
Plant Cell 2007  19  2064-76
Rice WRKY45 plays a crucial role in benzothiadiazole-inducible blast resistance.
Chern,M., Canlas,P.E., Fitzgerald,H.A. and Ronald,P.C.
Plant J. 2005  43(5)  623-635
Rice NRR, a negative regulator of disease resistance, interacts with Arabidopsis NPR1 and rice NH1.
Xiao Qiang Liu, Xian Quan Bai, Qian Q., Xiu Jie Wang, Ming Sheng Chen, Cheng Cai Chu
Cell Res. 2005  15(8)  593-603
OsWRKY03, a rice transcriptional activator that functions in defense signaling pathway upstream of OsNPR1.
Chern,M., Fitzgerald,H.A., Canlas,P.E., Navarre,D.A. and Ronald,P.C.
Mol. Plant Microbe Interact. 2005  18(6)  511-520
Overexpression of a rice NPR1 homolog leads to constitutive activation of defense response and hypersensitivity to light.
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DB Reference
Gramene ID -
Gene Ontology defense response to fungus( GO:0050832 )
induced systemic resistance( GO:0009682 )
response to wounding( GO:0009611 )
response to heat( GO:0009408 )
defense response( GO:0006952 )
root development( GO:0048364 )
positive regulation of cell death( GO:0010942 )
response to stress( GO:0006950 )
negative regulation of defense response( GO:0031348 )
positive regulation of transcription, DNA-dependent( GO:0045893 )
response to insect( GO:0009625 )
transcription activator activity( GO:0016563 )
salicylic acid mediated signaling pathway( GO:0009863 )
response to molecule of bacterial origin( GO:0002237 )
defense response to bacterium( GO:0042742 )
response to abscisic acid stimulus( GO:0009737 )
cell death( GO:0008219 )
regulation of systemic acquired resistance( GO:0010112 )
response to chitin( GO:0010200 )
defense response to insect( GO:0002213 )
auxin mediated signaling pathway( GO:0009734 )
defense response, incompatible interaction( GO:0009814 )
Trait Ontology plant growth hormone sensitivity( TO:0000401 )
bacterial blight disease resistance( TO:0000175 )
disease resistance( TO:0000112 )
blast disease( TO:0000074 )
auxin sensitivity( TO:0000163 )
root development trait( TO:0000656 )
seed number( TO:0000445 )
seed weight( TO:0000181 )
plant height( TO:0000207 )
tiller number( TO:0000346 )
jasmonic acid sensitivity( TO:0000172 )
brown planthopper resistance( TO:0000424 )
abscisic acid sensitivity( TO:0000615 )
Plant Ontology root development stage( PO:0007520 )
stem elongation stage( PO:0007089 )
Related Strains
Phenotype images
Last updated
Jul 28, 2020