Gene - Detail

Detail of Gene

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Basic Information
CGSNL Gene Symbol APX2
Gene Symbol Synonym OsAPX2, OsAPx02, APXb, OsAPx2, OSAPX2, APx2, cAPX, OsAPX1, APX1
Gene Name Synonym "L-ascorbate peroxidase 2, cytosolic", ascorbate peroxidase 2, ascorbate peroxidase b
Allele Osapx2
Chromosome No. 7
Explanation KC626128-KC626136 (O. sativa and wild rice species, partial cds). D25238. Q9FE01. AB053297. BAA20889. AB050724. EC= Cytosolic Ascorbate Peroxidase. cAPX in Zhang et al. 2014. OsAPX1 in Huang et al. 2018, Gu et al. 2022. GO:0071588: hydrogen peroxide mediated signaling pathway.
Trait Class Biochemical character
Tolerance and resistance - Disease resistance
Tolerance and resistance - Stress tolerance
cDNA Accession No. AK068430
MSU ID LOC_Os07g49400.1
RAP ID Os07g0694700
Links Oryzabase Chromosome View ( IRGSP 1.0 / Build5 )
RAP-DB ( IRGSP 1.0 / Build5 )
Related IDs List ( IRGSP 1.0 / Build5 )
INSD Accession List
(Test version)
Link to INSD Accession List
Link map Classical linkage map
Huang P., Ding Z., Duan M., Xiong Y., Li X., Yuan X., Huang J.
Int J Mol Sci 2023  24(7) 
<i>OsLUX</i> Confers Rice cold tolerance as a Positive Regulatory Factor.
Purwestri Y.A., Nurbaiti S., Putri S.P.M., Wahyuni I.M., Yulyani S.R., Sebastian A., Nuringtyas T.R., Yamaguchi N.
Plants (Basel) 2023  12(15) 
Seed Halopriming: A Promising Strategy to Induce salt tolerance in Indonesian Pigmented Rice.
Lou D., Lu S., Chen Z., Lin Y., Yu D., Yang X.
BMC Plant Biol. 2023  23(1)  53
Molecular characterization reveals that OsSAPK3 improves drought tolerance and grain yield in rice.
Gu S., Zhuang J., Zhang Z., Chen W., Xu H., Zhao M., Ma D.
Front Plant Sci 2022  13  1110724
Multi-omics approach reveals the contribution of <i>OsSEH1</i> to rice cold tolerance.
Liu X., Deng X.J., Li C.Y., Xiao Y.K., Zhao K., Guo J., Yang X.R., Zhang H.S., Chen C.P., Luo Y.T., Tang Y.L., Yang B., Sun C.H., Wang P.R.
Int J Mol Sci 2022  23(10) 
Mutation of Protoporphyrinogen IX Oxidase Gene Causes Spotted and rolled leaf and Its Overexpression Generates Herbicide Resistance in Rice.
Zhang C., Li N., Hu Z., Liu H., Hu Y., Tan Y., Sun Q., Liu X., Xiao L., Wang W., Wang R.
Int J Mol Sci 2022  23(22) 
Mutation of <i>leaf senescence 1</i> Encoding a C2H2 Zinc Finger Protein Induces ROS Accumulation and Accelerates leaf senescence in Rice.
Zhu F., Wang K., Li D., Liu Z., Li M., Wang Z., Li X., Lan X., Guan Q.
Rice (N Y) 2022  15(1)  69
OsSAP6 Positively Regulates Soda Saline-Alkaline Stress Tolerance in Rice.
Luo C., Min W., Akhtar M., Lu X., Bai X., Zhang Y., Tian L., Li P.
Int J Mol Sci 2022  23(20) 
Melatonin Enhances Drought Tolerance in Rice Seedlings by Modulating Antioxidant Systems, Osmoregulation, and Corresponding Gene Expression.
Lu X., Min W., Shi Y., Tian L., Li P., Ma T., Zhang Y., Luo C.
Front Plant Sci 2022  13  849553
Exogenous Melatonin Alleviates Alkaline Stress by Removing Reactive Oxygen Species and Promoting Antioxidant Defence in Rice Seedlings.
He Y., Zhang X., Shi Y., Xu X., Li L., Wu J.L.
Rice (N Y) 2021  14(1)  53
PREMATURE SENESCENCE LEAF 50 Promotes Heat Stress Tolerance in Rice (Oryza sativa L.).
Jiang J., Yang G., Xin Y., Wang Z., Yan W., Chen Z., Tang X., Xia J.
Genes (Basel) 2021  12(5) 
Overexpression of <i>OsMed16</i> Inhibits the Growth of Rice and Causes Spontaneous Cell Death.
Liu Q., Dong G.R., Ma Y.Q., Zhao S.M., Liu X., Li X.K., Li Y.J., Hou B.K.
Front Plant Sci 2021  12  790195
Rice Glycosyltransferase Gene <i>UGT85E1</i> Is Involved in Drought Stress Tolerance Through Enhancing Abscisic Acid Response.
Mostofa M.G., Ha C.V., Rahman M.M., Nguyen K.H., Keya S.S., Watanabe Y., Itouga M., Hashem A., Abd Allah EF., Fujita M., Tran L.P.
Antioxidants (Basel) 2021  10(11) 
Strigolactones Modulate Cellular Antioxidant Defense Mechanisms to Mitigate Arsenate Toxicity in Rice Shoots.
Jung Y.J., Go J.Y., Lee H.J., Park J.S., Kim J.Y., Lee Y.J., Ahn M.J., Kim M.S., Cho Y.G., Kwak S.S., Kim H.S., Kang K.K.
Genes (Basel) 2021  12(12) 
Overexpression of Orange Gene (<i>OsOr</i>-R115H) Enhances Heat Tolerance and Defense-Related Gene Expression in Rice (<i>Oryza sativa</i> L.).
Zhou D., Li T., Yang Y., Qu Z., Ouyang L., Jiang Z., Lin X., Zhu C., Peng L., Fu J., Peng X., Bian J., Tang W., Xu J., He H.
Front Plant Sci 2020  11  782
<i>OsPLS4</i> Is Involved in Cuticular Wax Biosynthesis and Affects leaf senescence in Rice.
Zhou J., Li Z., Xiao G., Zhai M., Pan X., Huang R., Zhang H.
J. Exp. Bot. 2019   
OsCYP71D8L as a key regulator involved in growth and stress response by mediating gibberellins homeostasis in rice.
Zhang Q., Shen L., Wang Z., Hu G., Ren D., Hu J., Zhu L., Gao Z., Zhang G., Guo L., Zeng D., Qian Q.
Int J Mol Sci 2019  20(18) 
OsCAF1, a CRM Domain Containing Protein, Influences Chloroplast Development.
Zhang W., Sheng J., Xu Y., Xiong F., Wu Y., Wang W., Wang Z., Yang J., Zhang J.
BMC Plant Biol. 2019  19(1)  409
Role of brassinosteroids in rice spikelet differentiation and degeneration under soil-drying during panicle development.
Xiong H., Yu J., Miao J., Li J., Zhang H., Wang X., Liu P., Zhao Y., Jiang C., Yin Z., Li Y., Guo Y., Fu B., Wang W., Li Z., Ali J., Li Z.
Plant Physiol. 2018  178(1)  451-467
Natural Variation in <i>OsLG3</i> Increases drought tolerance in Rice by Inducing ROS Scavenging.
Huang L., Jia J., Zhao X., Zhang M., Huang X., E Ji, Ni L., Jiang M.
Biochem. Biophys. Res. Commun. 2018  495(1)  339-345
The ascorbate peroxidase APX1 is a direct target of a zinc finger transcription factor ZFP36 and a late embryogenesis abundant protein OsLEA5 interacts with ZFP36 to co-regulate OsAPX1 in seed germination in rice.
Huang B., Zhang J.M., Chen X.L., Xin X., Yin G.K., He J.J., Lu X.X., Zhou Y.C.
Plant Cell Rep. 2018   
Oxidative damage and antioxidative indicators in 48 h germinated rice embryos during the vitrification-cryopreservation procedure.
Huang L., Zhang M., Jia J., Zhao X., Huang X., Ji E., Ni L., Jiang M.
Plant Cell Physiol. 2018  59(5)  916-929
An Atypical Late Embryogenesis Abundant Protein OsLEA5 Plays a Positive Role in ABA-Induced Antioxidant Defense in Oryza sativa L.
Leng Y., Yang Y., Ren D., Huang L., Dai L., Wang Y., Chen L., Tu Z., Gao Y., Li X., Zhu L., Hu J., Zhang G., Gao Z., Guo L., Kong Z., Lin Y., Qian Q., Zeng D.
Plant Physiol. 2017   
A rice pectate lyase-LIKE gene is required for plant growth and leaf senescence.
Auler P.A., Benitez L.C., do Amaral MN., Vighi I.L., Rodrigues G.S., da Maia LC., Braga E.J.B.
Genet. Mol. Res. 2017  16(2) 
Selection of candidate reference genes and validation for real-time PCR studies in rice plants exposed to low temperatures.
Lou D., Wang H., Liang G., Yu D.
Front Plant Sci 2017  8  993
OsSAPK2 Confers Abscisic Acid Sensitivity and Tolerance to Drought Stress in Rice.
Jiang G., Yin D., Zhao J., Chen H., Guo L., Zhu L., Zhai W.
Sci Rep 2016  6  26104
The rice thylakoid membrane-bound ascorbate peroxidase OsAPX8 functions in tolerance to bacterial blight.
Guan Q.J., Ma H.Y., Wang Z.J., Wang Z.Y., Bu Q.Y., Liu S.K.
BMC Genomics 2016  17(1)  142
A rice LSD1-like-type ZFP gene OsLOL5 enhances saline-alkaline tolerance in transgenic Arabidopsis thaliana, yeast and rice.
Bonifacio A., Carvalho F.E., Martins M.O., Lima Neto MC., Cunha J.R., Ribeiro C.W., Margis-Pinheiro M., Silveira J.A.
J. Plant Physiol. 2016  201  17-27
Silenced rice in both cytosolic ascorbate peroxidases displays pre-acclimation to cope with oxidative stress induced by 3-aminotriazole-inhibited catalase.
Wang D., Qin B., Li X., Tang D., Zhang Y., Cheng Z., Xue Y.
PLoS Genet. 2016  12(2)  e1005844
Nucleolar DEAD-box RNA helicase TOGR1 Regulates Thermotolerant Growth as a Pre-rRNA Chaperone in Rice.
Yang Y., Xu J., Huang L., Leng Y., Dai L., Rao Y., Chen L., Wang Y., Tu Z., Hu J., Ren D., Zhang G., Zhu L., Guo L., Qian Q., Zeng D.
J. Exp. Bot. 2015   
PGL, encoding chlorophyllide a oxygenase 1, impacts leaf senescence and indirectly affects grain yield and quality in rice.
Zhu,T., Xu,P.Z., Liu,J.P., Peng,S., Mo,X.C. and Gao,L.Z.
Mol. Phylogenet. Evol. 2014  70  348-361
Phylogenetic relationships and genome divergence among the AA- genome species of the genus Oryza as revealed by 53 nuclear genes and 16 intergenic regions
Hayashi G., Shibato J., Imanaka T., Cho K., Kubo A., Kikuchi S., Satoh K., Kimura S., Ozawa S., Fukutani S., Endo S., Ichikawa K., Agrawal G.K., Shioda S., Fukumoto M., Rakwal R.
J. Hered. 2014  105(5)  723-38
Unraveling low-level gamma radiation--responsive changes in expression of early and late genes in leaves of rice seedlings at litate Village, Fukushima.
Li Z., Su D., Lei B., Wang F., Geng W., Pan G., Cheng F.
J. Plant Physiol. 2014  176C  1-15
Transcriptional profile of genes involved in ascorbate glutathione cycle in senescing leaves for an early senescence leaf (esl) rice mutant.
Suzuki K., Aoki N., Matsumura H., Okamura M., Ohsugi R., Shimono H.
Plant Cell Environ. 2014   
Cooling water before panicle initiation increases chilling-induced male sterility and disables chilling-induced expression of genes encoding OsFKBP65 and heat shock proteins in rice spikelets.
Zhang H., Liu Y., Wen F., Yao D., Wang L., Guo J., Ni L., Zhang A., Tan M., Jiang M.
J. Exp. Bot. 2014  65(20)  5795-809
A novel rice C2H2-type zinc finger protein, ZFP36, is a key player involved in abscisic acid-induced antioxidant defence and oxidative stress tolerance in rice.
Song Y.a, Cui J.a, Zhang H.b, Wang G.a, Zhao F.J.c, Shen Z.a
Plant Soil 2013  366  647-658
Proteomic analysis of copper stress responses in the roots of two rice (Oryza sativa L.) varieties differing in Cu tolerance
Zhang Z., Zhang Q., Wu J., Zheng X., Zheng S., Sun X., Qiu Q., Lu T.
PLoS ONE 2013  8(2)  e57472
Gene knockout study reveals that cytosolic ascorbate peroxidase 2(OsAPX2) plays a critical role in growth and reproduction in rice under drought, salt and cold stresses.
Guan Q., Takano T., Liu S.
PLoS ONE 2012  7(7)  e41233
Genetic Transformation and Analysis of Rice OsAPx2 Gene in Medicago sativa.
Chou T.S., Chao Y.Y., Kao C.H.
J. Plant Physiol. 2012  169(5)  478-86
Involvement of hydrogen peroxide in heat shock- and cadmium-induced expression of ascorbate peroxidase and glutathione reductase in leaves of rice seedlings.
Ribeiro C.W., Carvalho F.E., Rosa S.B., Alves-Ferreira M., Andrade C.M., Ribeiro-Alves M., Silveira J.A., Margis R., Margis-Pinheiro M.
Plant Biol (Stuttg) 2012  14(6)  944-55
Modulation of genes related to specific metabolic pathways in response to cytosolic ascorbate peroxidase knockdown in rice plants.
Asano T., Hayashi N., Kobayashi M., Aoki N., Miyao A., Mitsuhara I., Ichikawa H., Komatsu S., Hirochika H., Kikuchi S., Ohsugi R.
Plant J. 2012  69  26-36
A rice calcium-dependent protein kinase OsCPK12 oppositely modulates salt-stress tolerance and blast disease resistance.
Bonifacio A., Martins M.O., Ribeiro C.W., Fontenele A.V., Carvalho F.E., Margis-Pinheiro M., Silveira J.A.
Plant Cell Environ. 2011  34(10)  1705-22
Role of peroxidases in the compensation of cytosolic ascorbate peroxidase knockdown in rice plants under abiotic stress.
Fukao T,Yeung E,Bailey-Serres J
Plant Cell 2011  23(1)  412-27
The Submergence Tolerance Regulator SUB1A Mediates Crosstalk between Submergence and Drought Tolerance in Rice.
Park SH, Yi N, Kim YS, Jeong MH, Bang SW, Choi YD, Kim JK.
J. Exp. Bot. 2010  61(9)  2459-67.
Analysis of five novel putative constitutive gene promoters in transgenic rice plants.
Sílvia B Rosa, Andréia Caverzan, Felipe K Teixeira, Lazzarotto F., Joaquim A G Silveira, Sérgio Luiz Ferreira-Silva, João Abreu-Neto, Rogério Margis, Márcia Margis-Pinheiro
Phytochemistry 2010  71(5-6)  548-58
Cytosolic APx knockdown indicates an ambiguous redox responses in rice.
Rakwal R., Ganesh Kumar Agrawal, Shibato J., Imanaka T., Fukutani S., Tamogami S., Endo S., Sarata Kumar Sahoo, Masuo Y., Kimura S.
Int J Mol Sci 2009  10(3)  1215-25
Ultra low-dose radiation: stress responses and impacts using rice as a grass model.
Seong ES,Guo J,Kim YH,Cho JH,Lim CK,Hyun Hur J,Wang MH
Biochem. Biophys. Res. Commun. 2007  363  126-32
Regulations of marker genes involved in biotic and abiotic stress by overexpression of the AtNDPK2 gene in rice.
Hong CY,Hsu YT,Tsai YC,Kao CH
J. Exp. Bot. 2007  58  3273-83
Expression of ASCORBATE PEROXIDASE 8 in roots of rice (Oryza sativa L.) seedlings in response to NaCl.
Teixeira FK,Menezes-Benavente L,Galvao VC,Margis R,Margis-Pinheiro M
Planta. 2006  224  300-14
Rice ascorbate peroxidase gene family encodes functionally diverse isoforms localized in different subcellular compartments.
Lu,Z., Takano,T. and Liu,S.
Biotechnol. Lett. 2005  27(1)  63-67
Purification and characterization of two ascorbate peroxidases of rice (Oryza sativa L.) expressed in Escherichia coli.
Teixeira,F.K., Menezes-Benavente,L., Margis,R. and Margis-Pinheiro,M.
J. Mol. Evol. 2004  59(6)  761-770
Analysis of the molecular evolutionary history of the ascorbate peroxidase gene family: inferences from the rice genome.
Ganesh Kumar Agrawal, Nam Soo Jwa, Iwahashi H., Rakwal R.
Gene 2003  322  93-103
Importance of ascorbate peroxidases OsAPX1 and OsAPX2 in the rice pathogen response pathways and growth and reproduction revealed by their transcriptional profiling.
Ganesh Kumar Agrawal, Rakwal R., Yonekura M., Kubo A., Saji H.
Proteomics 2002  2(8)  947-59
Proteome analysis of differentially displayed proteins as a tool for investigating ozone stress in rice (Oryza sativa L.) seedlings.
Y Sato, T Murakami, H Funatsuki, S Matsuba, H Saruyama, M Tanida
Journal of Experimental Botany 2001  52(354)  145-51
Heat shock-mediated APX gene expression and protection against chilling injury in rice seedlings.
Morita,S., Kaminaka,H., Yokoi,H., Masumura,T. and Tanaka,K.
Plant Physiol. 1997  113  306
Cloning and characterization of cytosolic ascorbate peroxidase cDNA from rice (PGR97-012)
Ye J., Yang Y.L., Wei X.H., Niu X.J., Wang S., Xu Q., Yuan X.P., Yu H.Y., Wang Y.P., Feng Y., Wang S.
J Zhejiang Univ Sci B   19(4)  263-273
PGL3 is required for chlorophyll synthesis and impacts leaf senescence in rice.
TextPresso Search Search textpresso for APX2 ( Recent references may be retrievable, but without any warranty )
DB Reference
Gramene ID -
Gene Ontology response to alkalinity( GO:0010446 )
response to salt stress( GO:0009651 )
response to arsenic( GO:0046685 )
response to hormone stimulus( GO:0009725 )
response to heat( GO:0009408 )
response to abscisic acid stimulus( GO:0009737 )
heme binding( GO:0020037 )
potassium ion binding( GO:0030955 )
hydrogen peroxide catabolic process( GO:0042744 )
calcium ion binding( GO:0005509 )
L-ascorbate peroxidase activity( GO:0016688 )
response to gamma radiation( GO:0010332 )
response to cold( GO:0009409 )
response to oxidative stress( GO:0006979 )
regulation of hydrogen peroxide metabolic process( GO:0010310 )
defense response to bacterium( GO:0042742 )
oxidation reduction( GO:0055114 )
response to copper ion( GO:0046688 )
seed germination( GO:0009845 )
abscisic acid mediated signaling( GO:0009738 )
peroxidase activity( GO:0004601 )
cytoplasm( GO:0005737 )
superoxide metabolic process( GO:0006801 )
response to water deprivation( GO:0009414 )
brassinosteroid mediated signaling( GO:0009742 )
Trait Ontology cold tolerance( TO:0000303 )
bacterial blight disease resistance( TO:0000175 )
copper sensitivity( TO:0000021 )
abscisic acid sensitivity( TO:0000615 )
oxidative stress( TO:0002657 )
drought tolerance( TO:0000276 )
brassinosteroid sensitivity( TO:0002677 )
heat tolerance( TO:0000259 )
plant growth hormone sensitivity( TO:0000401 )
salt tolerance( TO:0006001 )
alkali sensitivity( TO:0000481 )
Plant Ontology 0 seed germination stage( PO:0007057 )
shoot system( PO:0009006 )
Related Strains
Phenotype images
Last updated
Nov 23, 2023