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Detail of Gene

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Basic Information
CGSNL Gene Symbol APX1
Gene Symbol Synonym OsAPX1, APXa, OsAPXa, OsAPx01, OsAPx1, OSAPX1, APx1, cAPX, APX2, cAPXa, OscAPXa
Gene Name Synonym "L-ascorbate peroxidase 1, cytosolic", Ascorbate peroxidase, cytosolic Ascorbate Peroxidase, ascorbate peroxidase 1, ascorbate peroxidase a
Chromosome No. 3
Explanation EC= A2XFC7(indica). Q10N21(japonica). B7E6Z4. D45423. C28227. AY254495. BAA08264. C25998, AU092225. PMDBID: PM0078091. BGIOSGA012374. GO:0072593: reactive oxygen species metabolic process. GO:0071588: hydrogen peroxide mediated signaling pathway. APX2 in Zhou et al. 2021.
Trait Class Biochemical character
Tolerance and resistance - Disease resistance
Tolerance and resistance - Stress tolerance
cDNA Accession No. AK061841
MSU ID LOC_Os03g17690.1
RAP ID Os03g0285700
Links Oryzabase Chromosome View ( IRGSP 1.0 / Build5 )
RAP-DB ( IRGSP 1.0 / Build5 )
Related IDs List ( IRGSP 1.0 / Build5 )
INSD Accession List
(Test version)
Link to INSD Accession List
Link map Classical linkage map
Mei W., Chen W., Wang Y., Liu Z., Dong Y., Zhang G., Deng H., Liu X., Lu X., Wang F., Chen G., Tang W., Xiao Y.
Int J Mol Sci 2023  24(7) 
Exogenous Kinetin Modulates ROS Homeostasis to Affect heat tolerance in Rice Seedlings.
Gupta A., Singh A.N., Tiwari R.K., Sahu P.K., Yadav J., Srivastava A.K., Kumar S.
Plants (Basel) 2023  12(5) 
Salinity Alleviation and Reduction in Oxidative Stress by Endophytic and Rhizospheric Microbes in Two Rice Cultivars.
Huang P., Ding Z., Duan M., Xiong Y., Li X., Yuan X., Huang J.
Int J Mol Sci 2023  24(7) 
<i>OsLUX</i> Confers Rice cold tolerance as a Positive Regulatory Factor.
Liu X., Deng X.J., Li C.Y., Xiao Y.K., Zhao K., Guo J., Yang X.R., Zhang H.S., Chen C.P., Luo Y.T., Tang Y.L., Yang B., Sun C.H., Wang P.R.
Int J Mol Sci 2022  23(10) 
Mutation of Protoporphyrinogen IX Oxidase Gene Causes Spotted and rolled leaf and Its Overexpression Generates Herbicide Resistance in Rice.
Guo Z., Cai L., Liu C., Chen Z., Guan S., Ma W., Pan G.
Sci Rep 2022  12(1)  6224
Low-temperature stress affects reactive oxygen species, osmotic adjustment substances, and antioxidants in rice (Oryza sativa L.) at the reproductive stage.
Chen Z., Wang Y., Huang R., Zhang Z., Huang J., Yu F., Lin Y., Guo Y., Liang K., Zhou Y., Chen F.
BMC Plant Biol. 2022  22(1)  137
Integration of transcriptomic and proteomic analyses reveals several levels of metabolic regulation in the excess starch and early senescent leaf mutant LSES1 in rice.
Wang Y., Teng Z., Li H., Wang W., Xu F., Sun K., Chu J., Qian Y., Loake G.J., Chu C., Tang J.
Plant Commun 2022    100459
An activated form of NB-ARC protein RLS1 functions with cysteine-rich receptor-like protein RMC to trigger cell death in rice.
Freeg H.A., Attia K.A., Casson S., Fiaz S., Ramadan E.A., Banna A.E., Zoulias N., Aboshosha A., Alamery S.
PLoS ONE 2022  17(3)  e0266087
Physio-biochemical responses and expressional profiling analysis of drought tolerant genes in new promising rice genotype.
Wang A., Shu X., Jing X., Jiao C., Chen L., Zhang J., Ma L., Jiang Y., Yamamoto N., Li S., Deng Q., Wang S., Zhu J., Liang Y., Zou T., Liu H., Wang L., Huang Y., Li P., Zheng A.
Plant Biotechnol. J. 2021   
Identification of rice (Oryza sativa L.) genes involved in sheath blight resistance via a genome-wide association study.
He Y., Zhang X., Shi Y., Xu X., Li L., Wu J.L.
Rice (N Y) 2021  14(1)  53
PREMATURE SENESCENCE LEAF 50 Promotes Heat Stress Tolerance in Rice (Oryza sativa L.).
Mostofa M.G., Ha C.V., Rahman M.M., Nguyen K.H., Keya S.S., Watanabe Y., Itouga M., Hashem A., Abd Allah EF., Fujita M., Tran L.P.
Antioxidants (Basel) 2021  10(11) 
Strigolactones Modulate Cellular Antioxidant Defense Mechanisms to Mitigate Arsenate Toxicity in Rice Shoots.
Zhou H., Zhou Y., Zhang F., Guan W., Su Y., Yuan X., Xie Y.
Int J Mol Sci 2021  22(22) 
Persulfidation of nitrate reductase 2 Is Involved in l-Cysteine Desulfhydrase-Regulated Rice drought tolerance.
Hu B., Zhou Y., Zhou Z., Sun B., Zhou F., Yin C., Ma W., Chen H., Lin Y.
Plant Biotechnol. J. 2021   
Repressed OsMESL expression triggers reactive oxygen species-mediated broad-spectrum disease resistance in rice.
Fang G., Yang S., Ruan B., Liu C., Zhang A., Jiang H., Ding S., Tian B., Zhang Y., Jahan N., Zhu L., Zhang G., Dong G., Zhang Q., Zeng D., Guo L., Gao Z., Qian Q.
Rice (N Y) 2020  13(1)  49
Isolation of TSCD11 Gene for Early Chloroplast Development under High Temperature in Rice.
Zhou D., Li T., Yang Y., Qu Z., Ouyang L., Jiang Z., Lin X., Zhu C., Peng L., Fu J., Peng X., Bian J., Tang W., Xu J., He H.
Front Plant Sci 2020  11  782
<i>OsPLS4</i> Is Involved in Cuticular Wax Biosynthesis and Affects leaf senescence in Rice.
Shi Y., Chang Y.L., Wu H.T., Shalmani A., Liu W.T., Li W.Q., Xu J.W., Chen K.M.
Plant Cell Rep. 2020  39(12)  1767-1784
OsRbohB-mediated ROS production plays a crucial role in drought stress tolerance of rice.
L L Liu, J You, Z Zhu, K Y Chen, M M Hu, H Gu, Z W Liu, Z Y Wang, Y H Wang, S J Liu, L M Chen, X Liu, Y L Tian, S R Zhou, L Jiang, J M Wan
Plant Cell Rep. 2020  39(1)  19-33
WHITE STRIPE LEAF8, encoding a deoxyribonucleoside kinase, is involved in chloroplast development in rice.
Xu Y., Wang R., Wang Y., Zhang L., Yao S.
Plant Cell Environ. 2020  43(4)  992-1007
A point mutation in ltt1 enhances cold tolerance at the booting stage in rice.
Fang C., Zhang P., Li L., Yang L., Mu D., Yan X., Li Z., Lin W.
BMC Plant Biol. 2020  20(1)  236
serine hydroxymethyltransferase localised in the endoplasmic reticulum plays a role in scavenging H2O2 to enhance rice chilling tolerance.
Zhang Q., Shen L., Wang Z., Hu G., Ren D., Hu J., Zhu L., Gao Z., Zhang G., Guo L., Zeng D., Qian Q.
Int J Mol Sci 2019  20(18) 
OsCAF1, a CRM Domain Containing Protein, Influences Chloroplast Development.
Zhang W., Sheng J., Xu Y., Xiong F., Wu Y., Wang W., Wang Z., Yang J., Zhang J.
BMC Plant Biol. 2019  19(1)  409
Role of brassinosteroids in rice spikelet differentiation and degeneration under soil-drying during panicle development.
Das P., Lakra N., Nutan K.K., Singla-Pareek SL., Pareek A.
Rice (N Y) 2019  12(1)  58
A unique bZIP transcription factor imparting multiple stress tolerance in Rice.
Xiong H., Yu J., Miao J., Li J., Zhang H., Wang X., Liu P., Zhao Y., Jiang C., Yin Z., Li Y., Guo Y., Fu B., Wang W., Li Z., Ali J., Li Z.
Plant Physiol. 2018  178(1)  451-467
Natural Variation in <i>OsLG3</i> Increases drought tolerance in Rice by Inducing ROS Scavenging.
Lin S., Nie P., Ding S., Zheng L., Chen C., Feng R., Wang Z., Wang L., Wang J., Fang Z., Zhou S., Ma H., Zhao H.
Int J Mol Sci 2018  19(7) 
Quantitative Proteomic Analysis Provides Insights into Rice Defense Mechanisms against <i>Magnaporthe oryzae</i>.
Kim Y., Mun B.G., Khan A.L., Waqas M., Kim H.H., Shahzad R., Imran M., Yun B.W., Lee I.J.
PLoS ONE 2018  13(3)  e0192650
Regulation of reactive oxygen and nitrogen species by salicylic acid in rice plants under salinity stress conditions.
Ning X., Sun Y., Wang C., Zhang W., Sun M., Hu H., Liu J., Yang L.
Front Plant Sci 2018  9  111
A Rice CPYC-type Glutaredoxin <i>OsGRX20</i> in Protection against Bacterial Blight, Methyl Viologen and Salt Stresses.
Leng Y., Yang Y., Ren D., Huang L., Dai L., Wang Y., Chen L., Tu Z., Gao Y., Li X., Zhu L., Hu J., Zhang G., Gao Z., Guo L., Kong Z., Lin Y., Qian Q., Zeng D.
Plant Physiol. 2017   
A rice pectate lyase-LIKE gene is required for plant growth and leaf senescence.
Ghneim-Herrera T., Selvaraj M.G., Meynard D., Fabre D., Peña A., Ben Romdhane W., Ben Saad R., Ogawa S., Rebolledo M.C., Ishitani M., Tohme J., Al-Doss A., Guiderdoni E., Hassairi A.
Front Plant Sci 2017  8  994
Expression of the Aeluropus littoralis AlSAP Gene Enhances Rice Yield under Field Drought at the Reproductive Stage.
Rossatto T., do Amaral MN., Benitez L.C., Vighi I.L., Braga E.J.B., de Magalhães Júnior AM., Maia M.A.C., da Silva Pinto L.
Physiol Mol Biol Plants 2017  23(4)  865-875
Gene expression and activity of antioxidant enzymes in rice plants, cv. BRS AG, under saline stress.
Jing P., Zou J., Kong L., Hu S., Wang B., Yang J., Xie G.
Plant Sci. 2016  247  104-14
OsCCD1, a novel small calcium-binding protein with one EF-hand motif, positively regulates osmotic and salt tolerance in rice.
Morino K., Kimizu M., Fujiwara M.
Proteome Sci 2016  15  6
Disulfide proteomics of rice cultured cells in response to OsRacl and probenazole-related immune signaling pathway in rice.
Bonifacio A., Carvalho F.E., Martins M.O., Lima Neto MC., Cunha J.R., Ribeiro C.W., Margis-Pinheiro M., Silveira J.A.
J. Plant Physiol. 2016  201  17-27
Silenced rice in both cytosolic ascorbate peroxidases displays pre-acclimation to cope with oxidative stress induced by 3-aminotriazole-inhibited catalase.
Tripathy M.K., Tiwari B.S., Reddy M.K., Deswal R., Sopory S.K.
Protoplasma 2015   
Ectopic expression of PgRab7 in rice plants (Oryza sativa L.) results in differential tolerance at the vegetative and seed setting stage during salinity and drought stress.
Yang Y., Xu J., Huang L., Leng Y., Dai L., Rao Y., Chen L., Wang Y., Tu Z., Hu J., Ren D., Zhang G., Zhu L., Guo L., Qian Q., Zeng D.
J. Exp. Bot. 2015   
PGL, encoding chlorophyllide a oxygenase 1, impacts leaf senescence and indirectly affects grain yield and quality in rice.
Hayashi G., Shibato J., Imanaka T., Cho K., Kubo A., Kikuchi S., Satoh K., Kimura S., Ozawa S., Fukutani S., Endo S., Ichikawa K., Agrawal G.K., Shioda S., Fukumoto M., Rakwal R.
J. Hered. 2014  105(5)  723-38
Unraveling low-level gamma radiation--responsive changes in expression of early and late genes in leaves of rice seedlings at litate Village, Fukushima.
Suzuki K., Aoki N., Matsumura H., Okamura M., Ohsugi R., Shimono H.
Plant Cell Environ. 2014   
Cooling water before panicle initiation increases chilling-induced male sterility and disables chilling-induced expression of genes encoding OsFKBP65 and heat shock proteins in rice spikelets.
Li Z., Su D., Lei B., Wang F., Geng W., Pan G., Cheng F.
J. Plant Physiol. 2014  176C  1-15
Transcriptional profile of genes involved in ascorbate glutathione cycle in senescing leaves for an early senescence leaf (esl) rice mutant.
Singh I., Shah K.
Biometals 2014  27(2)  247-63
Evidences for structural basis of altered ascorbate peroxidase activity in cadmium-stressed rice plants exposed to jasmonate.
Song Y.a, Cui J.a, Zhang H.b, Wang G.a, Zhao F.J.c, Shen Z.a
Plant Soil 2013  366  647-658
Proteomic analysis of copper stress responses in the roots of two rice (Oryza sativa L.) varieties differing in Cu tolerance
Ben Saad R., Fabre D., Mieulet D., Meynard D., Dingkuhn M., Al-Doss A., Guiderdoni E., Hassairi A.
Plant Cell Environ. 2012  35(3)  626-43
Expression of the Aeluropus littoralis AlSAP gene in rice confers broad tolerance to abiotic stresses through maintenance of photosynthesis.
Ribeiro C.W., Carvalho F.E., Rosa S.B., Alves-Ferreira M., Andrade C.M., Ribeiro-Alves M., Silveira J.A., Margis R., Margis-Pinheiro M.
Plant Biol (Stuttg) 2012  14(6)  944-55
Modulation of genes related to specific metabolic pathways in response to cytosolic ascorbate peroxidase knockdown in rice plants.
Chou T.S., Chao Y.Y., Kao C.H.
J. Plant Physiol. 2012  169(5)  478-86
Involvement of hydrogen peroxide in heat shock- and cadmium-induced expression of ascorbate peroxidase and glutathione reductase in leaves of rice seedlings.
Parlanti S., Kudahettige N.P., Lombardi L., Mensuali-Sodi A., Alpi A., Perata P., Pucciariello C.
Ann. Bot. 2011  107(8)  1335-43
Distinct mechanisms for aerenchyma formation in leaf sheaths of rice genotypes displaying a quiescence or escape strategy for flooding tolerance.
Fukao T,Yeung E,Bailey-Serres J
Plant Cell 2011  23(1)  412-27
The Submergence Tolerance Regulator SUB1A Mediates Crosstalk between Submergence and Drought Tolerance in Rice.
Ruan S.L., Ma H.S., Wang S.H., Fu Y.P., Xin Y., Liu W.Z., Wang F., Tong J.X., Wang S.Z., Chen H.Z.
BMC Plant Biology 2011  11  -
Proteomic identification of OsCYP2, a rice cyclophilin that confers salt tolerance in rice (Oryza sativa L.) seedlings when overexpressed
Xu S., Hu B., He Z., Ma F., Feng J., Shen W., Yang J.
Int J Mol Sci 2011  12(4)  2488-501
Enhancement of Salinity Tolerance during Rice Seed Germination by Presoaking with Hemoglobin.
Bonifacio A., Martins M.O., Ribeiro C.W., Fontenele A.V., Carvalho F.E., Margis-Pinheiro M., Silveira J.A.
Plant Cell Environ. 2011  34(10)  1705-22
Role of peroxidases in the compensation of cytosolic ascorbate peroxidase knockdown in rice plants under abiotic stress.
Sílvia B Rosa, Andréia Caverzan, Felipe K Teixeira, Lazzarotto F., Joaquim A G Silveira, Sérgio Luiz Ferreira-Silva, João Abreu-Neto, Rogério Margis, Márcia Margis-Pinheiro
Phytochemistry 2010  71(5-6)  548-58
Cytosolic APx knockdown indicates an ambiguous redox responses in rice.
Rakwal R., Ganesh Kumar Agrawal, Shibato J., Imanaka T., Fukutani S., Tamogami S., Endo S., Sarata Kumar Sahoo, Masuo Y., Kimura S.
Int J Mol Sci 2009  10(3)  1215-25
Ultra low-dose radiation: stress responses and impacts using rice as a grass model.
Hong CY,Hsu YT,Tsai YC,Kao CH
J. Exp. Bot. 2007  58  3273-83
Expression of ASCORBATE PEROXIDASE 8 in roots of rice (Oryza sativa L.) seedlings in response to NaCl.
Seong ES,Guo J,Kim YH,Cho JH,Lim CK,Hyun Hur J,Wang MH
Biochem. Biophys. Res. Commun. 2007  363  126-32
Regulations of marker genes involved in biotic and abiotic stress by overexpression of the AtNDPK2 gene in rice.
Teixeira FK,Menezes-Benavente L,Galvao VC,Margis R,Margis-Pinheiro M
Planta. 2006  224  300-14
Rice ascorbate peroxidase gene family encodes functionally diverse isoforms localized in different subcellular compartments.
Yu-Chang Tsai, Chwan-Yang Hong, Li-Fei Liu, Ching Huei Kao
Journal of plant physiology 2005  162(3)  291-9
Expression of ascorbate peroxidase and glutathione reductase in roots of rice seedlings in response to NaCl and H2O2.
Lu,Z., Takano,T. and Liu,S.
Biotechnol. Lett. 2005  27(1)  63-67
Purification and characterization of two ascorbate peroxidases of rice (Oryza sativa L.) expressed in Escherichia coli.
Teixeira,F.K., Menezes-Benavente,L., Margis,R. and Margis-Pinheiro,M.
J. Mol. Evol. 2004  59(6)  761-770
Analysis of the molecular evolutionary history of the ascorbate peroxidase gene family: inferences from the rice genome.
Yamaguchi,T., Nakayama,K., Hayashi,T., Yazaki,J., Kishimoto,N., Kikuchi,S. and Koike,S.
Biosci. Biotechnol. Biochem. 2004  68(6)  1315-1323
cDNA Microarray Analysis of Rice Anther Genes under Chilling Stress at the Microsporogenesis Stage Revealed Two Genes with DNA Transposon Castaway in the 5'-Flanking Region.
Ganesh Kumar Agrawal, Nam Soo Jwa, Iwahashi H., Rakwal R.
Gene 2003  322  93-103
Importance of ascorbate peroxidases OsAPX1 and OsAPX2 in the rice pathogen response pathways and growth and reproduction revealed by their transcriptional profiling.
Ganesh Kumar Agrawal, Rakwal R., Yonekura M., Kubo A., Saji H.
Proteomics 2002  2(8)  947-59
Proteome analysis of differentially displayed proteins as a tool for investigating ozone stress in rice (Oryza sativa L.) seedlings.
Y Sato, T Murakami, H Funatsuki, S Matsuba, H Saruyama, M Tanida
Journal of Experimental Botany 2001  52(354)  145-51
Heat shock-mediated APX gene expression and protection against chilling injury in rice seedlings.
Morita S, Kaminaka H, Masumura T, Tanaka K
Plant Cell Physiol. 1999  40(4)  417-422
Induction of Rice Cytosolic Ascorbate Peroxidase mRNA by Oxidative Stress; the Involvement of Hydrogen Peroxide in Oxidative Stress Signalling
Morita,S., Kaminaka,H., Yokoi,H., Masumura,T. and Tanaka,K.
Plant Physiol. 1997  113  306
Cloning and characterization of cytosolic ascorbate peroxidase cDNA from rice (PGR97-012)
TextPresso Search Search textpresso for APX1 ( Recent references may be retrievable, but without any warranty )
DB Reference
Gramene ID GR:0061471
Gene Ontology response to cytokinin stimulus( GO:0009735 )
response to symbiotic bacterium( GO:0009609 )
response to cold( GO:0009409 )
response to arsenic( GO:0046685 )
response to gamma radiation( GO:0010332 )
response to heat( GO:0009408 )
response to salt stress( GO:0009651 )
cytoplasm( GO:0005737 )
L-ascorbate peroxidase activity( GO:0016688 )
potassium ion binding( GO:0030955 )
oxidation reduction( GO:0055114 )
response to oxidative stress( GO:0006979 )
regulation of hydrogen peroxide metabolic process( GO:0010310 )
response to redox state( GO:0051775 )
heme binding( GO:0020037 )
hydrogen peroxide catabolic process( GO:0042744 )
response to copper ion( GO:0046688 )
calcium ion binding( GO:0005509 )
fructose catabolic process( GO:0006001 )
response to osmotic stress( GO:0006970 )
response to salicylic acid stimulus( GO:0009751 )
defense response to fungus( GO:0050832 )
brassinosteroid mediated signaling( GO:0009742 )
response to water deprivation( GO:0009414 )
Trait Ontology temperature response trait( TO:0000432 )
jasmonic acid sensitivity( TO:0000172 )
osmotic response sensitivity( TO:0000095 )
salt tolerance( TO:0006001 )
oxidative stress( TO:0002657 )
copper sensitivity( TO:0000021 )
abiotic stress trait( TO:0000168 )
blast disease( TO:0000074 )
drought tolerance( TO:0000276 )
brassinosteroid sensitivity( TO:0002677 )
heat tolerance( TO:0000259 )
cold tolerance( TO:0000303 )
cytokinin sensitivity( TO:0000167 )
Plant Ontology whole plant( PO:0000003 )
shoot system( PO:0009006 )
Related Strains
Phenotype images
Last updated
Aug 22, 2023