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Detail of Gene

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Basic Information
CGSNL Gene Symbol MSRMK2
Gene Symbol Synonym OsMSRMK2, OsMAPK5, OsMAP1, OsMPK3, OsBIMK1, OsMAPK2, MPK5, BIMK1, MAPK2, MAPK5, MPK3, OsMPK5, OsMAPK3, OsMAPK5b, MAPK3
Gene Name Synonym multiple stress responsive MAP kinase 2, Mitogen-activated protein kinase 5, MAP kinase 5, Benzothiadiazole-induced MAP kinase 1, BTH-induced MAPK 1, MAP kinase 2, Multiple stress-responsive MAP kinase 2, MAP kinase 3
Allele mpk3ko, mpk3-1, mpk3-3
Chromosome No. 3
Explanation AJ486975, AF479883, AF216315, AF479884, AJ250311. AF332873. BF889466. EC= A2XFC8(indica), Q10N20(japonica). DQ826422 (indica). a putative meiosis-related gene. OsMPK3 in Jalmi and Sinha 2016, Hu et al. 2018, Ye et al. 2021, Hong et al. 2022, Singh et al. 2015, Yang et al. 2021, Wang et al. 2023, Laflamme 2023, Han et al. 2023. MPK5 in Lin et al. 2017, Zhang et al. 2018, Nanda et al. 2018, Guo et al. 2020, Jiang et al. 2021, He et al. 2021, Islam et al. 2023. up-regulated after fertilization (Abiko et al. 2013). OsMAPK3 in Zhang et al. 2017, Xia et al. 2021, Li et al. 2022, Xia et al. 2023, Wang et al. 2023. GO:1900150: regulation of defense response to fungus. GO:2000022: regulation of jasmonic acid mediated signaling pathway.
Trait Class Vegetative organ - Root
Reproductive organ - Pollination, fertilization, fertility - Meiosis
Tolerance and resistance - Disease resistance
Tolerance and resistance - Insect resistance
Tolerance and resistance - Stress tolerance
cDNA Accession No. AK104834
MSU ID LOC_Os03g17700.1
RAP ID Os03g0285800
Links Oryzabase Chromosome View ( IRGSP 1.0 / Build5 )
RAP-DB ( IRGSP 1.0 / Build5 )
Related IDs List ( IRGSP 1.0 / Build5 )
INSD Accession List
(Test version)
Link to INSD Accession List
Link map Classical linkage map
Laflamme B.
Plant Cell 2023  35(6)  1968-1969
WRKYng together: Coordination between kinase cascades and transcription factors contributes to immunity in rice.
Wang S., Han S., Zhou X., Zhao C., Guo L., Zhang J., Liu F., Huo Q., Zhao W., Guo Z., Chen X.
Plant Cell 2023  35(6)  2391-2412
Phosphorylation and ubiquitination of OsWRKY31 are integral to OsMKK10-2-mediated defense responses in rice.
Han S., Shen Z., Gao Q., Jin N., Lou Y.
Int J Mol Sci 2023  24(19) 
Knocking Out <i>OsRLK7-1</i> Impairs Rice Growth and Development but Enhances Its Resistance to Planthoppers.
Islam F., Khan M.S.S., Ahmed S., Abdullah M., Hannan F., Chen J.
Free Radic. Biol. Med. 2023  199  2-16
OsLPXC negatively regulates tolerance to cold stress via modulating oxidative stress, antioxidant defense and JA accumulation in rice.
Wang L., Xu G., Li L., Ruan M., Bennion A., Wang G.L., Li R., Qu S.
Proc. Natl. Acad. Sci. U.S.A. 2023  120(13)  e2211102120
The OsBDR1-MPK3 module negatively regulates blast resistance by suppressing the jasmonate signaling and terpenoid biosynthesis pathway.
Xia C., Liang G., Chong K., Xu Y.
Nat Commun 2023  14(1)  3104
The COG1-OsSERL2 complex senses cold to trigger signaling network for chilling tolerance in japonica rice.
Hong Y., Wang H., Gao Y., Bi Y., Xiong X., Yan Y., Wang J., Li D., Song F.
Int J Mol Sci 2022  23(2) 
ERF Transcription Factor OsBIERF3 Positively Contributes to Immunity against Fungal and Bacterial Diseases but Negatively Regulates cold tolerance in Rice.
Li Y., Liu P., Mei L., Jiang G., Lv Q., Zhai W., Li C.
Front Plant Sci 2022  13  1065253
Knockout of a papain-like cysteine protease gene <i>OCP</i> enhances blast resistance in rice.
Jiang J., Yang G., Xin Y., Wang Z., Yan W., Chen Z., Tang X., Xia J.
Genes (Basel) 2021  12(5) 
Overexpression of <i>OsMed16</i> Inhibits the Growth of Rice and Causes Spontaneous Cell Death.
He Z.D., Tao M.L., Leung D.W.M., Yan X.Y., Chen L., Peng X.X., Liu E.E.
Plant Physiol. 2021   
The rice germin-like protein OsGLP1 participates in acclimation to UV-B radiation.
Xia C., Gong Y., Chong K., Xu Y.
Plant Cell Environ. 2021  44(2)  491-505
Phosphatase OsPP2C27 directly dephosphorylates OsMAPK3 and OsbHLH002 to negatively regulate cold tolerance in rice.
Ye M., Kuai P., Chen S., Lin N., Ye M., Hu L., Lou Y.
Int J Mol Sci 2021  22(22) 
Silencing a Simple extracellular leucine-rich repeat Gene <i>OsI-BAK1</i> Enhances the Resistance of Rice to Brown Planthopper <i>Nilaparvata lugens</i>.
Chen J., Wang L., Yuan M.
Int J Mol Sci 2021  22(4) 
Update on the Roles of Rice MAPK Cascades.
Yang J., Ji L., Liu S., Jing P., Hu J., Jin D., Wang L., Xie G.
J. Exp. Bot. 2021   
The CaM1-Associated CCaMK-MKK1/6 cascade positively affects the lateral root growth through auxin signaling under salt stress in rice.
Guo T., Lu Z.Q., Shan J.X., Ye W.W., Dong N.Q., Lin H.X.
Plant Cell 2020  32(9)  2763-2779
<i>ERECTA1</i> Acts Upstream of the OsMKKK10-OsMKK4-OsMPK6 Cascade to Control spikelet number by Regulating Cytokinin Metabolism in Rice.
Qi D., Wen Q., Meng Z., Yuan S., Guo H., Zhao H., Cui S.
Plant J. 2020  104(4)  901-916
OsLFR is essential for early endosperm and embryo development by interacting with SWI/SNF complex members in Oryza sativa.
Hong Y., Liu Q., Cao Y., Zhang Y., Chen D., Lou X., Cheng S., Cao L.
Front Plant Sci 2019  10  752
The <i>OsMPK15</i> Negatively Regulates <i>Magnaporthe oryza</i> and <i>Xoo</i> disease resistance via SA and JA Signaling Pathway in Rice.
Ye M., Glauser G., Lou Y., Erb M., Hu L.
Plant Cell 2019  31(3)  687-698
Molecular Dissection of Early Defense Signaling Underlying Volatile-Mediated Defense Regulation and Herbivore Resistance in Rice.
Monaghan J.
Trends Plant Sci. 2018  23(7)  554-557
Conserved Degradation of Orthologous RLCKs Regulates Immune Homeostasis.
Hu L., Ye M., Kuai P., Ye M., Erb M., Lou Y.
New Phytol. 2018  219(3)  1097-1111
OsLRR-RLK1, an early responsive leucine-rich repeat receptor-like kinase, initiates rice defense responses against a chewing herbivore.
Nanda S., Wan P.J., Yuan S.Y., Lai F.X., Wang W.X., Fu Q.
Int J Mol Sci 2018  19(12) 
Differential Responses of <i>OsMPK</i>s in IR56 Rice to Two BPH Populations of Different Virulence Levels.
Zhang D., Wang Y., Shen J., Yin J., Li D., Gao Y., Xu W., Liang J.
Rice (N Y) 2018  11(1)  45
OsRACK1A, encodes a circadian clock-regulated WD40 protein, negatively affect salt tolerance in rice.
Lin C.W., Huang L.Y., Huang C.L., Wang Y.C., Lai P.H., Wang H.V., Chang W.C., Chiang T.Y., Huang H.J.
Plant Cell Physiol. 2017  58(3)  546-559
Common Stress Transcriptome Analysis Reveals Functional and Genomic Architecture Differences Between Early and Delayed Response Genes.
Zhang Z., Li J., Li F., Liu H., Yang W., Chong K., Xu Y.
Dev. Cell 2017  43(6)  731-743.e5
OsMAPK3 Phosphorylates OsbHLH002/OsICE1 and Inhibits Its Ubiquitination to Activate OsTPP1 and Enhances Rice Chilling Tolerance.
Yamada K., Yamaguchi K., Yoshimura S., Terauchi A., Kawasaki T.
Plant Cell Physiol. 2017   
Conservation of chitin-induced MAPK signaling pathways in rice and Arabidopsis.
Ma H., Chen J., Zhang Z., Ma L., Yang Z., Zhang Q., Li X., Xiao J., Wang S.
Plant J. 2017   
MAPK kinase 10.2 Promotes Disease Resistance and drought tolerance by Activating Different MAPKs in rice.
Jalmi S.K., Sinha A.K.
Sci Rep 2016  6  37974
Functional Involvement of a Mitogen Activated Protein Kinase Module, OsMKK3-OsMPK7-OsWRK30 in Mediating Resistance against Xanthomonas oryzae in Rice.
Singh P., Sinha A.K.
Plant Cell 2016   
A Positive Feedback Loop Governed by SUB1A1 Interaction with MITOGEN ACTIVATED PROTEIN KINASE 3 Imparts submergence tolerance in Rice.
Singh P., Mohanta T.K., Sinha A.K.
PLoS ONE 2015  10(4)  e0123620
Unraveling the Intricate Nexus of Molecular Mechanisms Governing Rice Root Development: OsMPK3/6 and Auxin-Cytokinin Interplay.
Mohanta T.K., Mohanta N., Parida P., Bae H.
Biol Proced Online 2015  17  13
Mitogen Activated Protein Kinase (MPK) Interacts With Auxin Influx Carrier (OsAux/LAX1) Involved in Auxin Signaling in Plant.
Zhang B., Xu M., Bian S., Hou L., Tang D., Li Y., Gu M., Cheng Z., Yu H.
PLoS ONE 2015  10(9)  e0137399
Global Identification of Genes Specific for Rice Meiosis.
Xie K., Chen J., Wang Q., Yang Y.
Plant Cell 2014  26(7)  3077-89
Direct phosphorylation and activation of a mitogen-activated protein kinase by a calcium-dependent protein kinase in rice.
Chujo T., Miyamoto K., Ogawa S., Masuda Y., Shimizu T., Kishi-Kaboshi M., Takahashi A., Nishizawa Y., Minami E., Nojiri H., Yamane H., Okada K.
PLoS ONE 2014  9(6)  e98737
Overexpression of phosphomimic mutated OsWRKY53 leads to enhanced blast resistance in rice.
Zhao F.Y.a, Han M.M.a, Zhang S.Y.b, Ren J.a, Hu F.a, Wang X.a
Russian Journal of Plant Physiology 2014  61  608-618
MAPKs as a cross point in H2O2 and auxin signaling under combined cadmium and zinc stress in rice roots
Zhang H., Liu Y., Wen F., Yao D., Wang L., Guo J., Ni L., Zhang A., Tan M., Jiang M.
J. Exp. Bot. 2014  65(20)  5795-809
A novel rice C2H2-type zinc finger protein, ZFP36, is a key player involved in abscisic acid-induced antioxidant defence and oxidative stress tolerance in rice.
Li C.H., Wang G., Zhao J.L., Zhang L.Q., Ai L.F., Han Y.F., Sun D.Y., Zhang S.W., Sun Y.
Plant Cell 2014  26(6)  2538-2553
The Receptor-Like Kinase SIT1 Mediates salt sensitivity by Activating MAPK3/6 and Regulating Ethylene Homeostasis in Rice.
Schmidt R., Mieulet D., Hubberten H.M., Obata T., Hoefgen R., Fernie A.R., Fisahn J., San Segundo B., Guiderdoni E., Schippers J.H., Mueller-Roeber B.
Plant Cell 2013  25(6)  2115-31
SALT-RESPONSIVE ERF1 Regulates Reactive Oxygen Species-Dependent Signaling during the Initial Response to SALT Stress in Rice.
Park H.L., Lee S.W., Jung K.H., Hahn T.R., Cho M.H.
Phytochemistry 2013  96  57-71
Transcriptomic analysis of UV-treated rice leaves reveals UV-induced phytoalexin biosynthetic pathways and their regulatory networks in rice.
Ye M., Song Y., Long J., Wang R., Baerson S.R., Pan Z., Zhu-Salzman K., Xie J., Cai K., Luo S., Zeng R.
Proc. Natl. Acad. Sci. U.S.A. 2013  110(38)  E3631-9
Priming of jasmonate-mediated antiherbivore defense responses in rice by silicon.
Yamaguchi K., Yamada K., Ishikawa K., Yoshimura S., Hayashi N., Uchihashi K., Ishihama N., Kishi-Kaboshi M., Takahashi A., Tsuge S., Ochiai H., Tada Y., Shimamoto K., Yoshioka H., Kawasaki T.
Cell Host Microbe 2013  13(3)  347-57
A receptor-like cytoplasmic kinase targeted by a plant pathogen effector is directly phosphorylated by the chitin receptor and mediates rice immunity.
Yang D.L., Yang Y., He Z.
Mol Plant 2013  6(3)  675-85
Role of plant hormones and their cross-talks in rice immunity.
Abiko M., Maeda H., Tamura K., Hara-Nishimura I., Okamoto T.
J. Exp. Bot. 2013  64(7)  1927-40
Gene expression profiles in rice gametes and zygotes: identification of gamete-enriched genes and up- or down-regulated genes in zygotes after fertilization.
Xie G., Kato H., Imai R.
Biochem. J. 2012  443(1)  95-102
Biochemical identification of the OsMKK6-OsMPK3 signalling pathway for chilling stress tolerance in rice1.
Wamaitha M.J., Yamamoto R., Wong H.L., Kawasaki T., Kawano Y., Shimamoto K.
Rice (N Y) 2012  5  35
OsRap2.6 transcription factor contributes to rice innate immunity through its interaction with receptor for activated Kinase-C 1 (RACK1)
Kim S.H., Oikawa T., Kyozuka J., Wong H.L., Umemura K., Kishi-Kaboshi M., Takahashi A., Kawano Y., Kawasaki T., Shimamoto K.
Plant Cell Physiol. 2012  53(4)  740-54
The bHLH Rac Immunity1 (RAI1) Is Activated by OsRac1 via OsMAPK3 and OsMAPK6 in Rice Immunity.
Heo J.B., Yi Y.B., Bahk J.D.
Biochem. Biophys. Res. Commun. 2011  414(4)  814-9
Rice GDP dissociation inhibitor 3 inhibits OsMAPK2 activity through physical interaction.
Hu J. , Zhou J. , Peng X. , Xu H. , Liu C. , Du B. , Yuan H. , Zhu L. , He G.
Plant Physiol. 2011  156(2)  856-72
The bphi008a gene interacts with the ethylene pathway and transcriptionally regulates MAPK genes in the response of rice to brown planthopper feeding.
Qi J., Zhou G., Yang L., Erb M., Lu Y., Sun X., Cheng J., Lou Y.
Plant Physiol. 2011  157(4)  1987-99
The Chloroplast-Localized Phospholipases D alpha4 and alpha5 Regulate Herbivore-Induced Direct and Indirect Defenses in Rice.
Kishi-Kaboshi M., Okada K., Kurimoto L., Murakami S., Umezawa T., Shibuya N., Yamane H., Miyao A., Takatsuji H., Takahashi A., Hirochika H.
Plant Journal 2010  63(4)  599-612
A rice fungal MAMP-responsive MAPK cascade regulates metabolic flow to antimicrobial metabolite synthesis.
Xie G., Kato H., Sasaki K., Imai R.
FEBS Lett. 2009  583(17)  2734-8
A cold-induced thioredoxin h of rice, OsTrx23, negatively regulates kinase activities of OsMPK3 and OsMPK6 in vitro.
Yara,A., Yaeno,T., Hasegawa,M., Seto,H., Montillet,J.L., Kusumi,K., Seo,S. and Iba,K.
Plant Cell Physiol. 2007  48(9)  1263-1274
Disease resistance against Magnaporthe grisea is enhanced in transgenic rice with suppression of omega-3 fatty acid desaturases
Ren H., Gu G., Long J., Yin Q., Wu T., Song T., Zhang S., Chen Z., Dong H.
J. Biosci. 2006  31(5)  617-27
Combinative effects of a bacterial type-III effector and a biocontrol bacterium on rice growth and disease resistance.
Ren H., Song T., Wu T., Sun L., Liu Y., Yang F., Chen Z., Dong H.
Ann. Microbiol. 2006  56  281-287
Effects of a biocontrol bacterium on growth and defence of transgenic rice plants expressing a bacterial type-III effector
Song,D., Chen,J., Song,F. and Zheng,Z.
Plant Biol. 2006  8(5)  587-596
A novel rice MAPK gene, OsBIMK2, is involved in disease-resistance responses.
Xiong,L. and Yang,Y.
Plant Cell 2003  15(3)  745-759
Disease Resistance and Abiotic Stress Tolerance in Rice Are Inversely Modulated by an Abscisic Acid-Inducible Mitogen-Activated Protein Kinase.
Wen,J.Q., Oono,K. and Imai,R.
Plant Physiol. 2002  129(4)  1880-1891
Two Novel Mitogen-Activated Protein Signaling Components, OsMEK1 and OsMAP1, Are Involved in a Moderate Low-Temperature Signaling Pathway in Rice.
Song F., Robert M Goodman
Planta 2002  215(6)  997-1005
OsBIMK1, a rice MAP kinase gene involved in disease resistance responses.
Agrawal,G.K., Rakwal,R. and Iwahashi,H.
Biochem. Biophys. Res. Commun. 2002  294(5)  1009-1016
Isolation of novel rice (Oryza sativa L.) multiple stress responsive MAP kinase gene, OsMSRMK2, whose mRNA accumulates rapidly in response to environmental cues.
L Xiong, M W Lee, M Qi, Y Yang
Mol. Plant Microbe Interact. 2001  14(5)  685-92
Identification of defense-related rice genes by suppression subtractive hybridization and differential screening.
TextPresso Search Search textpresso for MSRMK2 ( Recent references may be retrievable, but without any warranty )
DB Reference
Gramene ID -
Gene Ontology terpenoid biosynthetic process( GO:0016114 )
cytoplasm( GO:0005737 )
positive regulation of defense response( GO:0031349 )
response to jasmonic acid stimulus( GO:0009753 )
response to abscisic acid stimulus( GO:0009737 )
response to water deprivation( GO:0009414 )
defense response to bacterium( GO:0042742 )
ATP binding( GO:0005524 )
root development( GO:0048364 )
response to auxin stimulus( GO:0009733 )
response to cytokinin stimulus( GO:0009735 )
MAP kinase activity( GO:0004707 )
MAPKKK cascade( GO:0000165 )
response to bacterium( GO:0009617 )
response to hydrogen peroxide( GO:0042542 )
response to salicylic acid stimulus( GO:0009751 )
embryonic development( GO:0009790 )
defense response, incompatible interaction( GO:0009814 )
jasmonic acid mediated signaling pathway( GO:0009867 )
response to flooding( GO:0009413 )
meiosis( GO:0007126 )
response to ethylene stimulus( GO:0009723 )
defense response to insect( GO:0002213 )
auxin mediated signaling pathway( GO:0009734 )
defense response( GO:0006952 )
regulation of stomatal complex development( GO:2000038 )
protein amino acid phosphorylation( GO:0006468 )
response to osmotic stress( GO:0006970 )
activation of MAPK activity involved in osmosensory signaling pathway( GO:0000169 )
priming of cellular response to stress( GO:0080136 )
response to chitin( GO:0010200 )
response to salt stress( GO:0009651 )
camalexin biosynthetic process( GO:0010120 )
response to UV( GO:0009411 )
response to wounding( GO:0009611 )
response to oxidative stress( GO:0006979 )
regulation of stomatal complex patterning( GO:2000037 )
response to cold( GO:0009409 )
defense response to fungus( GO:0050832 )
ovule development( GO:0048481 )
abscisic acid mediated signaling( GO:0009738 )
response to herbivore( GO:0080027 )
Trait Ontology cold tolerance( TO:0000303 )
diterpenoid phytoalexin content( TO:0002669 )
brown planthopper resistance( TO:0000424 )
UV light sensitivity( TO:0000160 )
blast disease( TO:0000074 )
abscisic acid sensitivity( TO:0000615 )
auxin sensitivity( TO:0000163 )
cytokinin sensitivity( TO:0000167 )
jasmonic acid sensitivity( TO:0000172 )
disease resistance( TO:0000112 )
bacterial blight disease resistance( TO:0000175 )
submergence sensitivity( TO:0000286 )
ethylene sensitivity( TO:0000173 )
bacterial disease resistance( TO:0000315 )
cytokinin content( TO:0002660 )
jasmonic acid content( TO:0002668 )
armyworm resistance( TO:0000273 )
stem borer resistance( TO:0000454 )
oligosaccharide content( TO:0006003 )
drought tolerance( TO:0000276 )
salt tolerance( TO:0006001 )
fungal disease resistance( TO:0000439 )
Plant Ontology root development stage( PO:0007520 )
Related Strains
Phenotype images
Last updated
Dec 20, 2023