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Basic Information
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CGSNL Gene Symbol
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KO4
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Gene Symbol Synonym
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OsKO4, OsKOL4, KOS1, CYP701A8, OsCYP701A8, OsKO2, CYP701A8/OsKOL4
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CGSNL Gene Name
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ENT-KAURENE OXIDASE 4
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Gene Name Synonym
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rice ent-kaurene oxidase4, cytochrome P450 701A8
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Protein Name
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ENT-KAURENE OXIDASE 4
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Allele
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Chromosome No.
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6
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Explanation
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This gene encodes one of the GA metabolic enzymes, ent-kaurene exidase (KO). It is located on chromosome 6 at 76cM forming a gene cluster with 5 tandem repeats, OsKOL1 to OsKOL5. AY579214. OsKO2 in Chen et al. 2015 and Burman et al. 2017, Tang et al. 2018, Lee et al. 2020, Jang et al. 2021, Huang et al. 2023.
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Trait Class
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Biochemical character
Vegetative organ - Culm
Tolerance and resistance - Disease resistance
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Expression
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Sequence/Locus
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cDNA Accession No.
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AK287607
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MSU ID
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LOC_Os06g37300.1
LOC_Os06g37300.2
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RAP ID
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Os06g0569500
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Links
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Oryzabase Chromosome View
(
IRGSP 1.0
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Build5
)
RAP-DB
(
IRGSP 1.0
/
Build5
)
Related IDs List (
IRGSP 1.0
/
Build5
)
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INSD Accession List
(Test version)
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Link to INSD Accession List
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Map
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Locate(cM)
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Link map
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Classical linkage map
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References
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Huang Y., Song J., Hao Q., Mou C., Wu H., Zhang F., Zhu Z., Wang P., Ma T., Fu K., Chen Y., Nguyen T., Liu S., Jiang L., Wan J.
Plant Physiol. Biochem. 2023 202 107923
WEAK seed dormancy 1, an aminotransferase protein, regulates seed dormancy in rice through the GA and ABA pathways.
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Liu C., Zhu X., Zhang J., Shen M., Chen K., Fu X., Ma L., Liu X., Zhou C., Zhou D.X., Wang G.
Plant Biotechnol. J. 2022 20(12) 2357-2371
eQTLs play critical roles in regulating gene expression and identifying key regulators in rice.
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Tang L., Xu H., Wang Y., Wang H., Li Z., Liu X., Shu Y., Li G., Liu W., Ying J., Tong X., Yao J., Xiao W., Tang S., Ni S., Zhang J.
Int J Mol Sci 2021 22(22)
OsABF1 Represses Gibberellin Biosynthesis to Regulate plant height and Seed Germination in Rice (<i>Oryza sativa</i> L.).
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Wang Y., Du F., Wang J., Li Y., Zhang Y., Zhao X., Zheng T., Li Z., Xu J., Wang W., Fu B.
Int J Mol Sci 2021 22(17)
Molecular Dissection of the Gene <i>OsGA2ox8</i> Conferring Osmotic Stress Tolerance in Rice.
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Yuan X., Wang H., Bi Y., Yan Y., Gao Y., Xiong X., Wang J., Li D., Song F.
Front Plant Sci 2021 12 749186
ONAC066, A Stress-Responsive NAC Transcription Activator, Positively Contributes to Rice Immunity Against <i>Magnaprothe oryzae</i> Through Modulating Expression of <i>OsWRKY62</i> and Three Cytochrome P450 Genes.
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Jang S., Cho J.Y., Do G.R., Kang Y., Li H.Y., Song J., Kim H.Y., Kim B.G., Hsing Y.I.
Int J Mol Sci 2021 22(15)
Modulation of Rice leaf angle and grain size.by Expressing <i>OsBCL1</i> and <i>OsBCL2</i> under the Control of <i>OsBUL1</i> Promoter.
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Kitaoka N., Zhang J., Oyagbenro R.K., Brown B., Wu Y., Yang B., Li Z., Peters R.J.
Plant Cell 2021 33(2) 290-305
Interdependent evolution of biosynthetic gene clusters for momilactone production in rice.
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M T AP., Ramchander S., K K K., Muthamilarasan M., Pillai M.A.
PLoS ONE 2021 16(1) e0245603
Assessment of efficacy of mutagenesis of gamma-irradiation in plant height and days to maturity through expression analysis in rice.
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Lee J., Moon S., Jang S., Lee S., An G., Jung K.H., Park S.K.
Plants (Basel) 2020 9(4)
<i>OsbHLH073</i> Negatively Regulates Internode Elongation and plant height by Modulating GA Homeostasis in Rice.
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Murphy K.M., Zerbe P.
Phytochemistry 2020 172 112289
Specialized diterpenoid metabolism in monocot crops: Biosynthesis and chemical diversity.
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Tang Y., Liu H., Guo S., Wang B., Li Z., Chong K., Xu Y.
Plant Physiol. 2018 176(1) 946-959
OsmiR396d Affects Gibberellin and Brassinosteroid Signaling to Regulate Plant Architecture in Rice.
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Burman N., Bhatnagar A., Khurana J.P.
Plant Physiol. 2017
OsbZIP48, a HY5 transcription factor ortholog, exerts pleiotropic effects in light-regulated development.
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Chen X., Lu S., Wang Y., Zhang X., Lv B., Luo L., Xi D., Shen J., Ma H., Ming F.
Plant J. 2015 82(2) 302-14
OsNAC2 encoding a NAC transcription factor that affects plant height through mediating the gibberellic acid pathway in rice.
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Phanchaisri B., Samsang N., Yu L., Singkarat S., Anuntalabhochai S.
Mutat. Res. 2012 734(1-2) 56-61
Expression of OsSPY and 14-3-3 genes involved in plant height variations of ion-beam-induced KDML 105 rice mutants.
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Wang Q., Hillwig M.L., Wu Y., Peters R.J.
Plant Physiol. 2012 158(3) 1418-25
CYP701A8: a rice ent-kaurene oxidase paralog diverted to more specialized diterpenoid metabolism.
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Zhu,S., Gao,F., Cao,X., Chen,M., Ye,G., Wei,C. and Li,Y.
Plant Physiol. 2005 139(4) 1935-1945
The Rice Dwarf Virus P2 Protein Interacts with ent-Kaurene Oxidases in Vivo, Leading to Reduced Biosynthesis of Gibberellins and Rice Dwarf Symptoms.
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Itoh, H., Tatsumi, T., Sakamoto, T., Otomo, K., Toyomasu, T., Kitano, H., Ashikari, M., Ichikawa, S. and Matsuoka, M.
Plant Mol. Biol. 2004 54 533-547
A rice semi-dwarf gene, Tan-Ginbozu (D35), encodes the gibberellin biosynthesis enzyme, ent-kaurene oxidase.
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Sakamoto, T., K. Miura, H. Itoh, T. Tatsumi, M. Ueguchi-Tanaka, K. Ishiyama, M. Kobayashi, G.K. Agrawal, S. Takeda, K. Abe, A. Miyao, H. Hirochika, H. Kitano, M. Ashikari and M. Matsuoka
Plant Physiol. 2004 134 1642-1653
An overview of gibberellin metabolism enzyme genes and their related mutants in rice.
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DB Reference
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Gramene ID
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-
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Ontologies
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Gene Ontology
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diterpene phytoalexin biosynthetic process( GO:0051502 )
response to abiotic stimulus( GO:0009628 )
response to jasmonic acid stimulus( GO:0009753 )
defense response( GO:0006952 )
defense response to fungus( GO:0050832 )
response to gibberellin stimulus( GO:0009739 )
gibberellic acid homeostasis( GO:0010336 )
internode patterning( GO:0080006 )
ent-kaurene oxidase activity( GO:0010241 )
monooxygenase activity( GO:0004497 )
electron carrier activity( GO:0009055 )
gibberellin biosynthetic process( GO:0009686 )
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen( GO:0016705 )
heme binding( GO:0020037 )
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Trait Ontology
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gibberellic acid content( TO:0002675 )
internode length( TO:0000145 )
plant height( TO:0000207 )
gibberellic acid sensitivity( TO:0000166 )
blast disease( TO:0000074 )
disease resistance( TO:0000112 )
jasmonic acid sensitivity( TO:0000172 )
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Plant Ontology
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Related Strains
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Phenotype images
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Last updated
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Jan 11, 2024
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Update info.