Gene - Detail

Detail of Gene

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Basic Information
CGSNL Gene Symbol KO4
Gene Symbol Synonym OsKO4, OsKOL4, KOS1, CYP701A8, OsCYP701A8, OsKO2, CYP701A8/OsKOL4
Gene Name Synonym rice ent-kaurene oxidase4, cytochrome P450 701A8
Chromosome No. 6
Explanation This gene encodes one of the GA metabolic enzymes, ent-kaurene exidase (KO). It is located on chromosome 6 at 76cM forming a gene cluster with 5 tandem repeats, OsKOL1 to OsKOL5. AY579214. OsKO2 in Chen et al. 2015 and Burman et al. 2017, Tang et al. 2018, Lee et al. 2020, Jang et al. 2021, Huang et al. 2023.
Trait Class Biochemical character
Vegetative organ - Culm
Tolerance and resistance - Disease resistance
cDNA Accession No. AK287607
MSU ID LOC_Os06g37300.1
RAP ID Os06g0569500
Links Oryzabase Chromosome View ( IRGSP 1.0 / Build5 )
RAP-DB ( IRGSP 1.0 / Build5 )
Related IDs List ( IRGSP 1.0 / Build5 )
INSD Accession List
(Test version)
Link to INSD Accession List
Link map Classical linkage map
Huang Y., Song J., Hao Q., Mou C., Wu H., Zhang F., Zhu Z., Wang P., Ma T., Fu K., Chen Y., Nguyen T., Liu S., Jiang L., Wan J.
Plant Physiol. Biochem. 2023  202  107923
WEAK seed dormancy 1, an aminotransferase protein, regulates seed dormancy in rice through the GA and ABA pathways.
Liu C., Zhu X., Zhang J., Shen M., Chen K., Fu X., Ma L., Liu X., Zhou C., Zhou D.X., Wang G.
Plant Biotechnol. J. 2022  20(12)  2357-2371
eQTLs play critical roles in regulating gene expression and identifying key regulators in rice.
Tang L., Xu H., Wang Y., Wang H., Li Z., Liu X., Shu Y., Li G., Liu W., Ying J., Tong X., Yao J., Xiao W., Tang S., Ni S., Zhang J.
Int J Mol Sci 2021  22(22) 
OsABF1 Represses Gibberellin Biosynthesis to Regulate plant height and Seed Germination in Rice (<i>Oryza sativa</i> L.).
Wang Y., Du F., Wang J., Li Y., Zhang Y., Zhao X., Zheng T., Li Z., Xu J., Wang W., Fu B.
Int J Mol Sci 2021  22(17) 
Molecular Dissection of the Gene <i>OsGA2ox8</i> Conferring Osmotic Stress Tolerance in Rice.
Yuan X., Wang H., Bi Y., Yan Y., Gao Y., Xiong X., Wang J., Li D., Song F.
Front Plant Sci 2021  12  749186
ONAC066, A Stress-Responsive NAC Transcription Activator, Positively Contributes to Rice Immunity Against <i>Magnaprothe oryzae</i> Through Modulating Expression of <i>OsWRKY62</i> and Three Cytochrome P450 Genes.
Jang S., Cho J.Y., Do G.R., Kang Y., Li H.Y., Song J., Kim H.Y., Kim B.G., Hsing Y.I.
Int J Mol Sci 2021  22(15) 
Modulation of Rice leaf angle and grain Expressing <i>OsBCL1</i> and <i>OsBCL2</i> under the Control of <i>OsBUL1</i> Promoter.
Kitaoka N., Zhang J., Oyagbenro R.K., Brown B., Wu Y., Yang B., Li Z., Peters R.J.
Plant Cell 2021  33(2)  290-305
Interdependent evolution of biosynthetic gene clusters for momilactone production in rice.
M T AP., Ramchander S., K K K., Muthamilarasan M., Pillai M.A.
PLoS ONE 2021  16(1)  e0245603
Assessment of efficacy of mutagenesis of gamma-irradiation in plant height and days to maturity through expression analysis in rice.
Lee J., Moon S., Jang S., Lee S., An G., Jung K.H., Park S.K.
Plants (Basel) 2020  9(4) 
<i>OsbHLH073</i> Negatively Regulates Internode Elongation and plant height by Modulating GA Homeostasis in Rice.
Murphy K.M., Zerbe P.
Phytochemistry 2020  172  112289
Specialized diterpenoid metabolism in monocot crops: Biosynthesis and chemical diversity.
Tang Y., Liu H., Guo S., Wang B., Li Z., Chong K., Xu Y.
Plant Physiol. 2018  176(1)  946-959
OsmiR396d Affects Gibberellin and Brassinosteroid Signaling to Regulate Plant Architecture in Rice.
Burman N., Bhatnagar A., Khurana J.P.
Plant Physiol. 2017   
OsbZIP48, a HY5 transcription factor ortholog, exerts pleiotropic effects in light-regulated development.
Chen X., Lu S., Wang Y., Zhang X., Lv B., Luo L., Xi D., Shen J., Ma H., Ming F.
Plant J. 2015  82(2)  302-14
OsNAC2 encoding a NAC transcription factor that affects plant height through mediating the gibberellic acid pathway in rice.
Phanchaisri B., Samsang N., Yu L., Singkarat S., Anuntalabhochai S.
Mutat. Res. 2012  734(1-2)  56-61
Expression of OsSPY and 14-3-3 genes involved in plant height variations of ion-beam-induced KDML 105 rice mutants.
Wang Q., Hillwig M.L., Wu Y., Peters R.J.
Plant Physiol. 2012  158(3)  1418-25
CYP701A8: a rice ent-kaurene oxidase paralog diverted to more specialized diterpenoid metabolism.
Zhu,S., Gao,F., Cao,X., Chen,M., Ye,G., Wei,C. and Li,Y.
Plant Physiol. 2005  139(4)  1935-1945
The Rice Dwarf Virus P2 Protein Interacts with ent-Kaurene Oxidases in Vivo, Leading to Reduced Biosynthesis of Gibberellins and Rice Dwarf Symptoms.
Itoh, H., Tatsumi, T., Sakamoto, T., Otomo, K., Toyomasu, T., Kitano, H., Ashikari, M., Ichikawa, S. and Matsuoka, M.
Plant Mol. Biol. 2004  54  533-547
A rice semi-dwarf gene, Tan-Ginbozu (D35), encodes the gibberellin biosynthesis enzyme, ent-kaurene oxidase.
Sakamoto, T., K. Miura, H. Itoh, T. Tatsumi, M. Ueguchi-Tanaka, K. Ishiyama, M. Kobayashi, G.K. Agrawal, S. Takeda, K. Abe, A. Miyao, H. Hirochika, H. Kitano, M. Ashikari and M. Matsuoka
Plant Physiol. 2004  134  1642-1653
An overview of gibberellin metabolism enzyme genes and their related mutants in rice.
TextPresso Search Search textpresso for KO4 ( Recent references may be retrievable, but without any warranty )
DB Reference
Gramene ID -
Gene Ontology diterpene phytoalexin biosynthetic process( GO:0051502 )
response to abiotic stimulus( GO:0009628 )
response to jasmonic acid stimulus( GO:0009753 )
defense response( GO:0006952 )
defense response to fungus( GO:0050832 )
response to gibberellin stimulus( GO:0009739 )
gibberellic acid homeostasis( GO:0010336 )
internode patterning( GO:0080006 )
ent-kaurene oxidase activity( GO:0010241 )
monooxygenase activity( GO:0004497 )
electron carrier activity( GO:0009055 )
gibberellin biosynthetic process( GO:0009686 )
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen( GO:0016705 )
heme binding( GO:0020037 )
Trait Ontology gibberellic acid content( TO:0002675 )
internode length( TO:0000145 )
plant height( TO:0000207 )
gibberellic acid sensitivity( TO:0000166 )
blast disease( TO:0000074 )
disease resistance( TO:0000112 )
jasmonic acid sensitivity( TO:0000172 )
Plant Ontology -
Related Strains
Phenotype images
Last updated
Jan 11, 2024