Gene - Detail

Detail of Gene

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Basic Information
CGSNL Gene Symbol KS4
Gene Symbol Synonym OsKS4, KS4, KSL4, OsKSL4, DTS2, OsDTS2, OsTPS16, TPS16, TPS8, OsTPS8
Gene Name Synonym rice ent-kaurene synthase4, Ent-kaurene synthase 4, Ent-kaurene synthase-like 4, Ent-kaurene synthase like-4, "Syn-pimara-7,15-diene synthase", "9-beta-pimara-7,15-diene synthase", syn-pimara-7 15-diene synthase, syn Pimaradiene synthase, KAURENE SYNTHASE-LIKE 4, terpene synthase 16
Chromosome No. 4
Explanation This gene encodes one of the GA metabolic enzymes; ent-kaurene synthase (KS). It is located on chromosome 4 at 14.3cM linked with OsCPS4. EC= Q0JEZ8(japonica). Q66QH3(indica). GRO:0007047; 02-seedling ; GRO:0007139; A-vegetative stage ; GRO:0007040; rice growth stage. AY616862. AB126934. AY347880. momilactone biosynthetic pathway. GO:0140426: PAMP-triggered immunity signalling pathway. TPS8 in Sun et al. 2022.
Trait Class Biochemical character
Tolerance and resistance - Disease resistance
Tolerance and resistance - Insect resistance
Tolerance and resistance - Stress tolerance
cDNA Accession No. AK119327
MSU ID LOC_Os04g10060.1
RAP ID Os04g0179700
Links Oryzabase Chromosome View ( IRGSP 1.0 / Build5 )
RAP-DB ( IRGSP 1.0 / Build5 )
Related IDs List ( IRGSP 1.0 / Build5 )
INSD Accession List
(Test version)
Link to INSD Accession List
Link map Classical linkage map
Huang Q., Lin B., Cao Y., Zhang Y., Song H., Huang C., Sun T., Long C., Liao J., Zhuo K.
Front Plant Sci 2023  14  1134653
CRISPR/Cas9-mediated mutagenesis of the susceptibility gene <i>OsHPP04</i> in rice confers enhanced resistance to rice root-knot nematode.
Jiang W., Ye Q., Wu Z., Zhang Q., Wang L., Liu J., Hu X., Guo D., Wang X., Zhang Z., He H., Hu L.
Genes (Basel) 2023  14(1) 
Analysis of CAT Gene Family and Functional Identification of OsCAT3 in Rice.
Miyata K., Hosotani M., Akamatsu A., Takeda N., Jiang W., Sugiyama T., Takaoka R., Matsumoto K., Abe S., Shibuya N., Kaku H.
Plant Cell Physiol. 2023  64(4)  378-391
OsSYMRK Plays an Essential Role in AM Symbiosis in Rice (Oryza sativa).
Sun Y., Zhang P.T., Kou D.R., Han Y.C., Fang J.C., Ni J.P., Jiang B., Wang X., Zhang Y.J., Wang W., Kong X.D.
Front Plant Sci 2022  13  905982
Terpene Synthases in Rice Pan-Genome and Their Responses to <i>Chilo suppressalis</i> Larvae Infesting.
Qiu J., Xie J., Chen Y., Shen Z., Shi H., Naqvi N.I., Qian Q., Liang Y., Kou Y.
Mol Plant 2022  15(4)  723-739
Warm temperature compromises JA-regulated basal resistance to enhance Magnaporthe oryzae infection in rice.
Zhang L.L., Huang Y.Y., Zheng Y.P., Liu X.X., Zhou S.X., Yang X.M., Liu S.L., Li Y., Li J.L., Zhao S.L., Wang H., Ji Y.P., Zhang J.W., Pu M., Zhao Z.X., Fan J., Wang W.M.
Plant J. 2022  110(1)  166-178
Osa-miR535 targets SQUAMOSA promoter binding protein-like 4 to regulate blast disease resistance in rice.
Liu C., Zhu X., Zhang J., Shen M., Chen K., Fu X., Ma L., Liu X., Zhou C., Zhou D.X., Wang G.
Plant Biotechnol. J. 2022  20(12)  2357-2371
eQTLs play critical roles in regulating gene expression and identifying key regulators in rice.
Ninkuu V., Yan J., Zhang L., Fu Z., Yang T., Li S., Li B., Duan J., Ren J., Li G., Yang X., Zeng H.
Front Plant Sci 2022  13  980821
Hrip1 mediates rice cell wall fortification and phytoalexins elicitation to confer immunity against <i>Magnaporthe oryzae</i>.
Dash M., Somvanshi V.S., Budhwar R., Godwin J., Shukla R.N., Rao U.
Planta 2021  253(5)  108
A rice root-knot nematode Meloidogyne graminicola-resistant mutant rice line shows early expression of plant-defence genes.
Kitaoka N., Zhang J., Oyagbenro R.K., Brown B., Wu Y., Yang B., Li Z., Peters R.J.
Plant Cell 2021  33(2)  290-305
Interdependent evolution of biosynthetic gene clusters for momilactone production in rice.
Fang C., Yang L., Chen W., Li L., Zhang P., Li Y., He H., Lin W.
J. Exp. Bot. 2020  71(6)  2127-2141
MYB57 transcriptionally regulates MAPK11 to interact with PAL2;3 and modulate rice allelopathy.
Li X.P., Ma X.C., Wang H., Zhu Y., Liu X.X., Li T.T., Zheng Y.P., Zhao J.Q., Zhang J.W., Huang Y.Y., Pu M., Feng H., Fan J., Li Y., Wang W.M.
Rice (N Y) 2020  13(1)  38
Osa-miR162a fine-tunes rice resistance to Magnaporthe oryzae and Yield.
Mao L., Kawaide H., Higuchi T., Chen M., Miyamoto K., Hirata Y., Kimura H., Miyazaki S., Teruya M., Fujiwara K., Tomita K., Yamane H., Hayashi K.I., Nojiri H., Jia L., Qiu J., Ye C., Timko M.P., Fan L., Okada K.
Proc. Natl. Acad. Sci. U.S.A. 2020  117(22)  12472-12480
Genomic evidence for convergent evolution of gene clusters for momilactone biosynthesis in land plants.
Murphy K.M., Zerbe P.
Phytochemistry 2020  172  112289
Specialized diterpenoid metabolism in monocot crops: Biosynthesis and chemical diversity.
Shinya T., Yasuda S., Hyodo K., Tani R., Hojo Y., Fujiwara Y., Hiruma K., Ishizaki T., Fujita Y., Saijo Y., Galis I.
Plant J. 2018  94(4)  626-637
Integration of danger peptide signals with herbivore-associated molecular pattern signaling amplifies anti-herbivore defense responses in rice.
Chen J., Hu L., Sun L., Lin B., Huang K., Zhuo K., Liao J.
Mol. Plant Pathol. 2018   
A novel Meloidogyne graminicola effector, MgMO237, interacts with multiple host defence-related proteins to manipulate plant basal immunity and promote parasitism.
Li Z., Ding B., Zhou X., Wang G.L.
PLoS Pathog. 2017  13(1)  e1006157
The Rice Dynamin-Related Protein OsDRP1E Negatively Regulates Programmed Cell Death by Controlling the Release of cytochrome c from mitochondria.
Yoshida Y., Miyamoto K., Yamane H., Nishizawa Y., Minami E., Nojiri H., Okada K.
Physiol Plant 2017   
OsTGAP1 is responsible for JA-inducible diterpenoid phytoalexin biosynthesis in rice roots with biological impacts on allelopathic interaction.
Park C.H., Shirsekar G., Bellizzi M., Chen S., Songkumarn P., Xie X., Shi X., Ning Y., Zhou B., Suttiviriya P., Wang M., Umemura K., Wang G.L.
PLoS Pathog. 2016  12(3)  e1005529
The E3 ligase APIP10 Connects the Effector AvrPiz-t to the NLR receptor Piz-t in Rice.
Hu H., Wang J., Shi C., Yuan C., Peng C., Yin J., Li W., He M., Wang J., Ma B., Wang Y., Li S., Chen X.
Rice (N Y) 2015  8(1)  34
A receptor like kinase gene with expressional responsiveness on Xanthomonas oryzae pv. oryzae is essential for Xa21-mediated disease resistance.
Shirsekar G.S., Vega-Sánchez ME., Bordeos A., Baraoidan M., Swisshelm A., Fan J., Park C.H., Leung H., Wang G.L.
Mol. Plant Microbe Interact. 2014  27(6)  528-36
Identification and characterization of suppressor mutants of spl11- mediated cell death in rice.
Lee G.W., Lee S., Chung M.S., Jeong Y.S., Chung B.Y.
Protoplasma 2014   
Rice terpene synthase 20 (OsTPS20) plays an important role in producing terpene volatiles in response to abiotic stresses.
Toyomasu T.a, Usui M.a, Sugawara C.a, Otomo K.a, Hirose Y.a, Miyao A.b, Hirochika H.b, Okada K.c, Shimizu T.c j, Koga J.d, Hasegawa M.e, Chuba M.f, Kawana Y.g, Kuroda M.h, Minami E.i, Mitsuhashi W.a, Yamane H.c k
Physiol Plant 2014  150  55-62
Reverse-genetic approach to verify physiological roles of rice phytoalexins: Characterization of a knockdown mutant of OsCPS4 phytoalexin biosynthetic gene in rice
Wankhede D.P.a, Kumar K.a b, Singh P.a, Sinha A.K.a
Rice (N Y) 2013  6  35
Involvement of mitogen activated protein kinase kinase 6 in UV induced transcripts accumulation of genes in phytoalexin biosynthesis in rice
Liu H., Li X., Xiao J., Wang S.
Plant Methods 2012  8(1)  2
A convenient method for simultaneous quantification of multiple phytohormones and metabolites: application in study of rice-bacterium interaction.
Park C.H., Chen S., Shirsekar G., Zhou B., Khang C.H., Songkumarn P., Afzal A.J., Ning Y., Wang R., Bellizzi M., Valent B., Wang G.L.
Plant Cell 2012  24(11)  4748-62
The Magnaporthe oryzae effector AvrPiz-t targets the RING E3 ubiquitin ligase APIP6 to suppress pathogen-associated molecular pattern-triggered immunity in rice.
Kato-Noguchi H.
J. Plant Physiol. 2011  168(13)  1511-6
Convergent or parallel molecular evolution of momilactone A and B: potent allelochemicals, momilactones have been found only in rice and the moss Hypnum plumaeforme.
Kurusu T,Hamada J,Nokajima H,Kitagawa Y,Kiyoduka M,Takahashi A,Hanamata S,Ohno R,Hayashi T,Okada K,Koga J,Hirochika H,Yamane H,Kuchitsu K
Plant Physiol. 2010  153  678-92
Regulation of microbe-associated molecular pattern-induced hypersensitive cell death, phytoalexin production, and defense gene expression by calcineurin B-like protein-interacting protein kinases, OsCIPK14/15, in rice cultured cells.
Mizutani M., Ohta D.
Annu Rev Plant Biol 2010  61  291-315
Diversification of P450 genes during land plant evolution.
Shimizu T., Nakano T., Takamizawa D., Desaki Y., Ishii-Minami N., Nishizawa Y., Minami E., Okada K., Yamane H., Kaku H., Shibuya N.
Plant J. 2010  64(2)  204-214
Two LysM receptor molecules, CEBiP and OsCERK1, cooperatively regulate chitin elicitor signaling in rice.
Okada A,Okada K,Miyamoto K,Koga J,Shibuya N,Nojiri H,Yamane H
J. Biol. Chem. 2009  284(39)  26510-8
OsTGAP1, a bZIP transcription factor, coordinately regulates the inductive production of diterpenoid phytoalexins in rice.
Swaminathan S,Morrone D,Wang Q,Fulton DB,Peters RJ
Plant Cell 2009  21(10)  3315-25
CYP76M7 is an ent-cassadiene C11alpha-hydroxylase defining a second multifunctional diterpenoid biosynthetic gene cluster in rice.
Shimizu T,Jikumaru Y,Okada A,Okada K,Koga J,Umemura K,Minami E,Shibuya N,Hasegawa M,Kodama O,Nojiri H,Yamane H
Phytochemistry 2008  69  973-81
Effects of a bile acid elicitor, cholic acid, on the biosynthesis of diterpenoid phytoalexins in suspension-cultured rice cells.
Shimura K,Okada A,Okada K,Jikumaru Y,Ko KW,Toyomasu T,Sassa T,Hasegawa M,Kodama O,Shibuya N,Koga J,Nojiri H,Yamane H
J. Biol. Chem. 2007  282  34013-8
Identification of a biosynthetic gene cluster in rice for momilactones.
Xu,M., Wilderman,P.R., Morrone,D., Xu,J., Roy,A., Margis-Pinheiro,M., Upadhyaya,N.M., Coates,R.M. and Peters,R.J.
Phytochemistry 2007  68(3)  312-326
Functional characterization of the rice kaurene synthase-like gene family
Kanno,Y., Otomo,K., Kenmoku,H., Mitsuhashi,W., Yamane,H., Oikawa,H., Toshima,H., Matsuoka,M., Sassa,T. and Toyomasu,T.
Biosci. Biotechnol. Biochem. 2006  70(7)  1702-1710
Characterization of a rice gene family encoding type-a diterpene cyclases.
Phytochemistry 2006  67(21)  2307-2317
Uncovering the complex metabolic network underlying diterpenoid phytoalexin biosynthesis in rice and other cereal crop plants.
Margis-Pinheiro,M., Zhou,X.R., Zhu,Q.H., Dennis,E.S. and Upadhyaya,N.M.
Plant Cell Rep. 2005  23(12)  819-833
Isolation and characterization of a Ds-tagged rice (Oryza sativa L.) GA-responsive dwarf mutant defective in an early step of the gibberellin biosynthesis pathway.
Wilderman,P.R., Xu,M., Jin,Y., Coates,R.M. and Peters,R.J.
Plant Physiol. 2004  135(4)  2098-2105
Identification of syn-pimara-7,15-diene synthase reveals functional clustering of terpene synthases involved in rice phytoalexin/allelochemical biosynthesis.
Otomo,K., Kanno,Y., Motegi,A., Kenmoku,H., Yamane,H., Mitsuhashi,W., Oikawa,H., Toshima,H., Itoh,H., Matsuoka,M., Sassa,T. and Toyomasu,T.
Biosci. Biotechnol. Biochem. 2004  68(9)  2001-2006
Diterpene cyclases responsible for the biosynthesis of phytoalexins, momilactones a, B, and oryzalexins a-f in rice.
Sakamoto, T., K. Miura, H. Itoh, T. Tatsumi, M. Ueguchi-Tanaka, K. Ishiyama, M. Kobayashi, G.K. Agrawal, S. Takeda, K. Abe, A. Miyao, H. Hirochika, H. Kitano, M. Ashikari and M. Matsuoka
Plant Physiol. 2004  134  1642-1653
An overview of gibberellin metabolism enzyme genes and their related mutants in rice.
TextPresso Search Search textpresso for KS4 ( Recent references may be retrievable, but without any warranty )
DB Reference
Gramene ID GR:0020070
Gene Ontology diterpene phytoalexin biosynthetic process( GO:0051502 )
response to jasmonic acid stimulus( GO:0009753 )
response to abiotic stimulus( GO:0009628 )
lyase activity( GO:0016829 )
ent-kaurene synthase activity( GO:0009899 )
plastid( GO:0009536 )
syn-pimara-7,15-diene synthase activity( GO:0034279 )
defense response to nematode( GO:0002215 )
defense response to insect( GO:0002213 )
response to temperature stimulus( GO:0009266 )
defense response to fungus( GO:0050832 )
response to chitin( GO:0010200 )
diterpene phytoalexin metabolic process( GO:0051501 )
defense response( GO:0006952 )
magnesium ion binding( GO:0000287 )
metabolic process( GO:0008152 )
response to molecule of fungal origin( GO:0002238 )
response to molecule of bacterial origin( GO:0002237 )
defense response to bacterium( GO:0042742 )
phytoalexin biosynthetic process( GO:0052315 )
Trait Ontology growth and development trait( TO:0000357 )
enzyme activity( TO:0000599 )
UV light sensitivity( TO:0000160 )
diterpenoid phytoalexin content( TO:0002669 )
momilactone A content( TO:0002670 )
bacterial blight disease resistance( TO:0000175 )
blast disease( TO:0000074 )
temperature response trait( TO:0000432 )
insect damage resistance( TO:0000261 )
stem borer resistance( TO:0000454 )
nematode damage resistance( TO:0000384 )
abiotic stress trait( TO:0000168 )
disease resistance( TO:0000112 )
jasmonic acid sensitivity( TO:0000172 )
Plant Ontology -
Related Strains
Phenotype images
Last updated
Sep 15, 2023