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Basic Information
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CGSNL Gene Symbol
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CPS4
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Gene Symbol Synonym
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OsCPS4, CYC1, OsCYC1, OsCyc1, cpsl3, OsCPSL3, OsCPSsyn, OsCyc1/OsCPS4, OsTPS15, Os-CPS4, TPS11, OsTPS11
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CGSNL Gene Name
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ENT-COPALYL DIPHOSPHATE SYNTHASE 4
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Gene Name Synonym
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rice ent-copalyl diphosphate (CDP) synthase4, ent-copalyl diphosphate synthase 4, ent-copalyl diphosphate synthase like 3, syn-copalyl diphosphate synthase, syn-copalyl diphosphate synthase, cyclase1, cyclase 1, syn-CDP synthase, terpene synthase 15
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Protein Name
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ENT-COPALYL DIPHOSPHATE SYNTHASE 4
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Allele
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cps4-tos
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Chromosome No.
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4
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Explanation
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Q0JF02. Q6E7D7. AY530101. AB066270. PDB ID: 8KBW. This gene encodes one of the GA metabolic enzymes; ent-copalyl diphosphate synthase (CPS). It is located on chromosome 4 at 14.3cM. EC=5.5.1.14 Syn-copalyl diphosphate synthase, Syn-CPP synthase, OsCPSsyn. GRO:0007139; A-vegetative stage ; GRO:0007040; rice growth stage. momilactone biosynthetic pathway. GO:1900425: negative regulation of defense response to bacterium. TPS11 in Sun et al. 2022.
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Trait Class
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Tolerance and resistance - Stress tolerance
Vegetative organ - Culm
Biochemical character
Tolerance and resistance - Disease resistance
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Expression
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Sequence/Locus
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cDNA Accession No.
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AK100631
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MSU ID
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LOC_Os04g09900.1
LOC_Os04g09900.2
LOC_Os04g09900.3
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RAP ID
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Os04g0178300
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Links
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Oryzabase Chromosome View
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IRGSP 1.0
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Build5
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RAP-DB
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IRGSP 1.0
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Build5
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Related IDs List (
IRGSP 1.0
/
Build5
)
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INSD Accession List
(Test version)
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Link to INSD Accession List
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Map
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Locate(cM)
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Link map
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Classical linkage map
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References
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Zhou S., Zhang R., Wang Q., Zhu J., Zhou J., Sun Y., Shen S., Luo J.
Int J Mol Sci 2024 25(22)
OsbHLH5 Synergically Regulates Phenolamide and Diterpenoid Phytoalexins Involved in the Defense of Rice Against Pathogens.
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Jiang W., Ye Q., Wu Z., Zhang Q., Wang L., Liu J., Hu X., Guo D., Wang X., Zhang Z., He H., Hu L.
Genes (Basel) 2023 14(1)
Analysis of CAT Gene Family and Functional Identification of OsCAT3 in Rice.
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Ma X., Xu H., Tong Y., Luo Y., Dong Q., Jiang T.
Commun Chem 2023 6(1) 240
Structural and functional investigations of <EM class="new_gene">syn-copalyl diphosphate synthase</EM> from Oryza sativa.
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Liu C., Zhu X., Zhang J., Shen M., Chen K., Fu X., Ma L., Liu X., Zhou C., Zhou D.X., Wang G.
Plant Biotechnol. J. 2022 20(12) 2357-2371
eQTLs play critical roles in regulating gene expression and identifying key regulators in rice.
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Ninkuu V., Yan J., Zhang L., Fu Z., Yang T., Li S., Li B., Duan J., Ren J., Li G., Yang X., Zeng H.
Front Plant Sci 2022 13 980821
Hrip1 mediates rice cell wall fortification and phytoalexins elicitation to confer immunity against <i>Magnaporthe oryzae</i>.
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Sun Y., Zhang P.T., Kou D.R., Han Y.C., Fang J.C., Ni J.P., Jiang B., Wang X., Zhang Y.J., Wang W., Kong X.D.
Front Plant Sci 2022 13 905982
Terpene Synthases in Rice Pan-Genome and Their Responses to <i>Chilo suppressalis</i> Larvae Infesting.
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Ma J., Morel J.B., Riemann M., Nick P.
BMC Plant Biol. 2022 22(1) 601
Jasmonic acid contributes to rice resistance against Magnaporthe oryzae.
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Kitaoka N., Zhang J., Oyagbenro R.K., Brown B., Wu Y., Yang B., Li Z., Peters R.J.
Plant Cell 2021 33(2) 290-305
Interdependent evolution of biosynthetic gene clusters for momilactone production in rice.
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Tian X., He M., Mei E., Zhang B., Tang J., Xu M., Liu J., Li X., Wang Z., Tang W., Guan Q., Bu Q.
Plant Cell 2021
WRKY53 Integrates Classic Brassinosteroid Signaling and the Mitogen-Activated Protein Kinase Pathway to Regulate Rice Architecture and seed size.
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Wu T., Zhang H., Bi Y., Yu Y., Liu H., Yang H., Yuan B., Ding X., Chu Z.
Int J Mol Sci 2021 22(24)
Tal2c Activates the Expression of <i>OsF3H04g</i> to Promote Infection as a Redundant TALE of Tal2b in <i>Xanthomonas oryzae</i> pv. <i>oryzicola</i>.
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Valette M., Rey M., Doré J., Gerin F., Wisniewski-Dyé F.
Physiol Mol Biol Plants 2020 26(12) 2537-2551
Identification of a small set of genes commonly regulated in rice roots in response to beneficial rhizobacteria.
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Murphy K.M., Zerbe P.
Phytochemistry 2020 172 112289
Specialized diterpenoid metabolism in monocot crops: Biosynthesis and chemical diversity.
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Liang J., He Y., Zhang Q., Wang W., Zhang Z.
Int J Mol Sci 2020 21(3)
Plasma Membrane Ca2+ Permeable Mechanosensitive Channel <i>Osdmt1</i> Is Involved in Regulation of Plant Architecture and Ion Homeostasis in Rice.
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Mao L., Kawaide H., Higuchi T., Chen M., Miyamoto K., Hirata Y., Kimura H., Miyazaki S., Teruya M., Fujiwara K., Tomita K., Yamane H., Hayashi K.I., Nojiri H., Jia L., Qiu J., Ye C., Timko M.P., Fan L., Okada K.
Proc. Natl. Acad. Sci. U.S.A. 2020 117(22) 12472-12480
Genomic evidence for convergent evolution of gene clusters for momilactone biosynthesis in land plants.
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Salvador-Guirao R., Baldrich P., Tomiyama S., Hsing Y.I., Okada K., San Segundo B.
Ann. Bot. 2019 123(1) 79-93
OsDCL1a activation impairs phytoalexin biosynthesis and compromises disease resistance in rice.
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Sánchez-Sanuy F., Peris-Peris C., Tomiyama S., Okada K., Hsing Y.I., San Segundo B., Campo S.
BMC Plant Biol. 2019 19(1) 563
Osa-miR7695 enhances transcriptional priming in defense responses against the rice blast fungus.
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Lu X., Zhang J., Brown B., Li R., Rodríguez-Romero J., Berasategui A., Liu B., Xu M., Luo D., Pan Z., Baerson S.R., Gershenzon J., Li Z., Sesma A., Yang B., Peters R.J.
Plant Cell 2018 30(5) 1119-1131
Inferring Roles in Defense from Metabolic Allocation of Rice Diterpenoids.
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Fukushima S., Mori M., Sugano S., Takatsuji H.
Plant Cell Physiol. 2016 57(12) 2541-2551
Transcription Factor WRKY62 Plays a Role in Pathogen Defense and Hypoxia-Responsive Gene Expression in Rice.
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Liu J., Chen X., Liang X., Zhou X., Yang F., Liu J., He S.Y., Guo Z.
Plant Physiol. 2016
Alternative splicing of rice WRKY62 and WRKY76 transcription factor genes in pathogen defense.
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Lee G.W., Lee S., Chung M.S., Jeong Y.S., Chung B.Y.
Protoplasma 2014
Rice terpene synthase 20 (OsTPS20) plays an important role in producing terpene volatiles in response to abiotic stresses.
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Yokotani N., Tsuchida-Mayama T., Ichikawa H., Mitsuda N., Ohme-Takagi M., Kaku H., Minami E., Nishizawa Y.
Mol. Plant Microbe Interact. 2014 27(10) 1027-34
OsNAC111, a blast disease-responsive transcription factor in rice, positively regulates the expression of defense-related genes.
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Toyomasu T.a, Usui M.a, Sugawara C.a, Otomo K.a, Hirose Y.a, Miyao A.b, Hirochika H.b, Okada K.c, Shimizu T.c j, Koga J.d, Hasegawa M.e, Chuba M.f, Kawana Y.g, Kuroda M.h, Minami E.i, Mitsuhashi W.a, Yamane H.c k
Physiol Plant 2014 150 55-62
Reverse-genetic approach to verify physiological roles of rice phytoalexins: Characterization of a knockdown mutant of OsCPS4 phytoalexin biosynthetic gene in rice
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Wei L.a b, Gu L.a, Song X.a, Cui X.a b, Lu Z.a, Zhou M.a, Wang L.a, Hu F.c, Zhai J.d e, Meyers B.C.d e, Cao X.a
Proc. Natl. Acad. Sci. U.S.A. 2014 111 3877-3882
Dicer-like 3 produces transposable element-associated 24-nt siRNAs that control agricultural traits in rice
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Liu H., Li X., Xiao J., Wang S.
Plant Methods 2012 8(1) 2
A convenient method for simultaneous quantification of multiple phytohormones and metabolites: application in study of rice-bacterium interaction.
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Kato-Noguchi H.
J. Plant Physiol. 2011 168(13) 1511-6
Convergent or parallel molecular evolution of momilactone A and B: potent allelochemicals, momilactones have been found only in rice and the moss Hypnum plumaeforme.
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Kurusu T,Hamada J,Nokajima H,Kitagawa Y,Kiyoduka M,Takahashi A,Hanamata S,Ohno R,Hayashi T,Okada K,Koga J,Hirochika H,Yamane H,Kuchitsu K
Plant Physiol. 2010 153 678-92
Regulation of microbe-associated molecular pattern-induced hypersensitive cell death, phytoalexin production, and defense gene expression by calcineurin B-like protein-interacting protein kinases, OsCIPK14/15, in rice cultured cells.
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Mizutani M., Ohta D.
Annu Rev Plant Biol 2010 61 291-315
Diversification of P450 genes during land plant evolution.
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Okada A,Okada K,Miyamoto K,Koga J,Shibuya N,Nojiri H,Yamane H
J. Biol. Chem. 2009 284(39) 26510-8
OsTGAP1, a bZIP transcription factor, coordinately regulates the inductive production of diterpenoid phytoalexins in rice.
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Swaminathan S,Morrone D,Wang Q,Fulton DB,Peters RJ
Plant Cell 2009 21(10) 3315-25
CYP76M7 is an ent-cassadiene C11alpha-hydroxylase defining a second multifunctional diterpenoid biosynthetic gene cluster in rice.
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Shimizu T,Jikumaru Y,Okada A,Okada K,Koga J,Umemura K,Minami E,Shibuya N,Hasegawa M,Kodama O,Nojiri H,Yamane H
Phytochemistry 2008 69 973-81
Effects of a bile acid elicitor, cholic acid, on the biosynthesis of diterpenoid phytoalexins in suspension-cultured rice cells.
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Okada,A., Shimizu,T., Okada,K., Kuzuyama,T., Koga,J., Shibuya,N., Nojiri,H. and Yamane,H.
Plant Mol. Biol. 2007 65(1-2) 177-187
Elicitor induced activation of the methylerythritol phosphate pathway toward phytoalexins biosynthesis in rice
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Kanno,Y., Otomo,K., Kenmoku,H., Mitsuhashi,W., Yamane,H., Oikawa,H., Toshima,H., Matsuoka,M., Sassa,T. and Toyomasu,T.
Biosci. Biotechnol. Biochem. 2006 70(7) 1702-1710
Characterization of a rice gene family encoding type-a diterpene cyclases.
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Tanaka N,Matsuoka M,Kitano H,Asano T,Kaku H,Komatsu S
Plant Cell Environ. 2006 29 619-31
gid1, a gibberellin-insensitive dwarf mutant, shows altered regulation of probenazole-inducible protein (PBZ1) in response to cold stress and pathogen attack.
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Sakamoto, T., K. Miura, H. Itoh, T. Tatsumi, M. Ueguchi-Tanaka, K. Ishiyama, M. Kobayashi, G.K. Agrawal, S. Takeda, K. Abe, A. Miyao, H. Hirochika, H. Kitano, M. Ashikari and M. Matsuoka
Plant Physiol. 2004 134 1642-1653
An overview of gibberellin metabolism enzyme genes and their related mutants in rice.
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Xu,M., Hillwig,M.L., Prisic,S., Coates,R.M. and Peters,R.J.
Plant J. 2004 39(3) 309-318
Functional identification of rice syn-copalyl diphosphate synthase and its role in initiating biosynthesis of diterpenoid phytoalexin/allelopathic natural products.
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Otomo,K., Kenmoku,H., Oikawa,H., Konig,W.A., Toshima,H., Mitsuhashi,W., Yamane,H., Sassa,T. and Toyomasu,T.
Plant J. 2004 39(6) 886-893
Biological functions of ent- and syn-copalyl diphosphate synthases in rice: key enzymes for the branch point of gibberellin and phytoalexin biosynthesis.
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Nemoto,T., Cho,E.M., Okada,A., Okada,K., Otomo,K., Kanno,Y., Toyomasu,T., Mitsuhashi,W., Sassa,T., Minami,E., Shibuya,N., Nishiyama,M., Nojiri,H. and Yamane,H.
FEBS Lett. 2004 571(1-3) 182-186
Stemar-13-ene synthase, a diterpene cyclase involved in the biosynthesis of the phytoalexin oryzalexin S in rice.
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DB Reference
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Gramene ID
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GR:0020066
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Ontologies
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Gene Ontology
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diterpene phytoalexin biosynthetic process( GO:0051502 )
response to iron ion( GO:0010039 )
defense response to bacterium( GO:0042742 )
response to jasmonic acid stimulus( GO:0009753 )
response to abiotic stimulus( GO:0009628 )
defense response to fungus( GO:0050832 )
gibberellin metabolic process( GO:0009685 )
defense response( GO:0006952 )
diterpene phytoalexin precursor biosynthetic process pathway( GO:0051504 )
metabolic process( GO:0008152 )
response to UV( GO:0009411 )
lyase activity( GO:0016829 )
syn-copalyl diphosphate synthase activity( GO:0051498 )
response to molecule of fungal origin( GO:0002238 )
response to symbiotic bacterium( GO:0009609 )
magnesium ion binding( GO:0000287 )
plastid( GO:0009536 )
cyclase activity( GO:0009975 )
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Trait Ontology
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gibberellic acid content( TO:0002675 )
iron sensitivity( TO:0000224 )
abiotic stress trait( TO:0000168 )
jasmonic acid sensitivity( TO:0000172 )
disease resistance( TO:0000112 )
growth and development trait( TO:0000357 )
momilactone A content( TO:0002670 )
momilactone B content( TO:0002671 )
plant height( TO:0000207 )
allelopathic effect( TO:0000624 )
fungal disease resistance( TO:0000439 )
enzyme activity( TO:0000599 )
UV light sensitivity( TO:0000160 )
bacterial blight disease resistance( TO:0000175 )
blast disease( TO:0000074 )
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Plant Ontology
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root( PO:0009005 )
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Related Strains
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Phenotype images
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Last updated
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May 28, 2025
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Update info.