Gene - Detail

Detail of Gene

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Basic Information
CGSNL Gene Symbol CPS4
Gene Symbol Synonym OsCPS4, CYC1, OsCYC1, OsCyc1, cpsl3, OsCPSL3, OsCPSsyn, OsCyc1/OsCPS4, OsTPS15, Os-CPS4, TPS11, OsTPS11
Gene Name Synonym rice ent-copalyl diphosphate (CDP) synthase4, ent-copalyl diphosphate synthase 4, ent-copalyl diphosphate synthase like 3, syn-copalyl diphosphate synthase, syn-copalyl diphosphate synthase, cyclase1, cyclase 1, syn-CDP synthase, terpene synthase 15
Allele cps4-tos
Chromosome No. 4
Explanation Q0JF02. Q6E7D7. AY530101. AB066270. PDB ID: 8KBW. This gene encodes one of the GA metabolic enzymes; ent-copalyl diphosphate synthase (CPS). It is located on chromosome 4 at 14.3cM. EC= Syn-copalyl diphosphate synthase, Syn-CPP synthase, OsCPSsyn. GRO:0007139; A-vegetative stage ; GRO:0007040; rice growth stage. momilactone biosynthetic pathway. GO:1900425: negative regulation of defense response to bacterium. TPS11 in Sun et al. 2022.
Trait Class Tolerance and resistance - Stress tolerance
Vegetative organ - Culm
Biochemical character
Tolerance and resistance - Disease resistance
cDNA Accession No. AK100631
MSU ID LOC_Os04g09900.1
RAP ID Os04g0178300
Links Oryzabase Chromosome View ( IRGSP 1.0 / Build5 )
RAP-DB ( IRGSP 1.0 / Build5 )
Related IDs List ( IRGSP 1.0 / Build5 )
INSD Accession List
(Test version)
Link to INSD Accession List
Link map Classical linkage map
Ma X., Xu H., Tong Y., Luo Y., Dong Q., Jiang T.
Commun Chem 2023  6(1)  240
Structural and functional investigations of <EM class="new_gene">syn-copalyl diphosphate synthase</EM> from Oryza sativa.
Jiang W., Ye Q., Wu Z., Zhang Q., Wang L., Liu J., Hu X., Guo D., Wang X., Zhang Z., He H., Hu L.
Genes (Basel) 2023  14(1) 
Analysis of CAT Gene Family and Functional Identification of OsCAT3 in Rice.
Sun Y., Zhang P.T., Kou D.R., Han Y.C., Fang J.C., Ni J.P., Jiang B., Wang X., Zhang Y.J., Wang W., Kong X.D.
Front Plant Sci 2022  13  905982
Terpene Synthases in Rice Pan-Genome and Their Responses to <i>Chilo suppressalis</i> Larvae Infesting.
Ma J., Morel J.B., Riemann M., Nick P.
BMC Plant Biol. 2022  22(1)  601
Jasmonic acid contributes to rice resistance against Magnaporthe oryzae.
Liu C., Zhu X., Zhang J., Shen M., Chen K., Fu X., Ma L., Liu X., Zhou C., Zhou D.X., Wang G.
Plant Biotechnol. J. 2022  20(12)  2357-2371
eQTLs play critical roles in regulating gene expression and identifying key regulators in rice.
Ninkuu V., Yan J., Zhang L., Fu Z., Yang T., Li S., Li B., Duan J., Ren J., Li G., Yang X., Zeng H.
Front Plant Sci 2022  13  980821
Hrip1 mediates rice cell wall fortification and phytoalexins elicitation to confer immunity against <i>Magnaporthe oryzae</i>.
Tian X., He M., Mei E., Zhang B., Tang J., Xu M., Liu J., Li X., Wang Z., Tang W., Guan Q., Bu Q.
Plant Cell 2021   
WRKY53 Integrates Classic Brassinosteroid Signaling and the Mitogen-Activated Protein Kinase Pathway to Regulate Rice Architecture and seed size.
Wu T., Zhang H., Bi Y., Yu Y., Liu H., Yang H., Yuan B., Ding X., Chu Z.
Int J Mol Sci 2021  22(24) 
Tal2c Activates the Expression of <i>OsF3H04g</i> to Promote Infection as a Redundant TALE of Tal2b in <i>Xanthomonas oryzae</i> pv. <i>oryzicola</i>.
Kitaoka N., Zhang J., Oyagbenro R.K., Brown B., Wu Y., Yang B., Li Z., Peters R.J.
Plant Cell 2021  33(2)  290-305
Interdependent evolution of biosynthetic gene clusters for momilactone production in rice.
Liang J., He Y., Zhang Q., Wang W., Zhang Z.
Int J Mol Sci 2020  21(3) 
Plasma Membrane Ca2+ Permeable Mechanosensitive Channel <i>Osdmt1</i> Is Involved in Regulation of Plant Architecture and Ion Homeostasis in Rice.
Valette M., Rey M., Doré J., Gerin F., Wisniewski-Dyé F.
Physiol Mol Biol Plants 2020  26(12)  2537-2551
Identification of a small set of genes commonly regulated in rice roots in response to beneficial rhizobacteria.
Mao L., Kawaide H., Higuchi T., Chen M., Miyamoto K., Hirata Y., Kimura H., Miyazaki S., Teruya M., Fujiwara K., Tomita K., Yamane H., Hayashi K.I., Nojiri H., Jia L., Qiu J., Ye C., Timko M.P., Fan L., Okada K.
Proc. Natl. Acad. Sci. U.S.A. 2020  117(22)  12472-12480
Genomic evidence for convergent evolution of gene clusters for momilactone biosynthesis in land plants.
Murphy K.M., Zerbe P.
Phytochemistry 2020  172  112289
Specialized diterpenoid metabolism in monocot crops: Biosynthesis and chemical diversity.
Salvador-Guirao R., Baldrich P., Tomiyama S., Hsing Y.I., Okada K., San Segundo B.
Ann. Bot. 2019  123(1)  79-93
OsDCL1a activation impairs phytoalexin biosynthesis and compromises disease resistance in rice.
Sánchez-Sanuy F., Peris-Peris C., Tomiyama S., Okada K., Hsing Y.I., San Segundo B., Campo S.
BMC Plant Biol. 2019  19(1)  563
Osa-miR7695 enhances transcriptional priming in defense responses against the rice blast fungus.
Lu X., Zhang J., Brown B., Li R., Rodríguez-Romero J., Berasategui A., Liu B., Xu M., Luo D., Pan Z., Baerson S.R., Gershenzon J., Li Z., Sesma A., Yang B., Peters R.J.
Plant Cell 2018  30(5)  1119-1131
Inferring Roles in Defense from Metabolic Allocation of Rice Diterpenoids.
Liu J., Chen X., Liang X., Zhou X., Yang F., Liu J., He S.Y., Guo Z.
Plant Physiol. 2016   
Alternative splicing of rice WRKY62 and WRKY76 transcription factor genes in pathogen defense.
Fukushima S., Mori M., Sugano S., Takatsuji H.
Plant Cell Physiol. 2016  57(12)  2541-2551
Transcription Factor WRKY62 Plays a Role in Pathogen Defense and Hypoxia-Responsive Gene Expression in Rice.
Toyomasu T.a, Usui M.a, Sugawara C.a, Otomo K.a, Hirose Y.a, Miyao A.b, Hirochika H.b, Okada K.c, Shimizu T.c j, Koga J.d, Hasegawa M.e, Chuba M.f, Kawana Y.g, Kuroda M.h, Minami E.i, Mitsuhashi W.a, Yamane H.c k
Physiol Plant 2014  150  55-62
Reverse-genetic approach to verify physiological roles of rice phytoalexins: Characterization of a knockdown mutant of OsCPS4 phytoalexin biosynthetic gene in rice
Wei L.a b, Gu L.a, Song X.a, Cui X.a b, Lu Z.a, Zhou M.a, Wang L.a, Hu F.c, Zhai J.d e, Meyers B.C.d e, Cao X.a
Proc. Natl. Acad. Sci. U.S.A. 2014  111  3877-3882
Dicer-like 3 produces transposable element-associated 24-nt siRNAs that control agricultural traits in rice
Lee G.W., Lee S., Chung M.S., Jeong Y.S., Chung B.Y.
Protoplasma 2014   
Rice terpene synthase 20 (OsTPS20) plays an important role in producing terpene volatiles in response to abiotic stresses.
Yokotani N., Tsuchida-Mayama T., Ichikawa H., Mitsuda N., Ohme-Takagi M., Kaku H., Minami E., Nishizawa Y.
Mol. Plant Microbe Interact. 2014  27(10)  1027-34
OsNAC111, a blast disease-responsive transcription factor in rice, positively regulates the expression of defense-related genes.
Liu H., Li X., Xiao J., Wang S.
Plant Methods 2012  8(1)  2
A convenient method for simultaneous quantification of multiple phytohormones and metabolites: application in study of rice-bacterium interaction.
Kato-Noguchi H.
J. Plant Physiol. 2011  168(13)  1511-6
Convergent or parallel molecular evolution of momilactone A and B: potent allelochemicals, momilactones have been found only in rice and the moss Hypnum plumaeforme.
Mizutani M., Ohta D.
Annu Rev Plant Biol 2010  61  291-315
Diversification of P450 genes during land plant evolution.
Kurusu T,Hamada J,Nokajima H,Kitagawa Y,Kiyoduka M,Takahashi A,Hanamata S,Ohno R,Hayashi T,Okada K,Koga J,Hirochika H,Yamane H,Kuchitsu K
Plant Physiol. 2010  153  678-92
Regulation of microbe-associated molecular pattern-induced hypersensitive cell death, phytoalexin production, and defense gene expression by calcineurin B-like protein-interacting protein kinases, OsCIPK14/15, in rice cultured cells.
Swaminathan S,Morrone D,Wang Q,Fulton DB,Peters RJ
Plant Cell 2009  21(10)  3315-25
CYP76M7 is an ent-cassadiene C11alpha-hydroxylase defining a second multifunctional diterpenoid biosynthetic gene cluster in rice.
Okada A,Okada K,Miyamoto K,Koga J,Shibuya N,Nojiri H,Yamane H
J. Biol. Chem. 2009  284(39)  26510-8
OsTGAP1, a bZIP transcription factor, coordinately regulates the inductive production of diterpenoid phytoalexins in rice.
Shimizu T,Jikumaru Y,Okada A,Okada K,Koga J,Umemura K,Minami E,Shibuya N,Hasegawa M,Kodama O,Nojiri H,Yamane H
Phytochemistry 2008  69  973-81
Effects of a bile acid elicitor, cholic acid, on the biosynthesis of diterpenoid phytoalexins in suspension-cultured rice cells.
Okada,A., Shimizu,T., Okada,K., Kuzuyama,T., Koga,J., Shibuya,N., Nojiri,H. and Yamane,H.
Plant Mol. Biol. 2007  65(1-2)  177-187
Elicitor induced activation of the methylerythritol phosphate pathway toward phytoalexins biosynthesis in rice
Kanno,Y., Otomo,K., Kenmoku,H., Mitsuhashi,W., Yamane,H., Oikawa,H., Toshima,H., Matsuoka,M., Sassa,T. and Toyomasu,T.
Biosci. Biotechnol. Biochem. 2006  70(7)  1702-1710
Characterization of a rice gene family encoding type-a diterpene cyclases.
Tanaka N,Matsuoka M,Kitano H,Asano T,Kaku H,Komatsu S
Plant Cell Environ. 2006  29  619-31
gid1, a gibberellin-insensitive dwarf mutant, shows altered regulation of probenazole-inducible protein (PBZ1) in response to cold stress and pathogen attack.
Sakamoto, T., K. Miura, H. Itoh, T. Tatsumi, M. Ueguchi-Tanaka, K. Ishiyama, M. Kobayashi, G.K. Agrawal, S. Takeda, K. Abe, A. Miyao, H. Hirochika, H. Kitano, M. Ashikari and M. Matsuoka
Plant Physiol. 2004  134  1642-1653
An overview of gibberellin metabolism enzyme genes and their related mutants in rice.
Xu,M., Hillwig,M.L., Prisic,S., Coates,R.M. and Peters,R.J.
Plant J. 2004  39(3)  309-318
Functional identification of rice syn-copalyl diphosphate synthase and its role in initiating biosynthesis of diterpenoid phytoalexin/allelopathic natural products.
Otomo,K., Kenmoku,H., Oikawa,H., Konig,W.A., Toshima,H., Mitsuhashi,W., Yamane,H., Sassa,T. and Toyomasu,T.
Plant J. 2004  39(6)  886-893
Biological functions of ent- and syn-copalyl diphosphate synthases in rice: key enzymes for the branch point of gibberellin and phytoalexin biosynthesis.
Nemoto,T., Cho,E.M., Okada,A., Okada,K., Otomo,K., Kanno,Y., Toyomasu,T., Mitsuhashi,W., Sassa,T., Minami,E., Shibuya,N., Nishiyama,M., Nojiri,H. and Yamane,H.
FEBS Lett. 2004  571(1-3)  182-186
Stemar-13-ene synthase, a diterpene cyclase involved in the biosynthesis of the phytoalexin oryzalexin S in rice.
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DB Reference
Gramene ID GR:0020066
Gene Ontology diterpene phytoalexin biosynthetic process( GO:0051502 )
response to iron ion( GO:0010039 )
defense response to bacterium( GO:0042742 )
response to jasmonic acid stimulus( GO:0009753 )
response to abiotic stimulus( GO:0009628 )
defense response to fungus( GO:0050832 )
gibberellin metabolic process( GO:0009685 )
defense response( GO:0006952 )
diterpene phytoalexin precursor biosynthetic process pathway( GO:0051504 )
metabolic process( GO:0008152 )
response to UV( GO:0009411 )
lyase activity( GO:0016829 )
syn-copalyl diphosphate synthase activity( GO:0051498 )
response to molecule of fungal origin( GO:0002238 )
response to symbiotic bacterium( GO:0009609 )
magnesium ion binding( GO:0000287 )
plastid( GO:0009536 )
cyclase activity( GO:0009975 )
Trait Ontology gibberellic acid content( TO:0002675 )
iron sensitivity( TO:0000224 )
abiotic stress trait( TO:0000168 )
jasmonic acid sensitivity( TO:0000172 )
disease resistance( TO:0000112 )
growth and development trait( TO:0000357 )
momilactone A content( TO:0002670 )
momilactone B content( TO:0002671 )
plant height( TO:0000207 )
allelopathic effect( TO:0000624 )
fungal disease resistance( TO:0000439 )
enzyme activity( TO:0000599 )
UV light sensitivity( TO:0000160 )
bacterial blight disease resistance( TO:0000175 )
blast disease( TO:0000074 )
Plant Ontology root( PO:0009005 )
Related Strains
Phenotype images
Last updated
May 13, 2024