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Basic Information
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CGSNL Gene Symbol
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NHX1
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Gene Symbol Synonym
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OsNHX1, OcNHX1, OgNHX1, OrNHX1, OpNHX1, ObNHX1, OsNHX3, NHX3
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CGSNL Gene Name
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NA+/H+ ANTIPORTER
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Gene Name Synonym
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Na+/H+ antiporter, NHX-type antiporter 1, Sodium/hydrogen antiporter 1, Na+/H+ exchanger 3
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Protein Name
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NA+/H+ ANTIPORTER
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Allele
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nhx1, osnhx1
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Chromosome No.
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7
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Explanation
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This gene encodes a vacuolar (Na+m K+)/H+ antiporter. Overexpression of OsNHX1 under high concentration of NaCl and KCl improves the salt tolerance. AB021878. KC610941-KC610951 (O. sativa and wild rice species, partial cds). GO:0090332: stomatal closure. GO:1990069: stomatal opening. TO: 0020095: stomatal process related trait. Oryza sativa subsp. Indica: BGIOSGA026347, Oryza rufipogon: ORUFI07G26490, Oryza meridionalis: OMERI07G22210, Oryza nivara: ONIVA07G25170, Oryza barthii: OBART07G25570, Oryza glumipatula: OGLUM07G25540, Oryza punctata: OPUNC07G23980, Oryza brachyantha: OB07G30930. OsNHX3 in Islam et al. 2025.
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Trait Class
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Biochemical character
Tolerance and resistance - Stress tolerance
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Expression
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Sequence/Locus
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cDNA Accession No.
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AK064004
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MSU ID
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LOC_Os07g47100.1
LOC_Os07g47100.2
LOC_Os07g47100.3
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RAP ID
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Os07g0666900
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Links
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Oryzabase Chromosome View
(
IRGSP 1.0
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Build5
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RAP-DB
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IRGSP 1.0
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Build5
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Related IDs List (
IRGSP 1.0
/
Build5
)
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INSD Accession List
(Test version)
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Link to INSD Accession List
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Map
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Locate(cM)
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Link map
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Classical linkage map
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References
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Luo C., Xu Z., Iqbal Z., Li Y., Essemine J., Fang S., Li N., Huang K., Meng X., Li Z., Chen G., Qu M.
Commun Biol 2025 8(1) 1286
The phytochrome-interacting factor PIL13 enhances water use efficiency under fluctuating light and drought resilience in rice and soybean.
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Cheng F., Qi Y., Lei K., Yang H., Lei Y., Ahmed T., Qi X., Li Z.
Front Plant Sci 2025 16 1653494
Laser diode irradiation mitigates salt stress in rice through coordinated physiological and molecular responses.
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Chen H., Wan J., Zhu J., Wang Z., Mao C., Xu W., Yang J., Kong Y., Zan X., Chen R., Zhu J., Xu Z., Li L.
Front Plant Sci 2025 16 1458467
Overexpression of <i>OsDUF868.12</i> enhances salt tolerance in rice.
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Islam M.S.U., Akter N., Zohra F.T., Rashid S.B., Hasan N., Rahman S.M., Sarkar M.A.R.
PLoS ONE 2025 20(1) e0317008
Genome-wide identification and characterization of cation-proton antiporter (CPA) gene family in rice (Oryza sativa L.) and their expression profiles in response to phytohormones.
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Song J., Yang H., Qiao C., Zhu C., Bai T., Du H., Ma S., Wang N., Luo C., Zhang Y., Ma T., Li P., Tian L.
Front Plant Sci 2023 14 1095929
Natural variations of chlorophyll fluorescence and ion transporter genes influenced the differential response of <i>japonica</i> rice germplasm with different salt tolerances.
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Liu J., Shen L., Guo L., Zhang G., Gao Z., Zhu L., Hu J., Dong G., Ren D., Zhang Q., Li Q., Zeng D., Yan C., Qian Q.
Rice (N Y) 2023 16(1) 47
OsSTS, a Novel Allele of Mitogen-Activated Protein Kinase Kinase 4 (OsMKK4), Controls grain size and salt tolerance in Rice.
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Yoo Y., Yoo Y.H., Lee D.Y., Jung K.H., Lee S.W., Park J.C.
Antioxidants (Basel) 2023 12(11)
Caffeine Produced in Rice Plants Provides Tolerance to Water-Deficit Stress.
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Prodjinoto H., Irakoze W., Gandonou C., Quinet M., Lutts S.
PLoS ONE 2023 18(11) e0290752
Comparison between the impact of osmotic and NaCl treatments on the expression of genes coding for ion transporters in Oryza glaberrima Steud.
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Adhikari A., Aneefi A.G., Sisuvanh H., Singkham S., Pius M.V., Akter F., Kwon E.H., Kang S.M., Woo Y.J., Yun B.W., Lee I.J.
Int J Mol Sci 2023 24(24)
Dynamics of Humic Acid, Silicon, and Biochar under Heavy Metal, Drought, and Salinity with Special Reference to Phytohormones, Antioxidants, and Melatonin Synthesis in Rice.
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Yu N., Liang Y., Wang Q., Peng X., He Z., Hou X.
Sci Rep 2022 12(1) 6736
Transcriptomic analysis of OsRUS1 overexpression rice lines with rapid and dynamic leaf rolling morphology.
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Solis C.A., Yong M.T., Zhou M., Venkataraman G., Shabala L., Holford P., Shabala S., Chen Z.H.
Int J Mol Sci 2022 23(4)
Evolutionary Significance of NHX Family and NHX1 in Salinity Stress Adaptation in the Genus <i>Oryza</i>.
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Farooq M., Park J.R., Jang Y.H., Kim E.G., Kim K.M.
Front Plant Sci 2021 12 680131
Rice Cultivars Under Salt Stress Show Differential Expression of Genes Related to the Regulation of Na+/K+ Balance.
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Kim J.H., Lim S.D., Jang C.S.
Physiol Plant 2021
Oryza sativa, C4HC3-type really interesting new gene (RING), OsRFPv6, is a positive regulator in response to salt stress by regulating Na+ absorption.
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Qu M., Essemine J., Xu J., Ablat G., Perveen S., Wang H., Chen K., Zhao Y., Chen G., Chu C., Zhu X.
Plant J. 2020 104(5) 1334-1347
Alterations in stomatal response to fluctuating light increase biomass and yield of rice under drought conditions.
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Neang S., Goto I., Skoulding N.S., Cartagena J.A., Kano-Nakata M., Yamauchi A., Mitsuya S.
BMC Plant Biol. 2020 20(1) 502
Tissue-specific expression analysis of Na+ and Cl- transporter genes associated with salt removal ability in rice leaf sheath.
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Chakraborty K., Mondal S., Ray S., Samal P., Pradhan B., Chattopadhyay K., Kar M.K., Swain P., Sarkar R.K.
Front Plant Sci 2020 11 265
Tissue Tolerance Coupled With Ionic Discrimination Can Potentially Minimize the Energy Cost of Salinity Tolerance in Rice.
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Fang C., Li K., Wu Y., Wang D., Zhou J., Liu X., Li Y., Jin C., Liu X., Mur L.A.J., Luo J.
Plant Cell Environ. 2019 42(5) 1503-1512
OsTSD2-mediated cell wall modification affects ion homeostasis and salt tolerance.
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Ijaz B., Formentin E., Ronci B., Locato V., Barizza E., Hyder M.Z., Lo Schiavo F., Yasmin T.
PLoS ONE 2019 14(4) e0213986
Salt tolerance in indica rice cell cultures depends on a fine tuning of ROS signalling and homeostasis.
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Subramanyam K., Du Laing G., Van Damme EJM.
Front Plant Sci 2019 10 116
Sodium Selenate Treatment Using a Combination of Seed Priming and Foliar Spray Alleviates Salinity Stress in Rice.
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Wang Y., Li D., Gao J., Li X., Zhang R., Jin X., Hu Z., Zheng B., Persson S., Chen P.
J. Exp. Bot. 2017
The 2'-O-methyladenosine nucleoside modification gene OsTrm13 positively regulates salt stress tolerance in rice.
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Manimaran P., Venkata Reddy S., Moin M., Raghurami Reddy M., Yugandhar P., Mohanraj S.S., Balachandran S.M., Kirti P.B.
Sci Rep 2017 7(1) 9341
Activation-tagging in indica rice identifies a novel transcription factor subunit, NF-YC13 associated with salt tolerance.
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Li L., Wang F., Yan P., Jing W., Zhang C., Kudla J., Zhang W.
New Phytol. 2017 214(3) 1172-1187
A phosphoinositide-specific phospholipase C pathway elicits stress-induced Ca(2+) signals and confers salt tolerance to rice.
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Cui P., Liu H., Islam F., Li L., Farooq M.A., Ruan S., Zhou W.
Front Plant Sci 2016 7 1357
OsPEX11, a Peroxisomal Biogenesis Factor 11, Contributes to Salt Stress Tolerance in Oryza sativa.
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Almeida D.M., Gregorio G.B., Oliveira M.M., Saibo N.J.
Plant Mol. Biol. 2016
Five novel transcription factors as potential regulators of OsNHX1 gene expression in a salt tolerant rice genotype.
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Zhu N., Cheng S., Liu X., Du H., Dai M., Zhou D.X., Yang W., Zhao Y.
Plant Sci. 2015 236 146-56
The R2R3-type MYB gene OsMYB91 has a function in coordinating plant growth and salt stress tolerance in rice.
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Tripathy M.K., Tiwari B.S., Reddy M.K., Deswal R., Sopory S.K.
Protoplasma 2015
Ectopic expression of PgRab7 in rice plants (Oryza sativa L.) results in differential tolerance at the vegetative and seed setting stage during salinity and drought stress.
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Sun L.J., Zhang Q., Wu J.X., Zhang L.Q., Jiao X.W., Zhang S.W., Zhang Z.G., Sun D.Y., Lu T.G., Sun Y.
Plant Physiol. 2014 165(1) 335-45
Two rice histidine phosphotransfer proteins, OsAHP1 and OsAHP2, mediate cytokinin signaling and stress responses in rice.
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Ke Y.G.a b, Yang Z.J.a, Yu S.W.b, Li T.F.b, Wu J.H.b, Gao H.b, Fu Y.P.c, Luo L.J.a b
Journal of Plant Biology 2014 57 150-161
Characterization of OsDREB6 responsive to osmotic and cold stresses in rice
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Zhu,T., Xu,P.Z., Liu,J.P., Peng,S., Mo,X.C. and Gao,L.Z.
Mol. Phylogenet. Evol. 2014 70 348-361
Phylogenetic relationships and genome divergence among the AA- genome species of the genus Oryza as revealed by 53 nuclear genes and 16 intergenic regions
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Liu C., Mao B., Ou S., Wang W., Liu L., Wu Y., Chu C., Wang X.
Plant Mol. Biol. 2013
OsbZIP71, a bZIP transcription factor, confers salinity and drought tolerance in rice.
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Yang C., Zhao N., Xu C., Liu B., Shi D.
Aust J Crop Sci 2012 6 724-731
Regulation of ion homeostasis in rice subjected to salt and alkali stresses
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Wang H., Wu Z., Han J., Zheng W., Yang C.
PLoS ONE 2012 7(5) e37817
Comparison of ion balance and nitrogen metabolism in old and young leaves of alkali-stressed rice plants.
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Vu H.T.T., Manangkil O.E., Mori N., Yoshida S., Nakamura C.
Biotechnology and Biotechnological Equipment 2012 26 2945-2951
Induction and repression of gene expression mediating ethylene biosynthesis and sodium/proton exchange in rice seedlings under submergence stress
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Asano T., Hakata M., Nakamura H., Aoki N., Komatsu S., Ichikawa H., Hirochika H., Ohsugi R.
Plant Mol. Biol. 2011 75(1) 179-191
Functional characterisation of OsCPK21, a calcium-dependent protein kinase that confers salt tolerance in rice.
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Fukuda,A., Nakamura,A., Hara,N., Toki,S. and Tanaka,Y.
Planta 2011 233(1) 175-188
Molecular and functional analyses of rice NHX-type Na+/H+ antiporter genes
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Francki, Michael G.
Molecular Genetics & Genomics (Molecular General Genetics up to 2001) 2007 277 199-212
Arabidopsis-rice-wheat gene orthologues for Na transport and transcript analysis in wheat-L. elongatum aneuploids under salt stress.
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Fukuda, A., A. Nakamura, A. Tagiri, H. Tanaka, A. Miyao, H. Hirochika and Y. Tanaka
Plant Cell Physiol. 2004 45 (2) 146-159
Function, intracellular localization and the importance in salt tolerance of a vacuolar Na+/H+ antiporter from rice.
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Fukuda,A., Nakamura,A. and Tanaka,Y.
Biochim. Biophys. Acta 1999 1446(1-2) 149-155
Molecular cloning and expression of the Na+/H+ exchanger gene in Oryza sativa.
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DB Reference
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Gramene ID
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-
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Ontologies
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Gene Ontology
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response to light stimulus( GO:0009416 )
regulation of stomatal movement( GO:0010119 )
response to abscisic acid stimulus( GO:0009737 )
response to auxin stimulus( GO:0009733 )
response to gibberellin stimulus( GO:0009739 )
vacuole( GO:0005773 )
vacuolar sequestering of sodium ion( GO:0043182 )
sodium ion homeostasis( GO:0055078 )
potassium ion homeostasis( GO:0055075 )
integral to membrane( GO:0016021 )
water homeostasis( GO:0030104 )
stomatal movement( GO:0010118 )
response to light intensity( GO:0009642 )
sodium:hydrogen antiporter activity( GO:0015385 )
regulation of pH( GO:0006885 )
response to salt stress( GO:0009651 )
response to water deprivation( GO:0009414 )
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Trait Ontology
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salt tolerance( TO:0006001 )
drought tolerance( TO:0000276 )
sodium to potassium content ratio( TO:0000525 )
light intensity sensitivity( TO:0000460 )
water use efficiency( TO:0001017 )
relative yield( TO:0000153 )
relative biomass( TO:0000143 )
relative plant height( TO:0001034 )
gibberellic acid sensitivity( TO:0000166 )
auxin sensitivity( TO:0000163 )
abscisic acid sensitivity( TO:0000615 )
stomatal closure rate( TO:0000520 )
light sensitivity( TO:0000075 )
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Plant Ontology
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root( PO:0009005 )
leaf( PO:0025034 )
leaf sheath( PO:0020104 )
shoot system( PO:0009006 )
pollen( PO:0025281 )
anther( PO:0009066 )
inflorescence( PO:0009049 )
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Related Strains
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Phenotype images
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Last updated
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Jan 19, 2026
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Update info.