Gene - Detail

Detail of Gene

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Basic Information
CGSNL Gene Symbol NAS1
Gene Symbol Synonym OsNAS1
Gene Name Synonym rice nicotianamine synthase1, NA synthase gene 1, Nicotianamine synthase 1, S-adenosyl-L-methionine:S-adenosyl-L-methionine:S-adenosyl-methionine 3-amino-3-carboxypropyltransferase 1
Chromosome No. 3
Explanation The nicotianamine is a crucial components of the iron acqusition apparatus of graminaeceous plant. AB046401. D24418. AB021746. EC= A2XFU5(indica). Q0DSH9(japonica). TO:0006049: iron concentration. TO:0020089: iron content trait. TO:0006053: zinc concentration. GO:1990641: response to iron ion starvation.
Trait Class Biochemical character
Tolerance and resistance - Stress tolerance
cDNA Accession No. AK112069
MSU ID LOC_Os03g19427.1
RAP ID Os03g0307300
Links Oryzabase Chromosome View ( IRGSP 1.0 / Build5 )
RAP-DB ( IRGSP 1.0 / Build5 )
Related IDs List ( IRGSP 1.0 / Build5 )
INSD Accession List
(Test version)
Link to INSD Accession List
Link map Classical linkage map
Wang W., Shinwari K.I., Zhang H., Zhang H., Dong L., He F., Zheng L.
Int J Mol Sci 2022  23(23) 
The bHLH Transcription Factor OsbHLH057 Regulates Iron Homeostasis in Rice.
Kobayashi T., Maeda K., Suzuki Y., Nishizawa N.K.
Rice (N Y) 2022  15(1)  54
Simultaneous Enhancement of iron Deficiency Tolerance and Iron Accumulation in Rice by Combining the Knockdown of OsHRZ Ubiquitin Ligases with the Introduction of Engineered Ferric-chelate Reductase.
Regon P., Dey S., Rehman M., Pradhan A.K., Chowra U., Tanti B., Talukdar A.D., Panda S.K.
Front Plant Sci 2022  13  798580
Transcriptomic Analysis Revealed Reactive Oxygen Species Scavenging Mechanisms Associated With Ferrous Iron Toxicity in Aromatic Keteki Joha Rice.
Cao L., Gao Y., Yu J., Niu S., Zeng J., Yao Q., Wang X., Bu Z., Xu T., Liu X., Zhu Y.
Plant Physiol. Biochem. 2021  158  275-283
Streptomyces hygroscopicus OsiSh-2-induced mitigation of Fe deficiency in rice plants.
Yang A., Li Q., Chen L., Zhang W.H.
J. Exp. Bot. 2020   
A rice small GTPase, OsRab6a, is involved in the regulation of grain yield and iron nutrition in response to CO2 enrichment.
Wang S., Li L., Ying Y., Wang J., Shao J.F., Yamaji N., Whelan J., Ma J.F., Shou H.
New Phytol. 2020  225(3)  1247-1260
A transcription factor OsbHLH156 regulates Strategy II iron acquisition through localising IRO2 to the nucleus in rice.
Liang G., Zhang H., Li Y., Pu M., Yang Y., Li C., Lu C., Xu P., Yu D.
J Integr Plant Biol 2020  62(5)  668-689
Oryza sativa FER-LIKE FE DEFICIENCY-INDUCED TRANSCRIPTION FACTOR (OsFIT/OsbHLH156) interacts with OsIRO2 to regulate iron homeostasis.
Kobayashi T., Ozu A., Kobayashi S., An G., Jeon J.S., Nishizawa N.K.
Plant Mol. Biol. 2019  101(4-5)  471-486
OsbHLH058 and OsbHLH059 transcription factors positively regulate iron deficiency responses in rice.
Aung M.S., Kobayashi T., Masuda H., Nishizawa N.K.
Physiol Plant 2018   
Rice HRZ ubiquitin ligases are crucial for response to excess iron.
Shi X., Chen S., Peng Y., Wang Y., Chen J., Hu Z., Wang B., Li A., Chao D., Li Y., Teng S.
J Integr Plant Biol 2018  60(2)  112-129
TSC1 enables plastid development under dark conditions, contributing to rice adaptation to transplantation shock.
Wang B., Wei H., Xue Z., Zhang W.H.
Ann. Bot. 2017  119(6)  945-956
Gibberellins regulate iron deficiency-response by influencing iron transport and translocation in rice seedlings (Oryza sativa).
Andrés-Bordería A., Andrés F., Garcia-Molina A., Perea-García A., Domingo C., Puig S., Peñarrubia L.
Plant Mol. Biol. 2017   
Copper and ectopic expression of the Arabidopsis transport protein COPT1 alter iron homeostasis in rice (Oryza sativa L.).
Zhang H., Li Y., Yao X., Liang G., Yu D.
Plant Physiol. 2017  175(1)  543-554
Masuda H., Shimochi E., Hamada T., Senoura T., Kobayashi T., Aung M.S., Ishimaru Y., Ogo Y., Nakanishi H., Nishizawa N.K.
PLoS ONE 2017  12(3)  e0173441
A new transgenic rice line exhibiting enhanced ferric iron reduction and phytosiderophore production confers tolerance to low iron availability in calcareous soil.
Moreno-Moyano LT., Bonneau J.P., Sánchez-Palacios JT., Tohme J., Johnson A.A.
Front Plant Sci 2016  7  1463
Association of Increased Grain Iron and Zinc Concentrations with Agro-morphological Traits of Biofortified Rice.
Kobayashi T., Itai R.N., Senoura T., Oikawa T., Ishimaru Y., Ueda M., Nakanishi H., Nishizawa N.K.
Plant Mol. Biol. 2016  91(4-5)  533-47
Jasmonate signaling is activated in the very early stages of iron deficiency responses in rice roots.
Yang A., Zhang W.H.
Plant Cell Physiol. 2016  57(6)  1271-80
A Small GTPase, OsRab6a, is Involved in the Regulation of Iron Homeostasis in Rice.
Tan S., Liu F., Pan X.X., Zang Y.P., Jin F., Zu W.X., Qi X.T., Xiao W., Yin L.P.
Sci Rep 2016  6  25485
CSN6, a subunit of the COP9 signalosome, is involved in early response to iron deficiency in Oryza sativa.
Bashir K., Ishimaru Y., Itai R.N., Senoura T., Takahashi M., An G., Oikawa T., Ueda M., Sato A., Uozumi N., Nakanishi H., Nishizawa N.K.
Plant Mol. Biol. 2015  88(1-2)  165-76
Iron deficiency regulated OsOPT7 is essential for iron homeostasis in rice.
Hu B., Wang W., Deng K., Li H., Zhang Z., Zhang L., Chu C.
Front Plant Sci 2015  6  188
MicroRNA399 is involved in multiple nutrient starvation responses in rice.
Agarwal S., Tripura Venkata VG., Kotla A., Mangrauthia S.K., Neelamraju S.
Gene 2014  546(2)  430-6
Expression patterns of QTL based and other candidate genes in Madhukar × Swarna RILs with contrasting levels of iron and zinc in unpolished rice grains.
Kobayashi T.a b, Nakanishi Itai R.c, Nishizawa N.K.b
Rice 2014  7 
Iron deficiency responses in rice roots
Yang A., Li Y., Xu Y., Zhang W.H.
J. Exp. Bot. 2013  64(16)  5009-20
A receptor-like protein RMC is involved in regulation of iron acquisition in rice.
Anuradha K., Agarwal S., Rao Y.V., Rao K.V., Viraktamath B.C., Sarla N.
Gene 2012  508(2)  233-40
Mapping QTLs and candidate genes for iron and zinc concentrations in unpolished rice of Madhukar×Swarna RILs.
Wang L., Ying Y., Narsai R., Ye L., Zheng L., Tian J., Whelan J., Shou H.
Plant Cell Environ. 2012  36(1)  224-36.
Identification of OsbHLH133 as a regulator of iron distribution between roots and shoots in Oryza sativa.
Kobayashi T., Naoko K Nishizawa
Annu Rev Plant Biol 2012  63  131-52
Iron uptake, translocation, and regulation in higher plants.
Suzuki M., Bashir K., Inoue H., Takahashi M., Nakanishi H., Nishizawa N.K.
Rice (N Y) 2012  5  9
Accumulation of starch in Zn-deficient rice
Johnson A.A., Kyriacou B., Callahan D.L., Carruthers L., Stangoulis J., Lombi E., Tester M.
PLoS ONE 2011  6(9)  e24476
Constitutive overexpression of the OsNAS gene family reveals single-gene strategies for effective iron- and zinc-biofortification of rice endosperm.
Ishimaru Y., Masuda H., Bashir K., Inoue H., Tsukamoto T., Takahashi M., Nakanishi H., Aoki N., Hirose T., Ohsugi R., Naoko K Nishizawa
Plant J. 2010  62(3)  379-90
Rice metal-nicotianamine transporter, OsYSL2, is required for the long-distance transport of iron and manganese.
Kobayashi T,Itai RN,Ogo Y,Kakei Y,Nakanishi H,Takahashi M,Nishizawa NK
Plant J. 2009  60(6)  948-61
The rice transcription factor IDEF1 is essential for the early response to iron deficiency, and induces vegetative expression of late embryogenesis abundant genes.
Narayanan NN, Vasconcelos MW, Grusak MA.
Plant Physiol. Biochem. 2007  45(5)  277-86.
Expression profiling of Oryza sativa metal homeostasis genes in different rice cultivars using a cDNA macroarray.
Ogo,Y., Itai,R.N., Nakanishi,H., Inoue,H., Kobayashi,T., Suzuki,M., Takahashi,M., Mori,S. and Nishizawa,N.K.
J. Exp. Bot. 2006  57(11)  2867-2878
Isolation and characterization of IRO2, a novel iron-regulated bHLH transcription factor in graminaceous plants
Suzuki,M., Takahashi,M., Tsukamoto,T., Watanabe,S., Matsuhashi,S., Yazaki,J., Kishimoto,N., Kikuchi,S., Nakanishi,H., Mori,S. and Nishizawa,N.K.
Plant J. 2006  48(1)  85-97
Biosynthesis and secretion of mugineic acid family phytosiderophores in zinc-deficient barley
Kobayashi,T., Suzuki,M., Inoue,H., Itai,R.N., Takahashi,M., Nakanishi,H., Mori,S. and Nishizawa,N.K.
J. Exp. Bot. 2005  56  1305-1316
Expression of iron-acquisition-related genes in iron-deficient rice is co-ordinately induced by partially conserved iron-deficiency-responsive elements
Nozoye T., Reiko Nakanishi Ita, Nagasaki S., Takahashi M., Nakanishi H., Mori S., Naoko K Nishikawa
Soil Sci Plant Nutr 2004  50(7)  1125-1131
Diurnal Changes in the Expression of Genes That Participate in Phytosiderophore Synthesis in Rice
Inoue, H., K. Higuchi, M. Takahashi, H. Nakanishi, S. Mori and N.K. Nishizawa
Plant J. 2003  36 (3)  366-381
Three rice nicotianamine synthase genes, OsNAS1, OsNAS2, and OsNAS3 are expressed in cells involved in long-distance transport of iron and differentially regulated by iron.
Higuchi,K., Watanabe,S., Takahashi,M., Kawasaki,S., Nakanishi,H., Nishizawa,N.K. and Mori,S.
Plant J. 2001  25(2)  159-167
Nicotianamine synthase gene expression differs in barley and rice under Fe-deficient conditions.
Higuchi K, Suzuki K, Nakanishi H, Yamaguchi H, Nishizawa NK, Mori S.
Plant Physiol. 1999  119(2)  471-480
Cloning of nicotianamine synthase genes, novel genes involved in the biosynthesis of phytosiderophores.
TextPresso Search Search textpresso for NAS1 ( Recent references may be retrievable, but without any warranty )
DB Reference
Gramene ID GR:0080047
Gene Ontology response to iron(II) ion( GO:0010040 )
iron ion homeostasis( GO:0055072 )
response to symbiotic bacterium( GO:0009609 )
response to starvation( GO:0042594 )
iron ion transport( GO:0006826 )
nicotianamine synthase activity( GO:0030410 )
cellular amino acid biosynthetic process( GO:0008652 )
cellular response to iron ion starvation( GO:0010106 )
cellular response to zinc ion starvation( GO:0034224 )
carboxylic acid biosynthetic process( GO:0046394 )
nicotianamine biosynthetic process( GO:0030418 )
response to gibberellin stimulus( GO:0009739 )
response to iron ion( GO:0010039 )
response to copper ion( GO:0046688 )
Trait Ontology iron sensitivity( TO:0000224 )
chlorophyll content( TO:0000495 )
zinc sensitivity( TO:0000351 )
gibberellic acid sensitivity( TO:0000166 )
copper sensitivity( TO:0000021 )
Plant Ontology companion cell( PO:0000071 )
root hair cell( PO:0000256 )
root cortex( PO:0000258 )
vascular bundle( PO:0005020 )
root epidermis( PO:0006036 )
protoxylem( PO:0000272 )
bulliform cell( PO:0004001 )
leaf sheath( PO:0020104 )
vascular leaf( PO:0009025 )
root cap( PO:0020123 )
root stele( PO:0020124 )
root( PO:0009005 )
lateral root( PO:0020121 )
pericycle( PO:0006203 )
Related Strains
Phenotype images
Last updated
Jun 1, 2023