Gene - Detail

Detail of Gene

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Basic Information
CGSNL Gene Symbol RAC1
Gene Symbol Synonym OsRAC1, OsRac1, Os Rac1, Rac1, Os-Rac1
Gene Name Synonym small GTP-binding protein 1, Rac-like GTP-binding protein 1, GTPase Rac homolog, Rice homolog of mammalian Rac-GTPase RAC1
Chromosome No. 1
Explanation This gene regulates cell death against blast disease infection, i.e. hyper sensitiveness. AB029508. Q9SSX0. PO:0009011; plant structure ; PO:0000003; whole plant. GO:2000377: regulation of reactive oxygen species metabolic process. KC611164-KC611172 (O. sativa and wild rice species, partial cds). Integrator of PTI (PAMP-triggered immunity) and ETI (effector-triggered immunity). GO:2000379: positive regulation of reactive oxygen species metabolic process. GO:1900150: regulation of defense response to fungus. TO:0000975: grain width. TO:0000845: collective phyllome structure morphology trait. GO:1903426: regulation of reactive oxygen species biosynthetic process.
Trait Class Character as QTL - Yield and productivity
Tolerance and resistance - Disease resistance
Seed - Morphological traits - Grain shape
cDNA Accession No. AK071126
MSU ID LOC_Os01g12900.1
RAP ID Os01g0229400
Links Oryzabase Chromosome View ( IRGSP 1.0 / Build5 )
RAP-DB ( IRGSP 1.0 / Build5 )
Related IDs List ( IRGSP 1.0 / Build5 )
INSD Accession List
(Test version)
Link to INSD Accession List
Link map Classical linkage map
Bai F., Ma H., Cai Y., Shahid M.Q., Zheng Y., Lang C., Chen Z., Wu J., Liu X., Wang L.
Plant Physiol. 2023   
Natural Allelic Variation in GRAIN SIZE.AND WEIGHT 3 of Wild Rice Regulates the GRAIN SIZE.and Weight.
Li G.B., He J.X., Wu J.L., Wang H., Zhang X., Liu J., Hu X.H., Zhu Y., Shen S., Bai Y.F., Yao Z.L., Liu X.X., Zhao J.H., Li D.Q., Li Y., Huang F., Huang Y.Y., Zhao Z.X., Zhang J.W., Zhou S.X., Ji Y.P., Pu M., Qin P., Li S., Chen X., Wang J., He M., Li W., Wu X.J., Xu Z.J., Wang W.M., Fan J.
Mol Plant 2022  15(11)  1790-1806
Overproduction of OsRACK1A, an effector-targeted scaffold protein promoting OsRBOHB-mediated ROS production, confers rice floral resistance to false smut disease without yield penalty.
Yu M., Zhou Z., Liu X., Yin D., Li D., Zhao X., Li X., Li S., Chen R., Lu L., Yang D., Tang D., Zhu L.
Plant Physiol. 2021  187(4)  2852-2864
The OsSPK1-OsRac1-RAI1 defense signaling pathway is shared by two distantly related NLR proteins in rice blast resistance.
Jing X.Q., Li W.Q., Zhou M.R., Shi P.T., Zhang R., Shalmani A., Muhammad I., Wang G.F., Liu W.T., Chen K.M.
Rice (N Y) 2021  14(1)  100
Rice Carbohydrate-Binding Malectin-Like Protein, OsCBM1, Contributes to Drought-Stress Tolerance by Participating in NADPH oxidase-Mediated ROS Production.
Bai P., Park C.H., Shirsekar G., Songkumarn P., Bellizzi M., Wang G.L.
Mol. Plant Pathol. 2019  20(4)  599-608
Role of lysine residues of the Magnaporthe oryzae effector AvrPiz-t in effector- and PAMP-triggered immunity.
Dong Z., Li W., Liu J., Li L., Pan S., Liu S., Gao J., Liu L., Liu X., Wang G.L., Dai L.
Sci Rep 2019  9(1)  5408
The Rice Phosphate Transporter Protein OsPT8 Regulates disease resistance and Plant Growth.
Tang J., Wang Y., Yin W., Dong G., Sun K., Teng Z., Wu X., Wang S., Qian Y., Pan X., Qian Q., Chu C.
Plant Physiol. 2019  181(3)  1295-1313
Mutation of a Nucleotide-Binding Leucine-Rich Repeat Immune Receptor-Type Protein Disrupts Immunity to Bacterial Blight.
Zhang Y., Xiong Y., Liu R., Xue H.W., Yang Z.
Proc. Natl. Acad. Sci. U.S.A. 2019  116(32)  16121-16126
The Rho-family GTPase <i>OsRac1</i> controls rice grain size and yield by regulating cell division.
Zhou Z., Pang Z., Zhao S., Zhang L., Lv Q., Yin D., Li D., Liu X., Zhao X., Li X., Wang W., Zhu L.
New Phytol. 2019  223(2)  828-838
Importance of OsRac1 and RAI1 in signalling of nucleotide-binding site leucine-rich repeat protein-mediated resistance to rice blast disease.
Wang Q., Li Y., Ishikawa K., Kosami K.I., Uno K., Nagawa S., Tan L., Du J., Shimamoto K., Kawano Y.
Proc. Natl. Acad. Sci. U.S.A. 2018  115(49)  E11551-E11560
Resistance protein Pit interacts with the GEF OsSPK1 to activate OsRac1 and trigger rice immunity.
Huang J., Liu H., Berberich T., Liu Y., Tao L.Z., Liu T.
Rice (N Y) 2018  11(1)  42
Guanine Nucleotide Exchange Factor 7B (RopGEF7B) is involved in floral organ development in Oryza sativa.
Morino K., Kimizu M., Fujiwara M.
Proteome Sci 2016  15  6
Disulfide proteomics of rice cultured cells in response to OsRacl and probenazole-related immune signaling pathway in rice.
Nagano M., Ishikawa T., Fujiwara M., Fukao Y., Kawano Y., Kawai-Yamada M., Shimamoto K.
Plant Cell 2016  28(8)  1966-83
Plasma Membrane Microdomains Are Essential for Rac1-RbohB/H-Mediated Immunity in Rice.
Liu J., Park C.H., He F., Nagano M., Wang M., Bellizzi M., Zhang K., Zeng X., Liu W., Ning Y., Kawano Y., Wang G.L.
PLoS Pathog. 2015  11(2)  e1004629
The RhoGAP Spin6 associates with SPL11 and OsRac1 and negatively regulates programmed cell death and innate immunity in rice.
Zhang H., Liu J., He F., Wang Z., Ning Y., Wang G.L.
Plant Signal Behav 2015  10(8)  e1039212
OsHUB1 and OsHub2 interact with SPIN6 and form homo- and hetero-dimers in rice.
Akamatsu A., Uno K., Kato M., Wong H.L., Shimamoto K., Kawano Y.
Plant Signal Behav 2015  10(7)  e1044702
New insights into the dimerization of small GTPase Rac/ROP guanine nucleotide exchange factors in rice.

PLoS Pathog. 2015  11(4)  e1004807
Correction: The RhoGAP SPIN6 Associates with SPL11 and OsRac1 and Negatively Regulates Programmed Cell Death and Innate Immunity in Rice.
Zhu,T., Xu,P.Z., Liu,J.P., Peng,S., Mo,X.C. and Gao,L.Z.
Mol. Phylogenet. Evol. 2014  70  348-361
Phylogenetic relationships and genome divergence among the AA- genome species of the genus Oryza as revealed by 53 nuclear genes and 16 intergenic regions
Kosami K., Ohki I., Nagano M., Furuita K., Sugiki T., Kawano Y., Kawasaki T., Fujiwara T., Nakagawa A., Shimamoto K., Kojima C.
J. Biol. Chem. 2014  289(41)  28569-78
The Crystal Structure of the plant small GTPase OsRac1 Reveals Its Mode of Binding to NADPH Oxidase.
Akamatsu A., Wong H.L., Fujiwara M., Okuda J., Nishide K., Uno K., Imai K., Umemura K., Kawasaki T., Kawano Y., Shimamoto K.
Cell Host Microbe 2013  13(4)  465-76
An OsCEBiP/OsCERK1-OsRacGEF1-OsRac1 Module Is an Essential Early Component of Chitin-Induced Rice Immunity.
Wamaitha M.J., Yamamoto R., Wong H.L., Kawasaki T., Kawano Y., Shimamoto K.
Rice (N Y) 2012  5  35
OsRap2.6 transcription factor contributes to rice innate immunity through its interaction with receptor for activated Kinase-C 1 (RACK1)
Liu J., Li W., Ning Y., Shirsekar G., Wang X., Dai L., Wang Z., Liu W., Wang G.L.
Plant Physiol. 2012  160(1)  28-37
The U-box E3 ligase SPL11/PUB13 Is a Convergence Point of Defense and Flowering Signaling in Plants.
Yamaguchi K., Imai K., Akamatsu A., Mihashi M., Hayashi N., Shimamoto K., Kawasaki T.
Plant J. 2012  70(3)  389-97
SWAP70 functions as a Rac/Rop guanine nucleotide-exchange factor in rice.
Kim S.H., Oikawa T., Kyozuka J., Wong H.L., Umemura K., Kishi-Kaboshi M., Takahashi A., Kawano Y., Kawasaki T., Shimamoto K.
Plant Cell Physiol. 2012  53(4)  740-54
The bHLH Rac Immunity1 (RAI1) Is Activated by OsRac1 via OsMAPK3 and OsMAPK6 in Rice Immunity.
Yoo J.H., Park J.H., Cho S.H., Yoo S.C., Li J., Zhang H., Kim K.S., Koh H.J., Paek N.C.
Plant Mol. Biol. 2011  77(6)  631-41
The rice bright green leaf (bgl) locus encodes OsRopGEF10, which activates the development of small cuticular papillae on leaf surfaces.
Chen L.
Thesis 2010   
Rac/Rop Small GTPases in Rice Innate Immunity
Chen L., Hamada S., Fujiwara M., Zhu T., Nguyen Phuong Thao, Hann Ling Wong, Krishna P., Ueda T., Kaku H., Shibuya N., Kawasaki T., Shimamoto K.
Cell Host Microbe 2010  7(3)  185-96
The Hop/Sti1-Hsp90 chaperone complex facilitates the maturation and transport of a PAMP receptor in rice innate immunity.
Nakashima A,Chen L,Thao NP,Fujiwara M,Wong HL,Kuwano M,Umemura K,Shirasu K,Kawasaki T,Shimamoto K
Plant Cell 2008  20  2265-79
RACK1 functions in rice innate immunity by interacting with the Rac1 immune complex.
Thao NP,Chen L,Nakashima A,Hara S,Umemura K,Takahashi A,Shirasu K,Kawasaki T,Shimamoto K
Plant Cell 2007  19  4035-45
RAR1 and HSP90 form a complex with Rac/Rop GTPase and function in innate-immune responses in rice.
Wong HL,Pinontoan R,Hayashi K,Tabata R,Yaeno T,Hasegawa K,Kojima C,Yoshioka H,Iba K,Kawasaki T,Shimamoto K
Plant Cell 2007  19  4022-34
Regulation of rice NADPH oxidase by binding of Rac GTPase to its N-terminal extension.
Kawasaki T, Koita H, Nakatsubo T, Hasegawa K, Wakabayashi K, Takahashi H, Umemura K, Umezawa T, Shimamoto K.
Proc. Natl. Acad. Sci. U.S.A. 2006  103(1)  230-5
Cinnamoyl-CoA reductase, a key enzyme in lignin biosynthesis, is an effector of small GTPase Rac in defense signaling in rice.
Yamaguchi T,Hayashi T,Nakayama K,Koike S
Biosci. Biotechnol. Biochem. 2006  70  639-45
Expression analysis of genes for callose synthases and Rho-type small GTP-binding proteins that are related to callose synthesis in rice anther.
Fujiwara M, Umemura K, Kawasaki T, Shimamoto K.
Plant Physiol. 2006  140(2)  734-45
Proteomics of Rac GTPase signaling reveals its predominant role in elicitor-induced defense response of cultured rice cells.
Jung YH, Agrawal GK, Rakwal R, Kim JA, Lee MO, Choi PG, Kim YJ, Kim MJ, Shibato J, Kim SH, Iwahashi H, Jwa NS.
Plant Physiol. Biochem. 2006  44(1)  68-77
Functional characterization of OsRacB GTPase--a potentially negative regulator of basal disease resistance in rice.
Miki D, Itoh R, Shimamoto K.
Plant Physiol. 2005  138(4)  1903-1913
RNA silencing of single and multiple members in a gene family of rice.
Lieberherr,D., Thao,N.P., Nakashima,A., Umemura,K., Kawasaki,T. and Shimamoto,K.
Plant Physiol. 2005  138(3)  1644-1652
A Sphingolipid Elicitor-Inducible Mitogen-Activated Protein Kinase Is Regulated by the Small GTPase OsRac1 and Heterotrimeric G-Protein in Rice.
Laetitia Perfus-Barbeoch, Alan M Jones, Sarah M Assmann
Curr. Opin. Plant Biol. 2004  7(6)  719-31
Plant heterotrimeric G protein function: insights from Arabidopsis and rice mutants.
Miki D., Shimamoto K.
Plant Cell Physiol. 2004  45(4)  490-5
Simple RNAi vectors for stable and transient suppression of gene function in rice.
Wong HL, Sakamoto T, Kawasaki T, Umemura K, Shimamoto K.
Plant Physiol. 2004  135(3)  1447-1456
Down-regulation of metallothionein, a reactive oxygen scavenger, by the small GTPase OsRac1 in rice.
Christensen,T.M., Vejlupkova,Z., Sharma,Y.K., Arthur,K.M., Spatafora,J.W., Albright,C.A., Meeley,R.B., Duvick,J.P., Quatrano,R.S. and Fowler,J.E.
Plant Physiol. 2003  133(4)  1791-1808
Conserved Subgroups and Developmental Regulation in the Monocot rop Gene Family.
Suharsono, U., Y. Fujisawa, T. Kawasaki, Y. Iwasaki, H. Satoh and K. Shimamoto
Proc. Natl. Acad. Sci. U.S.A. 2002  99  13307-13312
The heterotrimeric G protein α subunit acts upstream of the small GTPase Rac in disease resistance of rice.
Ono, E., H.L. Wong, T. Kawasaki, M. Hasegawa, O. Kodama, and K. Shimamoto
Proc. Natl. Acad. Sci. U.S.A. 2001  98  759-764
Essential role of the small GTPase Rac in disease resistance of rice.
Kawasaki,T., Henmi,K., Ono,E., Hatakeyama,S., Iwano,M., Satoh,H. and Shimamoto,K.
Proc. Natl. Acad. Sci. U.S.A. 1999  96(19)  10922-10926
The small GTP-binding protein rac is a regulator of cell death in plants.
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DB Reference
Gramene ID GR:0061388
Gene Ontology GTP binding( GO:0005525 )
cytoplasm( GO:0005737 )
apoptosis( GO:0006915 )
extrinsic to membrane( GO:0019898 )
plasma membrane( GO:0005886 )
response to molecule of fungal origin( GO:0002238 )
small GTPase mediated signal transduction( GO:0007264 )
defense response to fungus( GO:0050832 )
response to defense-related host reactive oxygen species production( GO:0052567 )
defense response( GO:0006952 )
regulation of defense response( GO:0031347 )
regulation of cell division( GO:0051302 )
Trait Ontology disease resistance( TO:0000112 )
fungal disease resistance( TO:0000439 )
blast disease( TO:0000074 )
grain size( TO:0000397 )
grain yield( TO:0000396 )
grain weight( TO:0000590 )
Plant Ontology whole plant( PO:0000003 )
plant structure( PO:0009011 )
anther( PO:0009066 )
Related Strains
Phenotype images
Last updated
Oct 31, 2023