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Basic Information
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CGSNL Gene Symbol
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TA2
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Gene Symbol Synonym
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ROS1A, ROS1a, DME1, OsROS1A, OsROS1, ROS1, mOsROS1, ROS1A/DNG702, DNG702, OsDNG702
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CGSNL Gene Name
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THICK ALEURONE 2
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Gene Name Synonym
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REPRESSOR OF SILENCING 1a, REPRESSOR OF SILENCING 1, thick aleurone 2, DNA glycosylase 702
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Protein Name
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Allele
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osros1, osros1a, ros1a, ta2-1, ta2-2, ta2-3, ta2-4, ta2-5, ta2-6
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Chromosome No.
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1
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Explanation
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a rice homolog of DME (DEMETER family DNA glycosylases). ROS ortholog. 5-methylcytosine DNA glycosylase. TO:0000942: aleurone layer morphology trait. GO:0035514: DNA demethylase activity. TO:0020076: phenolic compound content. TO:1000075: palmitic acid content. TO:0000975: grain width. TO:0001109: grain color trait.
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Trait Class
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Reproductive organ - Pollination, fertilization, fertility
Reproductive organ - Pollination, fertilization, fertility - Male sterility
Seed - Morphological traits - Endosperm
Seed - Morphological traits - Grain shape
Seed - Physiological traits - Dormancy
Seed - Physiological traits - Storage substances
Tolerance and resistance - Disease resistance
Tolerance and resistance - Stress tolerance
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Expression
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Sequence/Locus
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cDNA Accession No.
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AK241415
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MSU ID
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LOC_Os01g11900.1
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RAP ID
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Os01g0218032
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Links
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Oryzabase Chromosome View
(
IRGSP 1.0
/
Build5
)
RAP-DB
(
IRGSP 1.0
/
Build5
)
Related IDs List (
IRGSP 1.0
/
Build5
)
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INSD Accession List
(Test version)
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-
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Map
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Locate(cM)
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Link map
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Classical linkage map
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References
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Xie X., Yang X., Lu L., Li T., Qin M., Guan H., Zheng Y., Lan T., Wu W.
BMC Genomics 2025 26(1) 713
Exploring the molecular mechanism of OsROS1a in regulating resistance to bacterial leaf streak through transcriptome and DNA methylation profiling in rice (Oryza sativa L.).
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Li Y., Guo D.
Int J Mol Sci 2023 24(4)
Transcriptome and DNA Methylome Analysis of Two Contrasting Rice Genotypes under Salt Stress during Germination.
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Irshad F., Li C., Wu H.Y., Yan Y., Xu J.H.
Int J Mol Sci 2022 23(12)
The Function of DNA Demethylase Gene ROS1a Null Mutant on Seed Development in Rice (<i>Oryza Sativa</i>) Using the CRISPR/Cas9 System.
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Xu J.H., Irshad F., Yan Y., Li C.
Int J Mol Sci 2022 23(19)
Loss of Function of the RRMF Domain in OsROS1a Causes Sterility in Rice (<i>Oryza sativa</i> L.).
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Liu C., Li N., Lu Z., Sun Q., Pang X., Xiang X., Deng C., Xiong Z., Shu K., Yang F., Hu Z.
Front Plant Sci 2022 13 839457
CG and CHG Methylation Contribute to the Transcriptional Control of OsPRR37-output Genes in Rice.
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Zhou S., Li X., Liu Q., Zhao Y., Jiang W., Wu A., Zhou D.X.
Mol Plant 2021
DNA demethylases remodel DNA methylation in rice gametes and zygote and are required for reproduction.
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Yu R., Wu X., Liu J., Howitt C.A., Bird A.R., Liu C.M., Larkin P.J.
Rice (N Y) 2021 14(1) 102
Rice with Multilayer Aleurone: A Larger Sink for Multiple Micronutrients.
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Zhong H., Liu S., Meng X., Sun T., Deng Y., Kong W., Peng Z., Li Y.
BMC Genomics 2021 22(1) 86
Uncovering the genetic mechanisms regulating panicle architecture in rice with GPWAS and GWAS.
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Xu Y., Wang F., Chen Z., Wang J., Li W., Fan F., Tao Y., Jiang Y., Zhu Q.H., Yang J.
Plant Biotechnol. J. 2020
CRISPR/Cas9-targeted mutagenesis of the OsROS1 gene induces pollen and embryo sac defects in rice.
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Kim M.Y., Ono A., Scholten S., Kinoshita T., Zilberman D., Okamoto T., Fischer R.L.
Proc. Natl. Acad. Sci. U.S.A. 2019 116(19) 9652-9657
DNA demethylation by ROS1a in rice vegetative cells promotes methylation in sperm.
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Liu X.S., Feng S.J., Zhang B.Q., Wang M.Q., Cao H.W., Rono J.K., Chen X., Yang Z.M.
BMC Plant Biol. 2019 19(1) 283
OsZIP1 functions as a metal efflux transporter limiting excess zinc, copper and cadmium accumulation in rice.
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Lang Z., Gong Z.
Proc. Natl. Acad. Sci. U.S.A. 2018 115(46) 11659-11660
A role of <i>OsROS1</i> in aleurone development and nutrient improvement in rice.
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Liu J., Wu X., Yao X., Yu R., Larkin P.J., Liu C.M.
Proc. Natl. Acad. Sci. U.S.A. 2018 115(44) 11327-11332
Mutations in the DNA demethylase <i>OsROS1</i> result in a thickened aleurone and improved nutritional value in rice grains.
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Li S., Xia Q., Wang F., Yu X., Ma J., Kou H., Lin X., Gao X., Liu B.
Front Plant Sci 2017 8 363
Laser Irradiation-Induced DNA Methylation Changes Are Heritable and Accompanied with Transpositional Activation of mPing in Rice.
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Sun X., Ling S., Lu Z., Ouyang Y.D., Liu S., Yao J.
Gene 2014 551(2) 214-21
OsNF-YB1, a rice endosperm-specific gene, is essential for cell proliferation in endosperm development.
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Rodrigues J.A., Ruan R., Nishimura T., Sharma M.K., Sharma R., Ronald P.C., Fischer R.L., Zilberman D.
Proc. Natl. Acad. Sci. U.S.A. 2013 110(19) 7934-9
Imprinted expression of genes and small RNA is associated with localized hypomethylation of the maternal genome in rice endosperm.
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Ono A., Yamaguchi K., Fukada-Tanaka S., Terada R., Mitsui T., Iida S.
Plant J. 2012 71(4) 564-74
A null mutation of ROS1a for DNA demethylation in rice is not transmittable to progeny.
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La,H., Ding,B., Mishra,G.P., Zhou,B., Yang,H., Bellizzi Mdel,R., Chen,S., Meyers,B.C., Peng,Z., Zhu,J.K. and Wang,G.L.
Proc. Natl. Acad. Sci. U.S.A. 2011 108(37) 15498-15503
A 5-methylcytosine DNA glycosylase/lyase demethylates the retrotransposon Tos17 and promotes its transposition in rice
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Zemach A., M Yvonne Kim, Silva P., Jessica A Rodrigues, Dotson B., Matthew D Brooks, Zilberman D.
Proc. Natl. Acad. Sci. U.S.A. 2010 107(43) 18729-34
Local DNA hypomethylation activates genes in rice endosperm.
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DB Reference
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Gramene ID
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-
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Ontologies
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Gene Ontology
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embryonic development( GO:0009790 )
endosperm development( GO:0009960 )
seed dormancy( GO:0010162 )
nucleus( GO:0005634 )
gametophyte development( GO:0048229 )
DNA demethylation( GO:0080111 )
base-excision repair( GO:0006284 )
metal ion binding( GO:0046872 )
female gamete generation( GO:0007292 )
male gamete generation( GO:0048232 )
4 iron, 4 sulfur cluster binding( GO:0051539 )
DNA binding( GO:0003677 )
response to cadmium ion( GO:0046686 )
hydrolase activity( GO:0016787 )
embryo sac development( GO:0009553 )
pollen development( GO:0009555 )
seed development( GO:0048316 )
anther development( GO:0048653 )
response to salt stress( GO:0009651 )
defense response to bacterium( GO:0042742 )
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Trait Ontology
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seed dormancy( TO:0000253 )
seed anatomy and morphology trait( TO:0000184 )
protein content( TO:0000598 )
mineral and ion content related trait( TO:0000465 )
dietary fiber related trait( TO:0002642 )
floury endosperm( TO:0000104 )
total fat content( TO:0000602 )
seed viability( TO:0000345 )
pollen fertility( TO:0000421 )
phosphorus content( TO:0001024 )
oleic acid content( TO:0005002 )
linoleic acid content( TO:0005001 )
seed length( TO:0000146 )
seed width( TO:0000149 )
starch content( TO:0000696 )
amylose content( TO:0000196 )
grain size( TO:0000397 )
starch grain size( TO:0002655 )
starch grain shape( TO:0002656 )
grain core percent white( TO:0000390 )
embryo shape( TO:0000193 )
endosperm related trait( TO:0000575 )
seed shape( TO:0000484 )
grain length( TO:0000734 )
seed development trait( TO:0000653 )
sugar content( TO:0000333 )
seed fertility( TO:0000639 )
salt tolerance( TO:0006001 )
bacterial leaf streak disease resistance( TO:0000203 )
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Plant Ontology
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pollen development stage( PO:0001007 )
seed development stage( PO:0001170 )
anther development stage( PO:0001004 )
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Related Strains
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Phenotype images
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Last updated
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Dec 2, 2025
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Update info.