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Basic Information
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CGSNL Gene Symbol
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TFS2
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Gene Symbol Synonym
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HEI10, HEI10A, HEI10B, OsHEI10, OsRING434, RING434
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CGSNL Gene Name
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THERMO-SENSITIVE FEMALE STERILITY 2
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Gene Name Synonym
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ZMM protein HEI10, human enhancer of invasion 10, Human enhancer of invasion10, RING-type E3 ubiquitin ligase 434, shorter hei10 1
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Protein Name
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HUMAN ENHANCER OF INVASION 10
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Allele
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hei10, hei10-1, hei10-2, Oshei10, oshei10, sh1, tfs2
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Chromosome No.
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2
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Explanation
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JQ624877, JQ624878. a homolog of human HEI10. the most likely ortholog of (C. elegans) ZHP-3 and (Yeast) Zip3.
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Trait Class
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Reproductive organ - Pollination, fertilization, fertility - Male sterility
Reproductive organ - Pollination, fertilization, fertility - Meiosis
Reproductive organ - Pollination, fertilization, fertility - Female sterility
Tolerance and resistance - Stress tolerance
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Expression
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Sequence/Locus
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cDNA Accession No.
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AK100854
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MSU ID
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LOC_Os02g13810.1
LOC_Os02g13810.2
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RAP ID
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Os02g0232100
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Links
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Oryzabase Chromosome View
(
IRGSP 1.0
/
Build5
)
RAP-DB
(
IRGSP 1.0
/
Build5
)
Related IDs List (
IRGSP 1.0
/
Build5
)
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INSD Accession List
(Test version)
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-
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Map
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Locate(cM)
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Link map
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Classical linkage map
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References
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Zhang Z., Guo Y.Y., Wang Y.C., Zhou L., Fan J., Mao Y.C., Yang Y.M., Zhang Y.F., Huang X.H., Zhu J., Zhang C., Yang Z.N.
Plant J. 2024 118(2) 506-518
A point mutation in the meiotic crossover formation gene HEI10/tfs2 leads to thermosensitive genic sterility in rice.
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Tan Q., Zhang X., Luo Q., Xu Y.C., Zhang J., Liang W.Q.
Rice (N Y) 2024 17(1) 3
The RING Domain of Rice HEI10 is Essential for Male, But Not Female Fertility.
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Wang C., Qu S., Zhang J., Fu M., Chen X., Liang W.
Front Plant Sci 2022 13 1122202
OsPRD2 is essential for double-strand break formation, but not spindle assembly during rice meiosis.
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Wang R., You X., Zhang C., Fang H., Wang M., Zhang F., Kang H., Xu X., Liu Z., Wang J., Zhao Q., Wang X., Hao Z., He F., Tao H., Wang D., Wang J., Fang L., Qin M., Zhao T., Zhang P., Xing H., Xiao Y., Liu W., Xie Q., Wang G.L., Ning Y.
Genome Biol. 2022 23(1) 154
An ORFeome of rice E3 ubiquitin ligases for global analysis of the ubiquitination interactome.
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Ren L., Zhao T., Zhao Y., Du G., Yang S., Mu N., Tang D., Shen Y., Li Y., Cheng Z.
Cell Rep 2021 37(5) 109941
The E3 ubiquitin ligase DESYNAPSIS1 regulates synapsis and recombination in rice meiosis.
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Zhang C., Zhang F., Cheng X., Liu K., Tang J., Li Y., Tang D., Cheng Z., Yu H.
Plant Physiol. 2020 183(3) 1047-1057
OsATM Safeguards Accurate Repair of Meiotic Double-Strand Breaks in Rice.
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Zhang F., Ma L., Zhang C., Du G., Shen Y., Tang D., Li Y., Yu H., Ma B., Cheng Z.
Plant Physiol. 2020 183(4) 1517-1530
The SUN Domain Proteins OsSUN1 and OsSUN2 Play Critical but Partially Redundant Roles in Meiosis.
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Chang Z., Xu C., Huang X., Yan W., Qiu S., Yuan S., Ni H., Chen S., Xie G., Chen Z., Wu J., Tang X.
J. Exp. Bot. 2020 71(1) 204-218
The plant-specific ABERRANT GAMETOGENESIS 1 gene is essential for meiosis in rice.
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Shi W., Tang D., Shen Y., Xue Z., Zhang F., Zhang C., Ren L., Liu C., Du G., Li Y., Yan C., Cheng Z.
New Phytol. 2019 222(2) 805-819
Oshop2 regulates the maturation of crossovers by promoting homologous pairing and synapsis in rice meiosis.
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Zhang J., Wang C., Higgins J.D., Kim Y.J., Moon S., Jung K.H., Qu S., Liang W.
Plant Physiol. 2019 181(1) 221-235
A Multiprotein Complex Regulates Interference-Sensitive Crossover Formation in Rice.
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Li Y., Qin B., Shen Y., Zhang F., Liu C., You H., Du G., Tang D., Cheng Z.
Proc. Natl. Acad. Sci. U.S.A. 2018 115(42) 10810-10815
HEIP1 regulates crossover formation during meiosis in rice.
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Zhang F., Tang D., Shen Y., Xue Z., Shi W., Ren L., Du G., Li Y., Cheng Z.
Plant Cell 2017 29(10) 2597-2609
The F-box protein zygo1 Mediates Bouquet Formation to Promote Homologous Pairing, Synapsis, and Recombination in Rice Meiosis.
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Hu Q., Li Y., Wang H., Shen Y., Zhang C., Du G., Tang D., Cheng Z.
Plant Cell 2017 29(7) 1697-1708
Meiotic Chromosome Association 1 Interacts with TOP3alpha and Regulates Meiotic Recombination in Rice.
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Wang H., Hu Q., Tang D., Liu X., Du G., Shen Y., Li Y., Cheng Z.
Plant Physiol. 2016 171(1) 230-41
OsDMC1 Is Not Required for Homologous Pairing in Rice Meiosis.
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Zhang B., Xu M., Bian S., Hou L., Tang D., Li Y., Gu M., Cheng Z., Yu H.
PLoS ONE 2015 10(9) e0137399
Global Identification of Genes Specific for Rice Meiosis.
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Che L., Wang K., Tang D., Liu Q., Chen X., Li Y., Hu Q., Shen Y., Yu H., Gu M., Cheng Z.
PLoS Genet. 2014 10(6) e1004405
OsHUS1 facilitates accurate meiotic recombination in rice.
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Zhang L., Tang D., Luo Q., Chen X., Wang H., Li Y., Cheng Z.
Genetics 2014
Crossover Formation During Rice Meiosis Relies on Interaction of OsMSH4 and OsMSH5.
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Luo Q., Tang D., Wang M., Luo W., Zhang L., Qin B., Shen Y., Wang K., Li Y., Cheng Z.
Mol Plant 2013 6(3) 729-42
The Role of Osmsh5 in Crossover Formation during Rice Meiosis.
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Wang,K., Wang,M., Tang,D., Shen,Y., Miao,C., Hu,Q., Lu,T. and Cheng,Z.
PLoS Genet. 2012 8 (7) E1002809
The Role of Rice HEI10 in the Formation of Meiotic Crossovers
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DB Reference
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Gramene ID
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-
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Ontologies
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Gene Ontology
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zinc ion binding( GO:0008270 )
meiosis( GO:0007126 )
metal ion binding( GO:0046872 )
transferase activity( GO:0016740 )
chiasma formation( GO:0051026 )
protein ubiquitination( GO:0016567 )
reciprocal meiotic recombination( GO:0007131 )
synapsis( GO:0007129 )
chiasma( GO:0005712 )
chromosome( GO:0005694 )
embryo sac development( GO:0009553 )
microsporogenesis( GO:0009556 )
pollen development( GO:0009555 )
nucleus( GO:0005634 )
response to heat( GO:0009408 )
response to temperature stimulus( GO:0009266 )
carpel development( GO:0048440 )
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Trait Ontology
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male sterility( TO:0000437 )
female sterility( TO:0000358 )
pollen sterility( TO:0000053 )
pollen free( TO:0000245 )
seed set percent( TO:0000455 )
embryosac abortion( TO:0000416 )
temperature response trait( TO:0000432 )
heat tolerance( TO:0000259 )
genic male sterility-thermo sensitive( TO:0000067 )
pistil number( TO:0002659 )
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Plant Ontology
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pollen development stage( PO:0001007 )
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Related Strains
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Phenotype images
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Last updated
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Feb 21, 2026
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Update info.