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Basic Information
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CGSNL Gene Symbol
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BIN2
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Gene Symbol Synonym
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GSK2, Os GSK2, OsGSK2, Os BIN2, OsBIN2, BIN2/GSK2, OsSK22/OsGSK7, OsSK22, OsGSK7, SK22, GSK7, OsSK22/GSK2
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CGSNL Gene Name
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BRASSINOSTEROID-INSENSITIVE 2
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Gene Name Synonym
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GSK3/SHAGGY-Like Kinase 2, GSK3/SHAGGY-LIKE KINASE2, BRASSINOSTEROID-INSENSITIVE2, GSK3/SHAGGY-Like Kinase 22, GSK3-like Kinase 7, Shaggy/GSK3-like kinase 22, Glycogen synthase kinase 2
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Protein Name
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Allele
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OsGSK2typeA, OsGSK2typeB, OsGSK2-CR, Osgsk2
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Chromosome No.
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5
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Explanation
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a GSK3/SHAGGY-like kinase clade II member. one of the Arabidopsis AtSK21 orthologs in rice. GO:1900458: negative regulation of brassinosteroid mediated signaling pathway. OsSK22/OsGSK7 in Thitisaksakul et al. 2017. GO:2000022: regulation of jasmonic acid mediated signaling pathway. GO:1900458: negative regulation of brassinosteroid mediated signaling pathway. TO:0000789: bud morphology trait. TO:0020102: phosphate content. GO:1900150: regulation of defense response to fungus. GO:1900458: negative regulation of brassinosteroid mediated signaling pathway. GO:0140426: pathogen-associated molecular pattern receptor signaling pathway.
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Trait Class
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Vegetative organ - Leaf
Vegetative organ - Culm
Seed - Morphological traits - Grain shape
Tolerance and resistance - Disease resistance
Tolerance and resistance - Stress tolerance
Character as QTL - Yield and productivity
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Expression
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Sequence/Locus
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cDNA Accession No.
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AK073725
AK102147
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MSU ID
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LOC_Os05g11730.1
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RAP ID
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Os05g0207500
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Links
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Oryzabase Chromosome View
(
IRGSP 1.0
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Build5
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RAP-DB
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IRGSP 1.0
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Build5
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Related IDs List (
IRGSP 1.0
/
Build5
)
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INSD Accession List
(Test version)
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Map
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Locate(cM)
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Link map
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Classical linkage map
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References
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Gao Q., Ding J., Dong S., Zheng K., Liu X., Yuan C.
Rice (N Y) 2025 18(1) 31
Trihelix Transcription Factor OsTGS1 Regulates grain size and Weight in Rice.
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Zhang G., Wang H., Ren X., Xiao Y., Liu D., Meng W., Qiu Y., Hu B., Xie Q., Chu C., Tong H.
Plant Cell 2024
Brassinosteroid-dependent phosphorylation of PHOSPHATE STARVATION RESPONSE2 reduces its DNA-binding ability in rice.
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Zhang X., Meng W., Liu D., Pan D., Yang Y., Chen Z., Ma X., Yin W., Niu M., Dong N., Liu J., Shen W., Liu Y., Lu Z., Chu C., Qian Q., Zhao M., Tong H.
Science 2024 383(6687) eadk8838
Enhancing rice panicle branching and grain yield through tissue-specific brassinosteroid inhibition.
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Yan Y., Wang H., Bi Y., Wang J., Li D., Song F.
New Phytol. 2024 243(6) 2332-2350
A distinct protein posttranslational modifications-linked OsATL32-OsPPKL2-OsGSK2 loop modulates rice immunity against blast disease.
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Zhang Q., Wu R., Hong T., Wang D., Li Q., Wu J., Zhang H., Zhou K., Yang H., Zhang T., Liu J., Wang N., Ling Y., Yang Z., He G., Zhao F.
Nat Commun 2024 15(1) 8565
Natural variation in the promoter of qRBG1/OsBZR5 underlies enhanced rice yield.
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Tian P., Liu J., Yan B., Zhou C., Wang H., Shen R.
J. Exp. Bot. 2023 74(1) 283-295
BRASSINOSTEROID-SIGNALING KINASE1-1, a positive regulator of brassinosteroid signalling, modulates plant architecture and grain size in rice.
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Meng F., Zheng X., Wang J., Qiu T., Yang Q., Fang K., Bhadauria V., Peng Y.L., Zhao W.
Plant Biotechnol. J. 2023
The GRAS protein OsDLA involves in brassinosteroid signalling and positively regulates blast resistance by forming a module with GSK2 and OsWRKY53 in rice.
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Chen E., Hou Q., Liu K., Gu Z., Dai B., Wang A., Feng Q., Zhao Y., Zhou C., Zhu J., Shangguan Y., Wang Y., Lv D., Fan D., Huang T., Wang Z., Huang X., Han B.
Plant Physiol. 2023
Armadillo Repeat Only protein gs10 negatively regulates brassinosteroid signaling to control rice grain size.
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Li P., Jiang J., Zhang G., Miao S., Lu J., Qian Y., Zhao X., Wang W., Qiu X., Zhang F., Xu J.
Front Plant Sci 2022 13 1102938
Integrating GWAS and transcriptomics to identify candidate genes conferring heat tolerance in rice.
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Gong L., Liao S., Duan W., Liu Y., Zhu D., Zhou X., Xue B., Chu C., Yun-Kuan Liang
J Integr Plant Biol 2022 64(8) 1560-1574
OsCPL3 is involved in brassinosteroid signaling by regulating OsGSK2 stability.
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Kim S.H., Shim K.C., Lee H.S., Jeon Y.A., Adeva C., Luong N.H., Ahn S.N.
Front Plant Sci 2022 13 985559
Brassinosteroid biosynthesis gene <i>OsD2</i> is associated with low-temperature germinability in rice.
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Tian X., He M., Mei E., Zhang B., Tang J., Xu M., Liu J., Li X., Wang Z., Tang W., Guan Q., Bu Q.
Plant Cell 2021
WRKY53 Integrates Classic Brassinosteroid Signaling and the Mitogen-Activated Protein Kinase Pathway to Regulate Rice Architecture and seed size.
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Zheng J., Hong K., Zeng L., Wang L., Kang S., Qu M., Dai J., Zou L., Zhu L., Tang Z., Meng X., Wang B., Hu J., Zeng D., Zhao Y., Cui P., Wang Q., Qian Q., Wang Y., Li J., Xiong G.
Plant Cell 2020 32(9) 2780-2805
Karrikin Signaling Acts Parallel to and Additively with Strigolactone Signaling to Regulate Rice Mesocotyl Elongation in Darkness.
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Xiao Y., Zhang G., Liu D., Niu M., Tong H., Chu C.
Plant J. 2020
GSK2 stabilizes OFP3 to suppress brassinosteroid responses in rice.
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Hu J., Huang J., Xu H., Wang Y., Li C., Wen P., You X., Zhang X., Pan G., Li Q., Zhang H., He J., Wu H., Jiang L., Wang H., Liu Y., Wan J.
PLoS Pathog. 2020 16(8) e1008801
Rice stripe virus suppresses jasmonic acid-mediated resistance by hijacking brassinosteroid signaling pathway in rice.
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Wang B., Zhong Z., Wang X., Han X., Yu D., Wang C., Song W., Zheng X., Chen C., Zhang Y.
Int J Mol Sci 2020 21(7)
Knockout of the <i>OsNAC006</i> Transcription Factor Causes Drought and Heat Sensitivity in Rice.
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Fang Z., Ji Y., Hu J., Guo R., Sun S., Wang X.
Mol Plant 2020 13(4) 586-597
Strigolactones and Brassinosteroids Antagonistically Regulate the Stability of the D53-OsBZR1 Complex to Determine FC1 Expression in Rice Tillering.
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Seo H., Kim S.H., Lee B.D., Lim J.H., Lee S.J., An G., Paek N.C.
Int J Mol Sci 2020 21(6)
The Rice <i>Basic Helix-Loop-Helix 79</i> (<i>OsbHLH079</i>) Determines leaf angle and Grain Shape.
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He Y., Hong G., Zhang H., Tan X., Li L., Kong Y., Sang T., Xie K., Wei J., Li J., Yan F., Wang P., Tong H., Chu C., Chen J., Sun Z.
Plant Cell 2020 32(9) 2806-2822
The OsGSK2 Kinase Integrates Brassinosteroid and Jasmonic Acid Signaling by Interacting with OsJAZ4.
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Hughes P.W.
Plant Cell 2020 32(9) 2669-2670
OsGSK2 Integrates Jasmonic Acid and Brassinosteroid Signaling in Rice.
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Min H.J., Cui L.H., Oh T.R., Kim J.H., Kim T.W., Kim W.T.
Plant J. 2019 99(3) 426-438
OsBZR1 turnover mediated by OsSK22-regulated U-box E3 ligase OsPUB24 in rice BR response.
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Sun S., Wang T., Wang L., Li X., Jia Y., Liu C., Huang X., Xie W., Wang X.
Nat Commun 2018 9(1) 2523
Natural selection of a GSK3 determines rice mesocotyl domestication by coordinating strigolactone and brassinosteroid signaling.
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Zhao D.S., Li Q.F., Zhang C.Q., Zhang C., Yang Q.Q., Pan L.X., Ren X.Y., Lu J., Gu M.H., Liu Q.Q.
Nat Commun 2018 9(1) 1240
gs9 acts as a transcriptional activator to regulate rice grain shape and appearance quality.
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Qin R., Zeng D., Yang C., Akhter D., Alamin M., Jin X., Shi C.
Genes (Basel) 2018 9(6)
<i>LTBSG1</i>, a New Allele of <i>BRD2</i>, Regulates Panicle and Grain Development in Rice by Brassinosteroid Biosynthetic Pathway.
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Hu Z., Lu S.J., Wang M.J., He H., Sun L., Wang H., Liu X.H., Jiang L., Sun J.L., Xin X., Kong W., Chu C., Xue H.W., Yang J., Luo X., Liu J.X.
Mol Plant 2018 11(5) 736-749
A Novel QTL qTGW3 Encodes the GSK3/SHAGGY-Like Kinase OsGSK5/OsSK41 that Interacts with OsARF4 to Negatively Regulate grain size and Weight in Rice.
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Qiao S., Sun S., Wang L., Wu Z., Li C., Li X., Wang T., Leng L., Tian W., Lu T., Wang X.
Plant Cell 2017 29(2) 292-309
The RLA1/SMOS1 Transcription Factor Functions with OsBZR1 to Regulate Brassinosteroid Signaling and Rice Architecture.
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Hirano K., Kawamura M., Araki-Nakamura S., Fujimoto H., Ohmae-Shinohara K., Yamaguchi M., Fujii A., Sasaki H., Kasuga S., Sazuka T.
Sci Rep 2017 7(1) 126
Sorghum dw1 positively regulates brassinosteroid signaling by inhibiting the nuclear localization of BRASSINOSTEROID INSENSITIVE 2.
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Thitisaksakul M., Maria C. Arias, Dong S., Diane M. Beckles
Funct. Plant Biol. 2017 44 705-719
Overexpression of GSK3-like Kinase 5 (OsGSK5) in rice (Oryza sativa) enhances salinity tolerance in part via preferential carbon allocation to root starch
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Xiao Y., Liu D., Zhang G., Tong H., Chu C.
Front Plant Sci 2017 8 1698
Brassinosteroids Regulate OFP1, a DLT interacting protein, to Modulate Plant Architecture and Grain Morphology in Rice.
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Yang C., Shen W., He Y., Tian Z., Li J.
PLoS Genet. 2016 12(6) e1006118
OVATE Family Protein 8 Positively Mediates Brassinosteroid Signaling through Interacting with the GSK3-like Kinase in Rice.
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Tong H., Chu C.
Plant Cell 2016 28(4) 833-5
Reply: Brassinosteroid Regulates Gibberellin Synthesis to Promote Cell Elongation in Rice: Critical Comments on Ross and Quittenden's Letter.
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Tong H.a, Xiao Y.a, Liu D.a, Gao S.a, Liu L.a, Yin Y.b, Jin Y.c, Qian Q.d, Chu C.a
Plant Cell 2014 26 4376-4393
Brassinosteroid regulates cell elongation by modulating gibberellin metabolism in ricec w open
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Tong H., Liu L., Jin Y., Du L., Yin Y., Qian Q., Zhu L., Chu C.
Plant Cell 2012 24(6) 2562-77
DWARF AND LOW-TILLERING Acts as a Direct Downstream Target of a GSK3/SHAGGY-like kinase to Mediate Brassinosteroid Responses in Rice.
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Mi-Jeong Yoo, Victor A Albert, Pamela S Soltis, Douglas E Soltis
BMC Plant Biol. 2006 6 3
Phylogenetic diversification of glycogen synthase kinase 3/SHAGGY-like kinase genes in plants.
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DB Reference
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Gramene ID
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-
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Ontologies
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Gene Ontology
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protein serine/threonine kinase activity( GO:0004674 )
response to auxin stimulus( GO:0009733 )
cytoplasm( GO:0005737 )
nucleus( GO:0005634 )
negative regulation of growth( GO:0045926 )
jasmonic acid mediated signaling pathway( GO:0009867 )
defense response to virus( GO:0051607 )
ATP binding( GO:0005524 )
cytosol( GO:0005829 )
plasma membrane( GO:0005886 )
detection of brassinosteroid stimulus( GO:0009729 )
response to gibberellin stimulus( GO:0009739 )
brassinosteroid mediated signaling( GO:0009742 )
multidimensional cell growth( GO:0009825 )
leaf morphogenesis( GO:0009965 )
hyperosmotic salinity response( GO:0042538 )
positive regulation of protein export from nucleus( GO:0046827 )
regulation of cell proliferation( GO:0042127 )
unidimensional cell growth( GO:0009826 )
response to brassinosteroid stimulus( GO:0009741 )
response to heat( GO:0009408 )
regulation of cell growth( GO:0001558 )
regulation of cell division( GO:0051302 )
defense response to fungus( GO:0050832 )
cellular response to phosphate starvation( GO:0016036 )
response to starvation( GO:0042594 )
phosphate ion homeostasis( GO:0055062 )
peptidyl-serine phosphorylation( GO:0018105 )
negative regulation of immune response( GO:0050777 )
response to chitin( GO:0010200 )
response to molecule of fungal origin( GO:0002238 )
respiratory burst during defense response( GO:0002679 )
positive regulation of respiratory burst( GO:0060267 )
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Trait Ontology
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gibberellic acid sensitivity( TO:0000166 )
tiller number( TO:0000346 )
tillering ability( TO:0000329 )
grain size( TO:0000397 )
brassinosteroid sensitivity( TO:0002677 )
mesocotyl length( TO:0000544 )
jasmonic acid sensitivity( TO:0000172 )
viral disease resistance( TO:0000148 )
brassinosteroid content( TO:0002676 )
grain length( TO:0000734 )
black streak dwarf virus resistance( TO:0000020 )
leaf angle( TO:0000206 )
heat tolerance( TO:0000259 )
grain yield( TO:0000396 )
grain number( TO:0002759 )
leaf lamina joint bending( TO:0002688 )
tiller angle( TO:0000567 )
blast disease( TO:0000074 )
phosphorus sensitivity( TO:0000102 )
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Plant Ontology
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Related Strains
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Phenotype images
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Last updated
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Mar 8, 2026
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Update info.