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Basic Information
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CGSNL Gene Symbol
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MPK6
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Gene Symbol Synonym
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OsMPK6, OsDR6, DR6, OsMPK4, MPK4, OsMAPK4, MAPK4
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CGSNL Gene Name
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MITOGEN-ACTIVATED PROTEIN KINASE 6
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Gene Name Synonym
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mitogen-activated protein kinase 6, MAP kinase 4
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Protein Name
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MITOGEN-ACTIVATED PROTEIN KINASE 6
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Allele
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osmpk6, Osmpk4, Osmpk4-1, Osmpk4-4
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Chromosome No.
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10
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Explanation
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EF174189. FJ621301. Q336X9. defense-responsive protein. OsMPK4 in Wang et al. 2014, Mohanta et al. 2015, Jalmi and Sinha 2016, Li et al. 2021, Jing et al. 2021, Yang et al. 2021, Wang et al. 2023, Singh et al. 2023, Singh et al. 2024, Liu et al. 2026. GO:1903426: regulation of reactive oxygen species biosynthetic process. GO:0140426: pathogen-associated molecular pattern receptor signaling pathway. GO:1902893: regulation of miRNA transcription. GO:1900140: regulation of seedling development. TO:0000949: seedling growth and development trait.
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Trait Class
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Biochemical character
Vegetative organ - Culm
Reproductive organ - panicle
Reproductive organ - Pollination, fertilization, fertility - Female sterility
Seed
Tolerance and resistance
Tolerance and resistance - Disease resistance
Tolerance and resistance - Insect resistance
Tolerance and resistance - Stress tolerance
Character as QTL - Yield and productivity
Character as QTL - Plant growth activity
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Expression
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Sequence/Locus
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cDNA Accession No.
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AK111579
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MSU ID
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LOC_Os10g38950.1
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RAP ID
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Os10g0533600
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Links
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Oryzabase Chromosome View
(
IRGSP 1.0
/
Build5
)
RAP-DB
(
IRGSP 1.0
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Build5
)
Related IDs List (
IRGSP 1.0
/
Build5
)
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INSD Accession List
(Test version)
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-
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Map
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Locate(cM)
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Link map
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Classical linkage map
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References
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Liu C., You Y., Huang X., Xu Y., Zhang J., Shu D., Li G., Li S., Ding X., Yang Q., Xu J., Zhang S., Zhao J.
Proc. Natl. Acad. Sci. U.S.A. 2026 123(1) e2426754122
A MAPK cascade regulates nuclear migration during female gametogenesis to establish specific cell identity and rice female fertility.
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Singh D., Verma N., Rengasamy B., Banerjee G., Sinha A.K.
New Phytol. 2024 244(4) 1482-1497
The small RNA biogenesis in rice is regulated by MAP kinase-mediated OsCDKD phosphorylation.
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Singh D., Banerjee G., Verma N., Sinha A.K.
FEBS Lett. 2023
MAP kinases may mediate regulation of the cell cycle in rice by E2F2 phosphorylation.
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Wang S., Han S., Zhou X., Zhao C., Guo L., Zhang J., Liu F., Huo Q., Zhao W., Guo Z., Chen X.
Plant Cell 2023 35(6) 2391-2412
Phosphorylation and ubiquitination of OsWRKY31 are integral to OsMKK10-2-mediated defense responses in rice.
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Lv Y., Ma J., Wei H., Xiao F., Wang Y., Jahan N., Hazman M., Qian Q., Shang L., Guo L.
Front Plant Sci 2022 13 912637
Combining GWAS, Genome-Wide Domestication and a Transcriptomic Analysis Reveals the Loci and Natural Alleles of salt tolerance in Rice (<i>Oryza sativa</i> L.).
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Li N., Yang Z., Li J., Xie W., Qin X., Kang Y., Zhang Q., Li X., Xiao J., Ma H., Wang S.
Rice (N Y) 2021 14(1) 39
Two VQ Proteins are Substrates of the OsMPKK6-OsMPK4 Cascade in Rice Defense Against Bacterial Blight.
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Chen J., Wang L., Yuan M.
Int J Mol Sci 2021 22(4)
Update on the Roles of Rice MAPK Cascades.
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Wang D., Wang H., Liu Q., Tu R., Zhou X., Zhang Y., Wu W., Yu P., Chen D., Zhan X., Cao L., Cheng S., Shen X.
Plant Cell Rep. 2021 40(5) 835-850
Reduction of OsMPK6 activity by a R89K mutation induces cell death and bacterial blight resistance in rice.
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Jing X.Q., Li W.Q., Zhou M.R., Shi P.T., Zhang R., Shalmani A., Muhammad I., Wang G.F., Liu W.T., Chen K.M.
Rice (N Y) 2021 14(1) 100
Rice Carbohydrate-Binding Malectin-Like Protein, OsCBM1, Contributes to Drought-Stress Tolerance by Participating in NADPH oxidase-Mediated ROS Production.
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Dangol S., Nguyen N.K., Singh R., Chen Y., Wang J., Lee H.G., Hwang B.K., Jwa N.S.
Front Plant Sci 2021 12 710794
Mitogen-activated protein kinase OsMEK2 and OsMPK1 Signaling Is Required for Ferroptotic Cell Death in Rice-<i>Magnaporthe oryzae</i> Interactions.
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Yang J., Ji L., Liu S., Jing P., Hu J., Jin D., Wang L., Xie G.
J. Exp. Bot. 2021
The CaM1-Associated CCaMK-MKK1/6 cascade positively affects the lateral root growth through auxin signaling under salt stress in rice.
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Viana V.E., Carlos da Maia L., Busanello C., Pegoraro C., Costa de Oliveira A.
Plant Biol (Stuttg) 2021 23 Suppl 1 100-112
When rice gets the chills: comparative transcriptome profiling at germination shows WRKY transcription factor responses.
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Nanda S., Wan P.J., Yuan S.Y., Lai F.X., Wang W.X., Fu Q.
Int J Mol Sci 2018 19(12)
Differential Responses of <i>OsMPK</i>s in IR56 Rice to Two BPH Populations of Different Virulence Levels.
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Jalmi S.K., Sinha A.K.
Sci Rep 2016 6 37974
Functional Involvement of a Mitogen Activated Protein Kinase Module, OsMKK3-OsMPK7-OsWRK30 in Mediating Resistance against Xanthomonas oryzae in Rice.
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Mohanta T.K., Mohanta N., Parida P., Bae H.
Biol Proced Online 2015 17 13
Mitogen Activated Protein Kinase (MPK) Interacts With Auxin Influx Carrier (OsAux/LAX1) Involved in Auxin Signaling in Plant.
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Wang F., Jing W., Zhang W.
Plant Sci. 2014 227 181-9
The mitogen-activated protein kinase cascade MKK1-MPK4 mediates salt signaling in rice.
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Chujo T., Miyamoto K., Ogawa S., Masuda Y., Shimizu T., Kishi-Kaboshi M., Takahashi A., Nishizawa Y., Minami E., Nojiri H., Yamane H., Okada K.
PLoS ONE 2014 9(6) e98737
Overexpression of phosphomimic mutated OsWRKY53 leads to enhanced blast resistance in rice.
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Park H.L., Lee S.W., Jung K.H., Hahn T.R., Cho M.H.
Phytochemistry 2013 96 57-71
Transcriptomic analysis of UV-treated rice leaves reveals UV-induced phytoalexin biosynthetic pathways and their regulatory networks in rice.
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Campos-Soriano L., García-Martínez J., Segundo B.S.
Mol. Plant Pathol. 2012 13(6) 579-92
The arbuscular mycorrhizal symbiosis promotes the systemic induction of regulatory defence-related genes in rice leaves and confers resistance to pathogen infection.
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Xie G., Kato H., Imai R.
Biochem. J. 2012 443(1) 95-102
Biochemical identification of the OsMKK6-OsMPK3 signalling pathway for chilling stress tolerance in rice1.
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Shen X., Liu H., Yuan B., Li X., Xu C., Wang S.
Plant Cell Environ. 2011 34(2) 179-91
OsEDR1 negatively regulates rice bacterial resistance via activation of ethylene biosynthesis.
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Shen X,Yuan B,Liu H,Li X,Xu C,Wang S
Plant J. 2010 64(1) 86-99
Opposite functions of a rice mitogen-activated protein kinase in the process of resistance against Xanthomonas oryzae.
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Kishi-Kaboshi M., Okada K., Kurimoto L., Murakami S., Umezawa T., Shibuya N., Yamane H., Miyao A., Takatsuji H., Takahashi A., Hirochika H.
Plant Journal 2010 63(4) 599-612
A rice fungal MAMP-responsive MAPK cascade regulates metabolic flow to antimicrobial metabolite synthesis.
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Xie G., Kato H., Sasaki K., Imai R.
FEBS Lett. 2009 583(17) 2734-8
A cold-induced thioredoxin h of rice, OsTrx23, negatively regulates kinase activities of OsMPK3 and OsMPK6 in vitro.
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Yuan,B., Shen,X., Li,X., Xu,C. and Wang,S.
Planta. 2007 226(4) 953-960
Mitogen-activated protein kinase OsMPK6 negatively regulates rice disease resistance to bacterial pathogens
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DB Reference
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Gramene ID
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-
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Ontologies
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Gene Ontology
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female gamete generation( GO:0007292 )
embryo sac development( GO:0009553 )
nuclear migration( GO:0007097 )
response to salicylic acid stimulus( GO:0009751 )
ATP binding( GO:0005524 )
response to cold( GO:0009409 )
MAP kinase activity( GO:0004707 )
nucleus( GO:0005634 )
cytoplasm( GO:0005737 )
response to UV( GO:0009411 )
salicylic acid mediated signaling pathway( GO:0009863 )
hyperosmotic response( GO:0006972 )
auxin mediated signaling pathway( GO:0009734 )
defense response to bacterium( GO:0042742 )
response to hydrogen peroxide( GO:0042542 )
response to wounding( GO:0009611 )
defense response to insect( GO:0002213 )
hypotonic salinity response( GO:0042539 )
seed development( GO:0048316 )
response to water deprivation( GO:0009414 )
jasmonic acid mediated signaling pathway( GO:0009867 )
response to molecule of fungal origin( GO:0002238 )
response to molecule of bacterial origin( GO:0002237 )
response to light stimulus( GO:0009416 )
negative regulation of defense response( GO:0031348 )
negative regulation of programmed cell death( GO:0043069 )
response to abscisic acid stimulus( GO:0009737 )
jasmonic acid and ethylene-dependent systemic resistance( GO:0009861 )
MAPKKK cascade( GO:0000165 )
response to fungus( GO:0009620 )
regulation of cell cycle( GO:0051726 )
regulation of cell proliferation( GO:0042127 )
response to indolebutyric acid stimulus( GO:0080026 )
defense response to fungus( GO:0050832 )
response to salt stress( GO:0009651 )
cortical microtubule organization( GO:0043622 )
regulation of cell division( GO:0051302 )
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Trait Ontology
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endospermless( TO:0000231 )
giant embryo( TO:0000113 )
shrunken endosperm( TO:0000100 )
fertility related trait( TO:0000420 )
female sterility( TO:0000358 )
growth and development trait( TO:0000357 )
cold tolerance( TO:0000303 )
yield trait( TO:0000371 )
1000-seed weight( TO:0000382 )
seed set percent( TO:0000455 )
filled grain number( TO:0000447 )
grain number( TO:0002759 )
panicle length( TO:0000040 )
panicle number( TO:0000152 )
plant height( TO:0000207 )
UV light sensitivity( TO:0000160 )
blast disease( TO:0000074 )
salt tolerance( TO:0006001 )
auxin sensitivity( TO:0000163 )
hydrogen peroxide content( TO:0000605 )
light sensitivity( TO:0000075 )
bacterial blight disease resistance( TO:0000175 )
stem borer resistance( TO:0000454 )
jasmonic acid content( TO:0002668 )
mimic response( TO:0000063 )
drought tolerance( TO:0000276 )
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Plant Ontology
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seed development stage( PO:0001170 )
leaf( PO:0025034 )
leaf sheath( PO:0020104 )
root( PO:0009005 )
gametophyte development stage( PO:0028003 )
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Related Strains
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Phenotype images
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Last updated
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Aug 5, 2026
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Update info.