Sasado T, Yasuoka A, Abe K, Mitani H, Furutani-Seiki M, Tanaka M, Kondoh H. Distinct contributions of CXCR4b and CXCR7/RDC1 receptor systems in regulation of PGC migration revealed by medaka mutants kazura and yanagi. Dev Biol 2008/08/15.320(2).328-39.
Okuyama T, Yokoi S, Abe H, Isoe Y, Suehiro Y, Imada H, Tanaka M, Kawasaki T, Yuba S, Taniguchi Y, Kamei Y, Okubo K, Shimada A, Naruse K, Takeda H, Oka Y, Kubo T, Takeuchi H. A neural mechanism underlying mating preferences for familiar individuals in medaka fish. Science 2014/01/03.343(6166).91-4.
■ The RECIPIENT shall refer the following publication in any PUBLICATIONS. (Name of the Publication: Sasado T, Yasuoka A, Abe K, Mitani H, Furutani-Seiki M, Tanaka M, Kondoh H. Distinct contributions of CXCR4b and CXCR7/RDC1 receptor systems in regulation of PGC migration revealed by medaka mutants kazura and yanagi. Dev Biol. 2008/08/15.320(2).328-39. Liedtke D, Erhard I, Abe K, Furutani-Seiki M, Kondoh H, Schartl M. Xmrk-induced melanoma progression is affected by Sdf1 signals through Cxcr7. Pigment Cell Melanoma Res. 2014/03.27(2).221-33.)
Mutant of embryogeneses
National Institute for Basic Biology
Frozen sperm in NIBB
ERATO Kondoh Differentiation Signaling Project, Japan Science and Technology Agency
ERATO Kondoh Project
PGCs formed tight bilateral clumps in wild-type embryos at st. 27. In yanagi (yanj6-29C) mutant embryos, however, PGCs did not coalesce but were loosely aligned in bilateral rows in the region more anterior than normal PGC clusters. The positioning of lateral line organs were also affected in this mutant embryos (Yasuoka et al.,MOD121:729-738). Homozygotes of yan were viable and fertile.
○side view (lateral)
○anterior to left
●anterior to top
○anterior to right
○dorsal to top
○dorsal to right
Caption / Comment
Whole-mount in situ hybridization using the olvas probe at st. 27. In the wild-type embryo (top), PGCs are clustered at the ventrolateral regions of the trunk (indicated by black arrowheads) at the axial level where the posterior trunk detach from the yolk. In the mutant embryo (bottom), PGCs are dispersed along the bilateral lines (broken lines) anterior to the sites of normal PGC clustering. White arrowheads indicate the pigment cells.