Strain information
Strain ID MT373
Strain Name hiohgi^j102-5B
Strain Type Mutants
Symbol hio^j102-5B
Characteristics In medaka hiohgi (hio) embryos, the liver does not appear until st. 29 and is small and malformed. In addition to this liver defect, hio mutant embryos lack pectoral fins and die after hatching. Positional cloning revealed that the hio mutation affects the raldh2 gene encoding retinaldehyde dehydrogenase type2 (RALDH2), the enzyme principally responsible for retinoic acid (RA) iosynthesis.
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Special affairs [Address] ■ The RECIPIENT shall refer the following publication in any PUBLICATIONS.
(Name of the Publication:Negishi T et al. Retinoic acid signaling positively regulates liver specification by inducing wnt2bb gene expression in medaka. Hepatology. 2010/03.51(3).1037-45.)
Category Mutant of embryogeneses
Organization National Institute for Basic Biology
Frozen sperm in NIBB
Deposited by ERATO Kondoh Differentiation Signaling Project, Japan Science and Technology Agency
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Phenotype of hiohgi mutant