Mutations were induced by the CRISPR/Cas9 method on the long wavelength sensitive opsin (LWS) genes. The LWSa gene has 4-base deletion and 6-base insertion, and the LWSb gene has 5-base insertion. The mutant fish is insensitive to red light and does not show optomotor response at λ > 740 nm. No phenotypic difference between alleles. Background of this mutant is ci.
Shimmura T, Nakayama T, Shinomiya A, Fukamachi S, Yasugi M, Watanabe E, Shimo T, Senga T, Nishimura T, Tanaka M, Kamei Y, Naruse K, Yoshimura T. Dynamic plasticity in phototransduction regulates seasonal changes in color perception. Nat Commun 2017/09/04.8(1).412.
Kamijo M, Kawamura M, Fukamachi S. Loss of red opsin genes relaxes sexual isolation between skin-colour variants of medaka. Behav Processes 2018/05/01.150.25-28.
Homma N, Harada Y, Uchikawa T, Kamei Y, Fukamachi S. Protanopia (red color-blindness) in medaka: a simple system for producing color-blind fish and testing their spectral sensitivity. BMC Genet 2017/02/06.18(1).10.
■ The RECIPIENT shall refer the following publication in any PUBLICATIONS. (Name of the Publication: HOMMA, Noriko, et al. Protanopia (red color-blindness) in medaka: a simple system for producing color-blind fish and testing their spectral sensitivity. BMC genetics, 2017, 18.1: 10.)
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