Using TALEN technology, a constitutive mineralocorticoid receptor (MR)-KO medaka was generated as a mutant with a frameshift at the amino acid #42. Hyper- and hypo-osmoregulation were normal in homozygous mutant medaka. However, homozygous mutants failed to track moving dots despite having an increase in acceleration of swimming.
|Category||Mutants created by genome editing|
|Organization||National Institute for Basic Biology|
|Frozen sperm in NIBB||○|
|Deposited by||Okayama University|
Abnormal responses to visual motion stimuli in MR-KO medaka
Distance to the stimulus dot from the head and trajectory of a representative fish during stimulus presentation.
|Document (PDF)||MT1050_MR(del2)_Genotyping protocol|