contactin1b^E6-22

Strain information
Strain ID MT1170
Strain Name contactin1b^E6-22
Strain Type Mutants
Characteristics Mutations were induced by the CRISPR/Cas9 method on contactin1b (cntn1b) genes. The cntn1b gene has 22-base deletion in exon 6. All the cntn1b mutant juvenile and adult fish show abnormal wobbling and rolling swimming behaviors. They have defective optokinetic response (OKR) adaptation and abnormal rheotaxis (body positioning to water flow). It is difficult to generate a next generation by crossing the homozygous cntn1b mutant pairs.
Journal
  •    1  Hits.
    • Takeuchi M, Inoue C, Goshima A, Nagao Y, Shimizu K, Miyamoto H, Shimizu T, Hashimoto H, Yonemura S, Kawahara A, Hirata Y, Yoshida M, Hibi M. Medaka and zebrafish contactin1 mutants as a model for understanding neural circuits for motor coordination. Genes Cells 2017/06/24.22(8).723-741.
Special affairs [Address] ■ The RECIPIENT shall refer the following publication in any PUBLICATIONS.
(Name of the Publication: Takeuchi, M., et al. (2017) Medaka and zebrafish contactin1 mutants as a model for understanding neural circuits for motor coordination. Genes Cells. DOI: 10.1111/gtc.12509)
■ The RECIPIENT shall give proper credit to the DEVELOPER in any publications reporting results of research using any derivatives developed from the BIOLOGICAL MATERIALS (hereinafter referred to as “the DERIVATIVES”), and shall procure other institutionsto which the DERIVATIVES are provided (including when provided through the NBRP) to do the same.
Category Mutants created by genome editing
Organization National Institute for Basic Biology
Frozen sperm in NIBB
Deposited by Nagoya University
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Document (PDF) Genotyping protocol_MT1170_contactin1b^E6-22


/medaka