Tintachina

Strain information
Strain ID MT977
Strain Name Tintachina
Strain Type Mutants
Symbol tch
Characteristics Vacuolar-type H(+) ATPases (V-ATPases) are multimeric protein complexes that play a universal role in the acidification of intracellular compartments in eukaryotic cells. In a ENU screen, we have isolated the recessive medaka mutation tintachina (tch), which carries an inactivating modification of the conserved glycine residue (G75R) of the proton pump subunit atp6v1Ba/vatB1. Mutant embryos show normal morphology but penetrant pigmentation defects from stage 27 on. As development proceeds, embryos display progressive brain apoptosis and finally die before hatching.
Journal
  •    1  Hits.
    • Müller C, Maeso I, Wittbrodt J, Martínez-Morales JR. The medaka mutation tintachina sheds light on the evolution of V-ATPase B subunits in vertebrates. Sci Rep 2013/11/14.3.3217.
Special affairs [Address] ■ The RECIPIENT shall refer the following publication in any PUBLICATIONS. (Name of the Publication: The medaka mutation tintachina sheds light on the evolution of V-ATPase B subunits in vertebrates. Müller C, Maeso I, Wittbrodt J, Martínez-Morales JR. Sci Rep. (2013) 3:3217. )
Category Mutants created by TILLING
Organization National Institute for Basic Biology
Frozen sperm in NIBB
Deposited by Centro Andaluz de Biología del Desarrollo, CSIC/Universidad Pablo de Olavide
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Document (PDF) MT977_Genotyping protocol


/medaka