Strain information
Strain ID TG998
Strain Name Tg(PBiP-EGFP)
Strain Type Transgenics
Characteristics BiP is Hsp70 family protein in the ER. In response to ER stress, transcription of BiP is upregulated. The expression level of BiP reflects the level of ER stress.
  •    4  Hits.
    • Ishikawa T, Kashima M, Nagano AJ, Ishikawa-Fujiwara T, Kamei Y, Todo T, Mori K. Unfolded protein response transducer IRE1-mediated signaling independent of XBP1 mRNA splicing is not required for growth and development of medaka fish. Elife 2017/09/27.6.null.

      Ishikawa T, Toyama T, Nakamura Y, Tamada K, Shimizu H, Ninagawa S, Okada T, Kamei Y, Ishikawa-Fujiwara T, Todo T, Aoyama E, Takigawa M, Harada A, Mori K. UPR transducer BBF2H7 allows export of type II collagen in a cargo- and developmental stage-specific manner. J. Cell Biol. 2017/06/05.216(6).1761-1774.

      Ishikawa T, Okada T, Ishikawa-Fujiwara T, Todo T, Kamei Y, Shigenobu S, Tanaka M, Saito TL, Yoshimura J, Morishita S, Toyoda A, Sakaki Y, Taniguchi Y, Takeda S, Mori K. ATF6α/β-mediated adjustment of ER chaperone levels is essential for development of the notochord in medaka fish. Mol. Biol. Cell 2013/05.24(9).1387-95.

      Ishikawa T, Taniguchi Y, Okada T, Takeda S, Mori K. Vertebrate unfolded protein response: mammalian signaling pathways are conserved in Medaka fish. Cell Struct. Funct. 2011.36(2).247-59.
Special affairs [Address] ■ The RECIPIENT shall include the name(s) of following researcher(s) as co-authors in the first PUBLICATION. (Name(s) of researcher(s): Tokiro Ishikawa and Kazutoshi Mori)
Category Transgenic strains
Organization National Institute for Basic Biology
Frozen sperm in NIBB
Deposited by Kyoto University
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TG998-1002_Transgene map


1dpf fish without ER stress reagent Tm (-), and same fish after treatment of Tm 2ug/ml 24hour(+)