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lrp6(ins4)
| Strain information | |
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| Strain ID | MT1239 |
| Strain Name | lrp6(ins4) |
| Strain Type | Mutants |
| Characteristics | A 1 bp deletion and a 5 bp insertion were occurred in exon 2 of lrp6 (low-density lipoprotein receptor-related protein 6) gene by the CRISPR/Cas9 genome editing system. This mutation is expected to introduce frame-shift mutation and anticipated to produce dysfunction in the lrp6 protein. This mutant showed defect in development of trunk and tail. The homozygous mutant is lethal. |
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| Special affairs [Address] | ■ The RECIPIENT should make a prior contact with Keiji Inohaya (kinohaya@bio.titech.ac.jp), and arrange for collaborative research or offer conditions with a written form of consent. Then, the RECIPIENT shall make a request for this strain to NBRP Medaka at NIBB. |
| Category | Mutants created by genome editing |
| Organization | National Institute for Basic Biology |
| Frozen sperm in NIBB | ○ |
| Deposited by | Tokyo Institute of Technology |
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| Image |
MT1239_embryo The lrp6 mutant shows abnormal development of trunk and tail. Stage 22. Dorsal views. |
| Document (PDF) | Genotyping protocol_MT1239_lrp6(ins4) |
