Vacuolar-type H(+) ATPases (V-ATPases) are multimeric protein complexes that play a universal role in the acidification of intracellular compartments in eukaryotic cells. In a ENU screen, we have isolated the recessive medaka mutation tintachina (tch), which carries an inactivating modification of the conserved glycine residue (G75R) of the proton pump subunit atp6v1Ba/vatB1. Mutant embryos show normal morphology but penetrant pigmentation defects from stage 27 on. As development proceeds, embryos display progressive brain apoptosis and finally die before hatching.
Müller C, Maeso I, Wittbrodt J, Martínez-Morales JR. The medaka mutation tintachina sheds light on the evolution of V-ATPase B subunits in vertebrates. Sci Rep 2013/11/14.3.3217.
The RECIPIENT shall refer the following publication in any PUBLICATIONS. (Name of the Publication: The medaka mutation tintachina sheds light on the evolution of V-ATPase B subunits in vertebrates. Müller C, Maeso I, Wittbrodt J, Martínez-Morales JR. Sci Rep. (2013)3:3217.)
Category
Mutants created by TILLING
Organization
National Institute for Basic Biology
Frozen sperm in NIBB
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Deposited by
Centro Andaluz de Biología del Desarrollo, CSIC/Universidad Pablo de Olavide
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