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runx2(del7)
| Strain information | |
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| Strain ID | MT1245 |
| Strain Name | runx2(del7) |
| Strain Type | Mutants |
| Characteristics | A 7 bp was deleted in exon 2 of runx2 gene by the TALEN genome editing system. This mutation is expected to introduce frame-shift mutation, resulting in truncation of the C-terminus of the runx2 protein, including the runt domain. The homozygous mutant shows abnormal development of the head skeletal structures. runx2 is also known as cbfa1(core-binding factor subunit alpha-1). |
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| Special affairs [Address] | ■ The RECIPIENT should make a prior contact with Keiji Inohaya (kinohaya@bio.titech.ac.jp), and arrange for collaborative research or offer conditions with a written form of consent. Then, the RECIPIENT shall make a request for this strain to NBRP Medaka at NIBB. |
| Category | Mutants created by genome editing |
| Organization | National Institute for Basic Biology |
| Frozen sperm in NIBB | ○ |
| Deposited by | Tokyo Institute of Technology |
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| Image |
Fig_MT1245_Ventral-View The runx2 mutant has a defect in development of head skeletons. Day-3 larvae. Ventral views. cb5, ceratobranchial 5; cl, cleithrum; p, parasphenoid. |
| Image |
Fig_MT1245_Lateral-View The runx2 mutant has a defect in development of head skeletons. Day-3 larvae. Lateral views. bs, branchiostegal ray; op, opercular; p, parasphenoid; cl, cleithrum |
| Document (PDF) | Genotyping protocol_MT1245 |
