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sox10b^F110L
| Strain information | |
|---|---|
| Strain ID | MT1213 |
| Strain Name | sox10b^F110L |
| Strain Type | Mutants |
| Characteristics |
This mutant, isolated by TILLING screening, has a single nucleotide substitution in exon 1 of sox10b gene. The mutation causes an amino acid substitution (F to L) in the conserved sequence of HMG box. The homozygotes look normal and sometimes survive to adulthood. When crossed to sox10a mutant, sox10b mutant enhances the reduction of pigment cells in sox10a mutant. The original TILLING sox10b^F110L mutant with Cab background was crossed with Nagoya to replace b/b mutant allele with B wild-type allele. |
| Notes | Please note that we will use OK-Cab (MT830) for artificially insemination with frozen sperm of this strain. |
Journal
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| Special affairs [Address] |
■ The RECIPIENT shall refer the following publication in any PUBLICATIONS. (Name of the Publication:1. Nagao Y, Takada H, Miyadai M, Adachi T, Seki R, Kamei Y, Hara I, Taniguchi Y, Naruse K, Hibi M, Kelsh RN, Hashimoto H. (2018) Distinct interactions of Sox5 and Sox10 in fate specification of pigment cells in medaka and zebrafish. PLoS Genet, 14: e1007260. 2. Taniguchi Y, Takeda S, Furutani-Seiki M, Kamei Y, Todo T, Sasado T, Deguchi T, Kondoh H, Mudde J, Yamazoe M, Hidaka M, Mitani H, Toyoda A, Sakaki Y, Plasterk RH, Cuppen E. (2006) Generation of medaka gene knockout models by target-selected mutagenesis. Genome Biol. 7(12):R116) ■ The RECIPIENT shall give proper credit to the DEVELOPER in any publications reporting results of research using any derivatives developed from the BIOLOGICAL MATERIALS (hereinafter referred to as “the DERIVATIVES”), and shall procure other institutions to which the DERIVATIVES are provided (including when provided through the NBRP) to do the same. |
| Category | Mutants created by TILLING |
| Organization | National Institute for Basic Biology |
| Frozen sperm in NIBB | ○ |
| Deposited by | Nagoya University |
| Order |
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| Document (PDF) | Genotyping protocol_MT1213_sox10b^F110L.pdf |
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