MG1655
W3110
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Gene Report : murE
PEC Original Annotations
Essentiality
     Class essential
     References (PMID)  
Related gene (MG1655 PEC)
     Gene Search Search MG1655 PEC by gene name:  murE
Related strains
     Strains Search Search strains by gene name:  murE   Search strains by all related name:  murE b0085 ECK0086 JW0083

General information  (Go to Linear View:)
 Gene Name murE  
 Alternative name b0085,ECK0086,JW0083  
 Location, Length 93,166 - 94,653 (  +  ) ;   2.01 min ; 1488 (bp) ,   495 (aa) Go to Linear View
 Product UDP-N-acetylmuramoyl-L-alanyl-D-glutamate:meso- diaminopimelate ligase  
 Note ECK0086:JW0083:b0085  
 Function  
 PID 21321966  
SWISS-PROT  ( Show details )
  botton Entry name(Acc.no) MURE_ECOLI ( P22188 ; O07101 )
    -  Protein name RecName: Full=UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase; EC=6.3.2.13; AltName: Full=UDP-MurNAc-L-Ala-D-Glu:meso-diaminopimelate ligase; AltName: Full=Meso-diaminopimelate-adding enzyme; AltName: Full=Meso-A2pm-adding enzyme; AltName: Full=UDP-N-acetylmuramyl-tripeptide synthetase; AltName: Full=UDP-MurNAc-tripeptide synthetase;  
    -  Synonyms  
    -  Gene name Name=murE; OrderedLocusNames=b0085, JW0083;  

 Linear View
View Location
   80.0  –  105.0 (KBP)

Homology Analysis
BLAST
    Bacteria
         GTOP  
    PDB
        PSI-BLAST  
    SWISS-PROT
        BLAST  
         PSI-BLAST RecName: Full=UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase; AltName: Full=UDP-MurNAc-L-Ala-D-Glu:meso-diaminopimelate ligase; AltName: Full=Meso-diaminopimelate-adding enzyme; AltName: Full=Meso-A2pm-adding enzyme; AltName: Full=UDP-N-acetylmuramyl-tripeptide synthetase; AltName: Full=UDP-MurNAc-tripeptide synthetase
    nr
         BLAST UDP-N-acetylmuramoyl-L-alanyl-D-glutamate:meso-diaminopimelate ligase [Escherichia coli str. K-12 substr. MG1655]  
Pfam 27.0   (database updated : 2013-03 )
    Pfam

Other Cross-Reference
    EcoCyc murE 

MMBR References
Can J Microbiol. 1989;35(11):1051-4.
Nucleotide sequence of the murE gene of Escherichia coli.
Tao JS, Ishiguro EE. ( 2692800 )

Sequences
Amino acid
FASTA format
0001 MADRNLRDLL APWVPDAPSR ALREMTLDSR VAAAGDLFVA VVGHQADGRR YIPQAIAQGV AAIIAEAKDE 
0071 ATDGEIREMH GVPVIYLSQL NERLSALAGR FYHEPSDNLR LVGVTGTNGK TTTTQLLAQW SQLLGEISAV 
0141 MGTVGNGLLG KVIPTENTTG SAVDVQHELA GLVDQGATFC AMEVSSHGLV QHRVAALKFA ASVFTNLSRD 
0211 HLDYHGDMEH YEAAKWLLYS EHHCGQAIIN ADDEVGRRWL AKLPDAVAVS MEDHINPNCH GRWLKATEVN 
0281 YHDSGATIRF SSSWGDGEIE SHLMGAFNVS NLLLALATLL ALGYPLADLL KTAARLQPVC GRMEVFTAPG 
0351 KPTVVVDYAH TPDALEKALQ AARLHCAGKL WCVFGCGGDR DKGKRPLMGA IAEEFADVAV VTDDNPRTEE 
0421 PRAIINDILA GMLDAGHAKV MEGRAEAVTC AVMQAKENDV VLVAGKGHED YQIVGNQRLD YSDRVTVARL 
0491 LGVIA

Nucleotide
FASTA format

View sequence out neighbor 100bp
-100                                             GCCATCATGG GCGGCGTATT GCGTACCATG 
-070 AACATCGAGC CGGATGCGCT GACAACGGGC GATAAAAATG AATTTGTGAT TAATCAAGGC GAGGGGACAG 
0001 gtggcagatc gtaatttgcg cgaccttctt gctccgtggg tgccagacgc accttcgcga gcactgcgag 
0071 agatgacact cgacagccgt gtggctgcgg cgggcgatct ctttgtagct gtagtaggtc atcaggcgga 
0141 cgggcgtcga tatatcccgc aggcgatagc gcaaggtgtg gctgccatta ttgcagaggc gaaagatgag 
0211 gcgaccgatg gtgaaatccg tgaaatgcac ggcgtaccgg tcatctatct cagccagctc aacgagcgtt 
0281 tatctgcact ggcgggccgc ttttaccatg aaccctctga caatttacgt ctcgtgggcg taacgggcac 
0351 caacggcaaa accacgacta cccagctgtt ggcgcagtgg agccaactgc ttggcgaaat cagcgcggta 
0421 atgggcaccg ttggtaacgg cctgctgggg aaagtgatcc cgacagaaaa tacaaccggt tcggcagtcg 
0491 atgttcagca tgagctggcg gggctggtgg atcagggcgc gacgttttgc gcaatggaag tttcctccca 
0561 cgggctggta cagcaccgtg tggcggcatt gaaatttgcg gcgtcggtct ttaccaactt aagccgcgat 
0631 caccttgatt atcatggtga tatggaacac tacgaagccg cgaaatggct gctttattct gagcatcatt 
0701 gcggtcaggc gattattaac gccgacgatg aagtgggccg ccgctggctg gcaaaactgc cggacgcggt 
0771 tgcggtatca atggaagatc atattaatcc gaactgtcac ggacgctggt tgaaagcgac cgaagtgaac 
0841 tatcacgaca gcggtgcgac gattcgcttt agctcaagtt ggggcgatgg cgaaattgaa agccatctga 
0911 tgggcgcttt taacgtcagc aacctgctgc tcgcgctggc gacactgttg gcactcggct atccactggc 
0981 tgatctgctg aaaaccgccg cgcgtctgca accggtttgc ggacgtatgg aagtgttcac tgcgccaggc 
1051 aaaccgacgg tggtggtgga ttacgcgcat acgccggatg cactggaaaa agccttacag gcggcgcgtc 
1121 tgcactgtgc gggcaagctg tggtgtgtct ttggctgtgg tggcgatcgc gataaaggta agcgtccact 
1191 gatgggcgca attgccgaag agtttgctga cgtggcggtg gtgacggacg ataacccgcg taccgaagaa 
1261 ccgcgtgcca tcatcaacga tattctggcg ggaatgttag atgccggaca tgccaaagtg atggaaggcc 
1331 gtgctgaagc ggtgacttgc gccgttatgc aggctaaaga gaatgatgtg gtactggtcg cgggcaaagg 
1401 ccatgaagat taccagattg ttggcaatca gcgtctggac tactccgatc gcgtcacggt ggcgcgtctg 
1471 ctgggggtga ttgcatgaTT AGCGTAACCC TTAGCCAACT TACCGACATT CTCAACGGTG AACTGCAAGG 
1541 TGCAGATATC ACCCTTGATG CTGTAACCAC TGATACCCGA AAACTGAC