MG1655
W3110
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Gene Report : hemB
PEC Original Annotations
Essentiality
     Class essential
     References (PMID)  
Related gene (MG1655 PEC)
     Gene Search Search MG1655 PEC by gene name:  hemB
Related strains
     Strains Search Search strains by gene name:  hemB   Search strains by all related name:  hemB b0369 ECK0366 JW0361 ncf

General information  (Go to Linear View:)
 Gene Name hemB  
 Alternative name b0369,ECK0366,JW0361,ncf  
 Location, Length 387,977 - 388,951 (  -  ) ;   8.35 min ; 975 (bp) ,   324 (aa) Go to Linear View
 Product porphobilinogen synthase  
 Note ECK0366:JW0361:b0369  
 Function  
 PID 85674510  
SWISS-PROT  ( Show details )
  botton Entry name(Acc.no) HEM2_ECOLI ( P0ACB2 ; P15002; P78247; Q2MC56 )
    -  Protein name RecName: Full=Delta-aminolevulinic acid dehydratase; Short=ALADH; Short=ALAD; EC=4.2.1.24; AltName: Full=Porphobilinogen synthase;  
    -  Synonyms  
    -  Gene name Name=hemB; Synonyms=ncf; OrderedLocusNames=b0369, JW0361;  

 Linear View
View Location
   375.0  –  400.0 (KBP)

Homology Analysis
BLAST
    Bacteria
         GTOP  
    PDB
        PSI-BLAST  
    SWISS-PROT
        BLAST  
        PSI-BLAST
    nr
         BLAST delta-aminolevulinic acid dehydratase [Shigella flexneri 2a str. 301]  
Pfam 27.0   (database updated : 2013-03 )
    Pfam

Other Cross-Reference
    EcoCyc hemB 

MMBR References
J Bacteriol. 1991;173(1):94-100.
delta-Aminolevulinic acid dehydratase deficiency can cause delta-aminolevulinate auxotrophy in Escherichia coli.
O'Neill GP, Thorbjarnardottir S, Michelsen U, Palsson S, Soll D, Eggertsson G. ( 1987138 )

Sequences
Amino acid
FASTA format
0001 MTDLIQRPRR LRKSPALRAM FEETTLSLND LVLPIFVEEE IDDYKAVEAM PGVMRIPEKH LAREIERIAN 
0071 AGIRSVMTFG ISHHTDETGS DAWREDGLVA RMSRICKQTV PEMIVMSDTC FCEYTSHGHC GVLCEHGVDN 
0141 DATLENLGKQ AVVAAAAGAD FIAPSAAMDG QVQAIRQALD AAGFKDTAIM SYSTKFASSF YGPFREAAGS 
0211 ALKGDRKSYQ MNPMNRREAI RESLLDEAQG ADCLMVKPAG AYLDIVRELR ERTELPIGAY QVSGEYAMIK 
0281 FAALAGAIDE EKVVLESLGS IKRAGADLIF SYFALDLAEK KILR

Nucleotide
FASTA format

View sequence out neighbor 100bp
-100                                             tccattctct tcttgtcaac atcgcgacaa 
-070 ctttcgtaaa acatccctac cctgcttcag gtatactatg cccctcgatt ccacaaacat caggcagacc 
0001 atgacagact taatccaacg ccctcgtcgc ctgcgcaaat ctcctgcgct gcgcgctatg tttgaagaga 
0071 caacacttag ccttaacgac ctggtgttgc cgatctttgt tgaagaagaa attgacgact acaaagccgt 
0141 tgaagccatg ccaggcgtga tgcgcattcc agagaaacat ctggcacgcg aaattgaacg catcgccaac 
0211 gccggtattc gttccgtgat gacttttggc atctctcacc ataccgatga aaccggcagc gatgcctggc 
0281 gggaagatgg actggtggcg cgtatgtcgc gcatctgcaa gcagaccgtg ccagaaatga tcgttatgtc 
0351 agacacctgc ttctgtgaat acacttctca cggtcactgc ggtgtgctgt gcgagcatgg cgtcgacaac 
0421 gacgcgactc tggaaaattt aggcaagcaa gccgtggttg cagctgctgc aggtgcagac ttcatcgccc 
0491 cttccgccgc gatggacggc caggtacagg cgattcgtca ggcgctggac gctgcgggat ttaaagatac 
0561 ggcgattatg tcgtattcga ccaagttcgc ctcctccttt tatggcccgt tccgtgaagc tgccggaagc 
0631 gcattaaaag gcgaccgcaa aagctatcag atgaacccaa tgaaccgtcg tgaggcgatt cgtgaatcac 
0701 tgctggatga agcccagggc gcagactgcc tgatggttaa acctgctgga gcgtacctcg acatcgtgcg 
0771 tgagctgcgt gaacgtactg aattgccgat tggcgcgtat caggtgagcg gtgagtatgc gatgattaag 
0841 ttcgccgcgc tggcgggtgc tatagatgaa gagaaagtcg tgctcgaaag cttaggttcg attaagcgtg 
0911 cgggtgcgga tctgattttc agctactttg cgctggattt ggctgagaag aagattctgc gttaattttg 
0981 tttcctctca gaaaggggga gttaacctgt tgaaagtacg gtgaacgccc cctcacccta accctctccc 
1051 caagggggcg aggggaccgt ccact