MG1655
W3110
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Gene Report : proS
PEC Original Annotations
Essentiality
     Class essential
     References (PMID)  
Related gene (MG1655 PEC)
     Gene Search Search MG1655 PEC by gene name:  proS
Related strains
     Strains Search Search strains by gene name:  proS   Search strains by all related name:  proS b0194 drpA ECK0194 JW0190

General information  (Go to Linear View:)
 Gene Name proS  
 Alternative name b0194,drpA,ECK0194,JW0190  
 Location, Length 217,057 - 218,775 (  -  ) ;   4.67 min ; 1719 (bp) ,   572 (aa) Go to Linear View
 Product prolyl-tRNA synthetase  
 Note ECK0194:JW0190:b0194  
 Function  
 PID 85674379  
SWISS-PROT  ( Show details )
  botton Entry name(Acc.no) SYP_ECOLI ( P16659 ; P78272; Q59430 )
    -  Protein name RecName: Full=Prolyl-tRNA synthetase; EC=6.1.1.15; AltName: Full=Proline--tRNA ligase; Short=ProRS; AltName: Full=Global RNA synthesis factor;  
    -  Synonyms  
    -  Gene name Name=proS; Synonyms=drpA; OrderedLocusNames=b0194, JW0190;  

 Linear View
View Location
   205.0  –  230.0 (KBP)

Homology Analysis
BLAST
    Bacteria
         GTOP  
    PDB
        PSI-BLAST  
    SWISS-PROT
        BLAST  
        PSI-BLAST
    nr
         BLAST prolyl-tRNA synthetase [Escherichia coli str. K-12 substr. MG1655]  
Pfam 27.0   (database updated : 2013-03 )
    Pfam

Other Cross-Reference
    EcoCyc proS 

MMBR References
Mol Gen Genet. 1980;177(4):603-5.
A temperature-sensitive mutant in prolinyl-tRNA ligase of Escherichia coli K-12.
Bohman K, Isaksson LA. ( 6991867 )

Sequences
Amino acid
FASTA format
0001 MRTSQYLLST LKETPADAEV ISHQLMLRAG MIRKLASGLY TWLPTGVRVL KKVENIVREE MNNAGAIEVS 
0071 MPVVQPADLW QESGRWEQYG PELLRFVDRG ERPFVLGPTH EEVITDLIRN ELSSYKQLPL NFYQIQTKFR 
0141 DEVRPRFGVM RSREFLMKDA YSFHTSQESL QETYDAMYAA YSKIFSRMGL DFRAVQADTG SIGGSASHEF 
0211 QVLAQSGEDD VVFSDTSDYA ANIELAEAIA PKEPRAAATQ EMTLVDTPNA KTIAELVEQF NLPIEKTVKT 
0281 LLVKAVEGSS FPQVALLVRG DHELNEVKAE KLPQVASPLT FATEEEIRAV VKAGPGSLGP VNMPIPVVID 
0351 RTVAAMSDFA AGANIDGKHY FGINWDRDVA TPEVADIRNV VAGDPSPDGQ GRLLIKRGIE VGHIFQLGTK 
0421 YSEALKASVQ GEDGRNQILT MGCYGIGVTR VVAAAIEQNY DERGIVWPDA IAPFQVAILP MNMHKSFRVQ 
0491 ELAEKLYSEL RAQGIEVLLD DRKERPGVMF ADMELIGIPH TIVLGDRNLD NDDIEYKYRR NGEKQLIKTG 
0561 DIVEYLVKQI KG

Nucleotide
FASTA format

View sequence out neighbor 100bp
-100                                             tctcttttga catttctttt gcactggtaa 
-070 actaaatcac ttttttttgt cccaggctcg ccttgagcct gttctacctt ccaactggaa ccgtaacaac 
0001 atgcgtacta gccaatacct gctctccact ctcaaggaga cacctgccga cgccgaggtg atcagccatc 
0071 agctgatgct gcgcgccggg atgatccgca agctggcctc cgggttatat acctggctgc cgaccggcgt 
0141 gcgcgttctg aaaaaagtcg aaaacatcgt gcgtgaagag atgaacaacg ccggtgcgat cgaggtgtcg 
0211 atgccggtgg ttcagccagc cgatttgtgg caagagagtg gtcgttggga acagtacggt ccggaactgc 
0281 tgcgttttgt tgaccgtggc gagcgtccgt tcgtactcgg cccaactcat gaagaagtta tcactgacct 
0351 gattcgtaac gagcttagct cttacaaaca gctgccgctg aacttctatc agatccagac caagttccgc 
0421 gacgaagtgc gtccgcgttt cggcgtcatg cgttcccgcg aattcctgat gaaagatgct tactctttcc 
0491 atacttctca ggaatccctg caggaaacct acgatgcaat gtatgcggcc tacagcaaaa tcttcagccg 
0561 catggggctg gatttccgcg ccgtacaagc cgacaccggt tctatcggcg gcagcgcctc tcacgaattc 
0631 caggtgctgg cgcagagcgg tgaagacgat gtggtcttct ccgacacctc tgactatgca gcgaacattg 
0701 aactggcaga agctatcgcg ccgaaagaac cgcgcgctgc tgctacccag gaaatgacgc tggttgatac 
0771 gccgaacgcg aaaaccatcg cggaactggt tgaacagttc aatctgccga ttgagaaaac ggttaagact 
0841 ctgctggtta aagcggttga aggcagcagc ttcccgcagg ttgcgctgct ggtgcgcggt gatcacgagc 
0911 tgaacgaagt taaagcagaa aaactgccgc aggttgcaag cccgctgact ttcgcgaccg aagaagaaat 
0981 tcgtgccgtg gttaaagccg gtccgggttc actgggtccg gtaaacatgc cgattccggt ggtgattgac 
1051 cgtaccgttg cggcgatgag tgatttcgct gctggtgcta acatcgatgg taaacactac ttcggcatca 
1121 actgggatcg cgatgtcgct accccggaag ttgcagatat ccgtaacgtg gtggctggcg atccaagccc 
1191 ggatggccag ggtaggctgc tgatcaaacg tggtatcgaa gttggtcaca tcttccagct gggtaccaag 
1261 tactccgaag cactgaaagc ctccgtacag ggtgaagatg gccgtaacca aatcctgacg atgggttgct 
1331 acggtatcgg ggtaacgcgt gtggtagctg cggcgattga gcagaactac gacgaacgag gcatcgtatg 
1401 gcctgacgct atcgcgccgt tccaggtggc gattctgccg atgaacatgc acaaatcctt ccgcgtacaa 
1471 gagcttgctg agaaactgta cagcgaactg cgtgcacaag gtatcgaagt gctgctggat gaccgcaaag 
1541 agcgtccggg cgtgatgttt gctgatatgg aactgatcgg tattccgcac actattgtgc tgggcgaccg 
1611 taacctcgac aacgacgata tcgaatataa atatcgtcgc aacggcgaga aacagttaat taagactggt 
1681 gacatcgtcg aatatctggt gaaacagatt aaaggctgat gccagaaagg gtcctgaatt tcagggccct 
1751 ttttttacat ggattgtata aaatggataa accaaaggcg tactgccgcc tgtttctccc cagctttct