MG1655
W3110
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Gene Report : ispU
PEC Original Annotations
Essentiality
     Class essential
     References (PMID)
J Bacteriol. 1999;181(9):2733-8.
The Escherichia coli homologue of yeast RER2, a key enzyme of dolichol synthesis, is essential for carrier lipid formation in bacterial cell wall synthesis.
Kato J, Fujisaki S, Nakajima K, Nishimura Y, Sato M, Nakano A. ( 10217761 )
Related gene (MG1655 PEC)
     Gene Search Search MG1655 PEC by gene name:  ispU
Related strains
     Strains Search Search strains by gene name:  ispU   Search strains by all related name:  ispU b0174 ECK0173 JW0169 rth uppS yaeS

General information  (Go to Linear View:)
 Gene Name ispU  
 Alternative name b0174,ECK0173,JW0169,rth,uppS,yaeS  
 Location, Length 194,903 - 195,664 (  +  ) ;   4.19 min ; 762 (bp) ,   253 (aa) Go to Linear View
 Product undecaprenyl pyrophosphate synthase  
 Note ECK0173:JW0169:b0174  
 Function  
 PID 85674367  
SWISS-PROT  ( Show details )
  botton Entry name(Acc.no) UPPS_ECOLI ( P60472 ; P75668; Q47675; Q9R2E4 )
    -  Protein name RecName: Full=Undecaprenyl pyrophosphate synthetase; Short=UPP synthetase; EC=2.5.1.31; AltName: Full=Di-trans,poly-cis-decaprenylcistransferase; AltName: Full=Undecaprenyl diphosphate synthase; Short=UDS;  
    -  Synonyms  
    -  Gene name Name=uppS; Synonyms=ispU, rth, yaeS; OrderedLocusNames=b0174, JW0169;  

 Linear View
View Location
   185.0  –  210.0 (KBP)

Homology Analysis
BLAST
    Bacteria
         GTOP  
    PDB
        PSI-BLAST  
    SWISS-PROT
         BLAST RecName: Full=Undecaprenyl pyrophosphate synthetase; Short=UPP synthetase; AltName: Full=Di-trans,poly-cis-decaprenylcistransferase; AltName: Full=Undecaprenyl diphosphate synthase; Short=UDS  
        PSI-BLAST
    nr
         BLAST di-trans,poly-cis-decaprenylcistransferase [Escherichia coli O157:H7 str. EC4501]  
Pfam 27.0   (database updated : 2013-03 )
    Pfam

Other Cross-Reference
    EcoCyc ispU 

Sequences
Amino acid
FASTA format
0001 MMLSATQPLS EKLPAHGCRH VAIIMDGNGR WAKKQGKIRA FGHKAGAKSV RRAVSFAANN GIEALTLYAF 
0071 SSENWNRPAQ EVSALMELFV WALDSEVKSL HRHNVRLRII GDTSRFNSRL QERIRKSEAL TAGNTGLTLN 
0141 IAANYGGRWD IVQGVRQLAE KVQQGNLQPD QIDEEMLNQH VCMHELAPVD LVIRTGGEHR ISNFLLWQIA 
0211 YAELYFTDVL WPDFDEQDFE GALNAFANRE RRFGGTEPGD ETA

Nucleotide
FASTA format

View sequence out neighbor 100bp
-100                                             GCTTTATAAG GTCAGATATG CCGTGGTTTT 
-070 ACACGGCTTT TTTTTGTATA GGCTTCAGTA TTCCTGAGTA CCGTAAACCC TGTCAGGGAA TAAAAAACGC 
0001 gtgatgttgt ctgctactca accacttagc gaaaaattgc cagcgcatgg ctgccgtcat gttgcgatca 
0071 ttatggacgg caatggccgc tgggcaaaaa agcaagggaa gattcgtgcc tttgggcata aagccggggc 
0141 aaaatccgtc cgccgggctg tctcttttgc ggccaacaac ggtattgagg cgttaacgct gtatgccttt 
0211 agtagtgaaa actggaaccg accagcgcag gaagtcagtg cgttaatgga actgtttgtg tgggcgctcg 
0281 atagcgaagt aaaaagtctg caccgacata acgtgcgtct gcgtattatt ggcgatacca gtcgctttaa 
0351 ctcgcgtttg caagaacgta ttcgtaaatc tgaagcgcta acagccggga ataccggtct gacgctgaat 
0421 attgcggcga actacggtgg acgttgggat atagtccagg gagtcaggca actggctgaa aaggtgcagc 
0491 aaggaaacct gcaaccagat cagatagatg aagagatgct aaaccagcat gtctgtatgc atgaactggc 
0561 ccctgtagat ttagtaatta ggactggggg ggagcatcgc attagtaact ttttgctttg gcaaattgcc 
0631 tatgccgaac tttactttac agatgttctc tggcccgatt tcgatgaaca agactttgaa ggggcgttaa 
0701 atgcctttgc taatcgagag cgtcgtttcg gcggcaccga gcccggtgat gaaacagcct gaTGGGGGTC 
0771 GCTTTTGCTG AAGTATCGCC TGATATCTGC TTTTGTGTTA ATACCCGTCG TCATCGCGGC GTTGTTTCTG 
0841 TTGCCGCCGG TGGGGTTCGC CA