MG1655
W3110
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Gene Report : folK
PEC Original Annotations
Essentiality
     Class essential
     References (PMID)  
Related gene (MG1655 PEC)
     Gene Search Search MG1655 PEC by gene name:  folK
Related strains
     Strains Search Search strains by gene name:  folK   Search strains by all related name:  folK b0142 ECK0141 JW0138

General information  (Go to Linear View:)
 Gene Name folK  
 Alternative name b0142,ECK0141,JW0138  
 Location, Length 157,253 - 157,732 (  -  ) ;   3.38 min ; 480 (bp) ,   159 (aa) Go to Linear View
 Product 2-amino-4-hydroxy-6- hydroxymethyldihyropteridine pyrophosphokinase  
 Note ECK0141:JW0138:b0142  
 Function  
 PID 21238998  
SWISS-PROT  ( Show details )
  botton Entry name(Acc.no) HPPK_ECOLI ( P26281 )
    -  Protein name RecName: Full=2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase; EC=2.7.6.3; AltName: Full=7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; Short=HPPK; AltName: Full=6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase; Short=PPPK;  
    -  Synonyms  
    -  Gene name Name=folK; OrderedLocusNames=b0142, JW0138;  

 Linear View
View Location
   145.0  –  170.0 (KBP)

Homology Analysis
BLAST
    Bacteria
         GTOP  
    PDB
        PSI-BLAST  
    SWISS-PROT
         BLAST RecName: Full=2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase; AltName: Full=7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; Short=HPPK; AltName: Full=6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase; Short=PPPK  
         PSI-BLAST RecName: Full=2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase; AltName: Full=7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; Short=HPPK; AltName: Full=6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase; Short=PPPK
    nr
         BLAST 2-amino-4-hydroxy-6-hydroxymethyldihyropteridine pyrophosphokinase [Escherichia coli str. K-12 substr. MG1655]  
Pfam 27.0   (database updated : 2013-03 )
    Pfam

Other Cross-Reference
    EcoCyc folK 

MMBR References
J Bacteriol. 1992;174:5971-5977
Cloning, sequence analysis, and overexpression of Escherichia coli folK, the gene coding for 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase.
Talarico, T. L., P. H. Ray, I. K. Dev, B. M. Merrill, and W. S. Dallas.

Sequences
Amino acid
FASTA format
0001 MTVAYIAIGS NLASPLEQVN AALKALGDIP ESHILTVSSF YRTPPLGPQD QPDYLNAAVA LETSLAPEEL 
0071 LNHTQRIELQ QGRVRKAERW GPRTLDLDIM LFGNEVINTE RLTVPHYDMK NRGFMLWPLF EIAPELVFPD 
0141 GEMLRQILHT RAFDKLNKW

Nucleotide
FASTA format

View sequence out neighbor 100bp
-100                                             cagaccaaaa agggatgctc aacgagctgg 
-070 atgaagaacc gtcaccgcgt cgtcgtactc gtcgtccacg caaacgcgca ccacgtcgtg agggtaccgc 
0001 atgacagtgg cgtatattgc cataggcagc aatctggcct ctccgctgga gcaggtcaat gctgccctga 
0071 aagcattagg cgatatccct gaaagccaca ttcttaccgt ttcttcgttt taccgcaccc caccgctggg 
0141 gccgcaagat caacccgatt acttaaacgc agccgtggcg ctggaaacct ctcttgcacc tgaagagcta 
0211 ctcaatcaca cacagcgtat tgaattgcag caaggtcgcg tccgcaaagc tgaacgctgg ggaccacgca 
0281 cgctggatct cgacatcatg ctgtttggta atgaagtgat aaatactgaa cgcctgaccg ttccgcacta 
0351 cgatatgaag aatcgtggat ttatgctgtg gccgctgttt gaaatcgcgc cggagttggt gtttcctgat 
0421 ggggagatgt tgcgtcaaat cttacataca agagcatttg acaaattaaa caaatggtaa tttatttata 
0491 ttgcgaatat aaatattttc tgaaaatcat atctcatctc tttccttaat tacgatttta gtttaaacat 
0561 ctctttgcgg aaataatata