MG1655
W3110
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Gene Report : leuB
PEC Original Annotations
Essentiality
     Class non-essential
     References (PMID)  
Related gene (MG1655 PEC)
     Gene Search Search MG1655 PEC by gene name:  leuB
Related strains
     Strains Search Search strains by gene name:  leuB   Search strains by all related name:  leuB b0073 ECK0075 JW5807

General information  (Go to Linear View:)
 Gene Name leuB  
 Alternative name b0073,ECK0075,JW5807  
 Location, Length 80,867 - 81,958 (  -  ) ;   1.74 min ; 1092 (bp) ,   363 (aa) Go to Linear View
 Product 3-isopropylmalate dehydrogenase  
 Note ECK0075:JW5807:b0073  
 Function  
 PID 21321955  
SWISS-PROT  ( Show details )
  botton Entry name(Acc.no) LEU3_ECOLI ( P30125 ; P78043 )
    -  Protein name RecName: Full=3-isopropylmalate dehydrogenase; EC=1.1.1.85; AltName: Full=Beta-IPM dehydrogenase; Short=IMDH; AltName: Full=3-IPM-DH;  
    -  Synonyms  
    -  Gene name Name=leuB; OrderedLocusNames=b0073, JW5807;  

 Linear View
View Location
   70.0  –  95.0 (KBP)

Homology Analysis
BLAST
    Bacteria
         GTOP  
    PDB
         PSI-BLAST  
    SWISS-PROT
         BLAST RecName: Full=3-isopropylmalate dehydrogenase; AltName: Full=Beta-IPM dehydrogenase; Short=IMDH; AltName: Full=3-IPM-DH  
        PSI-BLAST
    nr
         BLAST 3-isopropylmalate dehydrogenase [Escherichia coli str. K-12 substr. W3110]  
Pfam 27.0   (database updated : 2013-03 )
    Pfam

Other Cross-Reference
    EcoCyc leuB 

MMBR References
J Bacteriol. 1977;129(2):1078-90.
Isolation and characterization of lambda pleu bacteriophages.
Davis MG, Calvo JM. ( 320178 )

Sequences
Amino acid
FASTA format 
0001 MSKNYHIAVL PGDGIGPEVM TQALKVLDAV RNRFAMRITT SHYDVGGAAI DNHGQPLPPA TVEGCEQADA 
0071 VLFGSVGGPK WEHLPPDQQP ERGALLPLRK HFKLFSNLRP AKLYQGLEAF CPLRADIAAN GFDILCVREL 
0141 TGGIYFGQPK GREGSGQYEK AFDTEVYHRF EIERIARIAF ESARKRRHKV TSIDKANVLQ SSILWREIVN 
0211 EIATEYPDVE LAHMYIDNAT MQLIKDPSQF DVLLCSNLFG DILSDECAMI TGSMGMLPSA SLNEQGFGLY 
0281 EPAGGSAPDI AGKNIANPIA QILSLALLLR YSLDADDAAC AIERAINRAL EEGIRTGDLA RGAAAVSTDE 
0351 MGDIIARYVA EGV
Nucleotide
FASTA format

View sequence out neighbor 100bp 
-100                                             ccatggtgca cgttctgaac aatatctggc 
-070 gtgccgcaga agtcgaaaaa gagttgcaac gcaaagctca acacaacgaa aacaacaagg aaaccgtgtg 
0001 atgtcgaaga attaccatat tgccgtattg ccgggggacg gtattggtcc ggaagtgatg acccaggcgc 
0071 tgaaagtgct ggatgccgtg cgcaaccgct ttgcgatgcg catcaccacc agccattacg atgtaggcgg 
0141 cgcagccatt gataaccacg ggcaaccact gccgcctgcg acggttgaag gttgtgagca agccgatgcc 
0211 gtgctgtttg gctcggtagg cggcccgaag tgggaacatt taccaccaga ccagcaacca gaacgcggcg 
0281 cgctgctgcc tctgcgtaag cacttcaaat tattcagcaa cctgcgcccg gcaaaactgt atcaggggct 
0351 ggaagcattc tgtccgctgc gtgcagacat tgccgcaaac ggcttcgaca tcctgtgtgt gcgcgaactg 
0421 accggcggca tctatttcgg tcagccaaaa ggccgcgaag gtagcggaca atatgaaaaa gcctttgata 
0491 ccgaggtgta tcaccgtttt gagatcgaac gtatcgcccg catcgcgttt gaatctgctc gcaagcgtcg 
0561 ccacaaagtg acgtcgatcg ataaagccaa cgtgctgcaa tcctctattt tatggcggga gatcgttaac 
0631 gagatcgcca cggaataccc ggatgtcgaa ctggcgcata tgtacatcga caacgccacc atgcagctga 
0701 ttaaagatcc atcacagttt gacgttctgc tgtgctccaa cctgtttggc gacattctgt ctgacgagtg 
0771 cgcaatgatc actggctcga tggggatgtt gccttccgcc agcctgaacg agcaaggttt tggactgtat 
0841 gaaccggcgg gcggctcggc accagatatc gcaggcaaaa acatcgccaa cccgattgca caaatccttt 
0911 cgctggcact gctgctgcgt tacagcctgg atgccgatga tgcggcttgc gccattgaac gcgccattaa 
0981 ccgcgcatta gaagaaggca ttcgcaccgg ggatttagcc cgtggcgctg ccgccgttag taccgatgaa 
1051 atgggcgata tcattgcccg ctatgtagca gaaggggtgt aatcatggct aagacgttat acgaaaaatt 
1121 gttcgacgct cacgttgtgt acgaagccga aaacgaaacc ccactgttat atatcgaccg ccacctggtg 
1191 ca