MG1655
W3110
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Gene Report : lipA
PEC Original Annotations
Essentiality
     Class non-essential
     References (PMID)  
Related gene (MG1655 PEC)
     Gene Search Search MG1655 PEC by gene name:  lipA
Related strains
     Strains Search Search strains by gene name:  lipA   Search strains by all related name:  lipA b0628 ECK0621 JW0623 lip

General information  (Go to Linear View:)
 Gene Name lipA  
 Alternative name b0628,ECK0621,JW0623,lip  
 Location, Length 659,673 - 660,638 (  -  ) ;   14.20 min ; 966 (bp) ,   321 (aa) Go to Linear View
 Product lipoate synthase  
 Note ECK0621:JW0623:b0628  
 Function  
 PID 1651257  
SWISS-PROT  ( Show details )
  botton Entry name(Acc.no) LIPA_ECOLI ( P60716 ; P25845; P77595 )
    -  Protein name RecName: Full=Lipoyl synthase; EC=2.8.1.8; AltName: Full=Lipoic acid synthase; AltName: Full=Lipoate synthase; AltName: Full=Sulfur insertion protein lipA; AltName: Full=Lip-syn; Short=LS;  
    -  Synonyms  
    -  Gene name Name=lipA; Synonyms=lip; OrderedLocusNames=b0628, JW0623;  

 Linear View
View Location
   650.0  –  675.0 (KBP)

Homology Analysis
BLAST
    Bacteria
         GTOP  
    PDB
        PSI-BLAST  
    SWISS-PROT
         BLAST RecName: Full=Lipoyl synthase; AltName: Full=Lipoic acid synthase; AltName: Full=Lipoate synthase; AltName: Full=Sulfur insertion protein lipA; AltName: Full=Lip-syn; Short=LS  
         PSI-BLAST RecName: Full=Lipoyl synthase; AltName: Full=Lipoic acid synthase; AltName: Full=Lipoate synthase; AltName: Full=Sulfur insertion protein lipA; AltName: Full=Lip-syn; Short=LS
    nr
         BLAST lipoyl synthase [Escherichia coli O157:H7 str. Sakai]  
Pfam 27.0   (database updated : 2013-03 )
    Pfam

Other Cross-Reference
    EcoCyc lipA 

MMBR References
J Bacteriol. 1991;173(20):6411-20.
Lipoic acid metabolism in Escherichia coli: isolation of null mutants defective in lipoic acid biosynthesis, molecular cloning and characterization of the E. coli lip locus, and identification of the lipoylated protein of the glycine cleavage system.
Vanden Boom TJ, Reed KE, Cronan JE Jr. ( 1655709 )

Sequences
Amino acid
FASTA format
0001 MSKPIVMERG VKYRDADKMA LIPVKNVATE REALLRKPEW MKIKLPADST RIQGIKAAMR KNGLHSVCEE 
0071 ASCPNLAECF NHGTATFMIL GAICTRRCPF CDVAHGRPVA PDANEPVKLA QTIADMALRY VVITSVDRDD 
0141 LRDGGAQHFA DCITAIREKS PQIKIETLVP DFRGRMDRAL DILTATPPDV FNHNLENVPR IYRQVRPGAD 
0211 YNWSLKLLER FKEAHPEIPT KSGLMVGLGE TNEEIIEVMR DLRRHGVTML TLGQYLQPSR HHLPVQRYVS 
0281 PDEFDEMKAE ALAMGFTHAA CGPFVRSSYH ADLQAKGMEV K

Nucleotide
FASTA format

View sequence out neighbor 100bp
-100                                             gatatactgc cagtcgttaa ttcaaaaata 
-070 gttgataatt acaacaatct attgaattga aacgctttcc ttcgtaattc gcaactggaa cacgcacgct 
0001 atgagtaaac ccattgtgat ggaacgcggt gttaaatacc gcgatgccga taagatggcc cttatcccgg 
0071 ttaaaaacgt ggcaacagag cgcgaagccc tgctgcgcaa gccggaatgg atgaaaatca agcttccagc 
0141 ggactctaca cgtatccagg gcatcaaagc cgcaatgcgc aaaaatggcc tgcattctgt ctgcgaggaa 
0211 gcctcctgcc ctaacctggc ggaatgcttc aaccacggca cagcaacgtt tatgatcctc ggcgctattt 
0281 gtacccgccg ttgtccgttc tgtgatgttg cccacggtcg cccggtagct cctgatgcca atgaaccagt 
0351 gaaactggcg cagaccattg ccgatatggc gctgcgttat gtggttatca cctccgttga ccgtgatgac 
0421 ctgcgcgatg gcggtgccca gcactttgcg gattgcatta ctgccattcg ggaaaaaagc ccgcaaatca 
0491 aaattgaaac tctggtgccg gatttccgcg gtcgtatgga tcgtgctctg gatattctga ctgcaacgcc 
0561 accagatgtg ttcaaccata acctggaaaa cgtaccgcgt atttaccgtc aggtacggcc tggtgcagat 
0631 tacaactggt cgctgaagct gctggaacgc tttaaagaag cgcatccgga aatcccgacc aagtctggtc 
0701 tgatggtggg actgggtgaa accaatgaag aaattattga ggtaatgcgc gacctgcgcc gtcatggtgt 
0771 gacgatgtta acgctggggc aatatttgca gccaagccgc catcacctgc cggttcaacg ttacgttagc 
0841 ccggatgagt tcgacgaaat gaaagccgaa gcgctggcga tgggctttac ccatgctgca tgcggtccgt 
0911 ttgtccgctc ttcttaccac gccgatttgc aggcgaaagg gatggaagtt aagtaatcct gtaataatta 
0981 cttacatctg tctgataaaa aacccgcttt ttgaagcggg ttttttgtat cgaacaagat attgagggag 
1051 cgtcctgctc gccacg