MG1655
W3110
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Gene Report : mrdA
PEC Original Annotations
Essentiality
     Class essential
     References (PMID)  
Related gene (MG1655 PEC)
     Gene Search Search MG1655 PEC by gene name:  mrdA
Related strains
     Strains Search Search strains by gene name:  mrdA   Search strains by all related name:  mrdA b0635 ECK0628 JW0630 pbpA

General information  (Go to Linear View:)
 Gene Name mrdA  
 Alternative name b0635,ECK0628,JW0630,pbpA  
 Location, Length 666,738 - 668,639 (  -  ) ;   14.35 min ; 1902 (bp) ,   633 (aa) Go to Linear View
 Product transpeptidase involved in peptidoglycan synthesis  
 Note ECK0628:JW0630:b0635; penicillin-binding protein 2  
 Function  
 PID 1651266  
SWISS-PROT  ( Show details )
  botton Entry name(Acc.no) PBP2_ECOLI ( P0AD65 ; P08150 )
    -  Protein name RecName: Full=Penicillin-binding protein 2; Short=PBP-2;  
    -  Synonyms  
    -  Gene name Name=mrdA; Synonyms=pbpA; OrderedLocusNames=b0635, JW0630;  

 Linear View
View Location
   655.0  –  680.0 (KBP)

Homology Analysis
BLAST
    Bacteria
         GTOP  
    PDB
        PSI-BLAST  
    SWISS-PROT
        BLAST  
        PSI-BLAST
    nr
         BLAST penicillin-binding protein 2 [Escherichia coli O157:H7 EDL933]  
Pfam 27.0   (database updated : 2013-03 )
    Pfam

Other Cross-Reference
    EcoCyc mrdA 

MMBR References
J Bacteriol. 1984;158(1):216-21.
Map location of the pcbA mutation and physiology of the mutant.
Bryan SK, Moses RE. ( 6325387 )

Sequences
Amino acid
FASTA format
0001 MKLQNSFRDY TAESALFVRR ALVAFLGILL LTGVLIANLY NLQIVRFTDY QTRSNENRIK LVPIAPSRGI 
0071 IYDRNGIPLA LNRTIYQIEM MPEKVDNVQQ TLDALRSVVD LTDDDIAAFR KERARSHRFT SIPVKTNLTE 
0141 VQVARFAVNQ YRFPGVEVKG YKRRYYPYGS ALTHVIGYVS KINDKDVERL NNDGKLANYA ATHDIGKLGI 
0211 ERYYEDVLHG QTGYEEVEVN NRGRVIRQLK EVPPQAGHDI YLTLDLKLQQ YIETLLAGSR AAVVVTDPRT 
0281 GGVLALVSTP SYDPNLFVDG ISSKDYSALL NDPNTPLVNR ATQGVYPPAS TVKPYVAVSA LSAGVITRNT 
0351 TLFDPGWWQL PGSEKRYRDW KKWGHGRLNV TRSLEESADT FFYQVAYDMG IDRLSEWMGK FGYGHYTGID 
0421 LAEERSGNMP TREWKQKRFK KPWYQGDTIP VGIGQGYWTA TPIQMSKALM ILINDGIVKV PHLLMSTAED 
0491 GKQVPWVQPH EPPVGDIHSG YWELAKDGMY GVANRPNGTA HKYFASAPYK IAAKSGTAQV FGLKANETYN 
0561 AHKIAERLRD HKLMTAFAPY NNPQVAVAMI LENGGAGPAV GTLMRQILDH IMLGDNNTDL PAENPAVAAA 
0631 EDH

Nucleotide
FASTA format

View sequence out neighbor 100bp
-100                                             cgtgctggtc gcagagagtc tgtaccgggc 
-070 gtggagcatc accaccaacc atccttatca ccgtgagtga taagggagct ttgagtagaa aacgcagcgg 
0001 atgaaactac agaactcttt tcgcgactat acggcagagt ccgcgctgtt tgtgcgccgg gcgctggtcg 
0071 cctttttggg gattttgctg ctgaccggcg tgcttatcgc caacctgtat aatctgcaaa ttgttcgctt 
0141 taccgactac cagacccgct ctaatgaaaa ccgcattaag ctggtgccta tcgcgcccag ccgcggcatt 
0211 atctacgatc gtaacggtat ccctctggcc ctcaaccgca ctatctacca gatagaaatg atgccggaga 
0281 aagtcgataa cgtgcagcaa acgctggacg ctttgcgcag cgtggtagat ctgaccgatg acgatattgc 
0351 tgcattccga aaagagcgcg cacgttcaca ccgtttcacc tctattccgg tgaaaactaa cctgaccgaa 
0421 gtacaagtag ctcgctttgc cgtcaatcag taccgttttc cgggtgtcga agttaaaggc tataaacgtc 
0491 gttactatcc ttacggttcg gcgttgaccc acgtcatcgg ctatgtgtcg aaaatcaacg ataaagacgt 
0561 cgaacgcctg aataatgacg gcaaactggc caactatgcg gcaacgcatg atatcggtaa gctgggcatt 
0631 gagcgttact atgaagatgt gctgcacggt cagaccggtt atgaagaggt tgaagttaac aaccgtgggc 
0701 gtgttattcg ccagttaaaa gaagtaccac cgcaagccgg acacgatatt tacctgacgc tggatctcaa 
0771 actccagcaa tatattgaaa cgctgctggc gggtagccgc gcagctgtgg tagtcaccga tccgcgtaca 
0841 ggtggggtgc tggcgctggt ttccacgcct agttatgacc caaacttgtt tgttgacggt atctccagca 
0911 aagattattc cgccttgttg aacgatccga atacaccgct ggtgaaccgc gccacacagg gggtttatcc 
0981 tcccgcgtct acagttaaac cctatgtggc ggtttcggca ttgagcgccg gggtgatcac gcgcaatacg 
1051 acgctgtttg acccaggctg gtggcaactg ccaggttcgg aaaaacgtta tcgtgactgg aaaaaatggg 
1121 gccacgggcg tctgaatgtc acaagatcgc tggaagaatc tgcggatacc ttcttctatc aggtggccta 
1191 cgatatgggg atcgatcgcc tctccgaatg gatgggtaaa ttcggttatg gtcattacac cggtatcgac 
1261 ctggcggaag aacgttccgg caacatgcct acccgcgaat ggaaacagaa acgctttaaa aaaccgtggt 
1331 atcagggtga caccattccg gttggtatcg gtcagggtta ctggacagcg accccaatcc agatgagtaa 
1401 ggcactgatg atcctgatta atgacggtat cgtgaaggtt cctcatttgc tgatgagcac cgccgaagac 
1471 ggcaaacagg tgccatgggt acagccgcat gaaccgcccg tcggcgatat tcattccggt tactgggagc 
1541 tggcgaaaga cggtatgtac ggtgttgcta accgccctaa cggtacggcg cataaatact ttgctagcgc 
1611 accgtacaaa attgcggcga aatccggtac cgctcaggtc ttcggtctga aagcgaacga aacctataat 
1681 gcgcacaaaa ttgccgagcg tttacgtgac cacaaactga tgaccgcctt tgcgccatac aacaatccgc 
1751 aagtggctgt cgccatgatt ctggagaacg gtggtgcggg tccggcggtt ggtacactga tgcgccagat 
1821 cctcgaccac attatgctgg gtgataacaa caccgatctg cctgcggaaa atccagcggt tgccgcagcg 
1891 gaggaccatt aatcatgacg gataatccga ataaaaaaac attctgggat aaagtccatc tcgatcccac 
1961 aatgctgctg atcttactgg cattgctggt ttacagcgcc ct