MG1655
W3110
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Gene Report : lpxC
PEC Original Annotations
Essentiality
     Class essential
     References (PMID)  
Related gene (MG1655 PEC)
     Gene Search Search MG1655 PEC by gene name:  lpxC
Related strains
     Strains Search Search strains by gene name:  lpxC   Search strains by all related name:  lpxC asmB b0096 ECK0097 envA JW0094

General information  (Go to Linear View:)
 Gene Name lpxC  
 Alternative name asmB,b0096,ECK0097,envA,JW0094  
 Location, Length 106,557 - 107,474 (  +  ) ;   2.29 min ; 918 (bp) ,   305 (aa) Go to Linear View
 Product UDP-3-O-acyl N-acetylglucosamine deacetylase  
 Note ECK0097:JW0094:b0096  
 Function  
 PID 21321977  
SWISS-PROT  ( Show simple )
  botton Entry name(Acc.no) LPXC_ECOLI ( P0A725 ; P07652 )
    -  Protein name RecName: Full=UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; EC=3.5.1.-; AltName: Full=UDP-3-O-acyl-GlcNAc deacetylase; AltName: Full=Protein envA;  
    -  Synonyms  
    -  Gene name Name=lpxC; Synonyms=asmB, envA; OrderedLocusNames=b0096, JW0094;  
    -  Comments
  • FUNCTION:Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
  • CATALYTIC ACTIVITY:UDP-3-O-(3-hydroxytetradecanoyl)-N-acetylglucosamine + H(2)O = UDP-3-O-(3-hydroxytetradecanoyl)-glucosamine + acetate.
  • PATHWAY:Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine:step 2/6.
  • SIMILARITY:Belongs to the lpxC family.  

  •  Linear View
    View Location
       95.0  –  120.0 (KBP)

    Homology Analysis
    BLAST
        Bacteria
             GTOP  
        PDB
            PSI-BLAST  
        SWISS-PROT
             BLAST RecName: Full=UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; AltName: Full=UDP-3-O-acyl-GlcNAc deacetylase; AltName: Full=Protein envA  
            PSI-BLAST
        nr
             BLAST UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase [Escherichia coli O157:H7 EDL933]  
    Pfam 27.0   (database updated : 2013-03 )
        Pfam

    Other Cross-Reference
        EcoCyc lpxC 

    MMBR References
    J Biol Chem. 1995;270:30384-30391
    The envA permeability/cell division gene of Escherichia coli encodes UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase.
    Young, K., L. L. Silver, D. Bramhill, P. Cameron, S. S. Eveland, C. R. Raetz, S. A. Hyland, and M. S. Anderson.

    Sequences
    Amino acid
    FASTA format
    0001 MIKQRTLKRI VQATGVGLHT GKKVTLTLRP APANTGVIYR RTDLNPPVDF PADAKSVRDT MLCTCLVNEH 
    0071 DVRISTVEHL NAALAGLGID NIVIEVNAPE IPIMDGSAAP FVYLLLDAGI DELNCAKKFV RIKETVRVED 
    0141 GDKWAEFKPY NGFSLDFTID FNHPAIDSSN QRYAMNFSAD AFMRQISRAR TFGFMRDIEY LQSRGLCLGG 
    0211 SFDCAIVVDD YRVLNEDGLR FEDEFVRHKM LDAIGDLFMC GHNIIGAFTA YKSGHALNNK LLQAVLAKQE 
    0281 AWEYVTFQDD AELPLAFKAP SAVLA
    
    
    Nucleotide
    FASTA format

    View sequence out neighbor 100bp
    -100                                             GAATTGACTG GAATTTGGGT TTCGAGGCTC 
    -070 TTTGTGCTAA ACTGGCCCGC CGAATGTATA GTACACTTCG GTTGGATAGG TAATTTGGCG AGATAATACG 
    0001 atgatcaaac aaaggacact taaacgtatc gttcaggcga cgggtgtcgg tttacatacc ggcaagaaag 
    0071 tcaccctgac gttacgccct gcgccggcca acaccggggt catctatcgt cgcaccgact tgaatccacc 
    0141 ggtagatttc ccggccgatg ccaaatctgt gcgtgatacc atgctctgta cgtgtctggt caacgagcat 
    0211 gatgtacgga tttcaaccgt agagcacctc aatgctgctc tcgcgggctt gggcatcgat aacattgtta 
    0281 tcgaagttaa cgcgccggaa atcccgatca tggacggcag cgccgctccg tttgtatacc tgctgcttga 
    0351 cgccggtatc gacgagttga actgcgccaa aaaatttgtt cgcatcaaag agactgttcg tgtcgaagat 
    0421 ggcgataagt gggctgaatt taagccgtac aatggttttt cgctggattt caccatcgat tttaaccatc 
    0491 cggctattga ttccagcaac cagcgctatg cgatgaactt ctccgctgat gcgtttatgc gccagatcag 
    0561 ccgtgcgcgt acgttcggtt tcatgcgtga tatcgaatat ctgcagtccc gtggtttgtg cctgggcggc 
    0631 agcttcgatt gtgccatcgt tgttgacgat tatcgcgtac tgaacgaaga cggcctgcgt tttgaagacg 
    0701 aatttgtgcg tcacaaaatg ctcgatgcga tcggtgactt gttcatgtgt ggtcacaata ttattggtgc 
    0771 atttaccgct tataaatccg gtcatgcact gaataacaaa ctgctgcagg ctgtcctggc gaaacaggaa 
    0841 gcctgggaat atgtgacctt ccaggacgac gcagaactgc cgttggcctt caaagcgcct tcagctgtac 
    0911 tggcataaCG ACATTTATAC TGTCGTATAA AATTCGACTG GCAAATCTGG CACTCTCTCC GGCCAGGTGA 
    0981 ACCAGTCGTT TTTTTTTGAA TTTTATAAGA GCTATAAA