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PEC Original Annotations
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Essentiality
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Class
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non-essential
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References (PMID)
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Related gene (MG1655 PEC)
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Gene Search
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Search MG1655 PEC by gene name:
metC
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Related strains
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Strains Search
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Search strains by gene name:
metC
Search strains by all related name:
metC b3008 ECK3000 JW2975
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General information (Go to Linear View: )
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Gene Name
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metC
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Alternative name
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b3008,ECK3000,JW2975
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Location, Length
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3,150,892 - 3,152,079
(
+
)
;
67.81
min
;
1188
(bp) ,
395
(aa)
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Product
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cystathionine beta-lyase, PLP-dependent
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Note
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ECK3000:JW2975:b3008
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Function
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PID
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85675812
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SWISS-PROT
(
Show simple
)
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Entry name(Acc.no)
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METC_ECOLI
(
P06721
;
Q2M9J1
)
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- Protein name
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RecName: Full=Cystathionine beta-lyase metC; Short=CBL; EC=4.4.1.8; AltName: Full=Beta-cystathionase; AltName: Full=Cysteine lyase;
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- Synonyms
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- Gene name
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Name=metC; OrderedLocusNames=b3008, JW2975;
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- Comments
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CATALYTIC ACTIVITY:L-cystathionine + H(2)O = L-homocysteine + NH(3) + pyruvate.
COFACTOR:Pyridoxal phosphate.
PATHWAY:Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homocysteine from L-cystathionine:step 1/1.
SUBUNIT:Homotetramer.
SUBCELLULAR LOCATION:Cytoplasm.
SIMILARITY:Belongs to the trans-sulfuration enzymes family.
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MMBR References
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FEMS Microbiol Lett. 1984;22:31-35.
The metC gene in Escherichia coli K-12: isolation and studies of relatedness in Enterobacteriaceae.
Michaeli, S., and E. Z. Ron.
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| Sequences |
Amino acid
FASTA format
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0001 MADKKLDTQL VNAGRSKKYT LGAVNSVIQR ASSLVFDSVE AKKHATRNRA NGELFYGRRG TLTHFSLQQA
0071 MCELEGGAGC VLFPCGAAAV ANSILAFIEQ GDHVLMTNTA YEPSQDFCSK ILSKLGVTTS WFDPLIGADI
0141 VKHLQPNTKI VFLESPGSIT MEVHDVPAIV AAVRSVVPDA IIMIDNTWAA GVLFKALDFG IDVSIQAATK
0211 YLVGHSDAMI GTAVCNARCW EQLRENAYLM GQMVDADTAY ITSRGLRTLG VRLRQHHESS LKVAEWLAEH
0281 PQVARVNHPA LPGSKGHEFW KRDFTGSSGL FSFVLKKKLN NEELANYLDN FSLFSMAYSW GGYESLILAN
0351 QPEHIAAIRP QGEIDFSGTL IRLHIGLEDV DDLIADLDAG FARIV
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Nucleotide
FASTA format
View sequence out neighbor 100bp
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-100 ATTTGCGAAA ATTTTCTGCT TTATGCCAAT
-070 TCTTCAGGAT GCGCCCGCGA ATATTCATGC TAGTTTAGAC ATCCAGACGT ATAAAAACAG GAATCCCGAC
0001 atggcggaca aaaagcttga tactcaactg gtgaatgcag gacgcagcaa aaaatacact ctcggcgcgg
0071 taaatagcgt gattcagcgc gcttcttcgc tggtctttga cagtgtagaa gccaaaaaac acgcgacacg
0141 taatcgcgcc aatggagagt tgttctatgg acggcgcgga acgttaaccc atttctcctt acaacaagcg
0211 atgtgtgaac tggaaggtgg cgcaggctgc gtgctatttc cctgcggggc ggcagcggtt gctaattcca
0281 ttcttgcttt tatcgaacag ggcgatcatg tgttgatgac caacaccgcc tatgaaccga gtcaggattt
0351 ctgtagcaaa atcctcagca aactgggcgt aacgacatca tggtttgatc cgctgattgg tgccgatatc
0421 gttaagcatc tgcagccaaa cactaaaatc gtgtttctgg aatcgccagg ctccatcacc atggaagtcc
0491 acgacgttcc ggcgattgtt gccgccgtac gcagtgtggt gccggatgcc atcattatga tcgacaacac
0561 ctgggcagcc ggtgtgctgt ttaaggcgct ggattttggc atcgatgttt ctattcaagc cgccaccaaa
0631 tatctggttg ggcattcaga tgcgatgatt ggcactgccg tgtgcaatgc ccgttgctgg gagcagctac
0701 gggaaaatgc ctatctgatg ggccagatgg tcgatgccga taccgcctat ataaccagcc gtggcctgcg
0771 cacattaggt gtgcgtttgc gtcaacatca tgaaagcagt ctgaaagtgg ctgaatggct ggcagaacat
0841 ccgcaagttg cgcgagttaa ccaccctgct ctgcctggca gtaaaggtca cgaattctgg aaacgagact
0911 ttacaggcag cagcgggcta ttttcctttg tgcttaagaa aaaactcaat aatgaagagc tggcgaacta
0981 tctggataac ttcagtttat tcagcatggc ctactcgtgg ggcgggtatg aatcgttgat cctggcaaat
1051 caaccagaac atatcgccgc cattcgccca caaggcgaga tcgattttag cgggaccttg attcgcctgc
1121 atattggtct ggaagatgtc gacgatctga ttgccgatct ggacgccggt tttgcgcgaa ttgtataaCA
1191 TTGCCACTTT TGGACAATTT TGCAGACATT TTATTGTGAA AAGTCTTAAA TTGTTGCGTC CGGGATCAAG
1261 GCGTCCCGGA CGATTCAGGA GTACAATA
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