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PEC Original Annotations
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Essentiality
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Class
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non-essential
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References (PMID)
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Related gene (MG1655 PEC)
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Gene Search
|
Search MG1655 PEC by gene name:
thrB
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Related strains
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Strains Search
|
Search strains by gene name:
thrB
Search strains by all related name:
thrB b0003 ECK0003 JW0002
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General information (Go to Linear View: )
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Gene Name
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thrB
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Alternative name
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b0003,ECK0003,JW0002
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Location, Length
|
2,801 - 3,733
(
+
)
;
0.06
min
;
933
(bp) ,
310
(aa)
|
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Product
|
homoserine kinase
|
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Note
|
ECK0003:JW0002:b0003
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Function
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PID
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85674277
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SWISS-PROT
(
Show simple
)
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Entry name(Acc.no)
|
KHSE_ECOLI
(
P00547
)
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- Protein name
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RecName: Full=Homoserine kinase; Short=HSK; Short=HK; EC=2.7.1.39;
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- Synonyms
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- Gene name
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Name=thrB; OrderedLocusNames=b0003, JW0002;
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- Comments
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CATALYTIC ACTIVITY:ATP + L-homoserine = ADP + O-phospho-L-homoserine.
PATHWAY:Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate:step 4/5.
SUBCELLULAR LOCATION:Cytoplasm (Probable).
SIMILARITY:Belongs to the GHMP kinase family. Homoserine kinase subfamily.
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Homology Analysis
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BLAST
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Bacteria
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GTOP
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PDB
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PSI-BLAST
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SWISS-PROT
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BLAST
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RecName: Full=Homoserine kinase; Short=HSK; Short=HK
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PSI-BLAST
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nr
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BLAST
|
homoserine kinase [Escherichia coli str. K-12 substr. MG1655]
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Pfam 27.0
(database updated :
2013-03
)
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Pfam
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MMBR References
|
Mol Gen Genet. 1979;175(1):39-44.
Construction and expression of a hybrid plasmid containing the Escherichia coli thrA and thrB genes.
Cossart P, Katinka M, Yaniv M, Saint Girons I, Cohen GN.
(
390305
)
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| Sequences |
Amino acid
FASTA format
|
0001 MVKVYAPASS ANMSVGFDVL GAAVTPVDGA LLGDVVTVEA AETFSLNNLG RFADKLPSEP RENIVYQCWE
0071 RFCQELGKQI PVAMTLEKNM PIGSGLGSSA CSVVAALMAM NEHCGKPLND TRLLALMGEL EGRISGSIHY
0141 DNVAPCFLGG MQLMIEENDI ISQQVPGFDE WLWVLAYPGI KVSTAEARAI LPAQYRRQDC IAHGRHLAGF
0211 IHACYSRQPE LAAKLMKDVI AEPYRERLLP GFRQARQAVA EIGAVASGIS GSGPTLFALC DKPETAQRVA
0281 DWLGKNYLQN QEGFVHICRL DTAGARVLEN
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Nucleotide
FASTA format
View sequence out neighbor 100bp
|
-100 CCGTTGGTAC TGCGCGGATA TGGTGCGGGC
-070 AATGACGTTA CAGCTGCCGG TGTCTTTGCT GATCTGCTAC GTACCCTCTC ATGGAAGTTA GGAGTCTGAC
0001 atggttaaag tttatgcccc ggcttccagt gccaatatga gcgtcgggtt tgatgtgctc ggggcggcgg
0071 tgacacctgt tgatggtgca ttgctcggag atgtagtcac ggttgaggcg gcagagacat tcagtctcaa
0141 caacctcgga cgctttgccg ataagctgcc gtcagaacca cgggaaaata tcgtttatca gtgctgggag
0211 cgtttttgcc aggaactggg taagcaaatt ccagtggcga tgaccctgga aaagaatatg ccgatcggtt
0281 cgggcttagg ctccagtgcc tgttcggtgg tcgcggcgct gatggcgatg aatgaacact gcggcaagcc
0351 gcttaatgac actcgtttgc tggctttgat gggcgagctg gaaggccgta tctccggcag cattcattac
0421 gacaacgtgg caccgtgttt tctcggtggt atgcagttga tgatcgaaga aaacgacatc atcagccagc
0491 aagtgccagg gtttgatgag tggctgtggg tgctggcgta tccggggatt aaagtctcga cggcagaagc
0561 cagggctatt ttaccggcgc agtatcgccg ccaggattgc attgcgcacg ggcgacatct ggcaggcttc
0631 attcacgcct gctattcccg tcagcctgag cttgccgcga agctgatgaa agatgttatc gctgaaccct
0701 accgtgaacg gttactgcca ggcttccggc aggcgcggca ggcggtcgcg gaaatcggcg cggtagcgag
0771 cggtatctcc ggctccggcc cgaccttgtt cgctctgtgt gacaagccgg aaaccgccca gcgcgttgcc
0841 gactggttgg gtaagaacta cctgcaaaat caggaaggtt ttgttcatat ttgccggctg gatacggcgg
0911 gcgcacgagt actggaaaac taaATGAAAC TCTACAATCT GAAAGATCAC AACGAGCAGG TCAGCTTTGC
0981 GCAAGCCGTA ACCCAGGGGT TGGGCAAAAA TCAGGGGCTG TTTTTTCCGC ACG
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