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PEC Original Annotations
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Essentiality
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Class
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non-essential
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References (PMID)
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Related gene (MG1655 PEC)
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Gene Search
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Search MG1655 PEC by gene name:
guaC
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Related strains
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Strains Search
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Search strains by gene name:
guaC
Search strains by all related name:
guaC b0104 ECK0104 JW0101
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General information (Go to Linear View: )
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Gene Name
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guaC
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Alternative name
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b0104,ECK0104,JW0101
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Location, Length
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113,444 - 114,487
(
+
)
;
2.44
min
;
1044
(bp) ,
347
(aa)
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Product
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GMP reductase
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Note
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ECK0104:JW0101:b0104
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Function
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PID
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85674329
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SWISS-PROT
(
Show simple
)
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Entry name(Acc.no)
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GUAC_ECOLI
(
P60560
;
P15344; P78048
)
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- Protein name
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RecName: Full=GMP reductase; EC=1.7.1.7; AltName: Full=Guanosine 5'-monophosphate oxidoreductase; Short=Guanosine monophosphate reductase;
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- Synonyms
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- Gene name
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Name=guaC; OrderedLocusNames=b0104, JW0101;
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- Comments
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FUNCTION:Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.
CATALYTIC ACTIVITY:Inosine 5'-phosphate + NH(3) + NADP(+) = guanosine 5'-phosphate + NADPH.
SUBUNIT:Homotetramer.
INTERACTION:P76015:dhaK; NbExp=1; IntAct=EBI-544491, EBI-544485; P15034:pepP; NbExp=2; IntAct=EBI-544491, EBI-554801;
SIMILARITY:Belongs to the IMPDH/GMPR family. GuaC type 1 subfamily.
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MMBR References
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J Bacteriol. 1988;170(1):463-7.
Genetic and molecular characterization of the guaC-nadC-aroP region of Escherichia coli K-12.
Roberts RE, Lienhard CI, Gaines CG, Smith JM, Guest JR.
(
3275629
)
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| Sequences |
Amino acid
FASTA format
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0001 MRIEEDLKLG FKDVLIRPKR STLKSRSDVE LERQFTFKHS GQSWSGVPII AANMDTVGTF SMASALASFD
0071 ILTAVHKHYS VEEWQAFINN SSADVLKHVM VSTGTSDADF EKTKQILDLN PALNFVCIDV ANGYSEHFVQ
0141 FVAKAREAWP TKTICAGNVV TGEMCEELIL SGADIVKVGI GPGSVCTTRV KTGVGYPQLS AVIECADAAH
0211 GLGGMIVSDG GCTTPGDVAK AFGGGADFVM LGGMLAGHEE SGGRIVEENG EKFMLFYGMS SESAMKRHVG
0281 GVAEYRAAEG KTVKLPLRGP VENTARDILG GLRSACTYVG ASRLKELTKR TTFIRVQEQE NRIFNNL
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Nucleotide
FASTA format
View sequence out neighbor 100bp
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-100 AGACAATTTC GCAGTCTTGC GCCGCATTGA
-070 TTAGTGCGTA TGATAGCGTC ACTGGAGTTG CGCTCTTACC CTTATAGCCA TTAACCCCAG GAATCCGCAC
0001 atgcgtattg aagaagatct gaagttaggt tttaaagacg ttctcatccg ccctaaacgc tccactctta
0071 aaagccgttc cgatgttgaa ctggaacgtc aattcacctt caaacattca ggtcagagct ggtccggcgt
0141 gccgattatc gccgcaaata tggacaccgt aggcacattt tctatggcct ctgcgctggc ttcttttgat
0211 attttgactg ctgtgcataa acactattct gtcgaagagt ggcaagcgtt tatcaacaat tcttccgctg
0281 atgtgctgaa acatgtgatg gtttctaccg gtacgtctga tgcggatttc gaaaaaacta aacagattct
0351 cgacctgaac ccggcattaa acttcgtttg tattgacgtg gcgaatggtt attccgaaca cttcgtgcag
0421 ttcgttgcga aagcgcgtga agcgtggccg accaaaacca tttgtgctgg taacgtagtg actggtgaaa
0491 tgtgtgagga gcttatcctc tcaggtgccg atatcgttaa agttggcatt ggcccaggtt ctgtttgtac
0561 aactcgcgtc aaaacaggcg tcggttatcc gcaactttct gcggtaatcg aatgtgccga tgctgcgcac
0631 ggtctgggcg gaatgatcgt cagcgatggt ggctgcacca cgccgggcga tgtggcgaaa gcctttggcg
0701 gcggtgccga tttcgtcatg cttggcggca tgctggcggg ccacgaagag agcggcggtc gcatcgttga
0771 ggagaacggc gagaaattta tgctgttcta cggcatgagc tccgagtctg cgatgaaacg tcacgttggc
0841 ggcgttgcgg aatatcgcgc agcagaaggt aaaaccgtta agctgccgct gcgaggcccg gttgaaaata
0911 ccgcgcgaga tattttgggc ggcctgcgtt cagcttgtac atacgttggg gcttcacgcc tgaaagagct
0981 gaccaagcgc accacgttta ttcgtgtgca ggaacaagaa aaccgcatct tcaacaacct gtaaTCTCCC
1051 AACGCTGGCG TGGAGCAACA CGCCAGCGTT ATCCCATCCC ACTCATCGCA TCGCCTAAAT GGAAAATTGG
1121 CAGATACATT GCCACCACCA GCGT
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