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PEC Original Annotations
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Essentiality
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Class
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essential
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References (PMID)
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Related gene (MG1655 PEC)
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Gene Search
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Search MG1655 PEC by gene name:
folK
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Related strains
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Strains Search
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Search strains by gene name:
folK
Search strains by all related name:
folK b0142 ECK0141 JW0138
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General information (Go to Linear View: )
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Gene Name
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folK
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Alternative name
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b0142,ECK0141,JW0138
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Location, Length
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157,253 - 157,732
(
-
)
;
3.38
min
;
480
(bp) ,
159
(aa)
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Product
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2-amino-4-hydroxy-6- hydroxymethyldihyropteridine pyrophosphokinase
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Note
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ECK0141:JW0138:b0142
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Function
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PID
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21238998
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SWISS-PROT
(
Show simple
)
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Entry name(Acc.no)
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HPPK_ECOLI
(
P26281
)
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- Protein name
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RecName: Full=2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase; EC=2.7.6.3; AltName: Full=7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; Short=HPPK; AltName: Full=6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase; Short=PPPK;
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- Synonyms
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- Gene name
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Name=folK; OrderedLocusNames=b0142, JW0138;
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- Comments
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CATALYTIC ACTIVITY:ATP + 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine = AMP + (2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate.
PATHWAY:Cofactor biosynthesis; tetrahydrofolate biosynthesis; 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate:step 4/4.
SUBUNIT:Monomer.
MISCELLANEOUS:This enzyme is heat stable.
SIMILARITY:Belongs to the HPPK family.
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MMBR References
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J Bacteriol. 1992;174:5971-5977
Cloning, sequence analysis, and overexpression of Escherichia coli folK, the gene coding for 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase.
Talarico, T. L., P. H. Ray, I. K. Dev, B. M. Merrill, and W. S. Dallas.
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| Sequences |
Amino acid
FASTA format
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0001 MTVAYIAIGS NLASPLEQVN AALKALGDIP ESHILTVSSF YRTPPLGPQD QPDYLNAAVA LETSLAPEEL
0071 LNHTQRIELQ QGRVRKAERW GPRTLDLDIM LFGNEVINTE RLTVPHYDMK NRGFMLWPLF EIAPELVFPD
0141 GEMLRQILHT RAFDKLNKW
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Nucleotide
FASTA format
View sequence out neighbor 100bp
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-100 cagaccaaaa agggatgctc aacgagctgg
-070 atgaagaacc gtcaccgcgt cgtcgtactc gtcgtccacg caaacgcgca ccacgtcgtg agggtaccgc
0001 atgacagtgg cgtatattgc cataggcagc aatctggcct ctccgctgga gcaggtcaat gctgccctga
0071 aagcattagg cgatatccct gaaagccaca ttcttaccgt ttcttcgttt taccgcaccc caccgctggg
0141 gccgcaagat caacccgatt acttaaacgc agccgtggcg ctggaaacct ctcttgcacc tgaagagcta
0211 ctcaatcaca cacagcgtat tgaattgcag caaggtcgcg tccgcaaagc tgaacgctgg ggaccacgca
0281 cgctggatct cgacatcatg ctgtttggta atgaagtgat aaatactgaa cgcctgaccg ttccgcacta
0351 cgatatgaag aatcgtggat ttatgctgtg gccgctgttt gaaatcgcgc cggagttggt gtttcctgat
0421 ggggagatgt tgcgtcaaat cttacataca agagcatttg acaaattaaa caaatggtaa tttatttata
0491 ttgcgaatat aaatattttc tgaaaatcat atctcatctc tttccttaat tacgatttta gtttaaacat
0561 ctctttgcgg aaataatata
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