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PEC Original Annotations
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Essentiality
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Class
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essential
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References (PMID)
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J Biol Chem. 1998;273(20):12466-75.
Function of Escherichia coli MsbA, an essential ABC family transporter, in lipid A and phospholipid biosynthesis.
Zhou Z, White KA, Polissi A, Georgopoulos C, Raetz CR.
(
9575204
)
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Deletion
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OCR53
(D)
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Related gene (W3110 PEC)
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Gene Search
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Search MG1655 PEC by gene name:
msbA
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Related strains
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Strains Search
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Search strains by gene name:
msbA
Search strains by all related name:
msbA b0914 ECK0905 JW0897
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General information (Go to Linear View: )
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Gene Name
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msbA
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Alternative name
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b0914,ECK0905,JW0897
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Location, Length
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965,844 - 967,592
(
+
)
;
20.82
min
;
1749
(bp) ,
582
(aa)
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Product
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fused lipid transporter subunits of ABCsuperfamily: membrane component/ATP-binding component
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Operon Name
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ycaI-msbA-lpxK-ycaQ
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Note
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ATP-binding transport protein; multicopy suppressor of htrB; GO_component: GO:0009274 - peptidoglycan-based cell wall; GO_component: GO:0019866 - organelle inner membrane
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Function
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transport; Transport of small molecules: Other
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Gene Ontology
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GO:0000166
;
nucleotide binding ( msbA )
GO:0005319
;
lipid transporter activity ( msbA )
GO:0005524
;
ATP binding ( msbA )
GO:0005624
;
membrane fraction ( msbA )
GO:0005886
;
plasma membrane ( msbA )
GO:0006810
;
transport ( msbA )
GO:0006869
;
lipid transport ( msbA )
GO:0009276
;
1-2nm peptidoglycan-based cell wall ( msbA )
GO:0016020
;
membrane ( msbA )
GO:0016021
;
integral to membrane ( msbA )
GO:0016787
;
hydrolase activity ( msbA )
GO:0016887
;
ATPase activity ( msbA )
GO:0017111
;
nucleoside-triphosphatase activity ( msbA )
GO:0042626
;
ATPase activity, coupled to transmembrane movement of substances ( msbA )
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PID
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1787143
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EC number
(KEGG Pathway)
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SWISS-PROT
(
Show details
[
2
more]
)
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Entry name(Acc.no)
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MSBA_ECOLI
(
P60752
;
P27299
)
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- Protein name
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Lipid A export ATP-binding/permease protein msbA.
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- Synonyms
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- Gene name
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Name=msbA; OrderedLocusNames=b0914;
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MMBR References
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Mol Microbiol. 1993;7(1):69-79.
The essential Escherichia coli msbA gene, a multicopy suppressor of null mutations in the htrB gene, is related to the universally conserved family of ATP-dependent translocators.
Karow M, Georgopoulos C.
(
8094880
)
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Mol Microbiol. 1996;20(6):1221-33.
Mutational analysis and properties of the msbA gene of Escherichia coli, coding for an essential ABC family transporter.
Polissi A, Georgopoulos C.
(
8809774
)
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| Sequences |
Amino acid
FASTA format
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0001 MHNDKDLSTW QTFRRLWPTI APFKAGLIVA GVALILNAAS DTFMLSLLKP LLDDGFGKTD RSVLVWMPLV
0071 VIGLMILRGI TSYVSSYCIS WVSGKVVMTM RRRLFGHMMG MPVSFFDKQS TGTLLSRITY DSEQVASSSS
0141 GALITVVREG ASIIGLFIMM FYYSWQLSII LIVLAPIVSI AIRVVSKRFR NISKNMQNTM GQVTTSAEQM
0211 LKGHKEVLIF GGQEVETKRF DKVSNRMRLQ GMKMVSASSI SDPIIQLIAS LALAFVLYAA SFPSVMDSLT
0281 AGTITVVFSS MIALMRPLKS LTNVNAQFQR GMAACQTLFT ILDSEQEKDE GKRVIERATG DVEFRNVTFT
0351 YPGRDVPALR NINLKIPAGK TVALVGRSGS GKSTIASLIT RFYDIDEGEI LMDGHDLREY TLASLRNQVA
0421 LVSQNVHLFN DTVANNIAYA RTEQYSREQI EEAARMAYAM DFINKMDNGL DTVIGENGVL LSGGQRQRIA
0491 IARALLRDSP ILILDEATSA LDTESERAIQ AALDELQKNR TSLVIAHRLS TIEKADEIVV VEDGVIVERG
0561 THNDLLEHRG VYAQLHKMQF GQ
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Nucleotide
FASTA format
View sequence out neighbor 100bp
|
-100 CAGGGAGCAA ATTTTACCTC GTTGGTATCA
-070 TCAGTGGTTT GGCGTGCCAG TGGATAACGG GTAGAATATG CGGCTATTTC AACAAATGCT GGTTTTTTGA
0001 atgcataacg acaaagatct ctctacgtgg cagacattcc gccgactgtg gccaaccatt gcgcctttca
0071 aagcgggtct gatcgtggcg ggcgtagcgt taatcctcaa cgcagccagc gataccttca tgttatcgct
0141 ccttaagcca cttcttgatg atggctttgg taaaacagat cgctccgtgc tggtgtggat gccgctggtg
0211 gtgatcgggc tgatgatttt acgtggtatc accagctatg tctccagcta ctgtatctcc tgggtatcag
0281 gaaaggtggt aatgaccatg cgtcgccgcc tgtttggtca catgatggga atgccagttt cattctttga
0351 caaacagtca acgggtacgc tgttgtcacg tattacctac gattccgaac aggttgcttc ttcttcttcc
0421 ggcgcactga ttactgttgt gcgtgaaggt gcgtcgatca tcggcctgtt catcatgatg ttctattaca
0491 gttggcaact gtcgatcatt ttgattgtgc tggcaccgat tgtttcgatt gcgattcgcg ttgtatcgaa
0561 gcgttttcgc aacatcagta aaaacatgca gaacaccatg gggcaggtga ccaccagcgc agaacaaatg
0631 ctgaagggcc acaaagaagt attgattttc ggtggtcagg aagtggaaac gaaacgcttt gataaagtca
0701 gcaaccgaat gcgtcttcag gggatgaaaa tggtttcagc ctcttccatc tctgatccga tcattcagct
0771 gatcgcctct ttggcgctgg cgtttgttct gtatgcggcg agcttcccaa gtgtcatgga tagcctgact
0841 gccggtacga ttaccgttgt tttctcttca atgattgcac tgatgcgtcc gctgaaatcg ctgaccaacg
0911 ttaacgccca gttccagcgc ggtatggcgg cttgtcagac gctgtttacc attctggaca gtgagcagga
0981 gaaagatgaa ggtaagcgcg tgatcgagcg tgcgactggc gacgtggaat tccgcaatgt cacctttact
1051 tatccgggac gtgacgtacc tgcattgcgt aacatcaacc tgaaaattcc ggcagggaag acggttgctc
1121 tggttggacg ctctggttcg ggtaaatcaa ccatcgccag cctgatcacg cgtttttacg atattgatga
1191 aggcgaaatc ctgatggatg gtcacgatct gcgcgagtat accctggcgt cgttacgtaa ccaggttgct
1261 ctggtgtcgc agaatgtcca tctgtttaac gatacggttg ctaacaacat tgcttacgca cggactgaac
1331 agtacagccg tgagcaaatt gaagaagcgg cgcgtatggc ctacgccatg gacttcatca ataagatgga
1401 taacggtctc gatacagtga ttggtgaaaa cggcgtgctg ctctctggcg gtcagcgtca gcgtattgct
1471 atcgctcgag ccttgttgcg tgatagcccg attctgattc tggacgaagc tacctcggct ctggataccg
1541 aatccgaacg tgcgattcag gcggcactgg atgagttgca gaaaaaccgt acctctctgg tgattgccca
1611 ccgcttgtct accattgaaa aggcagacga aatcgtggtc gtcgaggatg gtgtcattgt ggaacgcggt
1681 acgcataacg atttgcttga gcaccgcggc gtttacgcgc aacttcacaa aatgcagttt ggccaatgaT
1751 CGAAAAAATC TGGTCTGGTG AATCCCCTTT GTGGCGGCTA TTGCTGCCAC TCTCCTGGTT GTATGGCCTG
1821 GTGAGTGGCG CGATCCGTCT TTGCTATAA
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