|
PEC Original Annotations
|
|
Essentiality
|
|
Class
|
non-essential
|
|
References (PMID)
|
Proc Natl Acad Sci U S A. 1990;87(1):360-3.
Mutations in the bglY gene increase the frequency of spontaneous deletions in Escherichia coli K-12.
Lejeune P, Danchin A.
(
2404280
)
|
|
|
Deletion
|
15
(LD)
,
DE(pgl-grxA)502
,
DE(galETK-chlA)
,
15+dps
(LD)
,
OCR48,49-4
(D)
,
OCR48,50-8 (LD 15D::Cm)
(D)
|
|
Related gene (W3110 PEC)
|
|
Gene Search
|
Search MG1655 PEC by gene name:
modC
|
|
Related strains
|
|
Strains Search
|
Search strains by gene name:
modC
Search strains by all related name:
modC b0765 chlD ECK0754 JW0748 narD
|
General information (Go to Linear View: )
|
|
Gene Name
|
modC
|
|
Alternative name
|
b0765,chlD,ECK0754,JW0748,narD
|
|
Location, Length
|
795,777 - 796,835
(
+
)
;
17.15
min
;
1059
(bp) ,
352
(aa)
|
|
Product
|
molybdate transporter subunit
|
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Operon Name
|
modABC
|
|
Note
|
ATP-binding component of molybdate transport; GO_component: GO:0005737 - cytoplasm; GO_process: GO:0006777 - Mo-molybdopterin cofactor biosynthetic process
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Function
|
transport; Transport of small molecules: Anions
|
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Gene Ontology
|
GO:0000166
;
nucleotide binding ( modC )
GO:0005215
;
transporter activity ( modC )
GO:0005515
;
protein binding ( modC )
GO:0005524
;
ATP binding ( modC )
GO:0005886
;
plasma membrane ( modC )
GO:0006810
;
transport ( modC )
GO:0009276
;
1-2nm peptidoglycan-based cell wall ( modC )
GO:0015098
;
molybdate ion transmembrane transporter activity ( modC )
GO:0015412
;
molybdate transmembrane-transporting ATPase activity ( modC )
GO:0015689
;
molybdate ion transport ( modC )
GO:0016020
;
membrane ( modC )
GO:0016787
;
hydrolase activity ( modC )
GO:0016820
;
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances ( modC )
GO:0016887
;
ATPase activity ( modC )
GO:0017111
;
nucleoside-triphosphatase activity ( modC )
GO:0030151
;
molybdenum ion binding ( modC )
GO:0043190
;
ATP-binding cassette (ABC) transporter complex ( modC )
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PID
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1786981
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EC number
(KEGG Pathway)
|
3.6.3.29
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|
SWISS-PROT
(
Show details
[
2
more]
)
|
Entry name(Acc.no)
|
MODC_ECOLI
(
P09833
)
|
|
- Protein name
|
Molybdenum import ATP-binding protein modC
|
|
- Synonyms
|
EC 3.6.3.29
|
|
- Gene name
|
Name=modC; Synonyms=chlD, narD; OrderedLocusNames=b0765;
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Homology Analysis
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BLAST
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Bacteria
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GTOP
|
modC
(
homologous genes of other bacterias
)
|
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PDB
(database updated :
2007.02.20
)
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PSI-BLAST
|
Chain 1, Malk
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|
SWISS-PROT
(database updated :
2007.02.20
)
|
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BLAST
|
Molybdenum import ATP-binding protein modC
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|
PSI-BLAST
|
Sulfate/thiosulfate import ATP-binding protein cysA
|
|
nr
(database updated :
2007.02.20
)
|
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BLAST
|
molybdate transporter subunit [Escherichia coli K12]
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Pfam 28.0
(database updated :
2015-05
)
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Pfam
|
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PROSITE
|
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PROSITE
|
ASN_GLYCOSYLATION
GLYCOSAMINOGLYCAN
PKC_PHOSPHO_SITE
CK2_PHOSPHO_SITE
TYR_PHOSPHO_SITE
MYRISTYL
ATP_GTP_A
ABC_TRANSPORTER
|
|
MMBR References
|
J Bacteriol. 1982;149(2):469-78.
Molybdenum cofactor requirement for biotin sulfoxide reduction in Escherichia coli.
del Campillo-Campbell A, Campbell A.
(
6460021
)
|
J Bacteriol. 1979;138(3):726-30.
Use of chlC-lac fusions to determine regulation of gene chlC in Escherichia coli K-12.
Fimmel AL, Haddock BA.
(
110766
)
|
Mol Gen Genet. 1972;116(1):1-10.
Comparison of nitrate reductase mutants of Escherichia coli selected by alternative procedures.
Glaser JH, DeMoss JA.
(
4558444
)
|
Proc Natl Acad Sci U S A. 1968;61(3):956-62.
A deletion analysis of prophage lambda and adjacent genetic regions.
Adhya S, Cleary P, Campbell A.
(
5246560
)
|
Microbiol. Rev. 1983;47:180-230.
Linkage map of Escherichia coli K-12, edition 7.
Bachmann, B. J.
|
J Bacteriol. 1987;169(5):1911-6.
Cloning and nucleotide sequence of the chlD locus.
Johann S, Hinton SM.
(
3553151
)
|
J Bacteriol. 1996;178:4310-4312
Molybdenum cofactor biosynthesis in Escherichia coli mod and mog mutants.
Joshi, M. S., J. L. Johnson, and K. V. Rajagopalan.
|
J Bacteriol. 1995;177:4851-4856
Genetic analysis of the modABCD (molybdate transport) operon of Escherichia coli.
Maupin-Furlow, J. A., J. K. Rosentel, J. H. Lee, U. Deppenmeier, R. P. Gunsalus, and K. T. Shanmugam.
|
Nucleic Acids Symp Ser. 1995;-34:91-2.
Characterization and transcriptional regulation of the modABCD genes for molybdenum transport in Escherichia coli.
Miyake H, Yabu H, Satoh T, Yamamoto I.
(
8841567
)
|
J Bacteriol. 1995;177:1023-1029
Regulation of the molybdate transport operon, modABCD, of Escherichia coli in response to molybdate availability.
Rech, S., U. Deppenmeier, and R. P. Gunsalus.
|
Mol Microbiol. 1992;6(22):3452-4.
Proposed nomenclature for the genes involved in molybdenum metabolism in Escherichia coli and Salmonella typhimurium.
Shanmugam KT, Stewart V, Gunsalus RP, Boxer DH, Cole JA, Chippaux M, DeMoss JA, Giordano G, Lin EC, Rajagopalan KV.
(
1484496
)
|
Microbiol Res. 1995;150(4):347-61.
Molecular analysis of the molybdate uptake operon, modABCD, of Escherichia coli and modR, a regulatory gene.
Walkenhorst HM, Hemschemeier SK, Eichenlaub R.
(
8564363
)
|
| Sequences |
Amino acid
FASTA format
|
0001 MLELNFSQTL GNHCLTINET LPANGITAIF GVSGAGKTSL INAISGLTRP QKGRIVLNGR VLNDAEKGIC
0071 LTPEKRRVGY VFQDARLFPH YKVRGNLRYG MSKSMVDQFD KLVALLGIEP LLDRLPGSLS GGEKQRVAIG
0141 RALLTAPELL LLDEPLASLD IPRKRELLPY LQRLTREINI PMLYVSHSLD EILHLADRVM VLENGQVKAF
0211 GALEEVWGSS VMNPWLPKEQ QSSILKVTVL EHHPHYAMTA LALGDQHLWV NKLDEPLQAA LRIRIQASDV
0281 SLVLQPPQQT SIRNVLRAKV VNSYDDNGQV EVELEVGGKT LWARISPWAR DELAIKPGLW LYAQIKSVSI
0351 TA
|
Nucleotide
FASTA format
View sequence out neighbor 100bp
|
-100 CGGCGAGACT GTGCATTATT TCTATTGCGC
-070 TGGCGATGAT CTCCCTGTTG ATTTCAGAAT GGCTGGCCAG AATCAGCCGT GAACGGGCGG GGCGCTAATC
0001 atgctggaac tgaatttttc ccagacgttg ggcaaccatt gcctgactat taatgaaacg ctgcccgcca
0071 atggcatcac tgctatcttt ggcgtctccg gtgccggaaa aacttcgctg attaacgcca tcagtggact
0141 gacgcgcccg caaaaagggc ggattgtcct caatgggcgg gtactaaatg atgccgaaaa aggtatctgc
0211 ctgacgccgg aaaagcgtcg cgttggctat gtttttcagg atgcgcggct gttcccgcat tacaaagtgc
0281 gtggcaatct gcgctacggc atgtcgaaaa gtatggtcga tcagttcgat aagctggtgg cgcttttagg
0351 cattgaaccg ttgcttgacc gtttaccagg cagcctgtcc ggaggcgaaa aacagcgcgt ggcgattggt
0421 cgggctttgc tgacagcacc ggaattgctg ttgctggatg aaccgctggc gtcactggat attccgcgta
0491 aacgcgaact gttgccttat ctgcaacggc tgacacggga aatcaacatt ccgatgttgt atgtcagcca
0561 ttcgctggat gagatcctcc atctggcaga cagagtgatg gtactggaaa acggtcaggt gaaagccttt
0631 ggcgcgctgg aggaagtgtg gggcagtagc gtgatgaatc cgtggctgcc gaaagagcaa caaagtagca
0701 ttctgaaagt gacggtgctt gagcatcatc cgcattacgc gatgaccgcg ctggcgctgg gcgatcagca
0771 tttgtgggtc aataagctgg acgaaccgct gcaagctgcg ctacgtatcc gcattcaggc ttccgatgtt
0841 tctctggttt tacaaccgcc gcagcaaacc agcattcgta acgtattgcg ggcaaaagtt gttaatagtt
0911 atgacgacaa cggccaggtg gaagtggaac tggaagtcgg cggtaaaacg ctgtgggcgc gtatcagccc
0981 gtgggccagg gatgaactgg cgatcaaacc tggcctgtgg ctgtacgcgc aaattaaaag tgtgtcgata
1051 accgcctgaT TAAATCAGGT GGCTATAAAT GAACTGGGCA ATGCTGTCGG TGGTGTTATC ACCAATCACA
1121 ATGTTGGCGC GCGCTTTTAC CGCGTCATCG GCGTTGCCC
|
