|
PEC Original Annotations
|
|
Essentiality
|
|
Class
|
non-essential
|
|
References (PMID)
|
Gene. 1993;136(1-2):231-6.
Cloning and organization of the abc and mdl genes of Escherichia coli: relationship to eukaryotic multidrug resistance.
Allikmets R, Gerrard B, Court D, Dean M.
(
7904973
)
|
|
|
Deletion
|
OCR41
(D)
|
|
Related gene (W3110 PEC)
|
|
Gene Search
|
Search MG1655 PEC by gene name:
mdlA
|
|
Related strains
|
|
Strains Search
|
Search strains by gene name:
mdlA
Search strains by all related name:
mdlA b0448 b0449 ECK0442 JW0438 mdl o590 o593
|
General information (Go to Linear View: )
|
|
Gene Name
|
mdlA
|
|
Alternative name
|
b0448,b0449,ECK0442,JW0438,mdl,o590,o593
|
|
Location, Length
|
468,095 - 469,867
(
+
)
;
10.09
min
;
1773
(bp) ,
590
(aa)
|
|
Product
|
fused predicted multidrug transporter subunits of ABC superfamily: ATP-binding components
|
|
Operon Name
|
mdlAB
|
|
Note
|
GO_component: GO:0009274 - peptidoglycan-based cell wall; GO_component: GO:0019866 - organelle inner membrane; GO_process: GO:0042493 - response to drug
|
|
Function
|
|
|
Gene Ontology
|
GO:0000166
;
nucleotide binding ( mdlA )
GO:0005524
;
ATP binding ( mdlA )
GO:0005886
;
plasma membrane ( mdlA )
GO:0006810
;
transport ( mdlA )
GO:0008559
;
xenobiotic-transporting ATPase activity ( mdlA )
GO:0016020
;
membrane ( mdlA )
GO:0016021
;
integral to membrane ( mdlA )
GO:0016787
;
hydrolase activity ( mdlA )
GO:0016887
;
ATPase activity ( mdlA )
GO:0017111
;
nucleoside-triphosphatase activity ( mdlA )
GO:0042626
;
ATPase activity, coupled to transmembrane movement of substances ( mdlA )
|
|
PID
|
1786653
|
EC number
(KEGG Pathway)
|
|
|
SWISS-PROT
(
Show details
[
3
more]
)
|
Entry name(Acc.no)
|
MDLB_ECOLI
(
P75706
;
P30751; P77117
)
|
|
- Protein name
|
Multidrug resistance-like ATP-binding protein mdlB.
|
|
- Synonyms
|
|
|
- Gene name
|
OrderedLocusNames=b0449, c0566, z0559, ECs0503;
|
|
Homology Analysis
|
|
BLAST
|
|
Bacteria
|
|
GTOP
|
mdlA
(
homologous genes of other bacterias
)
|
|
PDB
(database updated :
2007.02.20
)
|
|
PSI-BLAST
|
Chain A, Multidrug Abc Transporter Sav1866
|
|
SWISS-PROT
(database updated :
2007.02.20
)
|
|
BLAST
|
Multidrug resistance-like ATP-binding protein mdlA
|
|
PSI-BLAST
|
Lipid A export ATP-binding/permease protein msbA
|
|
nr
(database updated :
2007.02.20
)
|
|
BLAST
|
fused predicted multidrug transporter subunits of ABC superfamily: ATP-binding components [Escherichia coli K12]
|
|
Pfam 28.0
(database updated :
2015-05
)
|
|
Pfam
|
|
|
PROSITE
|
|
PROSITE
|
|
| Sequences |
Amino acid
FASTA format
|
0001 MRLFAQLSWY FRREWRRYLG AVALLVIIAM LQLVPPKVVG IVVDGVTEQH FTTGQILMWI ATMVLIAVVV
0071 YLLRYVWRVL LFGASYQLAV ELREDYYRQL SRQHPEFYLR HRTGDLMARA TNDVDRVVFA AGEGVLTLVD
0141 SLVMGCAVLI MMSTQISWQL TLFSLLPMPV MAIMIKRNGD ALHERFKLAQ AAFSSLNDRT QESLTSIRMI
0211 KAFGLEDRQS ALFAADAEDT GKKNMRVARI DARFDPTIYI AIGMANLLAI GGGSWMVVQG SLTLGQLTSF
0281 MMYLGLMIWP MLALAWMFNI VERGSAAYSR IRAMLAEAPV VNDGSEPVPE GRGELDVNIH QFTYPQTDHP
0351 ALENVNFALK PGQMLGICGP TGSGKSTLLS LIQRHFDVSE GDIRFHDIPL TKLQLDSWRS RLAVVSQTPF
0421 LFSDTVANNI ALGCPNATQQ EIEHVARLAS VHDDILRLPQ GYDTEVGERG VMLSGGQKQR ISIARALLVN
0491 AEILILDDAL SAVDGRTEHQ ILHNLRQWGQ GRTVIISAHR LSALTEASEI IVMQHGHIAQ RGNHDVLAQQ
0561 SGWYRDMYRY QQLEAALDDA PENREEAVDA
|
Nucleotide
FASTA format
View sequence out neighbor 100bp
|
-100 GGCTGTCGGA CGTCACTTCC AGCTTCGCGA
-070 TGGAACAGAT TAAATACACC ACTTCTTTAC CCATCGAATA AATATCCAGA ATCAGGTCAG GACACAACGC
0001 gtgcgattat ttgctcaatt aagctggtat ttccgtcggg aatggcgtcg ctatctcggg gctgtcgcct
0071 tgcttgtcat tatcgcgatg ctgcaactgg ttccgccaaa agtggttggt attgttgtcg atggcgtgac
0141 agaacaacac tttactaccg ggcagatcct gatgtggatc gccaccatgg tgctgattgc cgttgtggtt
0211 tatctcctgc gttacgtctg gcgggtattg ctgtttggtg cgtcttatca actggctgtt gaactgcgtg
0281 aagattatta ccgtcagcta agccggcagc atcctgagtt ttacctgcgt catcgcaccg gtgacctcat
0351 ggctcgtgcg accaatgacg tcgatcgcgt cgtgtttgcc gccggagaag gggtgctgac gctggtggat
0421 tcactggtga tgggctgcgc tgtgttgatt atgatgtcta cgcaaattag ctggcagttg accttatttt
0491 ccctgttgcc gatgccagtg atggcgatca tgattaagcg caacggcgat gctttgcatg aacgctttaa
0561 gctggcacag gcggcgtttt ccagtcttaa tgaccgcacc caggaaagcc tcaccagtat ccgcatgatc
0631 aaagcctttg gtctggaaga tcgccagtcg gcgttatttg ccgcggatgc cgaagatacc ggcaaaaaaa
0701 acatgcgggt ggcgcgtatt gatgctcgtt tcgacccgac catctatatc gcgattggta tggcgaactt
0771 gctggcgatt ggcggcggta gttggatggt ggtgcagggc agtttaacgc tgggccagct caccagtttt
0841 atgatgtatt taggtctgat gatttggcca atgctggcgc tggcatggat gtttaacatt gtggaacgtg
0911 gtagtgctgc gtacagccgt attcgcgcga tgctggcgga agcgccggtg gtgaacgatg gtagcgaacc
0981 cgtgccggaa gggcgtggcg aactggatgt aaatattcac cagttcacgt atccgcagac tgaccatcct
1051 gcgctggaaa acgtcaattt cgccctgaaa cccggtcaga tgctgggtat ctgcgggccg actggttccg
1121 gcaaaagtac cctgttgtcg ctcattcagc gtcatttcga cgtcagcgag ggggatattc gctttcatga
1191 tattcctctg acgaagttac aactcgatag ctggcgtagc cgcctggcgg tagttagcca gacgccattc
1261 cttttttctg acactgtggc gaataacatc gcgctgggtt gcccgaatgc cacccagcaa gagattgagc
1331 atgtcgcgcg gttagccagc gtacatgacg atattttgcg tctaccgcaa ggttacgata cagaggtggg
1401 cgagcgcggt gtgatgcttt ccggcgggca aaaacagcgt atctccattg ctcgtgcgtt attagtcaac
1471 gcggaaatcc tcatccttga tgatgcgctt tcggcggtgg acggacgcac tgagcaccag atcctgcata
1541 acctgcgtca gtgggggcag ggaagaacgg taatcatcag tgcccatcgc ctttctgcac tgacggaagc
1611 cagtgaaatt attgtgatgc agcacggaca tatcgcccag cgtggcaatc atgatgtgct ggcacaacaa
1681 agcggctggt atcgcgatat gtatcgctat caacaactgg aggcggcgct cgacgacgct ccggaaaatc
1751 gcgaggaggc cgtcgatgcg tagTTTTAGC CAACTGTGGC CGACTCTCAA GCGCCTGTTA GCGTACGGTT
1821 CGCCGTGGCG TAAACCGCTG GGGATTGCGG TCCTGATGAT GTGGGTTGCG GCG
|
