MG1655
W3110
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Gene Report : argI
PEC Original Annotations
Essentiality
     Class non-essential
     References (PMID)
J Bacteriol. 1978;136(3):839-43.
Isolation of Escherichia coli mutants with changed regulation of uracil uptake.
Fast R. ( 363695 )
     Deletion OCR19 (D)  
Related gene (W3110 PEC)
     Gene Search Search MG1655 PEC by gene name:  argI
Related strains
     Strains Search Search strains by gene name:  argI   Search strains by all related name:  argI b4254 ECK4247 JW4211

General information  (Go to Linear View:)
 Gene Name argI  
 Alternative name b4254,ECK4247,JW4211  
 Location, Length 4,475,330 - 4,476,334 (  -  ) ;   96.46 min ; 1005 (bp) ,   334 (aa) Go to Linear View
 Product ornithine carbamoyltransferase 1  
 Operon Name argI  
 Note GO_component: GO:0005737 - cytoplasm; GO_process: GO:0006526 - arginine biosynthetic process  
 Function enzyme; Amino acid biosynthesis: Arginine  
 Gene Ontology GO:0004585; ornithine carbamoyltransferase activity ( argI )
GO:0005737; cytoplasm ( argI )
GO:0006520; amino acid metabolic process ( argI )
GO:0006526; arginine biosynthetic process ( argI )
GO:0008652; amino acid biosynthetic process ( argI )
GO:0009348; ornithine carbamoyltransferase complex ( argI )
GO:0016597; amino acid binding ( argI )
GO:0016740; transferase activity ( argI )
GO:0016743; carboxyl- or carbamoyltransferase activity ( argI )
 PID 1790703  
 EC number
  (KEGG Pathway)
 
2.1.3.3  
Verified Protein Starts (data compiled from literature and appropriate citations are available from EcoGene)
     EcoGene argI ( EG10069 )  
    Number of removed 1 aa cleaved  
SWISS-PROT  ( Show details [ 2 more] )
  botton Entry name(Acc.no) OTC1_ECOLI ( P04391 )
    -  Protein name Ornithine carbamoyltransferase chain I  
    -  Synonyms EC 2.1.3.3, OTCase-1  
    -  Gene name Name=argI; OrderedLocusNames=b4254;  

 Linear View (Whole Mode)
View Location
   4465.0  –  4490.0 (KBP)

Homology Analysis
BLAST
    Bacteria
         GTOP argI (  homologous genes of other bacterias  )  
    PDB     (database updated : 2007.02.20 )
         PSI-BLAST Chain A, Ornithine Transcarbamylase From Escherichia Coli  
    SWISS-PROT     (database updated : 2007.02.20 )
         BLAST Ornithine carbamoyltransferase chain I  
         PSI-BLAST Ornithine carbamoyltransferase
    nr     (database updated : 2007.02.20 )
         BLAST ornithine carbamoyltransferase 1 [Escherichia coli K12]  
Pfam 28.0   (database updated : 2015-05 )
    Pfam
PROSITE
    PROSITE ASN_GLYCOSYLATION    PKC_PHOSPHO_SITE    CK2_PHOSPHO_SITE    TYR_PHOSPHO_SITE    MYRISTYL    AMIDATION    CARBAMOYLTRANSFERASE     

Other Cross-Reference
    COG COG0078E 
    EcoCyc argI 

MMBR References
Nucleic Acids Res. 1983;11:8509-8518
The DNA sequence of argI from Escherichia coli K12.
Bencini, D. A., J. E. Houghton, T. A. Hoover, K. F. Folterman, J. R. Wild, and G. A. O'Donovan.
EMBO J. 1982;1(7):853-7.
Homologous control sites and DNA transcription starts in the related argF and argI genes of Escherichia coli K12.
Piette J, Cunin R, Van Vliet F, Charlier D, Crabeel M, Ota Y, Glansdorff N. ( 6329710 )
Mol Gen Genet. 1982;187(3):391-400.
The organization and regulation of the pyrBI operon in E. coli includes a rho-independent attenuator sequence.
Roof WD, Foltermann KF, Wild JR. ( 6294470 )

Sequences
Amino acid
FASTA format
0001 MSGFYHKHFL KLLDFTPAEL NSLLQLAAKL KADKKSGKEE AKLTGKNIAL IFEKDSTRTR CSFEVAAYDQ 
0071 GARVTYLGPS GSQIGHKESI KDTARVLGRM YDGIQYRGYG QEIVETLAEY ASVPVWNGLT NEFHPTQLLA 
0141 DLLTMQEHLP GKAFNEMTLV YAGDARNNMG NSMLEAAALT GLDLRLVAPQ ACWPEAALVT ECRALAQQNG 
0211 GNITLTEDVA KGVEGADFIY TDVWVSMGEA KEKWAERIAL LREYQVNSKM MQLTGNPEVK FLHCLPAFHD 
0281 DQTTLGKKMA EEFGLHGGME VTDEVFESAA SIVFDQAENR MHTIKAVMVA TLSK

Nucleotide
FASTA format

View sequence out neighbor 100bp
-100                                             cacctttgtg acaaagattt atgctttaga 
-070 cttgcaaatg aataatcatc catataaatt gaattttaat tcattgaggc gttagccaca ggagggatct 
0001 atgtccgggt tttatcataa gcatttcctg aaattactcg atttcacgcc agctgaactc aacagcctgc 
0071 tgcagttagc cgcgaagctg aaagccgata agaaaagcgg taaagaagaa gccaaactca ctggtaaaaa 
0141 catcgcgctc atcttcgaaa aagactcgac tcgtacccga tgctctttcg aagttgccgc atatgaccag 
0211 ggtgctcgcg ttacttatct cggcccaagc ggcagccaga ttggtcataa agagtcgatt aaagacactg 
0281 cccgcgtgct tggtcgcatg tatgacggta ttcagtatcg cggctatggt caggagattg tcgaaacact 
0351 ggcggaatac gctagcgtgc cggtatggaa tggcctgacc aatgagttcc atcccacgca gctgctggcg 
0421 gatcttctca ccatgcagga gcatttgccc ggcaaagcgt tcaacgaaat gacgctggtc tatgcaggtg 
0491 acgcgcgtaa caacatgggc aattcgatgc tcgaagctgc ggcgcttacc ggtctggatt tgcgtctggt 
0561 cgcgccacaa gcgtgctggc cggaagctgc gctggttacg gaatgccgcg ccctggcaca gcaaaatggt 
0631 gggaatatta cgctgactga agatgtcgcg aagggagttg aaggtgctga ctttatctat accgatgtgt 
0701 gggtgtcgat gggggaagca aaagagaaat gggcggaacg gattgcattg ctgcgtgaat atcaggtgaa 
0771 cagcaagatg atgcagttga ccggtaaccc ggaggtcaaa ttcctccact gcctgcccgc gtttcatgac 
0841 gaccaaacga cgcttggcaa gaaaatggcg gaagaatttg gcctacatgg cggtatggaa gtcactgatg 
0911 aggtcttcga atctgccgcc agcattgttt ttgatcaggc ggaaaaccgt atgcatacta tcaaagcggt 
0981 gatggtcgcg acgctcagta aataattgct atcgctataa agatgccggg aaatacaaac catcccggca 
1051 tcacattatt ttatgcagtg ataggtctat tcttccaccc aaagtgttct attgc