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PEC Original Annotations
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Essentiality
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Class
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non-essential
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References (PMID)
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Proc Natl Acad Sci U S A. 1986;83(7):2056-60.
A mutant of Escherichia coli fumarate reductase decoupled from electron transport.
Weiner JH, Cammack R, Cole ST, Condon C, Honore N, Lemire BD, Shaw G.
(
3008149
)
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Deletion
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OCR16-2
(D)
,
OCR16-4
(D)
,
OCR16-5
(D)
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Related gene (W3110 PEC)
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Gene Search
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Search MG1655 PEC by gene name:
frdA
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Related strains
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Strains Search
|
Search strains by gene name:
frdA
Search strains by all related name:
frdA b4154 ECK4150 JW4115
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General information (Go to Linear View: )
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Gene Name
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frdA
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Alternative name
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b4154,ECK4150,JW4115
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Location, Length
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4,378,533 - 4,380,341
(
-
)
;
94.37
min
;
1809
(bp) ,
602
(aa)
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Product
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fumarate reductase (anaerobic) catalytic andNAD/flavoprotein subunit
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Operon Name
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frdABCD
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Note
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fumarate reductase, anaerobic, flavoprotein subunit; GO_component: GO:0005737 - cytoplasm; GO_process: GO:0006113 - fermentation; GO_process: GO:0009061 - anaerobic respiration
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Function
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enzyme; Energy metabolism, carbon: Anaerobic respiration
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Gene Ontology
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GO:0000104
;
succinate dehydrogenase activity ( frdA )
GO:0005515
;
protein binding ( frdA )
GO:0006118
;
electron transport ( frdA )
GO:0006810
;
transport ( frdA )
GO:0009061
;
anaerobic respiration ( frdA )
GO:0016491
;
oxidoreductase activity ( frdA )
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PID
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1790597
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EC number
(KEGG Pathway)
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1.3.99.1
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SWISS-PROT
(
Show details
[
2
more]
)
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Entry name(Acc.no)
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FRDA_ECOLI
(
P00363
)
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- Protein name
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Fumarate reductase flavoprotein subunit
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- Synonyms
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EC 1.3.99.1
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- Gene name
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Name=frdA; OrderedLocusNames=b4154;
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MMBR References
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Nature. 1981;292(5820):269-71.
Recombination between short DNA homologies causes tandem duplication.
Edlund T, Normark S.
(
7019717
)
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Proc Natl Acad Sci U S A. 1982;79:1111-1115
Overlap between ampC and frd operons on the Escherichia coli chromosome.
Grundstrom, T., and B. Jaurin.
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J Bacteriol. 1985;164(3):1100-9.
Transcription of the Escherichia coli fumarate reductase genes (frdABCD) and their coordinate regulation by oxygen, nitrate, and fumarate.
Jones HM, Gunsalus RP.
(
2999070
)
|
Can J Biochem. 1981;59(3):158-64.
Cloning and expression of fumarate reductase gene of Escherichia coli.
Lohmeier E, Hagen DS, Dickie P, Weiner JH.
(
7013950
)
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J Biol Chem. 1989;264:13599-13604
Fumarate reductase mutants of Escherichia coli that lack covalently bound flavin.
Blaut, M., K. Whittaker, A. Valdovinos, B. A. Ackrell, R. P. Gunsalus, and G. Cecchini.
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Eur J Biochem. 1982;122:479-484
Nucleotide sequence coding for the flavoprotein subunit of the fumarate reductase of Escherichia coli.
Cole, S. T.
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Eur J Biochem. 1979;102:65-71
Production of a soluble form of fumarate reductase by multiple gene duplications in Escherichia coli K12.
Cole, S. T., and J. R. Guest.
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Mol Gen Genet. 1980;179(2):377-85.
Amplification of fumarate reductase synthesis with lambdafrdA transducing phages and orientation of frdA gene expression.
Cole ST, Guest JR.
(
6450867
)
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Mol Gen Genet. 1980;178(2):409-18.
Genetic and physical characterization of lambda transducing phages (lambda frdA) containing the fumarate reductase gene of Escherichia coli K12.
Cole ST, Guest JR.
(
6446651
)
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Eur J Biochem. 1982;126:211-216
Location and nucleotide sequence of frdB, the gene coding for the iron-sulphur protein subunit of the fumarate reductase of Escherichia coli.
Cole, S. T., T. Grundstrom, B. Jaurin, J. J. Robinson, and J. H. Weiner.
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| Sequences |
Amino acid
FASTA format
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0001 MQTFQADLAI VGAGGAGLRA AIAAAQANPN AKIALISKVY PMRSHTVAAE GGSAAVAQDH DSFEYHFHDT
0071 VAGGDWLCEQ DVVDYFVHHC PTEMTQLELW GCPWSRRPDG SVNVRRFGGM KIERTWFAAD KTGFHMLHTL
0141 FQTSLQFPQI QRFDEHFVLD ILVDDGHVRG LVAMNMMEGT LVQIRANAVV MATGGAGRVY RYNTNGGIVT
0211 GDGMGMALSH GVPLRDMEFV QYHPTGLPGS GILMTEGCRG EGGILVNKNG YRYLQDYGMG PETPLGEPKN
0281 KYMELGPRDK VSQAFWHEWR KGNTISTPRG DVVYLDLRHL GEKKLHERLP FICELAKAYV GVDPVKEPIP
0351 VRPTAHYTMG GIETDQNCET RIKGLFAVGE CSSVGLHGAN RLGSNSLAEL VVFGRLAGEQ ATERAATAGN
0421 GNEAAIEAQA AGVEQRLKDL VNQDGGENWA KIRDEMGLAM EEGCGIYRTP ELMQKTIDKL AELQERFKRV
0491 RITDTSSVFN TDLLYTIELG HGLNVAECMA HSAMARKESR GAHQRLDEGC TERDDVNFLK HTLAFRDADG
0561 TTRLEYSDVK ITTLPPAKRV YGGEADAADK AEAANKKEKA NG
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Nucleotide
FASTA format
View sequence out neighbor 100bp
|
-100 acctataaag gagcagtgga atagcgttcg
-070 cagaccgtaa ctttcaggta cttaccctga agtacgtggc tgtgggataa aaacaatctg gaggaatgtc
0001 gtgcaaacct ttcaagccga tcttgccatt gtaggcgccg gtggcgcggg attacgtgct gcaattgctg
0071 ccgcgcaggc aaatccgaat gcaaaaatcg cactaatctc aaaagtatac ccgatgcgta gccataccgt
0141 tgctgcagaa gggggctccg ccgctgtcgc gcaggatcat gacagcttcg aatatcactt tcacgataca
0211 gtagcgggtg gcgactggtt gtgtgagcag gatgtcgtgg attatttcgt ccaccactgc ccaaccgaaa
0281 tgacccaact ggaactgtgg ggatgcccat ggagccgtcg cccggatggt agcgtcaacg tacgtcgctt
0351 cggcggcatg aaaatcgagc gcacctggtt cgccgccgat aagaccggct tccatatgct gcacacgctg
0421 ttccagacct ctctgcaatt cccgcagatc cagcgttttg acgaacattt cgtgctggat attctggttg
0491 atgatggtca tgttcgcggc ctggtagcaa tgaacatgat ggaaggcacg ctggtgcaga tccgtgctaa
0561 cgcggtcgtt atggctactg gcggtgcggg tcgcgtttat cgttacaaca ccaacggcgg catcgttacc
0631 ggtgacggta tgggtatggc gctaagccac ggcgttccgc tgcgtgacat ggaattcgtt cagtatcacc
0701 caaccggtct gccaggttcc ggtatcctga tgaccgaagg ttgccgcggt gaaggcggta ttctggtcaa
0771 caaaaatggc taccgttatc tgcaagatta cggcatgggc ccggaaactc cgctgggcga gccgaaaaac
0841 aaatatatgg aactgggtcc acgcgacaaa gtctctcagg ccttctggca cgaatggcgt aaaggcaaca
0911 ccatctccac gccgcgtggc gatgtggttt atctcgactt gcgtcacctc ggcgagaaaa aactgcatga
0981 acgtctgccg ttcatctgcg aactggcgaa agcgtacgtt ggcgtcgatc cggttaaaga accgattccg
1051 gtacgtccga ccgcacacta caccatgggc ggtatcgaaa ccgatcagaa ctgtgaaacc cgcattaaag
1121 gtctgttcgc cgtgggtgaa tgttcctctg ttggtctgca cggtgcaaac cgtctgggtt ctaactccct
1191 ggcggaactg gtggtcttcg gccgtctggc cggtgaacaa gcgacagagc gtgcagcaac tgccggtaat
1261 ggcaacgaag cggcaattga agcgcaggca gctggcgttg aacaacgtct gaaagatctg gttaaccagg
1331 atggcggcga aaactgggcg aagatccgcg acgaaatggg cctggctatg gaagaaggct gcggtatcta
1401 ccgtacgccg gaactgatgc agaaaaccat cgacaagctg gcagagctgc aggaacgctt caagcgcgtg
1471 cgcatcaccg acacttccag cgtgttcaac accgacctgc tctacaccat tgaactgggc cacggtctga
1541 acgttgctga atgtatggcg cactccgcaa tggcacgtaa agagtcccgc ggcgcgcacc agcgtctgga
1611 cgaaggttgc accgagcgtg acgacgtcaa cttcctcaaa cacaccctcg ccttccgcga tgctgatggc
1681 acgactcgcc tggagtacag cgacgtgaag attactacgc tgccgccagc taaacgcgtt tacggtggcg
1751 aagcggatgc agccgataag gcggaagcag ccaataagaa ggagaaggcg aatggctgag atgaaaaacc
1821 tgaaaattga ggtggtgcgc tataacccgg aagtcgatac cgcaccgcat agcgcattct atgaagtgcc
1891 ttatgacgca actacctca
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