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PEC Original Annotations
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Essentiality
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Class
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non-essential
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References (PMID)
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Escherichia coli and Salmonella, Cellular and Molecular Biology Second Edition. ASM Press. 1996
Neidhart, F.C.
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Deletion
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OCR12,13-2
(D)
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Related gene (W3110 PEC)
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Gene Search
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Search MG1655 PEC by gene name:
uvrA
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Related strains
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Strains Search
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Search strains by gene name:
uvrA
Search strains by all related name:
uvrA b4058 dar ECK4050 JW4019 o940
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General information (Go to Linear View: )
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Gene Name
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uvrA
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Alternative name
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b4058,dar,ECK4050,JW4019,o940
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Location, Length
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4,269,072 - 4,271,894
(
-
)
;
92.01
min
;
2823
(bp) ,
940
(aa)
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Product
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ATPase and DNA damage recognition protein of nucleotide excision repair excinuclease UvrABC
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Operon Name
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uvrA
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Note
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excision nuclease subunit A; GO_component: GO:0005737 - cytoplasm; GO_process: GO:0006281 - DNA repair; GO_process: GO:0009314 - response to radiation; GO_process: GO:0009432 - SOS response
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Function
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enzyme; DNA - replication, repair,restriction/modification
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Gene Ontology
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GO:0000166
;
nucleotide binding ( uvrA )
GO:0003677
;
DNA binding ( uvrA )
GO:0004518
;
nuclease activity ( uvrA )
GO:0005515
;
protein binding ( uvrA )
GO:0005524
;
ATP binding ( uvrA )
GO:0005737
;
cytoplasm ( uvrA )
GO:0006281
;
DNA repair ( uvrA )
GO:0006289
;
nucleotide-excision repair ( uvrA )
GO:0006974
;
response to DNA damage stimulus ( uvrA )
GO:0008270
;
zinc ion binding ( uvrA )
GO:0009380
;
excinuclease repair complex ( uvrA )
GO:0009381
;
excinuclease ABC activity ( uvrA )
GO:0009432
;
SOS response ( uvrA )
GO:0016887
;
ATPase activity ( uvrA )
GO:0046872
;
metal ion binding ( uvrA )
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PID
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2367343
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EC number
(KEGG Pathway)
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Verified Protein Starts
(data
compiled from literature and appropriate citations are available from EcoGene)
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EcoGene
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uvrA
(
EG11061
)
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Number of removed
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0 aa cleaved
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SWISS-PROT
(
Show details
[
2
more]
)
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Entry name(Acc.no)
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UVRA_ECOLI
(
P07671
;
P76788
)
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- Protein name
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UvrABC system protein A
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- Synonyms
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UvrA protein, Excinuclease ABC subunit A
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- Gene name
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Name=uvrA; Synonyms=dinE; OrderedLocusNames=b4058, SF4146, S3583;
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MMBR References
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J Biol Chem. 1986;261:4895-4901
Sequences of Escherichia coli urvA gene and protein reveal two potential ATP binding sites.
Husain, I., B. Van Houten, D. C. Thomas, and A. Sancar.
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Nature. 1981;289(5800):808-10.
Expression of the E. coli uvrA gene is inducible.
Kenyon CJ, Walker GC.
(
6780917
)
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FEMS Microbiol Lett. 1994;117(2):217-23.
The cydD gene product, component of a heterodimeric ABC transporter, is required for assembly of periplasmic cytochrome c and of cytochrome bd in Escherichia coli.
Poole RK, Gibson F, Wu G.
(
8181727
)
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Annu Rev Biochem. 1996;65:43-81.
DNA excision repair.
Sancar A.
(
8811174
)
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Nature. 1982;298(5869):96-8.
LexA protein inhibits transcription of the E. coli uvrA gene in vitro.
Sancar A, Sancar GB, Rupp WD, Little JW, Mount DW.
(
6283374
)
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J Mol Biol. 1981;148(1):45-62.
Identification of the uvrA gene product.
Sancar A, Wharton RP, Seltzer S, Kacinski BM, Clarke ND, Rupp WD.
(
6273577
)
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Cell. 1983;33(1):249-60.
A novel repair enzyme: UVRABC excision nuclease of Escherichia coli cuts a DNA strand on both sides of the damaged region.
Sancar A, Rupp WD.
(
6380755
)
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| Sequences |
Amino acid
FASTA format
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0001 MDKIEVRGAR THNLKNINLV IPRDKLIVVT GLSGSGKSSL AFDTLYAEGQ RRYVESLSAY ARQFLSLMEK
0071 PDVDHIEGLS PAISIEQKST SHNPRSTVGT ITEIHDYLRL LFARVGEPRC PDHDVPLAAQ TVSQMVDNVL
0141 SQPEGKRLML LAPIIKERKG EHTKTLENLA SQGYIRARID GEVCDLSDPP KLELQKKHTI EVVVDRFKVR
0211 DDLTQRLAES FETALELSGG TAVVADMDDP KAEELLFSAN FACPICGYSM RELEPRLFSF NNPAGACPTC
0281 DGLGVQQYFD PDRVIQNPEL SLAGGAIRGW DRRNFYYFQM LKSLADHYKF DVEAPWGSLS ANVHKVVLYG
0351 SGKENIEFKY MNDRGDTSIR RHPFEGVLHN MERRYKETES SAVREELAKF ISNRPCASCE GTRLRREARH
0421 VYVENTPLPA ISDMSIGHAM EFFNNLKLAG QRAKIAEKIL KEIGDRLKFL VNVGLNYLTL SRSAETLSGG
0491 EAQRIRLASQ IGAGLVGVMY VLDEPSIGLH QRDNERLLGT LIHLRDLGNT VIVVEHDEDA IRAADHVIDI
0561 GPGAGVHGGE VVAEGPLEAI MAVPESLTGQ YMSGKRKIEV PKKRVPANPE KVLKLTGARG NNLKDVTLTL
0631 PVGLFTCITG VSGSGKSTLI NDTLFPIAQR QLNGATIAEP APYRDIQGLE HFDKVIDIDQ SPIGRTPRSN
0701 PATYTGVFTP VRELFAGVPE SRARGYTPGR FSFNVRGGRC EACQGDGVIK VEMHFLPDIY VPCDQCKGKR
0771 YNRETLEIKY KGKTIHEVLD MTIEEAREFF DAVPALARKL QTLMDVGLTY IRLGQSATTL SGGEAQRVKL
0841 ARELSKRGTG QTLYILDEPT TGLHFADIQQ LLDVLHKLRD QGNTIVVIEH NLDVIKTADW IVDLGPEGGS
0911 GGGEILVSGT PETVAECEAS HTARFLKPML
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Nucleotide
FASTA format
View sequence out neighbor 100bp
|
-100 tgtatattca ttcaggtcaa tttgtgtcat
-070 aattaaccgt ttgtgatcgc cggtagcacc atgccaccgg gcaaaaaagc gtttaatccg ggaaaggtga
0001 atggataaga tcgaagttcg gggcgcccgc acccataatc tcaaaaacat caacctcgtt atcccccgcg
0071 acaagctcat tgtcgtgacc gggctttcgg gttctggcaa atcctcgctc gctttcgaca ccttatatgc
0141 cgaagggcag cgccgttacg ttgaatccct ttccgcctac gcgcggcagt ttctgtcact gatggaaaag
0211 ccggacgtcg atcatattga ggggctttct cctgccatct caattgagca gaaatcgacg tctcataacc
0281 cgcgttctac ggtggggaca atcaccgaaa tccacgacta tttgcgtttg ttattcgccc gcgttggcga
0351 gccgcgctgt ccggaccacg acgtcccgct ggcggcgcaa accgtcagcc agatggtgga taacgtgctg
0421 tcgcagccgg aaggcaagcg tctgatgcta ctcgcgccaa tcattaaaga gcgcaaaggc gaacacacca
0491 aaacgctgga gaacctggca agccagggct acatccgtgc tcgtattgat ggcgaagtct gcgatctttc
0561 cgatccgcca aaactggaac tgcaaaagaa acataccatt gaagtggtgg ttgatcgctt caaggtgcgt
0631 gacgatctta cccaacgtct tgccgagtca tttgaaaccg cgctggagct ttccggtggt accgcggtag
0701 tggcggatat ggacgacccg aaagcggaag agctgctgtt ctccgccaac ttcgcctgcc caatttgcgg
0771 ctacagtatg cgtgaactgg agccgcgact gttttcgttt aacaacccgg cgggggcctg cccgacctgc
0841 gacggccttg gcgtacagca atatttcgat cctgatcgag tgatccagaa tccggaactg tcgctggctg
0911 gtggtgcgat ccgtggctgg gatcgccgca acttctatta tttccagatg ctgaaatcgc tggcagatca
0981 ctataagttc gacgtcgaag cgccgtgggg cagcctgagc gcgaacgtgc ataaagtggt gttgtacggt
1051 tctggcaaag aaaacattga attcaaatac atgaacgatc gtggcgatac ctccattcgt cgtcatccgt
1121 tcgaaggcgt gctgcataat atggagcgcc gctataaaga gacggaatcc agcgcggtac gcgaagaatt
1191 agccaagttt atcagtaatc gtccgtgcgc cagctgcgaa gggacgcgtc tgcgtcggga agcgcgccac
1261 gtgtatgtcg agaatacgcc gctgcctgct atctccgaca tgagcattgg tcatgcgatg gaattcttca
1331 acaatctcaa actcgcaggt cagcgggcga agattgcaga aaaaatcctt aaagagatcg gcgatcgtct
1401 gaaattcctc gttaacgtcg gcctgaatta cctgacgctt tcccgctcgg cagaaacgct ttctggcggt
1471 gaagcacagc gtatccgtct ggcgagccag attggtgcgg gcctggttgg cgttatgtac gtgctggacg
1541 agccgtctat cggcctgcac cagcgtgata acgagcgcct gttgggtacg cttatccatc tgcgcgatct
1611 cggtaatacc gtgattgtgg tggagcacga cgaagacgca attcgcgccg ctgaccatgt gatcgacatt
1681 ggcccgggcg caggtgttca cggcggtgaa gtggtcgcag aaggtccgct ggaagcgatt atggcggtgc
1751 cggagtcgtt gaccgggcag tacatgagcg gcaaacgcaa gattgaagtg ccgaagaaac gcgttccggc
1821 gaatccggaa aaagtgctga agctgacagg cgcacgcggc aacaacctga aggacgtgac gctgacgctg
1891 ccggtgggtc tgtttacctg catcaccggg gtttcaggtt ccggtaaatc gacgctgatt aacgacacac
1961 tgttcccgat tgcccaacgc cagttgaatg gggcgaccat cgccgaacca gcaccgtatc gcgatattca
2031 ggggctggag catttcgata aagtgatcga tatcgaccaa agcccaattg gtcgtactcc acgttctaac
2101 ccggcgacct ataccggcgt gtttacgcct gtgcgcgaac tgtttgcggg cgtaccggaa tcccgtgcgc
2171 gcggctatac gccgggacgt ttcagcttta acgttcgtgg cggacgctgc gaggcctgtc agggcgatgg
2241 cgtgatcaaa gtggagatgc acttcctgcc ggatatctac gtgccgtgcg accagtgcaa aggtaaacgc
2311 tataaccgtg aaacgctgga gattaagtac aaaggcaaaa ccatccacga agtgctggat atgaccatcg
2381 aagaggcgcg tgagttcttt gatgccgtac ctgcactggc gcgtaagctg caaacgttga tggacgttgg
2451 cctgacgtac attcgactgg ggcagtccgc aaccaccctt tcaggcggtg aagcccagcg cgtgaagctg
2521 gcgcgtgaac tgtcaaaacg cggcaccggg cagacgctgt atattctcga cgagccgacc accggtctgc
2591 acttcgccga tattcagcaa ctgctcgacg tactgcataa actgcgcgat cagggcaaca ccattgtggt
2661 gattgagcac aatctcgacg tgatcaaaac cgctgactgg attgtcgacc tgggaccaga aggcggcagt
2731 ggtggcggcg agatcctcgt ctccggtacg ccagaaaccg tcgcggagtg cgaagcatca cacacggcac
2801 gcttccttaa gccgatgctg taatcgttaa ggccgctttc tgagcggcct tttcctttca gagttgcacc
2871 agcaatttac gtttttcttc cggcagtaaa ttcaccgcct gctgataaga cgc
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