|
PEC Original Annotations
|
|
Essentiality
|
|
Class
|
essential
|
|
References (PMID)
|
Escherichia coli and Salmonella, Cellular and Molecular Biology Second Edition. ASM Press. 1996
Neidhart, F.C.
|
|
|
Deletion
|
OCR10,11-11 (AK1-16 / BK2-16)
(D)
,
OCR10,11-16 (BK5-16 / AK7-16)
(D)
|
|
Related gene (W3110 PEC)
|
|
Gene Search
|
Search MG1655 PEC by gene name:
coaA
|
|
Related strains
|
|
Strains Search
|
Search strains by gene name:
coaA
Search strains by all related name:
coaA b3974 ECK3966 JW3942 panK rts ts-9
|
General information (Go to Linear View: )
|
|
Gene Name
|
coaA
|
|
Alternative name
|
b3974,ECK3966,JW3942,panK,rts,ts-9
|
|
Location, Length
|
4,172,099 - 4,173,049
(
-
)
;
89.92
min
;
951
(bp) ,
316
(aa)
|
|
Product
|
pantothenate kinase
|
|
Operon Name
|
coaA
|
|
Note
|
GO_process: GO:0015937 - coenzyme A biosynthetic process
|
|
Function
|
enzyme; Biosynthesis of cofactors, carriers: Pantothenate
|
|
Gene Ontology
|
GO:0000166
;
nucleotide binding ( coaA )
GO:0004594
;
pantothenate kinase activity ( coaA )
GO:0005524
;
ATP binding ( coaA )
GO:0005737
;
cytoplasm ( coaA )
GO:0008152
;
metabolic process ( coaA )
GO:0015937
;
coenzyme A biosynthetic process ( coaA )
GO:0016301
;
kinase activity ( coaA )
GO:0016740
;
transferase activity ( coaA )
|
|
PID
|
1790409
|
EC number
(KEGG Pathway)
|
2.7.1.33
|
|
SWISS-PROT
(
Show details
)
|
Entry name(Acc.no)
|
COAA_ECOLI
(
P15044
)
|
|
- Protein name
|
Pantothenate kinase
|
|
- Synonyms
|
EC 2.7.1.33, Pantothenic acid kinase, Rts protein
|
|
- Gene name
|
OrderedLocusNames=b3974, c4933, z5545, ECs4901;
|
|
Homology Analysis
|
|
BLAST
|
|
Bacteria
|
|
GTOP
|
coaA
(
homologous genes of other bacterias
)
|
|
PDB
(database updated :
2007.02.20
)
|
|
PSI-BLAST
|
Chain A, Crystal Structure Of E. Coli Pantothenate Kinase
|
|
SWISS-PROT
(database updated :
2007.02.20
)
|
|
BLAST
|
Pantothenate kinase (Pantothenic acid kinase) (Rts protein)
|
|
PSI-BLAST
|
Phosphate import ATP-binding protein pstB
|
|
nr
(database updated :
2007.02.20
)
|
|
BLAST
|
pantothenate kinase [Escherichia coli CFT073]
|
|
Pfam 28.0
(database updated :
2015-05
)
|
|
Pfam
|
|
|
PROSITE
|
|
PROSITE
|
ASN_GLYCOSYLATION
PKC_PHOSPHO_SITE
CK2_PHOSPHO_SITE
ATP_GTP_A
|
|
MMBR References
|
Gene. 1988;74(2):555-8.
The nucleotide sequence of the Escherichia coli rts gene.
Flamm JA, Friesen JD, Otsuka AJ.
(
3073109
)
|
J Bacteriol. 1992;174:6411-6417
Cloning, sequencing, and expression of the pantothenate kinase (coaA) gene of Escherichia coli.
Song, W. J., and S. Jackowski.
|
J Bacteriol. 1992;174(5):1705-6.
coaA and rts are allelic and located at kilobase 3532 on the Escherichia coli physical map.
Song WJ, Jackowski S.
(
1311303
)
|
J Bacteriol. 1987;169(12):5795-800.
Isolation and characterization of temperature-sensitive pantothenate kinase (coaA) mutants of Escherichia coli.
Vallari DS, Rock CO.
(
2824448
)
|
| Sequences |
Amino acid
FASTA format
|
0001 MSIKEQTLMT PYLQFDRNQW AALRDSVPMT LSEDEIARLK GINEDLSLEE VAEIYLPLSR LLNFYISSNL
0071 RRQAVLEQFL GTNGQRIPYI ISIAGSVAVG KSTTARVLQA LLSRWPEHRR VELITTDGFL HPNQVLKERG
0141 LMKKKGFPES YDMHRLVKFV SDLKSGVPNV TAPVYSHLIY DVIPDGDKTV VQPDILILEG LNVLQSGMDY
0211 PHDPHHVFVS DFVDFSIYVD APEDLLQTWY INRFLKFREG AFTDPDSYFH NYAKLTKEEA IKTAMTLWKE
0281 INWLNLKQNI LPTRERASLI LTKSANHAVE EVRLRK
|
Nucleotide
FASTA format
View sequence out neighbor 100bp
|
-100 tggtgttacc ctcctgccca ttaacccatt
-070 caacagaact gtgacgcgcc atggcaaata tcgctttgcc gatagagcta tgaccgccag aaacatgctt
0001 atgagtataa aagagcaaac gttaatgacg ccttacctac agtttgaccg caaccagtgg gcagctctgc
0071 gtgattccgt acctatgacg ttatcggaag atgagatcgc ccgtctcaaa ggtattaatg aagatctctc
0141 gttagaagaa gttgccgaga tctatttacc tttgtcacgt ttgctgaact tctatataag ctcgaatctg
0211 cgccgtcagg cagttctgga acagtttctt ggtaccaacg ggcaacgcat tccttacatt atcagtattg
0281 ctggcagtgt cgcggtgggg aaaagtacaa ccgcccgtgt attgcaggcg ctattaagcc gttggccgga
0351 acatcgtcgt gttgaactga tcactacaga tggcttcctt caccctaatc aggttctgaa agaacgtggt
0421 ctgatgaaga agaaaggctt cccggaatcg tatgatatgc atcgcctggt gaagtttgtt tccgatctca
0491 aatccggcgt gccaaacgtt acagcacctg tttactcaca tcttatttat gatgtgatcc cggatggaga
0561 taaaacggtt gttcagcctg atattttaat tcttgaaggg ttaaatgtct tacagagcgg gatggattat
0631 ccacacgatc cacatcatgt atttgtttct gattttgtcg atttttcgat atatgttgat gcaccggaag
0701 acttacttca gacatggtat atcaaccgtt ttctgaaatt ccgcgaaggg gcttttaccg acccggattc
0771 ctattttcat aactacgcga aattaactaa agaagaagcg attaagactg ccatgacatt gtggaaagag
0841 atcaactggc tgaacttaaa gcaaaatatt ctacctactc gtgagcgcgc cagtttaatc ctgacgaaaa
0911 gtgctaatca tgcggtagaa gaggtcagac tacgcaaata atttgcaggg gagcgaatac tcccctttct
0981 tatttttctg cactacgcag ggatatttca ccgcccatcc agggttttat tattccatcc tgctcaagta
1051 a
|
