|
PEC Original Annotations
|
|
Essentiality
|
|
Class
|
non-essential
|
|
References (PMID)
|
Escherichia coli and Salmonella, Cellular and Molecular Biology Second Edition. ASM Press. 1996
Neidhart, F.C.
|
|
|
Deletion
|
9-1
(LD)
,
OCR36,37-6 (LD 9C::Ap)
(D)
,
OCR37
(D)
|
|
Related gene (W3110 PEC)
|
|
Gene Search
|
Search MG1655 PEC by gene name:
mhpF
|
|
Related strains
|
|
Strains Search
|
Search strains by gene name:
mhpF
Search strains by all related name:
mhpF b0351 ECK0348 JW0342 mhpE o316
|
General information (Go to Linear View: )
|
|
Gene Name
|
mhpF
|
|
Alternative name
|
b0351,ECK0348,JW0342,mhpE,o316
|
|
Location, Length
|
372,145 - 373,095
(
+
)
;
8.02
min
;
951
(bp) ,
316
(aa)
|
|
Product
|
acetaldehyde-CoA dehydrogenase II, NAD-binding
|
|
Operon Name
|
mhpABCDFE
|
|
Note
|
acetaldehyde dehydrogenase; GO_component: GO:0005737 - cytoplasm; GO_process: GO:0019395 - fatty acid oxidation
|
|
Function
|
enzyme; Degradation of small molecules: Carbon compounds
|
|
Gene Ontology
|
GO:0003824
;
catalytic activity ( mhpE )
GO:0003824
;
catalytic activity ( mhpF )
GO:0005488
;
binding ( mhpF )
GO:0005737
;
cytoplasm ( mhpF )
GO:0006520
;
amino acid metabolic process ( mhpF )
GO:0008152
;
metabolic process ( mhpE )
GO:0008152
;
metabolic process ( mhpF )
GO:0008774
;
acetaldehyde dehydrogenase (acetylating) activity ( mhpF )
GO:0016491
;
oxidoreductase activity ( mhpF )
GO:0016620
;
oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor ( mhpF )
GO:0016829
;
lyase activity ( mhpE )
GO:0016833
;
oxo-acid-lyase activity ( mhpE )
GO:0019439
;
aromatic compound catabolic process ( mhpE )
GO:0019439
;
aromatic compound catabolic process ( mhpF )
GO:0051287
;
NAD binding ( mhpF )
|
|
PID
|
1786547
|
EC number
(KEGG Pathway)
|
1.2.1.10
|
|
SWISS-PROT
(
Show details
[
3
more]
)
|
Entry name(Acc.no)
|
MHPE_ECOLI
(
P51020
;
P77787
)
|
|
- Protein name
|
4-hydroxy-2-oxovalerate aldolase
|
|
- Synonyms
|
EC 4.1.3.-, HOA
|
|
- Gene name
|
Name=mhpE; Synonyms=mhpF; OrderedLocusNames=b0352;
|
|
Homology Analysis
|
|
BLAST
|
|
Bacteria
|
|
GTOP
|
mhpF
(
homologous genes of other bacterias
)
mhpE
(
homologous genes of other bacterias
)
|
|
PDB
(database updated :
2007.02.20
)
|
|
PSI-BLAST
|
Chain B, Crystal Structure Of A Bifunctional Aldolase-Dehydrogenase : Sequestering A Reactive And Volatile Intermediate
|
|
SWISS-PROT
(database updated :
2007.02.20
)
|
|
BLAST
|
Acetaldehyde dehydrogenase
|
|
PSI-BLAST
|
Acetaldehyde dehydrogenase
|
|
nr
(database updated :
2007.02.20
)
|
|
BLAST
|
acetaldehyde dehydrogenase [Escherichia coli K12]
|
|
Pfam 28.0
(database updated :
2015-05
)
|
|
Pfam
|
|
|
PROSITE
|
|
PROSITE
|
PKC_PHOSPHO_SITE
CK2_PHOSPHO_SITE
MYRISTYL
|
|
MMBR References
|
In J. Blair (ed.), Chemistry and biology of pteridines. W. de Gruyter, New York, N.Y. 1983:585-589
Isolation and characterization of an E. coli mutant affected in dihydrofolate- and folylpolyglutamate-synthetase.
Ferone, R., S. C. Singer, M. H. Hanlon, and S. Roland.
|
J Bacteriol. 1997;179:2573-2581
Genetic characterization and expression in heterologous hosts of the 3-(3-hydroxyphenyl)propionate catabolic pathway of Escherichia coli K-12.
Ferrandez, A., J. L. Garcia, and E. Diaz.
|
| Sequences |
Amino acid
FASTA format
|
0001 MSKRKVAIIG SGNIGTDLMI KILRHGQHLE MAVMVGIDPQ SDGLARARRM GVATTHEGVI GLMNMPEFAD
0071 IDIVFDATSA GAHVKNDAAL REAKPDIRLI DLTPAAIGPY CVPVVNLEAN VDQLNVNMVT CGGQATIPMV
0141 AAVSRVARVH YAEIIASIAS KSAGPGTRAN IDEFTETTSR AIEVVGGAAK GKAIIVLNPA EPPLMMRDTV
0211 YVLSDEASQD DIEASINEMA EAVQAYVPGY RLKQRVQFEV IPQDKPVNLP GVGQFSGLKT AVWLEVEGAA
0281 HYLPAYAGNL DIMTSSALAT AEKMAQSLAR KAGEAA
|
Nucleotide
FASTA format
View sequence out neighbor 100bp
|
-100 TGGTGGCGGT GAATGCGGGC GATCGTTTTG
-070 AAGCCCATAT TGAAGGCATA GGTTCAGTTG CTGCGACATT TTCAAGCGCA GCCCCAAAAG GAAGTCTGTC
0001 atgagtaagc gtaaagtcgc cattatcggt tctggcaaca ttggtaccga tctgatgatt aaaattttgc
0071 gtcacggtca gcatctggag atggcggtga tggttggcat tgatcctcag tccgacggtc tggcgcgcgc
0141 cagacgtatg ggcgtcgcca ccacccatga aggggtgatc ggactgatga acatgcctga atttgctgat
0211 atcgacattg tatttgatgc gaccagcgcc ggtgctcatg tgaaaaacga tgccgcttta cgcgaagcga
0281 aaccggatat tcgcttaatt gacctgacgc ctgctgccat cggcccttac tgcgtgccgg tggttaacct
0351 cgaggcgaac gtcgatcaac tgaacgtcaa catggtcacc tgcggcggcc aggccaccat tccaatggtg
0421 gcggcagttt cacgcgtggc gcgtgttcat tacgccgaaa ttatcgcttc tatcgccagt aaatctgccg
0491 gacctggcac gcgtgccaat atcgatgaat ttacggaaac cacttcccga gccattgaag tggtgggcgg
0561 cgcggcaaaa gggaaggcga ttattgtgct taacccagca gagccaccgt tgatgatgcg tgacacggtg
0631 tatgtattga gcgacgaagc ttcacaagat gatatcgaag cctcaatcaa tgaaatggct gaggcggtgc
0701 aggcttacgt accgggttat cgcctgaaac agcgcgtgca gtttgaagtt atcccgcagg ataaaccggt
0771 caatttaccg ggcgtggggc aattctccgg actgaaaaca gcggtctggc tggaagtcga aggcgcagcg
0841 cattatctgc ctgcctatgc gggcaacctc gacattatga cttccagtgc gctggcgaca gcggaaaaaa
0911 tggcccagtc actggcgcgc aaggcaggag aagcggcatg aACGGTAAAA AACTTTATAT CTCGGACGTC
0981 ACATTGCGTG ACGGTATGCA CGCCATTCGT CATCAGTATT CGCTGGAAAA CGTTCGCCAG ATTGCCAAAG
1051 C
|
