|
PEC Original Annotations
|
|
Essentiality
|
|
Class
|
essential
|
|
References (PMID)
|
|
|
Deletion
|
OCL18,19-8 (AK1-13 / BK2-13)
(D)
|
|
Related gene (W3110 PEC)
|
|
Gene Search
|
Search MG1655 PEC by gene name:
asd
|
|
Related strains
|
|
Strains Search
|
Search strains by gene name:
asd
Search strains by all related name:
asd b3433 dap ECK3419 f367 hom JW3396
|
General information (Go to Linear View: )
|
|
Gene Name
|
asd
|
|
Alternative name
|
b3433,dap,ECK3419,f367,hom,JW3396
|
|
Location, Length
|
3,571,798 - 3,572,901
(
-
)
;
76.98
min
;
1104
(bp) ,
367
(aa)
|
|
Product
|
aspartate-semialdehyde dehydrogenase, NAD(P)-binding
|
|
Operon Name
|
asd
|
|
Note
|
aspartate-semialdehyde dehydrogenase; GO_process: GO:0009089 - lysine biosynthetic process via diaminopimelate; GO_process: GO:0009088 - threonine biosynthetic process; GO_process: GO:0009086 - methionine biosynthetic process; GO_process: GO:0009090 - homoserine biosynthetic process
|
|
Function
|
enzyme; Amino acid biosynthesis: Lysine
|
|
Gene Ontology
|
GO:0003824
;
catalytic activity ( asd )
GO:0004073
;
aspartate-semialdehyde dehydrogenase activity ( asd )
GO:0005488
;
binding ( asd )
GO:0005515
;
protein binding ( asd )
GO:0005737
;
cytoplasm ( asd )
GO:0006520
;
amino acid metabolic process ( asd )
GO:0008152
;
metabolic process ( asd )
GO:0008652
;
amino acid biosynthetic process ( asd )
GO:0009085
;
lysine biosynthetic process ( asd )
GO:0009089
;
lysine biosynthetic process via diaminopimelate ( asd )
GO:0016491
;
oxidoreductase activity ( asd )
GO:0016620
;
oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor ( asd )
GO:0019877
;
diaminopimelate biosynthetic process ( asd )
GO:0046983
;
protein dimerization activity ( asd )
GO:0050661
;
NADP binding ( asd )
GO:0051287
;
NAD binding ( asd )
|
|
PID
|
1789841
|
EC number
(KEGG Pathway)
|
1.2.1.11
|
|
Verified Protein Starts
(data
compiled from literature and appropriate citations are available from EcoGene)
|
|
EcoGene
|
asd
(
EG10088
)
|
|
Number of removed
|
0 aa cleaved
|
|
SWISS-PROT
(
Show details
[
1
more]
)
|
Entry name(Acc.no)
|
DHAS_ECOLI
(
P00353
)
|
|
- Protein name
|
Aspartate-semialdehyde dehydrogenase
|
|
- Synonyms
|
EC 1.2.1.11, ASA dehydrogenase, ASADH
|
|
- Gene name
|
OrderedLocusNames=b3433, z4797, ECs4278, SF3456, S4307;
|
|
MMBR References
|
Biochimie. 1982;64(3):227-30.
Identification of the promoter of the asd gene of Escherichia coli using in vitro fusion with the lac operon.
Haziza C, Cassan M, Patte JC.
(
6137244
)
|
EMBO J. 1982;1(3):379-84.
Nucleotide sequence of the asd gene of Escherichia coli: absence of a typical attenuation signal.
Haziza C, Stragier P, Patte JC.
(
6143662
)
|
J Biol Chem. 1981;256:6944-6952
Biosynthesis of bacterial glycogen. Cloning of the glycogen biosynthetic enzyme structural genes of Escherichia coli.
Okita, T. W., R. L. Rodriguez, and J. Preiss.
|
J Bacteriol. 1966;92(4):1083-9.
Location of the maltose A and B loci on the genetic map of Escherichia coli.
Schwartz M.
(
5332865
)
|
| Sequences |
Amino acid
FASTA format
|
0001 MKNVGFIGWR GMVGSVLMQR MVEERDFDAI RPVFFSTSQL GQAAPSFGGT TGTLQDAFDL EALKALDIIV
0071 TCQGGDYTNE IYPKLRESGW QGYWIDAASS LRMKDDAIII LDPVNQDVIT DGLNNGIRTF VGGNCTVSLM
0141 LMSLGGLFAN DLVDWVSVAT YQAASGGGAR HMRELLTQMG HLYGHVADEL ATPSSAILDI ERKVTTLTRS
0211 GELPVDNFGV PLAGSLIPWI DKQLDNGQSR EEWKGQAETN KILNTSSVIP VDGLCVRVGA LRCHSQAFTI
0281 KLKKDVSIPT VEELLAAHNP WAKVVPNDRE ITMRELTPAA VTGTLTTPVG RLRKLNMGPE FLSAFTVGDQ
0351 LLWGAAEPLR RMLRQLA
|
Nucleotide
FASTA format
View sequence out neighbor 100bp
|
-100 tttcacttgc gactttggct gctttttgta
-070 tggtgaaaga tgtgccaaga ggagaccggc acatttatac agcacacatc tttgcaggaa aaaaacgctt
0001 atgaaaaatg ttggttttat cggctggcgc ggtatggtcg gctccgttct catgcaacgc atggttgaag
0071 agcgcgactt cgacgccatt cgccctgtct tcttttctac ttctcagctt ggccaggctg cgccgtcttt
0141 tggcggaacc actggcacac ttcaggatgc ctttgatctg gaggcgctaa aggccctcga tatcattgtg
0211 acctgtcagg gcggcgatta taccaacgaa atctatccaa agcttcgtga aagcggatgg caaggttact
0281 ggattgacgc agcatcgtct ctgcgcatga aagatgacgc catcatcatt cttgaccccg tcaatcagga
0351 cgtcattacc gacggattaa ataatggcat caggactttt gttggcggta actgtaccgt aagcctgatg
0421 ttgatgtcgt tgggtggttt attcgccaat gatcttgttg attgggtgtc cgttgcaacc taccaggccg
0491 cttccggcgg tggtgcgcga catatgcgtg agttattaac ccagatgggc catctgtatg gccatgtggc
0561 agatgaactc gcgaccccgt cctctgctat tctcgatatc gaacgcaaag tcacaacctt aacccgtagc
0631 ggtgagctgc cggtggataa ctttggcgtg ccgctggcgg gtagcctgat tccgtggatc gacaaacagc
0701 tcgataacgg tcagagccgc gaagagtgga aagggcaggc ggaaaccaac aagatcctca acacatcttc
0771 cgtaattccg gtagatggtt tatgtgtgcg tgtcggggca ttgcgctgcc acagccaggc attcactatt
0841 aaattgaaaa aagatgtgtc tattccgacc gtggaagaac tgctggctgc gcacaatccg tgggcgaaag
0911 tcgttccgaa cgatcgggaa atcactatgc gtgagctaac cccagctgcc gttaccggca cgctgaccac
0981 gccggtaggc cgcctgcgta agctgaatat gggaccagag ttcctgtcag cctttaccgt gggcgaccag
1051 ctgctgtggg gggccgcgga gccgctgcgt cggatgcttc gtcaactggc gtaatcttta ttcattaaat
1121 ctggggcgcg atgccgcccc tgttagtgcg taatacagga gtaagcgcag atgtttcatg atttaccggg
1191 agttaaatag agca
|
